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8 similar compounds to monomer 127489

Compile data set for download or QSAR
Wt: 469.5
BDBM127385
Wt: 433.5
BDBM127390
Wt: 425.4
BDBM127384
Wt: 364.4
BDBM127407
Wt: 389.4
BDBM127410
Wt: 364.4
BDBM127403
Wt: 413.4
BDBM127462
Wt: 415.4
BDBM127490

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 127385,127390,127384,127407,127410,127403,127462,127490   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127490
PNG
(US8791131, 268)
Show SMILES Cn1c2cnc3ccc(nc3c2n([C@H]2CC[C@H](O)CC2)c1=O)-c1cnc2[nH]ncc2c1
Show InChI InChI=1/C22H21N7O2/c1-28-18-11-23-17-7-6-16(12-8-13-10-25-27-21(13)24-9-12)26-19(17)20(18)29(22(28)31)14-2-4-15(30)5-3-14/h6-11,14-15,30H,2-5H2,1H3,(H,24,25,27)/t14-,15-
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US Patent
0.117 -13.5n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127403
PNG
(US8791131, 168)
Show SMILES Cn1c2cnc3ccc(nc3c2n([C@H]2CC[C@H](O)CC2)c1=O)-c1cn[nH]c1
Show InChI InChI=1/C19H20N6O2/c1-24-16-10-20-15-7-6-14(11-8-21-22-9-11)23-17(15)18(16)25(19(24)27)12-2-4-13(26)5-3-12/h6-10,12-13,26H,2-5H2,1H3,(H,21,22)/t12-,13-
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US Patent
0.204 -13.2n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127490
PNG
(US8791131, 268)
Show SMILES Cn1c2cnc3ccc(nc3c2n([C@H]2CC[C@H](O)CC2)c1=O)-c1cnc2[nH]ncc2c1
Show InChI InChI=1/C22H21N7O2/c1-28-18-11-23-17-7-6-16(12-8-13-10-25-27-21(13)24-9-12)26-19(17)20(18)29(22(28)31)14-2-4-15(30)5-3-14/h6-11,14-15,30H,2-5H2,1H3,(H,24,25,27)/t14-,15-
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US Patent
0.366 -12.9n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127462
PNG
(US8791131, 236)
Show SMILES Cn1c2cnc3ccc(nc3c2n([C@H]2CC[C@H](O)CC2)c1=O)-c1cccc2[nH]ccc12
Show InChI InChI=1/C24H23N5O2/c1-28-21-13-26-20-10-9-19(16-3-2-4-18-17(16)11-12-25-18)27-22(20)23(21)29(24(28)31)14-5-7-15(30)8-6-14/h2-4,9-15,25,30H,5-8H2,1H3/t14-,15-
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US Patent
0.404 -12.8n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127410
PNG
(US8791131, 179)
Show SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n([C@H]4CC[C@H](O)CC4)c3c2n1
Show InChI InChI=1/C22H23N5O2/c1-13-3-4-14(11-23-13)17-9-10-18-20(25-17)21-19(12-24-18)26(2)22(29)27(21)15-5-7-16(28)8-6-15/h3-4,9-12,15-16,28H,5-8H2,1-2H3/t15-,16-
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US Patent
1.03 -12.3n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127385
PNG
(US8791131, 147)
Show SMILES Cn1c2cnc3ccc(nc3c2n([C@H]2CC[C@@H](CC2)OCCO)c1=O)-c1cnc2ccccc2c1
Show InChI InChI=1/C27H27N5O3/c1-31-24-16-29-23-11-10-22(18-14-17-4-2-3-5-21(17)28-15-18)30-25(23)26(24)32(27(31)34)19-6-8-20(9-7-19)35-13-12-33/h2-5,10-11,14-16,19-20,33H,6-9,12-13H2,1H3/t19-,20-
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US Patent
1.08 -12.2n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127384
PNG
(US8791131, 146)
Show SMILES Cn1c2cnc3ccc(nc3c2n([C@H]2CC[C@H](O)CC2)c1=O)-c1cnc2ccccc2c1
Show InChI InChI=1/C25H23N5O2/c1-29-22-14-27-21-11-10-20(16-12-15-4-2-3-5-19(15)26-13-16)28-23(21)24(22)30(25(29)32)17-6-8-18(31)9-7-17/h2-5,10-14,17-18,31H,6-9H2,1H3/t17-,18-
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US Patent
1.20 -12.2n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127390
PNG
(US8791131, 152)
Show SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n([C@H]4CC[C@@H](CC4)OCCO)c3c2n1
Show InChI InChI=1/C24H27N5O3/c1-15-3-4-16(13-25-15)19-9-10-20-22(27-19)23-21(14-26-20)28(2)24(31)29(23)17-5-7-18(8-6-17)32-12-11-30/h3-4,9-10,13-14,17-18,30H,5-8,11-12H2,1-2H3/t17-,18-
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US Patent
1.68 -12.0n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127410
PNG
(US8791131, 179)
Show SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n([C@H]4CC[C@H](O)CC4)c3c2n1
Show InChI InChI=1/C22H23N5O2/c1-13-3-4-14(11-23-13)17-9-10-18-20(25-17)21-19(12-24-18)26(2)22(29)27(21)15-5-7-16(28)8-6-15/h3-4,9-12,15-16,28H,5-8H2,1-2H3/t15-,16-
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US Patent
3.29 -11.6n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127384
PNG
(US8791131, 146)
Show SMILES Cn1c2cnc3ccc(nc3c2n([C@H]2CC[C@H](O)CC2)c1=O)-c1cnc2ccccc2c1
Show InChI InChI=1/C25H23N5O2/c1-29-22-14-27-21-11-10-20(16-12-15-4-2-3-5-19(15)26-13-16)28-23(21)24(22)30(25(29)32)17-6-8-18(31)9-7-17/h2-5,10-14,17-18,31H,6-9H2,1H3/t17-,18-
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US Patent
3.80 -11.5n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127403
PNG
(US8791131, 168)
Show SMILES Cn1c2cnc3ccc(nc3c2n([C@H]2CC[C@H](O)CC2)c1=O)-c1cn[nH]c1
Show InChI InChI=1/C19H20N6O2/c1-24-16-10-20-15-7-6-14(11-8-21-22-9-11)23-17(15)18(16)25(19(24)27)12-2-4-13(26)5-3-12/h6-10,12-13,26H,2-5H2,1H3,(H,21,22)/t12-,13-
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US Patent
4.17 -11.4n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127462
PNG
(US8791131, 236)
Show SMILES Cn1c2cnc3ccc(nc3c2n([C@H]2CC[C@H](O)CC2)c1=O)-c1cccc2[nH]ccc12
Show InChI InChI=1/C24H23N5O2/c1-28-21-13-26-20-10-9-19(16-3-2-4-18-17(16)11-12-25-18)27-22(20)23(21)29(24(28)31)14-5-7-15(30)8-6-14/h2-4,9-15,25,30H,5-8H2,1H3/t14-,15-
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US Patent
4.41 -11.4n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127385
PNG
(US8791131, 147)
Show SMILES Cn1c2cnc3ccc(nc3c2n([C@H]2CC[C@@H](CC2)OCCO)c1=O)-c1cnc2ccccc2c1
Show InChI InChI=1/C27H27N5O3/c1-31-24-16-29-23-11-10-22(18-14-17-4-2-3-5-21(17)28-15-18)30-25(23)26(24)32(27(31)34)19-6-8-20(9-7-19)35-13-12-33/h2-5,10-11,14-16,19-20,33H,6-9,12-13H2,1H3/t19-,20-
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US Patent
10.1 -10.9n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Peptidyl-prolyl cis-trans isomerase FKBP1B/Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))
BDBM127390
PNG
(US8791131, 152)
Show SMILES Cc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n([C@H]4CC[C@@H](CC4)OCCO)c3c2n1
Show InChI InChI=1/C24H27N5O3/c1-15-3-4-16(13-25-15)19-9-10-20-22(27-19)23-21(14-26-20)28(2)24(31)29(23)17-5-7-18(8-6-17)32-12-11-30/h3-4,9-10,13-14,17-18,30H,5-8,11-12H2,1-2H3/t17-,18-
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US Patent
11.4 -10.8n/an/an/an/an/a7.525



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM127407
PNG
(US8791131, 174)
Show SMILES Cn1c2cnc3ccc(nc3c2n([C@H]2CC[C@H](O)CC2)c1=O)-c1cc[nH]n1
Show InChI InChI=1/C19H20N6O2/c1-24-16-10-20-15-7-6-13(14-8-9-21-23-14)22-17(15)18(16)25(19(24)27)11-2-4-12(26)5-3-11/h6-12,26H,2-5H2,1H3,(H,21,23)/t11-,12-
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US Patent
23.3 -10.4n/an/an/an/an/a7.425



Pfizer Inc.

US Patent


Assay Description
Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...


US Patent US8791131 (2014)


BindingDB Entry DOI: 10.7270/Q23B5XV8
More data for this
Ligand-Target Pair