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57 similar compounds to monomer 50428111

Compile data set for download or QSAR
Wt: 438.5
BDBM127362
Wt: 466.5
BDBM127363
Wt: 468.5
BDBM127364
Wt: 467.5
BDBM127365
Wt: 481.5
BDBM127366
Wt: 480.5
BDBM127367
Wt: 495.5
BDBM127368
Wt: 463.4
BDBM127391
Wt: 463.4
BDBM127398
Wt: 482.5
BDBM127369
Wt: 496.5
BDBM127370
Wt: 424.4
BDBM127371
Wt: 488.5
BDBM127382
Wt: 495.5
BDBM127383
Wt: 475.5
BDBM127376
Displayed 1 to 15 (of 57 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 127362,127363,127364,127365,127366,127367,127368,127391,127398,127369,127370,127371,127382,127383,127376   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127363
PNG
(US8791131, 121)
Show SMILES CCC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C27H26N6O2/c1-3-24(34)32-12-10-19(11-13-32)33-26-23(31(2)27(33)35)16-29-22-9-8-21(30-25(22)26)18-14-17-6-4-5-7-20(17)28-15-18/h4-9,14-16,19H,3,10-13H2,1-2H3
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US Patent
0.539 -12.6n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127364
PNG
(US8791131, 122)
Show SMILES COC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C26H24N6O3/c1-30-22-15-28-21-8-7-20(17-13-16-5-3-4-6-19(16)27-14-17)29-23(21)24(22)32(25(30)33)18-9-11-31(12-10-18)26(34)35-2/h3-8,13-15,18H,9-12H2,1-2H3
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US Patent
0.806 -12.4n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127391
PNG
(US8791131, 154)
Show SMILES COc1ncc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)[C@H](C)O)c3c2n1
Show InChI InChI=1/C23H25N7O4/c1-13(31)21(32)29-8-6-15(7-9-29)30-20-18(28(2)23(30)33)12-24-17-5-4-16(27-19(17)20)14-10-25-22(34-3)26-11-14/h4-5,10-13,15,31H,6-9H2,1-3H3/t13-/s2
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0.822 -12.4n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127367
PNG
(US8791131, 125)
Show SMILES CC(C)C(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C28H28N6O2/c1-17(2)27(35)33-12-10-20(11-13-33)34-26-24(32(3)28(34)36)16-30-23-9-8-22(31-25(23)26)19-14-18-6-4-5-7-21(18)29-15-19/h4-9,14-17,20H,10-13H2,1-3H3
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US Patent
1.06 -12.2n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127369
PNG
(US8791131, 127)
Show SMILES CCOC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C27H26N6O3/c1-3-36-27(35)32-12-10-19(11-13-32)33-25-23(31(2)26(33)34)16-29-22-9-8-21(30-24(22)25)18-14-17-6-4-5-7-20(17)28-15-18/h4-9,14-16,19H,3,10-13H2,1-2H3
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1.38 -12.1n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127365
PNG
(US8791131, 123)
Show SMILES CNC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C26H25N7O2/c1-27-25(34)32-11-9-18(10-12-32)33-24-22(31(2)26(33)35)15-29-21-8-7-20(30-23(21)24)17-13-16-5-3-4-6-19(16)28-14-17/h3-8,13-15,18H,9-12H2,1-2H3,(H,27,34)
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US Patent
1.96 -11.9n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127382
PNG
(US8791131, 144)
Show SMILES CN(C)CC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(nc2)N(C)C)n(C)c1=O
Show InChI InChI=1S/C26H32N8O2/c1-30(2)16-23(35)33-12-10-18(11-13-33)34-25-21(32(5)26(34)36)15-27-20-8-7-19(29-24(20)25)17-6-9-22(28-14-17)31(3)4/h6-9,14-15,18H,10-13,16H2,1-5H3
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2.10 -11.8n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127376
PNG
(US8791131, 138)
Show SMILES COc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)CN(C)C)c3c2n1
Show InChI InChI=1S/C25H29N7O3/c1-29(2)15-22(33)31-11-9-17(10-12-31)32-24-20(30(3)25(32)34)14-26-19-7-6-18(28-23(19)24)16-5-8-21(35-4)27-13-16/h5-8,13-14,17H,9-12,15H2,1-4H3
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US Patent
2.23 -11.8n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127398
PNG
(US8791131, 161)
Show SMILES COCC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc(OC)nc2)n(C)c1=O
