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2 similar compounds to monomer 13262

Compile data set for download or QSAR
Wt: 324.4
BDBM13259
Wt: 345.8
BDBM13261

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 13259,13261   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13261
PNG
(BMS-354825 2-Heteroarylamino-thiazole Analog 12f |...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(Nc2cccnn2)s1
Show InChI InChI=1S/C15H12ClN5OS/c1-9-4-2-5-10(16)13(9)20-14(22)11-8-17-15(23-11)19-12-6-3-7-18-21-12/h2-8H,1H3,(H,20,22)(H,17,19,21)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 4n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13259
PNG
(BMS-354825 2-Heteroarylamino-thiazole Analog 12d |...)
Show SMILES Cc1cccc(C)c1NC(=O)c1cnc(Nc2ccccn2)s1
Show InChI InChI=1S/C17H16N4OS/c1-11-6-5-7-12(2)15(11)21-16(22)13-10-19-17(23-13)20-14-8-3-4-9-18-14/h3-10H,1-2H3,(H,21,22)(H,18,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.20n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair