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34 similar compounds to monomer 50428115

Compile data set for download or QSAR
Wt: 466.5
BDBM127363
Wt: 480.5
BDBM127367
Wt: 495.5
BDBM127368
Wt: 463.4
BDBM127391
Wt: 463.4
BDBM127398
Wt: 476.5
BDBM127399
Wt: 391.4
BDBM127378
Wt: 432.5
BDBM127375
Wt: 475.5
BDBM127376
Wt: 447.4
BDBM127377
Wt: 447.4
BDBM127380
Wt: 431.4
BDBM127408
Wt: 459.5
BDBM127409
Wt: 431.4
BDBM127411
Wt: 432.4
BDBM127412
Displayed 1 to 15 (of 34 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 127363,127367,127368,127391,127398,127399,127378,127375,127376,127377,127380,127408,127409,127411,127412   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127411
PNG
(US8791131, 180)
Show SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)CN)c3c2n1
Show InChI InChI=1S/C23H25N7O2/c1-14-3-4-15(12-25-14)17-5-6-18-21(27-17)22-19(13-26-18)28(2)23(32)30(22)16-7-9-29(10-8-16)20(31)11-24/h3-6,12-13,16H,7-11,24H2,1-2H3
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US Patent
0.320 -12.9n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127377
PNG
(US8791131, 139)
Show SMILES COc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC(N)=O)CC4)c3c2n1
Show InChI InChI=1S/C23H25N7O3/c1-28-18-12-25-17-5-4-16(14-3-6-20(33-2)26-11-14)27-21(17)22(18)30(23(28)32)15-7-9-29(10-8-15)13-19(24)31/h3-6,11-12,15H,7-10,13H2,1-2H3,(H2,24,31)
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US Patent
0.339 -12.9n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127363
PNG
(US8791131, 121)
Show SMILES CCC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C27H26N6O2/c1-3-24(34)32-12-10-19(11-13-32)33-26-23(31(2)27(33)35)16-29-22-9-8-21(30-25(22)26)18-14-17-6-4-5-7-20(17)28-15-18/h4-9,14-16,19H,3,10-13H2,1-2H3
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0.539 -12.6n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127378
PNG
(US8791131, 140)
Show SMILES COc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCOCC4)c3c2n1
Show InChI InChI=1S/C21H21N5O3/c1-25-17-12-22-16-5-4-15(13-3-6-18(28-2)23-11-13)24-19(16)20(17)26(21(25)27)14-7-9-29-10-8-14/h3-6,11-12,14H,7-10H2,1-2H3
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US Patent
0.668 -12.5n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127391
PNG
(US8791131, 154)
Show SMILES COc1ncc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)[C@H](C)O)c3c2n1
Show InChI InChI=1/C23H25N7O4/c1-13(31)21(32)29-8-6-15(7-9-29)30-20-18(28(2)23(30)33)12-24-17-5-4-16(27-19(17)20)14-10-25-22(34-3)26-11-14/h4-5,10-13,15,31H,6-9H2,1-3H3/t13-/s2
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US Patent
0.822 -12.4n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127408
PNG
(US8791131, 176)
Show SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC(N)=O)CC4)c3c2n1
Show InChI InChI=1S/C23H25N7O2/c1-14-3-4-15(11-25-14)17-5-6-18-21(27-17)22-19(12-26-18)28(2)23(32)30(22)16-7-9-29(10-8-16)13-20(24)31/h3-6,11-12,16H,7-10,13H2,1-2H3,(H2,24,31)
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0.882 -12.3n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127367
PNG
(US8791131, 125)
Show SMILES CC(C)C(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C28H28N6O2/c1-17(2)27(35)33-12-10-20(11-13-33)34-26-24(32(3)28(34)36)16-30-23-9-8-22(31-25(23)26)19-14-18-6-4-5-7-21(18)29-15-19/h4-9,14-17,20H,10-13H2,1-3H3
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US Patent
1.06 -12.2n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127412
PNG
(US8791131, 181)
Show SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)NN)c3c2n1
Show InChI InChI=1S/C22H24N8O2/c1-13-3-4-14(11-24-13)16-5-6-17-19(26-16)20-18(12-25-17)28(2)22(32)30(20)15-7-9-29(10-8-15)21(31)27-23/h3-6,11-12,15H,7-10,23H2,1-2H3,(H,27,31)
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US Patent
1.06 -12.2n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127380
PNG
(US8791131, 142)
Show SMILES CNC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(OC)nc2)n(C)c1=O
Show InChI InChI=1S/C23H25N7O3/c1-24-22(31)29-10-8-15(9-11-29)30-21-18(28(2)23(30)32)13-25-17-6-5-16(27-20(17)21)14-4-7-19(33-3)26-12-14/h4-7,12-13,15H,8-11H2,1-3H3,(H,24,31)
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US Patent