Show InChI InChI=1S/C23H25N7O4/c1-28-18-12-24-17-5-4-16(14-10-25-22(34-3)26-11-14)27-20(17)21(18)30(23(28)32)15-6-8-29(9-7-15)19(31)13-33-2/h4-5,10-12,15H,6-9,13H2,1-3H3
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US Patent
2.52 -11.7n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127368
PNG
(US8791131, 126)
Show SMILES CN(C)CC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C28H29N7O2/c1-32(2)17-25(36)34-12-10-20(11-13-34)35-27-24(33(3)28(35)37)16-30-23-9-8-22(31-26(23)27)19-14-18-6-4-5-7-21(18)29-15-19/h4-9,14-16,20H,10-13,17H2,1-3H3
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US Patent
2.55 -11.7n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127391
PNG
(US8791131, 154)
Show SMILES COc1ncc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)[C@H](C)O)c3c2n1
Show InChI InChI=1/C23H25N7O4/c1-13(31)21(32)29-8-6-15(7-9-29)30-20-18(28(2)23(30)33)12-24-17-5-4-16(27-19(17)20)14-10-25-22(34-3)26-11-14/h4-5,10-13,15,31H,6-9H2,1-3H3/t13-/s2
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2.59 -11.7n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127370
PNG
(US8791131, 128)
Show SMILES CC(C)OC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C28H28N6O3/c1-17(2)37-28(36)33-12-10-20(11-13-33)34-26-24(32(3)27(34)35)16-30-23-9-8-22(31-25(23)26)19-14-18-6-4-5-7-21(18)29-15-19/h4-9,14-17,20H,10-13H2,1-3H3
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US Patent
2.89 -11.6n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127362
PNG
(US8791131, 119)
Show SMILES CCN1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C26H26N6O/c1-3-31-12-10-19(11-13-31)32-25-23(30(2)26(32)33)16-28-22-9-8-21(29-24(22)25)18-14-17-6-4-5-7-20(17)27-15-18/h4-9,14-16,19H,3,10-13H2,1-2H3
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US Patent
3.19 -11.6n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127368
PNG
(US8791131, 126)
Show SMILES CN(C)CC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C28H29N7O2/c1-32(2)17-25(36)34-12-10-20(11-13-34)35-27-24(33(3)28(35)37)16-30-23-9-8-22(31-26(23)27)19-14-18-6-4-5-7-21(18)29-15-19/h4-9,14-16,20H,10-13,17H2,1-3H3
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US Patent
3.42 -11.5n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127383
PNG
(US8791131, 145)
Show SMILES Cn1c2cnc3ccc(nc3c2n(C2CCN(CC2)C(=O)C(C)(C)N)c1=O)-c1cnc2ccccc2c1
Show InChI InChI=1S/C28H29N7O2/c1-28(2,29)26(36)34-12-10-19(11-13-34)35-25-23(33(3)27(35)37)16-31-22-9-8-21(32-24(22)25)18-14-17-6-4-5-7-20(17)30-15-18/h4-9,14-16,19H,10-13,29H2,1-3H3
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3.92 -11.5n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127366
PNG
(US8791131, 124)
Show SMILES CCNC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C27H27N7O2/c1-3-28-26(35)33-12-10-19(11-13-33)34-25-23(32(2)27(34)36)16-30-22-9-8-21(31-24(22)25)18-14-17-6-4-5-7-20(17)29-15-18/h4-9,14-16,19H,3,10-13H2,1-2H3,(H,28,35)
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4.04 -11.4n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127369
PNG
(US8791131, 127)
Show SMILES CCOC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C27H26N6O3/c1-3-36-27(35)32-12-10-19(11-13-32)33-25-23(31(2)26(33)34)16-29-22-9-8-21(30-24(22)25)18-14-17-6-4-5-7-20(17)28-15-18/h4-9,14-16,19H,3,10-13H2,1-2H3
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US Patent
4.30 -11.4n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127367
PNG
(US8791131, 125)
Show SMILES CC(C)C(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C28H28N6O2/c1-17(2)27(35)33-12-10-20(11-13-33)34-26-24(32(3)28(34)36)16-30-23-9-8-22(31-25(23)26)19-14-18-6-4-5-7-21(18)29-15-19/h4-9,14-17,20H,10-13H2,1-3H3
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US Patent
4.87 -11.3n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127371
PNG
(US8791131, 129)
Show SMILES CN1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C25H24N6O/c1-29-11-9-18(10-12-29)31-24-22(30(2)25(31)32)15-27-21-8-7-20(28-23(21)24)17-13-16-5-3-4-6-19(16)26-14-17/h3-8,13-15,18H,9-12H2,1-2H3
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US Patent
4.90 -11.3n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127365
PNG
(US8791131, 123)
Show SMILES CNC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C26H25N7O2/c1-27-25(34)32-11-9-18(10-12-32)33-24-22(31(2)26(33)35)15-29-21-8-7-20(30-23(21)24)17-13-16-5-3-4-6-19(16)28-14-17/h3-8,13-15,18H,9-12H2,1-2H3,(H,27,34)
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US Patent
4.91 -11.3n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127398
PNG
(US8791131, 161)
Show SMILES COCC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc(OC)nc2)n(C)c1=O
Show InChI InChI=1S/C23H25N7O4/c1-28-18-12-24-17-5-4-16(14-10-25-22(34-3)26-11-14)27-20(17)21(18)30(23(28)32)15-6-8-29(9-7-15)19(31)13-33-2/h4-5,10-12,15H,6-9,13H2,1-3H3
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US Patent
4.97 -11.3n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127371
PNG
(US8791131, 129)
Show SMILES CN1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C25H24N6O/c1-29-11-9-18(10-12-29)31-24-22(30(2)25(31)32)15-27-21-8-7-20(28-23(21)24)17-13-16-5-3-4-6-19(16)26-14-17/h3-8,13-15,18H,9-12H2,1-2H3
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US Patent
5.92 -11.2n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127363
PNG
(US8791131, 121)
Show SMILES CCC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C27H26N6O2/c1-3-24(34)32-12-10-19(11-13-32)33-26-23(31(2)27(33)35)16-29-22-9-8-21(30-25(22)26)18-14-17-6-4-5-7-20(17)28-15-18/h4-9,14-16,19H,3,10-13H2,1-2H3
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US Patent
7.90 -11.0n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127382
PNG
(US8791131, 144)
Show SMILES CN(C)CC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(nc2)N(C)C)n(C)c1=O
Show InChI InChI=1S/C26H32N8O2/c1-30(2)16-23(35)33-12-10-18(11-13-33)34-25-21(32(5)26(34)36)15-27-20-8-7-19(29-24(20)25)17-6-9-22(28-14-17)31(3)4/h6-9,14-15,18H,10-13,16H2,1-5H3
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US Patent
7.99 -11.0n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127362
PNG
(US8791131, 119)
Show SMILES CCN1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C26H26N6O/c1-3-31-12-10-19(11-13-31)32-25-23(30(2)26(32)33)16-28-22-9-8-21(29-24(22)25)18-14-17-6-4-5-7-20(17)27-15-18/h4-9,14-16,19H,3,10-13H2,1-2H3
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US Patent
8.11 -11.0n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127370
PNG
(US8791131, 128)
Show SMILES CC(C)OC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C28H28N6O3/c1-17(2)37-28(36)33-12-10-20(11-13-33)34-26-24(32(3)27(34)35)16-30-23-9-8-22(31-25(23)26)19-14-18-6-4-5-7-21(18)29-15-19/h4-9,14-17,20H,10-13H2,1-3H3
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US Patent
9.72 -10.9n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127376
PNG
(US8791131, 138)
Show SMILES COc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)CN(C)C)c3c2n1
Show InChI InChI=1S/C25H29N7O3/c1-29(2)15-22(33)31-11-9-17(10-12-31)32-24-20(30(3)25(32)34)14-26-19-7-6-18(28-23(19)24)16-5-8-21(35-4)27-13-16/h5-8,13-14,17H,9-12,15H2,1-4H3
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US Patent
10.6 -10.9n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127364
PNG
(US8791131, 122)
Show SMILES COC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C26H24N6O3/c1-30-22-15-28-21-8-7-20(17-13-16-5-3-4-6-19(16)27-14-17)29-23(21)24(22)32(25(30)33)18-9-11-31(12-10-18)26(34)35-2/h3-8,13-15,18H,9-12H2,1-2H3
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US Patent
12.4 -10.8n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127383
PNG
(US8791131, 145)
Show SMILES Cn1c2cnc3ccc(nc3c2n(C2CCN(CC2)C(=O)C(C)(C)N)c1=O)-c1cnc2ccccc2c1
Show InChI InChI=1S/C28H29N7O2/c1-28(2,29)26(36)34-12-10-19(11-13-34)35-25-23(33(3)27(35)37)16-31-22-9-8-21(32-24(22)25)18-14-17-6-4-5-7-20(17)30-15-18/h4-9,14-16,19H,10-13,29H2,1-3H3
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US Patent
13.3 -10.7n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair