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32 similar compounds to monomer 127435

Compile data set for download or QSAR
Wt: 466.5
BDBM127363
Wt: 480.5
BDBM127367
Wt: 485.5
BDBM127388
Wt: 488.5
BDBM127382
Wt: 495.5
BDBM127383
Wt: 496.5
BDBM127381
Wt: 445.5
BDBM127421
Wt: 403.4
BDBM127419
Wt: 460.5
BDBM127422
Wt: 446.5
BDBM127423
Wt: 447.5
BDBM127424
Wt: 431.4
BDBM127408
Wt: 459.5
BDBM127409
Wt: 431.4
BDBM127411
Wt: 432.4
BDBM127412
Displayed 1 to 15 (of 32 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 127363,127367,127388,127382,127383,127381,127421,127419,127422,127423,127424,127408,127409,127411,127412   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127411
PNG
(US8791131, 180)
Show SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)CN)c3c2n1
Show InChI InChI=1S/C23H25N7O2/c1-14-3-4-15(12-25-14)17-5-6-18-21(27-17)22-19(13-26-18)28(2)23(32)30(22)16-7-9-29(10-8-16)20(31)11-24/h3-6,12-13,16H,7-11,24H2,1-2H3
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US Patent
0.320 -12.9n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127421
PNG
(US8791131, 195)
Show SMILES CN(C)c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(C)=O)c3c2n1
Show InChI InChI=1S/C24H27N7O2/c1-15(32)30-11-9-17(10-12-30)31-23-20(29(4)24(31)33)14-25-19-7-6-18(27-22(19)23)16-5-8-21(26-13-16)28(2)3/h5-8,13-14,17H,9-12H2,1-4H3
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US Patent
0.391 -12.8n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127423
PNG
(US8791131, 197)
Show SMILES CN(C)c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(N)=O)c3c2n1
Show InChI InChI=1S/C23H26N8O2/c1-28(2)19-7-4-14(12-26-19)16-5-6-17-20(27-16)21-18(13-25-17)29(3)23(33)31(21)15-8-10-30(11-9-15)22(24)32/h4-7,12-13,15H,8-11H2,1-3H3,(H2,24,32)
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US Patent
0.444 -12.8n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127419
PNG
(US8791131, 191)
Show SMILES CN(C)c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCNCC4)c3c2n1
Show InChI InChI=1S/C22H25N7O/c1-27(2)19-7-4-14(12-25-19)16-5-6-17-20(26-16)21-18(13-24-17)28(3)22(30)29(21)15-8-10-23-11-9-15/h4-7,12-13,15,23H,8-11H2,1-3H3
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US Patent
0.5 -12.7n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127363
PNG
(US8791131, 121)
Show SMILES CCC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C27H26N6O2/c1-3-24(34)32-12-10-19(11-13-32)33-26-23(31(2)27(33)35)16-29-22-9-8-21(30-25(22)26)18-14-17-6-4-5-7-20(17)28-15-18/h4-9,14-16,19H,3,10-13H2,1-2H3
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0.539 -12.6n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127381
PNG
(US8791131, 143)
Show SMILES Cn1c2cnc3ccc(nc3c2n(C2CCN(CC2)C(=O)C(C)(C)O)c1=O)-c1cnc2ccccc2c1
Show InChI InChI=1S/C28H28N6O3/c1-28(2,37)26(35)33-12-10-19(11-13-33)34-25-23(32(3)27(34)36)16-30-22-9-8-21(31-24(22)25)18-14-17-6-4-5-7-20(17)29-15-18/h4-9,14-16,19,37H,10-13H2,1-3H3
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0.568 -12.6n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127422
PNG
(US8791131, 196)
Show SMILES CNC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(nc2)N(C)C)n(C)c1=O
Show InChI InChI=1S/C24H28N8O2/c1-25-23(33)31-11-9-16(10-12-31)32-22-19(30(4)24(32)34)14-26-18-7-6-17(28-21(18)22)15-5-8-20(27-13-15)29(2)3/h5-8,13-14,16H,9-12H2,1-4H3,(H,25,33)
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US Patent
0.760 -12.4n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127408
PNG
(US8791131, 176)
Show SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC(N)=O)CC4)c3c2n1
Show InChI InChI=1S/C23H25N7O2/c1-14-3-4-15(11-25-14)17-5-6-18-21(27-17)22-19(12-26-18)28(2)23(32)30(22)16-7-9-29(10-8-16)13-20(24)31/h3-6,11-12,16H,7-10,13H2,1-2H3,(H2,24,31)
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US Patent
0.882 -12.3n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127423
PNG
(US8791131, 197)
Show SMILES CN(C)c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(N)=O)c3c2n1
Show InChI InChI=1S/C23H26N8O2/c1-28(2)19-7-4-14(12-26-19)16-5-6-17-20(27-16)21-18(13-25-17)29(3)23(33)31(21)15-8-10-30(11-9-15)22(24)32/h4-7,12-13,15H,8-11H2,1-3H3,(H2,24,32)
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US Patent
1.05 -12.2n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127367
PNG
(US8791131, 125)
Show SMILES CC(C)C(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C28H28N6O2/c1-17(2)27(35)33-12-10-20(11-13-33)34-26-24(32(3)28(34)36)16-30-23-9-8-22(31-25(23)26)19-14-18-6-4-5-7-21(18)29-15-19/h4-9,14-17,20H,10-13H2,1-3H3
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US Patent
1.06 -12.2n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127412
PNG
(US8791131, 181)
Show SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)NN)c3c2n1
Show InChI InChI=1S/C22H24N8O2/c1-13-3-4-14(11-24-13)16-5-6-17-19(26-16)20-18(12-25-17)28(2)22(32)30(20)15-7-9-29(10-8-15)21(31)27-23/h3-6,11-12,15H,7-10,23H2,1-2H3,(H,27,31)
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US Patent
1.06 -12.2n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127409
PNG
(US8791131, 178)
Show SMILES CN(C)CC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(C)nc2)n(C)c1=O
Show InChI InChI=1S/C25H29N7O2/c1-16-5-6-17(13-26-16)19-7-8-20-23(28-19)24-21(14-27-20)30(4)25(34)32(24)18-9-11-31(12-10-18)22(33)15-29(2)3/h5-8,13-14,18H,9-12,15H2,1-4H3
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US Patent
1.18 -12.2n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127408
PNG
(US8791131, 176)
Show SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC(N)=O)CC4)c3c2n1
Show InChI InChI=1S/C23H25N7O2/c1-14-3-4-15(11-25-14)17-5-6-18-21(27-17)22-19(12-26-18)28(2)23(32)30(22)16-7-9-29(10-8-16)13-20(24)31/h3-6,11-12,16H,7-10,13H2,1-2H3,(H2,24,31)
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US Patent
1.41 -12.1n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127421
PNG
(US8791131, 195)
Show SMILES CN(C)c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(C)=O)c3c2n1
Show InChI InChI=1S/C24H27N7O2/c1-15(32)30-11-9-17(10-12-30)31-23-20(29(4)24(31)33)14-25-19-7-6-18(27-22(19)23)16-5-8-21(26-13-16)28(2)3/h5-8,13-14,17H,9-12H2,1-4H3
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US Patent
1.72 -11.9n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127382
PNG
(US8791131, 144)
Show SMILES CN(C)CC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(nc2)N(C)C)n(C)c1=O
Show InChI InChI=1S/C26H32N8O2/c1-30(2)16-23(35)33-12-10-18(11-13-33)34-25-21(32(5)26(34)36)15-27-20-8-7-19(29-24(20)25)17-6-9-22(28-14-17)31(3)4/h6-9,14-15,18H,10-13,16H2,1-5H3
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US Patent
2.10 -11.8n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127422
PNG
(US8791131, 196)
Show SMILES CNC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(nc2)N(C)C)n(C)c1=O
Show InChI InChI=1S/C24H28N8O2/c1-25-23(33)31-11-9-16(10-12-31)32-22-19(30(4)24(32)34)14-26-18-7-6-17(28-21(18)22)15-5-8-20(27-13-15)29(2)3/h5-8,13-14,16H,9-12H2,1-4H3,(H,25,33)
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US Patent
3.01 -11.6n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127424
PNG
(US8791131, 198)
Show SMILES CN(C)c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CCO)CC4)c3c2n1
Show InChI InChI=1S/C24H29N7O2/c1-28(2)21-7-4-16(14-26-21)18-5-6-19-22(27-18)23-20(15-25-19)29(3)24(33)31(23)17-8-10-30(11-9-17)12-13-32/h4-7,14-15,17,32H,8-13H2,1-3H3
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US Patent
3.13 -11.6n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127412
PNG
(US8791131, 181)
Show SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)NN)c3c2n1
Show InChI InChI=1S/C22H24N8O2/c1-13-3-4-14(11-24-13)16-5-6-17-19(26-16)20-18(12-25-17)28(2)22(32)30(20)15-7-9-29(10-8-15)21(31)27-23/h3-6,11-12,15H,7-10,23H2,1-2H3,(H,27,31)
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US Patent
3.27 -11.6n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127424
PNG
(US8791131, 198)
Show SMILES CN(C)c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CCO)CC4)c3c2n1
Show InChI InChI=1S/C24H29N7O2/c1-28(2)21-7-4-16(14-26-21)18-5-6-19-22(27-18)23-20(15-25-19)29(3)24(33)31(23)17-8-10-30(11-9-17)12-13-32/h4-7,14-15,17,32H,8-13H2,1-3H3
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US Patent
3.52 -11.5n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127411
PNG
(US8791131, 180)
Show SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC4)C(=O)CN)c3c2n1