1.15 -12.2n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127409
PNG
(US8791131, 178)
Show SMILES CN(C)CC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(C)nc2)n(C)c1=O
Show InChI InChI=1S/C25H29N7O2/c1-16-5-6-17(13-26-16)19-7-8-20-23(28-19)24-21(14-27-20)30(4)25(34)32(24)18-9-11-31(12-10-18)22(33)15-29(2)3/h5-8,13-14,18H,9-12,15H2,1-4H3
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US Patent
1.18 -12.2n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127408
PNG
(US8791131, 176)
Show SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC(N)=O)CC4)c3c2n1
Show InChI InChI=1S/C23H25N7O2/c1-14-3-4-15(11-25-14)17-5-6-18-21(27-17)22-19(12-26-18)28(2)23(32)30(22)16-7-9-29(10-8-16)13-20(24)31/h3-6,11-12,16H,7-10,13H2,1-2H3,(H2,24,31)
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US Patent
1.41 -12.1n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127380
PNG
(US8791131, 142)
Show SMILES CNC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(OC)nc2)n(C)c1=O
Show InChI InChI=1S/C23H25N7O3/c1-24-22(31)29-10-8-15(9-11-29)30-21-18(28(2)23(30)32)13-25-17-6-5-16(27-20(17)21)14-4-7-19(33-3)26-12-14/h4-7,12-13,15H,8-11H2,1-3H3,(H,24,31)
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US Patent
1.60 -12.0n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127376
PNG
(US8791131, 138)
Show SMILES COc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)CN(C)C)c3c2n1
Show InChI InChI=1S/C25H29N7O3/c1-29(2)15-22(33)31-11-9-17(10-12-31)32-24-20(30(3)25(32)34)14-26-19-7-6-18(28-23(19)24)16-5-8-21(35-4)27-13-16/h5-8,13-14,17H,9-12,15H2,1-4H3
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US Patent
2.23 -11.8n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127398
PNG
(US8791131, 161)
Show SMILES COCC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc(OC)nc2)n(C)c1=O
Show InChI InChI=1S/C23H25N7O4/c1-28-18-12-24-17-5-4-16(14-10-25-22(34-3)26-11-14)27-20(17)21(18)30(23(28)32)15-6-8-29(9-7-15)19(31)13-33-2/h4-5,10-12,15H,6-9,13H2,1-3H3
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US Patent
2.52 -11.7n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127368
PNG
(US8791131, 126)
Show SMILES CN(C)CC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C28H29N7O2/c1-32(2)17-25(36)34-12-10-20(11-13-34)35-27-24(33(3)28(35)37)16-30-23-9-8-22(31-26(23)27)19-14-18-6-4-5-7-21(18)29-15-19/h4-9,14-16,20H,10-13,17H2,1-3H3
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US Patent
2.55 -11.7n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127391
PNG
(US8791131, 154)
Show SMILES COc1ncc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)[C@H](C)O)c3c2n1
Show InChI InChI=1/C23H25N7O4/c1-13(31)21(32)29-8-6-15(7-9-29)30-20-18(28(2)23(30)33)12-24-17-5-4-16(27-19(17)20)14-10-25-22(34-3)26-11-14/h4-5,10-13,15,31H,6-9H2,1-3H3/t13-/s2
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2.59 -11.7n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127412
PNG
(US8791131, 181)
Show SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)NN)c3c2n1
Show InChI InChI=1S/C22H24N8O2/c1-13-3-4-14(11-24-13)16-5-6-17-19(26-16)20-18(12-25-17)28(2)22(32)30(20)15-7-9-29(10-8-15)21(31)27-23/h3-6,11-12,15H,7-10,23H2,1-2H3,(H,27,31)
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US Patent
3.27 -11.6n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127377
PNG
(US8791131, 139)
Show SMILES COc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC(N)=O)CC4)c3c2n1
Show InChI InChI=1S/C23H25N7O3/c1-28-18-12-25-17-5-4-16(14-3-6-20(33-2)26-11-14)27-21(17)22(18)30(23(28)32)15-7-9-29(10-8-15)13-19(24)31/h3-6,11-12,15H,7-10,13H2,1-2H3,(H2,24,31)
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US Patent
3.32 -11.6n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127368
PNG
(US8791131, 126)
Show SMILES CN(C)CC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C28H29N7O2/c1-32(2)17-25(36)34-12-10-20(11-13-34)35-27-24(33(3)28(35)37)16-30-23-9-8-22(31-26(23)27)19-14-18-6-4-5-7-21(18)29-15-19/h4-9,14-16,20H,10-13,17H2,1-3H3
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US Patent
3.42 -11.5n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127375
PNG
(US8791131, 137)
Show SMILES COc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(C)C)c3c2n1
Show InChI InChI=1S/C24H28N6O2/c1-15(2)29-11-9-17(10-12-29)30-23-20(28(3)24(30)31)14-25-19-7-6-18(27-22(19)23)16-5-8-21(32-4)26-13-16/h5-8,13-15,17H,9-12H2,1-4H3
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3.48 -11.5n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127411
PNG
(US8791131, 180)
Show SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)CN)c3c2n1
Show InChI InChI=1S/C23H25N7O2/c1-14-3-4-15(12-25-14)17-5-6-18-21(27-17)22-19(13-26-18)28(2)23(32)30(22)16-7-9-29(10-8-16)20(31)11-24/h3-6,12-13,16H,7-11,24H2,1-2H3
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3.84 -11.5n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127409
PNG
(US8791131, 178)
Show SMILES CN(C)CC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(C)nc2)n(C)c1=O
Show InChI InChI=1S/C25H29N7O2/c1-16-5-6-17(13-26-16)19-7-8-20-23(28-19)24-21(14-27-20)30(4)25(34)32(24)18-9-11-31(12-10-18)22(33)15-29(2)3/h5-8,13-14,18H,9-12,15H2,1-4H3
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4.09 -11.4n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127399
PNG
(US8791131, 163)
Show SMILES COc1ncc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC(=O)N(C)C)CC4)c3c2n1
Show InChI InChI=1S/C24H28N8O3/c1-29(2)20(33)14-31-9-7-16(8-10-31)32-22-19(30(3)24(32)34)13-25-18-6-5-17(28-21(18)22)15-11-26-23(35-4)27-12-15/h5-6,11-13,16H,7-10,14H2,1-4H3
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4.70 -11.4n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127367
PNG
(US8791131, 125)
Show SMILES CC(C)C(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C28H28N6O2/c1-17(2)27(35)33-12-10-20(11-13-33)34-26-24(32(3)28(34)36)16-30-23-9-8-22(31-25(23)26)19-14-18-6-4-5-7-21(18)29-15-19/h4-9,14-17,20H,10-13H2,1-3H3
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US Patent
4.87 -11.3n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127398
PNG
(US8791131, 161)
Show SMILES COCC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc(OC)nc2)n(C)c1=O
Show InChI InChI=1S/C23H25N7O4/c1-28-18-12-24-17-5-4-16(14-10-25-22(34-3)26-11-14)27-20(17)21(18)30(23(28)32)15-6-8-29(9-7-15)19(31)13-33-2/h4-5,10-12,15H,6-9,13H2,1-3H3
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4.97 -11.3n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127378
PNG
(US8791131, 140)
Show SMILES COc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCOCC4)c3c2n1
Show InChI InChI=1S/C21H21N5O3/c1-25-17-12-22-16-5-4-15(13-3-6-18(28-2)23-11-13)24-19(16)20(17)26(21(25)27)14-7-9-29-10-8-14/h3-6,11-12,14H,7-10H2,1-2H3
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7.74 -11.1n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127363
PNG
(US8791131, 121)
Show SMILES CCC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C27H26N6O2/c1-3-24(34)32-12-10-19(11-13-32)33-26-23(31(2)27(33)35)16-29-22-9-8-21(30-25(22)26)18-14-17-6-4-5-7-20(17)28-15-18/h4-9,14-16,19H,3,10-13H2,1-2H3
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US Patent
7.90 -11.0n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127376
PNG
(US8791131, 138)
Show SMILES COc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)CN(C)C)c3c2n1
Show InChI InChI=1S/C25H29N7O3/c1-29(2)15-22(33)31-11-9-17(10-12-31)32-24-20(30(3)25(32)34)14-26-19-7-6-18(28-23(19)24)16-5-8-21(35-4)27-13-16/h5-8,13-14,17H,9-12,15H2,1-4H3
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10.6 -10.9n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127375
PNG
(US8791131, 137)
Show SMILES COc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(C)C)c3c2n1
Show InChI InChI=1S/C24H28N6O2/c1-15(2)29-11-9-17(10-12-29)30-23-20(28(3)24(30)31)14-25-19-7-6-18(27-22(19)23)16-5-8-21(32-4)26-13-16/h5-8,13-15,17H,9-12H2,1-4H3
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17.8 -10.6n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127399
PNG
(US8791131, 163)
Show SMILES COc1ncc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC(=O)N(C)C)CC4)c3c2n1
Show InChI InChI=1S/C24H28N8O3/c1-29(2)20(33)14-31-9-7-16(8-10-31)32-22-19(30(3)24(32)34)13-25-18-6-5-17(28-21(18)22)15-11-26-23(35-4)27-12-15/h5-6,11-13,16H,7-10,14H2,1-4H3
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18.4 -10.5n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair