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30 similar compounds to monomer 134505

Compile data set for download or QSAR
Wt: 523.7
BDBM134473
Wt: 523.7
BDBM134474
Wt: 537.7
BDBM134479
Wt: 523.7
BDBM134482
Wt: 535.7
BDBM134483
Wt: 523.7
BDBM134485
Wt: 550.7
BDBM134490
Purchase
Wt: 550.6
BDBM134491
Wt: 538.6
BDBM134496
Wt: 512.7
BDBM134498
Wt: 519.1
BDBM134501
Wt: 509.6
BDBM134503
Wt: 498.7
BDBM134506
Wt: 526.7
BDBM134507
Wt: 513.7
BDBM134508
Displayed 1 to 15 (of 30 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 134473,134474,134479,134482,134483,134485,134490,134491,134496,134498,134501,134503,134506,134507,134508   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM134490
PNG
(US8846656, 19-F)
Show SMILES CO[C@@H]1C[C@@H]2CC[C@H](C1)N2c1nc(nc2CCN(Cc12)c1cc(ccc1C)C(C)C)-c1c(C)ccc2[nH]nc(C)c12
Show InChI InChI=1S/C34H42N6O/c1-19(2)23-9-7-20(3)30(15-23)39-14-13-28-27(18-39)34(40-24-10-11-25(40)17-26(16-24)41-6)36-33(35-28)31-21(4)8-12-29-32(31)22(5)37-38-29/h7-9,12,15,19,24-26H,10-11,13-14,16-18H2,1-6H3,(H,37,38)/t24-,25+,26+
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n/an/a 4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...


US Patent US8846656 (2014)


BindingDB Entry DOI: 10.7270/Q2JW8CKR
More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM134507
PNG
(US8846656, 21-K)
Show SMILES CO[C@@H]1CCN([C@H](C)C1)c1nc(nc2CCN(Cc12)c1cc(ccc1C)C1(C)COC1)-c1c(C)cccc1C
Show InChI InChI=1S/C33H42N4O2/c1-21-10-11-25(33(5)19-39-20-33)17-29(21)36-14-13-28-27(18-36)32(37-15-12-26(38-6)16-24(37)4)35-31(34-28)30-22(2)8-7-9-23(30)3/h7-11,17,24,26H,12-16,18-20H2,1-6H3/t24-,26-/m1/s1
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Novartis AG

US Patent


Assay Description
Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...


US Patent US8846656 (2014)


BindingDB Entry DOI: 10.7270/Q2JW8CKR
More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM134474
PNG
(US8846656, 17-R)
Show SMILES CO[C@@H]1CCN([C@H](C)C1)c1nc(nc2CCN(Cc12)c1cc(ccc1C)C(C)C)-c1cccc2[nH]cc(C)c12
Show InChI InChI=1S/C33H41N5O/c1-20(2)24-11-10-21(3)30(17-24)37-14-13-28-27(19-37)33(38-15-12-25(39-6)16-23(38)5)36-32(35-28)26-8-7-9-29-31(26)22(4)18-34-29/h7-11,17-18,20,23,25,34H,12-16,19H2,1-6H3/t23-,25-/m1/s1
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Novartis AG

US Patent


Assay Description
Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...


US Patent US8846656 (2014)


BindingDB Entry DOI: 10.7270/Q2JW8CKR
More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM134498
PNG
(US8846656, 19-AD)
Show SMILES CO[C@H]1CCN(CC1(C)C)c1nc(nc2CCN(Cc12)c1cc(ccc1C)C(C)C)-c1c(C)cccc1C
Show InChI InChI=1S/C33H44N4O/c1-21(2)25-13-12-22(3)28(18-25)36-16-14-27-26(19-36)32(37-17-15-29(38-8)33(6,7)20-37)35-31(34-27)30-23(4)10-9-11-24(30)5/h9-13,18,21,29H,14-17,19-20H2,1-8H3/t29-/m0/s1
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Novartis AG

US Patent


Assay Description
Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...


US Patent US8846656 (2014)


BindingDB Entry DOI: 10.7270/Q2JW8CKR
More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM134485
PNG
(US8846656, 17-AY)
Show SMILES CO[C@H]1CCN(C[C@@H]1C)c1nc(nc2CCN(Cc12)c1cc(ccc1C)C(C)C)-c1cccc2[nH]cc(C)c12
Show InChI InChI=1S/C33H41N5O/c1-20(2)24-11-10-21(3)29(16-24)37-14-12-27-26(19-37)33(38-15-13-30(39-6)23(5)18-38)36-32(35-27)25-8-7-9-28-31(25)22(4)17-34-28/h7-11,16-17,20,23,30,34H,12-15,18-19H2,1-6H3/t23-,30-/m0/s1
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Novartis AG

US Patent


Assay Description
Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...


US Patent US8846656 (2014)


BindingDB Entry DOI: 10.7270/Q2JW8CKR
More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM134482
PNG
(US8846656, 17-AQ)
Show SMILES CO[C@H]1CCN(C[C@H]1C)c1nc(nc2CCN(Cc12)c1cc(ccc1C)C(C)C)-c1cccc2[nH]cc(C)c12
Show InChI InChI=1S/C33H41N5O/c1-20(2)24-11-10-21(3)29(16-24)37-14-12-27-26(19-37)33(38-15-13-30(39-6)23(5)18-38)36-32(35-27)25-8-7-9-28-31(25)22(4)17-34-28/h7-11,16-17,20,23,30,34H,12-15,18-19H2,1-6H3/t23-,30+/m1/s1
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Novartis AG

US Patent


Assay Description
Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...


US Patent US8846656 (2014)


BindingDB Entry DOI: 10.7270/Q2JW8CKR
More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM134508
PNG
(US8846656, 21-M)
Show SMILES CO[C@@H]1CCN(CC1(C)C)c1nc(nc2CCN(Cc12)c1cc(ccc1C)C(C)C)-c1c(C)cncc1C
Show InChI InChI=1S/C32H43N5O/c1-20(2)24-10-9-21(3)27(15-24)36-13-11-26-25(18-36)31(37-14-12-28(38-8)32(6,7)19-37)35-30(34-26)29-22(4)16-33-17-23(29)5/h9-10,15-17,20,28H,11-14,18-19H2,1-8H3/t28-/m1/s1
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n/an/a 56n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...


US Patent US8846656 (2014)


BindingDB Entry DOI: 10.7270/Q2JW8CKR
More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM134496
PNG
(US8846656, 19-AB)
Show SMILES CO[C@H]1CCN(CC1(C)C)c1nc(nc2CCN(Cc12)c1cc(ccc1C)C(F)(F)F)-c1c(C)cccc1C
Show InChI InChI=1S/C31H37F3N4O/c1-19-10-11-22(31(32,33)34)16-25(19)37-14-12-24-23(17-37)29(38-15-13-26(39-6)30(4,5)18-38)36-28(35-24)27-20(2)8-7-9-21(27)3/h7-11,16,26H,12-15,17-18H2,1-6H3/t26-/m0/s1
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Novartis AG

US Patent


Assay Description
Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...


US Patent US8846656 (2014)


BindingDB Entry DOI: 10.7270/Q2JW8CKR
More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM134506
PNG
(US8846656, 21-E)
Show SMILES CO[C@@H]1CCN([C@H](C)C1)c1nc(nc2CCN(Cc12)c1cc(ccc1C)C(C)C)-c1cc(C)ccc1C
Show InChI InChI=1S/C32H42N4O/c1-20(2)25-11-10-23(5)30(18-25)35-14-13-29-28(19-35)32(36-15-12-26(37-7)17-24(36)6)34-31(33-29)27-16-21(3)8-9-22(27)4/h8-11,16,18,20,24,26H,12-15,17,19H2,1-7H3/t24-,26-/m1/s1
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Novartis AG

US Patent


Assay Description
Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...


US Patent US8846656 (2014)


BindingDB Entry DOI: 10.7270/Q2JW8CKR
More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM134503
PNG
(US8846656, 19-AK)
Show SMILES CO[C@@H]1CCN(C[C@H]1C)c1nc(nc2CCN(Cc12)c1cc(ccc1C)C(C)C)-c1c(C)cccc1C#N
Show InChI InChI=1S/C32H39N5O/c1-20(2)24-11-10-21(3)28(16-24)36-14-12-27-26(19-36)32(37-15-13-29(38-6)23(5)18-37)35-31(34-27)30-22(4)8-7-9-25(30)17-33/h7-11,16,20,23,29H,12-15,18-19H2,1-6H3/t23-,29-/m1/s1
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Novartis AG

US Patent


Assay Description
Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...


US Patent US8846656 (2014)


BindingDB Entry DOI: 10.7270/Q2JW8CKR
More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM134483
PNG
(US8846656, 17-AS)
Show SMILES CO[C@@H]1C[C@@H]2CC[C@H](C1)N2c1nc(nc2CCN(Cc12)c1cc(ccc1C)C(C)C)-c1cccc2[nH]cc(C)c12
Show InChI InChI=1S/C34H41N5O/c1-20(2)23-10-9-21(3)31(15-23)38-14-13-29-28(19-38)34(39-24-11-12-25(39)17-26(16-24)40-5)37-33(36-29)27-7-6-8-30-32(27)22(4)18-35-30/h6-10,15,18,20,24-26,35H,11-14,16-17,19H2,1-5H3/t24-,25+,26+
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Novartis AG

US Patent


Assay Description
Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...


US Patent US8846656 (2014)


BindingDB Entry DOI: 10.7270/Q2JW8CKR
More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM134501
PNG
(US8846656, 19-AH)
Show SMILES CO[C@@H]1CCN(C[C@H]1C)c1nc(nc2CCN(Cc12)c1cc(ccc1C)C(C)C)-c1c(C)cccc1Cl
Show InChI InChI=1S/C31H39ClN4O/c1-19(2)23-11-10-20(3)27(16-23)35-14-12-26-24(18-35)31(36-15-13-28(37-6)22(5)17-36)34-30(33-26)29-21(4)8-7-9-25(29)32/h7-11,16,19,22,28H,12-15,17-18H2,1-6H3/t22-,28-/m1/s1
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Novartis AG

US Patent


Assay Description
Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...


US Patent US8846656 (2014)


BindingDB Entry DOI: 10.7270/Q2JW8CKR
More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM134473
PNG
(US8846656, 17-P)
Show SMILES CO[C@H]1CCN([C@H](C)C1)c1nc(nc2CCN(Cc12)c1cc(ccc1C)C(C)C)-c1cccc2[nH]cc(C)c12
Show InChI InChI=1S/C33H41N5O/c1-20(2)24-11-10-21(3)30(17-24)37-14-13-28-27(19-37)33(38-15-12-25(39-6)16-23(38)5)36-32(35-28)26-8-7-9-29-31(26)22(4)18-34-29/h7-11,17-18,20,23,25,34H,12-16,19H2,1-6H3/t23-,25+/m1/s1
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Novartis AG

US Patent


Assay Description
Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...


US Patent US8846656 (2014)


BindingDB Entry DOI: 10.7270/Q2JW8CKR
More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM134491
PNG
(US8846656, 19-K)
Show SMILES CO[C@H]1CCN(CC1(C)C)c1nc(nc2CCN(Cc12)c1cc(ccc1C)C1CC1)-c1ccccc1C(F)(F)F
Show InChI InChI=1S/C32H37F3N4O/c1-20-9-10-22(21-11-12-21)17-27(20)38-15-13-26-24(18-38)30(39-16-14-28(40-4)31(2,3)19-39)37-29(36-26)23-7-5-6-8-25(23)32(33,34)35/h5-10,17,21,28H,11-16,18-19H2,1-4H3/t28-/m0/s1
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Novartis AG

US Patent


Assay Description
Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...


US Patent US8846656 (2014)


BindingDB Entry DOI: 10.7270/Q2JW8CKR
More data for this
Ligand-Target Pair
C5a anaphylatoxin chemotactic receptor (C5aR)


(Homo sapiens (Human))
BDBM134479
PNG
(US8846656, 17-AM)
Show SMILES CO[C@@H]1CCN(CC1(C)C)c1nc(nc2CCN(Cc12)c1cc(ccc1C)C(C)C)-c1cccc2[nH]cc(C)c12
Show InChI InChI=1S/C34H43N5O/c1-21(2)24-12-11-22(3)29(17-24)38-15-13-27-26(19-38)33(39-16-14-30(40-7)34(5,6)20-39)37-32(36-27)25-9-8-10-28-31(25)23(4)18-35-28/h8-12,17-18,21,30,35H,13-16,19-20H2,1-7H3/t30-/m1/s1
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Novartis AG

US Patent


Assay Description
Compounds were tested for their ability to inhibit C5a-mediated calcium mobilization using a stable cell line over expressing the human C5aR & the Ga...


US Patent US8846656 (2014)


BindingDB Entry DOI: 10.7270/Q2JW8CKR
More data for this
Ligand-Target Pair