Show InChI InChI=1S/C23H25N7O2/c1-14-3-4-15(12-25-14)17-5-6-18-21(27-17)22-19(13-26-18)28(2)23(32)30(22)16-7-9-29(10-8-16)20(31)11-24/h3-6,12-13,16H,7-11,24H2,1-2H3
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3.84 -11.5n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127383
PNG
(US8791131, 145)
Show SMILES Cn1c2cnc3ccc(nc3c2n(C2CCN(CC2)C(=O)C(C)(C)N)c1=O)-c1cnc2ccccc2c1
Show InChI InChI=1S/C28H29N7O2/c1-28(2,29)26(36)34-12-10-19(11-13-34)35-25-23(33(3)27(35)37)16-31-22-9-8-21(32-24(22)25)18-14-17-6-4-5-7-20(17)30-15-18/h4-9,14-16,19H,10-13,29H2,1-3H3
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3.92 -11.5n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127409
PNG
(US8791131, 178)
Show SMILES CN(C)CC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(C)nc2)n(C)c1=O
Show InChI InChI=1S/C25H29N7O2/c1-16-5-6-17(13-26-16)19-7-8-20-23(28-19)24-21(14-27-20)30(4)25(34)32(24)18-9-11-31(12-10-18)22(33)15-29(2)3/h5-8,13-14,18H,9-12,15H2,1-4H3
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4.09 -11.4n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127367
PNG
(US8791131, 125)
Show SMILES CC(C)C(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C28H28N6O2/c1-17(2)27(35)33-12-10-20(11-13-33)34-26-24(32(3)28(34)36)16-30-23-9-8-22(31-25(23)26)19-14-18-6-4-5-7-21(18)29-15-19/h4-9,14-17,20H,10-13H2,1-3H3
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US Patent
4.87 -11.3n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127381
PNG
(US8791131, 143)
Show SMILES Cn1c2cnc3ccc(nc3c2n(C2CCN(CC2)C(=O)C(C)(C)O)c1=O)-c1cnc2ccccc2c1
Show InChI InChI=1S/C28H28N6O3/c1-28(2,37)26(35)33-12-10-19(11-13-33)34-25-23(32(3)27(34)36)16-30-22-9-8-21(31-24(22)25)18-14-17-6-4-5-7-20(17)29-15-18/h4-9,14-16,19,37H,10-13H2,1-3H3
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US Patent
7.21 -11.1n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127363
PNG
(US8791131, 121)
Show SMILES CCC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2cnc3ccccc3c2)n(C)c1=O
Show InChI InChI=1S/C27H26N6O2/c1-3-24(34)32-12-10-19(11-13-32)33-26-23(31(2)27(33)35)16-29-22-9-8-21(30-25(22)26)18-14-17-6-4-5-7-20(17)28-15-18/h4-9,14-16,19H,3,10-13H2,1-2H3
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7.90 -11.0n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127382
PNG
(US8791131, 144)
Show SMILES CN(C)CC(=O)N1CCC(CC1)n1c2c(cnc3ccc(nc23)-c2ccc(nc2)N(C)C)n(C)c1=O
Show InChI InChI=1S/C26H32N8O2/c1-30(2)16-23(35)33-12-10-18(11-13-33)34-25-21(32(5)26(34)36)15-27-20-8-7-19(29-24(20)25)17-6-9-22(28-14-17)31(3)4/h6-9,14-15,18H,10-13,16H2,1-5H3
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7.99 -11.0n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127419
PNG
(US8791131, 191)
Show SMILES CN(C)c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCNCC4)c3c2n1
Show InChI InChI=1S/C22H25N7O/c1-27(2)19-7-4-14(12-25-19)16-5-6-17-20(26-16)21-18(13-24-17)28(3)22(30)29(21)15-8-10-23-11-9-15/h4-7,12-13,15,23H,8-11H2,1-3H3
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8.41 -11.0n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127388
PNG
(US8791131, 150)
Show SMILES CN(C)c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC(F)(F)F)CC4)c3c2n1
Show InChI InChI=1S/C24H26F3N7O/c1-31(2)20-7-4-15(12-29-20)17-5-6-18-21(30-17)22-19(13-28-18)32(3)23(35)34(22)16-8-10-33(11-9-16)14-24(25,26)27/h4-7,12-13,16H,8-11,14H2,1-3H3
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US Patent
8.78 -11.0n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127388
PNG
(US8791131, 150)
Show SMILES CN(C)c1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCN(CC(F)(F)F)CC4)c3c2n1
Show InChI InChI=1S/C24H26F3N7O/c1-31(2)20-7-4-15(12-29-20)17-5-6-18-21(30-17)22-19(13-28-18)32(3)23(35)34(22)16-8-10-33(11-9-16)14-24(25,26)27/h4-7,12-13,16H,8-11,14H2,1-3H3
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12.5 -10.8n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127383
PNG
(US8791131, 145)
Show SMILES Cn1c2cnc3ccc(nc3c2n(C2CCN(CC2)C(=O)C(C)(C)N)c1=O)-c1cnc2ccccc2c1
Show InChI InChI=1S/C28H29N7O2/c1-28(2,29)26(36)34-12-10-19(11-13-34)35-25-23(33(3)27(35)37)16-31-22-9-8-21(32-24(22)25)18-14-17-6-4-5-7-20(17)30-15-18/h4-9,14-16,19H,10-13,29H2,1-3H3
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13.3 -10.7n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair