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26 similar compounds to monomer 160177

Compile data set for download or QSAR
Wt: 1044.1
BDBM135769
Wt: 1072.2
BDBM135758
Wt: 1086.2
BDBM135717
Wt: 1086.2
BDBM135764
Wt: 1058.1
BDBM135765
Wt: 1044.2
BDBM135719
Wt: 1087.2
BDBM135720
Wt: 1058.1
BDBM135767
Wt: 1086.2
BDBM135722
Wt: 1044.1
BDBM135771
Wt: 1002.1
BDBM135772
Wt: 1042.1
BDBM135727
Wt: 1002.1
BDBM135773
Wt: 1044.1
BDBM135776
Wt: 1030.1
BDBM135734
Displayed 1 to 15 (of 26 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 65 hits for monomerid = 135769,135758,135717,135764,135765,135719,135720,135767,135722,135771,135772,135727,135773,135776,135734   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135717
PNG
(US10179804, Example 102 | US8846601, 102 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N19O9/c1-28(70)63-34(16-8-22-59-48(52)53)42(73)67-37-19-20-40(71)58-21-7-15-33(41(51)72)64-47(78)39(26-30-27-62-32-14-6-5-13-31(30)32)69-44(75)36(18-10-24-61-50(56)57)66-46(77)38(25-29-11-3-2-4-12-29)68-43(74)35(65-45(37)76)17-9-23-60-49(54)55/h2-6,11-14,27,33-39,62H,7-10,15-26H2,1H3,(H2,51,72)(H,58,71)(H,63,70)(H,64,78)(H,65,76)(H,66,77)(H,67,73)(H,68,74)(H,69,75)(H4,52,53,59)(H4,54,55,60)(H4,56,57,61)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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0.700 -13.0n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135717
PNG
(US10179804, Example 102 | US8846601, 102 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N19O9/c1-28(70)63-34(16-8-22-59-48(52)53)42(73)67-37-19-20-40(71)58-21-7-15-33(41(51)72)64-47(78)39(26-30-27-62-32-14-6-5-13-31(30)32)69-44(75)36(18-10-24-61-50(56)57)66-46(77)38(25-29-11-3-2-4-12-29)68-43(74)35(65-45(37)76)17-9-23-60-49(54)55/h2-6,11-14,27,33-39,62H,7-10,15-26H2,1H3,(H2,51,72)(H,58,71)(H,63,70)(H,64,78)(H,65,76)(H,66,77)(H,67,73)(H,68,74)(H,69,75)(H4,52,53,59)(H4,54,55,60)(H4,56,57,61)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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0.700n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135717
PNG
(US10179804, Example 102 | US8846601, 102 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O
Show InChI InChI=1S/C50H75N19O9/c1-28(70)63-34(16-8-22-59-48(52)53)42(73)67-37-19-20-40(71)58-21-7-15-33(41(51)72)64-47(78)39(26-30-27-62-32-14-6-5-13-31(30)32)69-44(75)36(18-10-24-61-50(56)57)66-46(77)38(25-29-11-3-2-4-12-29)68-43(74)35(65-45(37)76)17-9-23-60-49(54)55/h2-6,11-14,27,33-39,62H,7-10,15-26H2,1H3,(H2,51,72)(H,58,71)(H,63,70)(H,64,78)(H,65,76)(H,66,77)(H,67,73)(H,68,74)(H,69,75)(H4,52,53,59)(H4,54,55,60)(H4,56,57,61)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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0.700n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135734
PNG
(US10179804, Example 119 | US8846601, 119 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H71N17O9/c1-27(66)59-33(14-8-22-56-47(51)52)41(69)61-34-15-7-21-55-39(67)18-17-32(40(50)68)60-46(74)38(25-29-26-58-31-13-6-5-12-30(29)31)65-43(71)35(16-9-23-57-48(53)54)62-45(73)37(24-28-10-3-2-4-11-28)64-44(72)36(19-20-49)63-42(34)70/h2-6,10-13,26,32-38,58H,7-9,14-25,49H2,1H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,74)(H,61,69)(H,62,73)(H,63,70)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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3n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135734
PNG
(US10179804, Example 119 | US8846601, 119 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H71N17O9/c1-27(66)59-33(14-8-22-56-47(51)52)41(69)61-34-15-7-21-55-39(67)18-17-32(40(50)68)60-46(74)38(25-29-26-58-31-13-6-5-12-30(29)31)65-43(71)35(16-9-23-57-48(53)54)62-45(73)37(24-28-10-3-2-4-11-28)64-44(72)36(19-20-49)63-42(34)70/h2-6,10-13,26,32-38,58H,7-9,14-25,49H2,1H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,74)(H,61,69)(H,62,73)(H,63,70)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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3 -12.1n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135734
PNG
(US10179804, Example 119 | US8846601, 119 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCN)NC1=O)C(N)=O
Show InChI InChI=1S/C48H71N17O9/c1-27(66)59-33(14-8-22-56-47(51)52)41(69)61-34-15-7-21-55-39(67)18-17-32(40(50)68)60-46(74)38(25-29-26-58-31-13-6-5-12-30(29)31)65-43(71)35(16-9-23-57-48(53)54)62-45(73)37(24-28-10-3-2-4-11-28)64-44(72)36(19-20-49)63-42(34)70/h2-6,10-13,26,32-38,58H,7-9,14-25,49H2,1H3,(H2,50,68)(H,55,67)(H,59,66)(H,60,74)(H,61,69)(H,62,73)(H,63,70)(H,64,72)(H,65,71)(H4,51,52,56)(H4,53,54,57)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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3n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135765
PNG
(US10179804, Example 150 | US8846601, 150 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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5n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135765
PNG
(US10179804, Example 150 | US8846601, 150 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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5 -11.8n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135765
PNG
(US10179804, Example 150 | US8846601, 150 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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5n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135720
PNG
(US10179804, Example 105 | US8846601, 105 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C50H74N18O10/c1-28(69)62-34(16-8-22-58-48(52)53)42(72)66-37-19-20-40(70)57-21-7-15-33(41(51)71)63-47(77)39(26-30-27-61-32-14-6-5-13-31(30)32)68-44(74)36(17-9-23-59-49(54)55)65-46(76)38(25-29-11-3-2-4-12-29)67-43(73)35(64-45(37)75)18-10-24-60-50(56)78/h2-6,11-14,27,33-39,61H,7-10,15-26H2,1H3,(H2,51,71)(H,57,70)(H,62,69)(H,63,77)(H,64,75)(H,65,76)(H,66,72)(H,67,73)(H,68,74)(H4,52,53,58)(H4,54,55,59)(H3,56,60,78)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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6n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135727
PNG
(US10179804, Example 112 | US8846601, 112 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](N)CN2C1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O9/c1-27(67)60-34(15-8-20-57-48(52)53)42(70)63-36-17-18-40(68)56-19-7-14-33(41(51)69)61-45(73)38(23-29-25-59-32-13-6-5-12-31(29)32)64-43(71)35(16-9-21-58-49(54)55)62-44(72)37(22-28-10-3-2-4-11-28)65-46(74)39-24-30(50)26-66(39)47(36)75/h2-6,10-13,25,30,33-39,59H,7-9,14-24,26,50H2,1H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,70)(H,64,71)(H,65,74)(H4,52,53,57)(H4,54,55,58)/t30-,33+,34+,35+,36+,37-,38+,39+/m1/s1
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6n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135767
PNG
(US10179804, Example 152 | US8846601, 152 | US94582...)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33+,34-,35-,36-,37+,38-/m0/s1
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6n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135776
PNG
(US10179804, Example 161 | US8846601, 161 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(15-8-20-56-47(51)52)41(70)62-34-17-18-39(68)55-19-7-14-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)33(16-9-21-57-48(53)54)61-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(34)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,73)(H,62,70)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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6n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135720
PNG
(US10179804, Example 105 | US8846601, 105 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C50H74N18O10/c1-28(69)62-34(16-8-22-58-48(52)53)42(72)66-37-19-20-40(70)57-21-7-15-33(41(51)71)63-47(77)39(26-30-27-61-32-14-6-5-13-31(30)32)68-44(74)36(17-9-23-59-49(54)55)65-46(76)38(25-29-11-3-2-4-12-29)67-43(73)35(64-45(37)75)18-10-24-60-50(56)78/h2-6,11-14,27,33-39,61H,7-10,15-26H2,1H3,(H2,51,71)(H,57,70)(H,62,69)(H,63,77)(H,64,75)(H,65,76)(H,66,72)(H,67,73)(H,68,74)(H4,52,53,58)(H4,54,55,59)(H3,56,60,78)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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6 -11.7n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135727
PNG
(US10179804, Example 112 | US8846601, 112 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](N)CN2C1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O9/c1-27(67)60-34(15-8-20-57-48(52)53)42(70)63-36-17-18-40(68)56-19-7-14-33(41(51)69)61-45(73)38(23-29-25-59-32-13-6-5-12-31(29)32)64-43(71)35(16-9-21-58-49(54)55)62-44(72)37(22-28-10-3-2-4-11-28)65-46(74)39-24-30(50)26-66(39)47(36)75/h2-6,10-13,25,30,33-39,59H,7-9,14-24,26,50H2,1H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,70)(H,64,71)(H,65,74)(H4,52,53,57)(H4,54,55,58)/t30-,33+,34+,35+,36+,37-,38+,39+/m1/s1
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6 -11.7n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135767
PNG
(US10179804, Example 152 | US8846601, 152 | US94582...)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33+,34-,35-,36-,37+,38-/m0/s1
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6 -11.7n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135776
PNG
(US10179804, Example 161 | US8846601, 161 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(15-8-20-56-47(51)52)41(70)62-34-17-18-39(68)55-19-7-14-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)33(16-9-21-57-48(53)54)61-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(34)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,73)(H,62,70)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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6 -11.7n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135720
PNG
(US10179804, Example 105 | US8846601, 105 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCNC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C50H74N18O10/c1-28(69)62-34(16-8-22-58-48(52)53)42(72)66-37-19-20-40(70)57-21-7-15-33(41(51)71)63-47(77)39(26-30-27-61-32-14-6-5-13-31(30)32)68-44(74)36(17-9-23-59-49(54)55)65-46(76)38(25-29-11-3-2-4-12-29)67-43(73)35(64-45(37)75)18-10-24-60-50(56)78/h2-6,11-14,27,33-39,61H,7-10,15-26H2,1H3,(H2,51,71)(H,57,70)(H,62,69)(H,63,77)(H,64,75)(H,65,76)(H,66,72)(H,67,73)(H,68,74)(H4,52,53,58)(H4,54,55,59)(H3,56,60,78)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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6n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135727
PNG
(US10179804, Example 112 | US8846601, 112 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@@H](N)CN2C1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O9/c1-27(67)60-34(15-8-20-57-48(52)53)42(70)63-36-17-18-40(68)56-19-7-14-33(41(51)69)61-45(73)38(23-29-25-59-32-13-6-5-12-31(29)32)64-43(71)35(16-9-21-58-49(54)55)62-44(72)37(22-28-10-3-2-4-11-28)65-46(74)39-24-30(50)26-66(39)47(36)75/h2-6,10-13,25,30,33-39,59H,7-9,14-24,26,50H2,1H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,73)(H,62,72)(H,63,70)(H,64,71)(H,65,74)(H4,52,53,57)(H4,54,55,58)/t30-,33+,34+,35+,36+,37-,38+,39+/m1/s1
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6n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135767
PNG
(US10179804, Example 152 | US8846601, 152 | US94582...)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33+,34-,35-,36-,37+,38-/m0/s1
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6n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135776
PNG
(US10179804, Example 161 | US8846601, 161 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(15-8-20-56-47(51)52)41(70)62-34-17-18-39(68)55-19-7-14-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)33(16-9-21-57-48(53)54)61-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(34)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,73)(H,62,70)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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6n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135764
PNG
(US10179804, Example 149 | US8846601, 149 | US94582...)
Show SMILES CC(=O)NCCC[C@@H]1NC(=O)[C@H](CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C51H75N17O10/c1-29(69)57-22-9-18-37-45(74)67-40(26-31-12-4-3-5-13-31)48(77)65-38(19-11-25-60-51(55)56)46(75)68-41(27-32-28-61-34-15-7-6-14-33(32)34)49(78)63-35(43(52)72)16-8-23-58-42(71)21-20-39(47(76)64-37)66-44(73)36(62-30(2)70)17-10-24-59-50(53)54/h3-7,12-15,28,35-41,61H,8-11,16-27H2,1-2H3,(H2,52,72)(H,57,69)(H,58,71)(H,62,70)(H,63,78)(H,64,76)(H,65,77)(H,66,73)(H,67,74)(H,68,75)(H4,53,54,59)(H4,55,56,60)/t35-,36-,37-,38-,39-,40+,41-/m0/s1
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7 -11.6n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135764
PNG
(US10179804, Example 149 | US8846601, 149 | US94582...)
Show SMILES CC(=O)NCCC[C@@H]1NC(=O)[C@H](CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C51H75N17O10/c1-29(69)57-22-9-18-37-45(74)67-40(26-31-12-4-3-5-13-31)48(77)65-38(19-11-25-60-51(55)56)46(75)68-41(27-32-28-61-34-15-7-6-14-33(32)34)49(78)63-35(43(52)72)16-8-23-58-42(71)21-20-39(47(76)64-37)66-44(73)36(62-30(2)70)17-10-24-59-50(53)54/h3-7,12-15,28,35-41,61H,8-11,16-27H2,1-2H3,(H2,52,72)(H,57,69)(H,58,71)(H,62,70)(H,63,78)(H,64,76)(H,65,77)(H,66,73)(H,67,74)(H,68,75)(H4,53,54,59)(H4,55,56,60)/t35-,36-,37-,38-,39-,40+,41-/m0/s1
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7n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135764
PNG
(US10179804, Example 149 | US8846601, 149 | US94582...)
Show SMILES CC(=O)NCCC[C@@H]1NC(=O)[C@H](CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C51H75N17O10/c1-29(69)57-22-9-18-37-45(74)67-40(26-31-12-4-3-5-13-31)48(77)65-38(19-11-25-60-51(55)56)46(75)68-41(27-32-28-61-34-15-7-6-14-33(32)34)49(78)63-35(43(52)72)16-8-23-58-42(71)21-20-39(47(76)64-37)66-44(73)36(62-30(2)70)17-10-24-59-50(53)54/h3-7,12-15,28,35-41,61H,8-11,16-27H2,1-2H3,(H2,52,72)(H,57,69)(H,58,71)(H,62,70)(H,63,78)(H,64,76)(H,65,77)(H,66,73)(H,67,74)(H,68,75)(H4,53,54,59)(H4,55,56,60)/t35-,36-,37-,38-,39-,40+,41-/m0/s1
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7n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135719
PNG
(US10179804, Example 104 | US8846601, 104 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C49H73N17O9/c1-28(67)60-34(17-9-23-57-48(52)53)42(70)64-37-19-20-40(68)56-22-8-16-33(41(51)69)61-47(75)39(26-30-27-59-32-14-6-5-13-31(30)32)66-44(72)36(18-10-24-58-49(54)55)63-46(74)38(25-29-11-3-2-4-12-29)65-43(71)35(15-7-21-50)62-45(37)73/h2-6,11-14,27,33-39,59H,7-10,15-26,50H2,1H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,75)(H,62,73)(H,63,74)(H,64,70)(H,65,71)(H,66,72)(H4,52,53,57)(H4,54,55,58)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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9n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135719
PNG
(US10179804, Example 104 | US8846601, 104 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C49H73N17O9/c1-28(67)60-34(17-9-23-57-48(52)53)42(70)64-37-19-20-40(68)56-22-8-16-33(41(51)69)61-47(75)39(26-30-27-59-32-14-6-5-13-31(30)32)66-44(72)36(18-10-24-58-49(54)55)63-46(74)38(25-29-11-3-2-4-12-29)65-43(71)35(15-7-21-50)62-45(37)73/h2-6,11-14,27,33-39,59H,7-10,15-26,50H2,1H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,75)(H,62,73)(H,63,74)(H,64,70)(H,65,71)(H,66,72)(H4,52,53,57)(H4,54,55,58)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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9 -11.4n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135719
PNG
(US10179804, Example 104 | US8846601, 104 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCN)NC1=O)C(N)=O
Show InChI InChI=1S/C49H73N17O9/c1-28(67)60-34(17-9-23-57-48(52)53)42(70)64-37-19-20-40(68)56-22-8-16-33(41(51)69)61-47(75)39(26-30-27-59-32-14-6-5-13-31(30)32)66-44(72)36(18-10-24-58-49(54)55)63-46(74)38(25-29-11-3-2-4-12-29)65-43(71)35(15-7-21-50)62-45(37)73/h2-6,11-14,27,33-39,59H,7-10,15-26,50H2,1H3,(H2,51,69)(H,56,68)(H,60,67)(H,61,75)(H,62,73)(H,63,74)(H,64,70)(H,65,71)(H,66,72)(H4,52,53,57)(H4,54,55,58)/t33-,34-,35-,36-,37-,38+,39-/m0/s1
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9n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135769
PNG
(US10179804, Example 154 | US8846601, 154 | US88466...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(14-8-20-56-47(51)52)41(70)61-33-15-7-19-55-39(68)18-17-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)34(16-9-21-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(33)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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13 -11.2n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135769
PNG
(US10179804, Example 154 | US8846601, 154 | US88466...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(14-8-20-56-47(51)52)41(70)61-33-15-7-19-55-39(68)18-17-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)34(16-9-21-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(33)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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13n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135758
PNG
(US10179804, Example 143 | US8846601, 143 | US94582...)
Show SMILES CC(=O)NCC[C@@H]1NC(=O)[C@H](CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C50H73N17O10/c1-28(68)56-24-20-38-46(75)66-39(25-30-11-4-3-5-12-30)47(76)63-36(17-10-23-59-50(54)55)44(73)67-40(26-31-27-60-33-14-7-6-13-32(31)33)48(77)62-34(42(51)71)15-8-21-57-41(70)19-18-37(45(74)65-38)64-43(72)35(61-29(2)69)16-9-22-58-49(52)53/h3-7,11-14,27,34-40,60H,8-10,15-26H2,1-2H3,(H2,51,71)(H,56,68)(H,57,70)(H,61,69)(H,62,77)(H,63,76)(H,64,72)(H,65,74)(H,66,75)(H,67,73)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37-,38-,39+,40-/m0/s1
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13n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135769
PNG
(US10179804, Example 154 | US8846601, 154 | US88466...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(14-8-20-56-47(51)52)41(70)61-33-15-7-19-55-39(68)18-17-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)34(16-9-21-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(33)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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13n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135758
PNG
(US10179804, Example 143 | US8846601, 143 | US94582...)
Show SMILES CC(=O)NCC[C@@H]1NC(=O)[C@H](CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C50H73N17O10/c1-28(68)56-24-20-38-46(75)66-39(25-30-11-4-3-5-12-30)47(76)63-36(17-10-23-59-50(54)55)44(73)67-40(26-31-27-60-33-14-7-6-13-32(31)33)48(77)62-34(42(51)71)15-8-21-57-41(70)19-18-37(45(74)65-38)64-43(72)35(61-29(2)69)16-9-22-58-49(52)53/h3-7,11-14,27,34-40,60H,8-10,15-26H2,1-2H3,(H2,51,71)(H,56,68)(H,57,70)(H,61,69)(H,62,77)(H,63,76)(H,64,72)(H,65,74)(H,66,75)(H,67,73)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37-,38-,39+,40-/m0/s1
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13 -11.2n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135758
PNG
(US10179804, Example 143 | US8846601, 143 | US94582...)
Show SMILES CC(=O)NCC[C@@H]1NC(=O)[C@H](CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC1=O)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O
Show InChI InChI=1S/C50H73N17O10/c1-28(68)56-24-20-38-46(75)66-39(25-30-11-4-3-5-12-30)47(76)63-36(17-10-23-59-50(54)55)44(73)67-40(26-31-27-60-33-14-7-6-13-32(31)33)48(77)62-34(42(51)71)15-8-21-57-41(70)19-18-37(45(74)65-38)64-43(72)35(61-29(2)69)16-9-22-58-49(52)53/h3-7,11-14,27,34-40,60H,8-10,15-26H2,1-2H3,(H2,51,71)(H,56,68)(H,57,70)(H,61,69)(H,62,77)(H,63,76)(H,64,72)(H,65,74)(H,66,75)(H,67,73)(H4,52,53,58)(H4,54,55,59)/t34-,35-,36-,37-,38-,39+,40-/m0/s1
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13n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135771
PNG
(US10179804, Example 156 | US8846601, 156 | US94582...)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(14-8-20-56-47(51)52)41(70)61-33-15-7-19-55-39(68)18-17-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)34(16-9-21-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(33)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32+,33-,34-,35+,36-,37-/m0/s1
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28n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135771
PNG
(US10179804, Example 156 | US8846601, 156 | US94582...)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(14-8-20-56-47(51)52)41(70)61-33-15-7-19-55-39(68)18-17-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)34(16-9-21-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(33)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32+,33-,34-,35+,36-,37-/m0/s1
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28 -10.7n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135771
PNG
(US10179804, Example 156 | US8846601, 156 | US94582...)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(14-8-20-56-47(51)52)41(70)61-33-15-7-19-55-39(68)18-17-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)34(16-9-21-57-48(53)54)62-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(33)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,70)(H,62,73)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32+,33-,34-,35+,36-,37-/m0/s1
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28n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135722
PNG
(US10179804, Example 107 | US8846601, 107 | US94582...)
Show SMILES CCNC(=O)[C@@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1
Show InChI InChI=1S/C51H75N17O10/c1-3-57-43(72)34-16-9-23-58-42(71)22-20-38(66-44(73)35(62-29(2)69)17-10-24-59-50(53)54)46(75)65-37(19-21-41(52)70)47(76)67-39(26-30-12-5-4-6-13-30)48(77)64-36(18-11-25-60-51(55)56)45(74)68-40(49(78)63-34)27-31-28-61-33-15-8-7-14-32(31)33/h4-8,12-15,28,34-40,61H,3,9-11,16-27H2,1-2H3,(H2,52,70)(H,57,72)(H,58,71)(H,62,69)(H,63,78)(H,64,77)(H,65,75)(H,66,73)(H,67,76)(H,68,74)(H4,53,54,59)(H4,55,56,60)/t34-,35-,36-,37-,38-,39+,40-/m0/s1
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34 -10.6n/an/an/an/an/an/a37



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay was performed employing Eu-NDP-α-MSH (PerkinElmer Life Sciences catalog No. AD0225) with determination b...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135722
PNG
(US10179804, Example 107 | US8846601, 107 | US94582...)
Show SMILES CCNC(=O)[C@@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1
Show InChI InChI=1S/C51H75N17O10/c1-3-57-43(72)34-16-9-23-58-42(71)22-20-38(66-44(73)35(62-29(2)69)17-10-24-59-50(53)54)46(75)65-37(19-21-41(52)70)47(76)67-39(26-30-12-5-4-6-13-30)48(77)64-36(18-11-25-60-51(55)56)45(74)68-40(49(78)63-34)27-31-28-61-33-15-8-7-14-32(31)33/h4-8,12-15,28,34-40,61H,3,9-11,16-27H2,1-2H3,(H2,52,70)(H,57,72)(H,58,71)(H,62,69)(H,63,78)(H,64,77)(H,65,75)(H,66,73)(H,67,76)(H,68,74)(H4,53,54,59)(H4,55,56,60)/t34-,35-,36-,37-,38-,39+,40-/m0/s1
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34n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135722
PNG
(US10179804, Example 107 | US8846601, 107 | US94582...)
Show SMILES CCNC(=O)[C@@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N1
Show InChI InChI=1S/C51H75N17O10/c1-3-57-43(72)34-16-9-23-58-42(71)22-20-38(66-44(73)35(62-29(2)69)17-10-24-59-50(53)54)46(75)65-37(19-21-41(52)70)47(76)67-39(26-30-12-5-4-6-13-30)48(77)64-36(18-11-25-60-51(55)56)45(74)68-40(49(78)63-34)27-31-28-61-33-15-8-7-14-32(31)33/h4-8,12-15,28,34-40,61H,3,9-11,16-27H2,1-2H3,(H2,52,70)(H,57,72)(H,58,71)(H,62,69)(H,63,78)(H,64,77)(H,65,75)(H,66,73)(H,67,76)(H,68,74)(H4,53,54,59)(H4,55,56,60)/t34-,35-,36-,37-,38-,39+,40-/m0/s1
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34n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135772
PNG
(US10179804, Example 157 | US8846601, 157 | US94582...)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C46H67N17O9/c47-28(12-6-19-55-45(50)51)39(67)59-31-14-7-18-54-37(65)17-16-30(38(49)66)58-43(71)34(22-26-24-57-29-13-5-4-11-27(26)29)62-41(69)32(15-8-20-56-46(52)53)60-42(70)33(21-25-9-2-1-3-10-25)61-44(72)35(23-36(48)64)63-40(31)68/h1-5,9-11,13,24,28,30-35,57H,6-8,12,14-23,47H2,(H2,48,64)(H2,49,66)(H,54,65)(H,58,71)(H,59,67)(H,60,70)(H,61,72)(H,62,69)(H,63,68)(H4,50,51,55)(H4,52,53,56)/t28-,30-,31-,32-,33+,34-,35-/m0/s1
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42 -10.5n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135772
PNG
(US10179804, Example 157 | US8846601, 157 | US94582...)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C46H67N17O9/c47-28(12-6-19-55-45(50)51)39(67)59-31-14-7-18-54-37(65)17-16-30(38(49)66)58-43(71)34(22-26-24-57-29-13-5-4-11-27(26)29)62-41(69)32(15-8-20-56-46(52)53)60-42(70)33(21-25-9-2-1-3-10-25)61-44(72)35(23-36(48)64)63-40(31)68/h1-5,9-11,13,24,28,30-35,57H,6-8,12,14-23,47H2,(H2,48,64)(H2,49,66)(H,54,65)(H,58,71)(H,59,67)(H,60,70)(H,61,72)(H,62,69)(H,63,68)(H4,50,51,55)(H4,52,53,56)/t28-,30-,31-,32-,33+,34-,35-/m0/s1
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42n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135772
PNG
(US10179804, Example 157 | US8846601, 157 | US94582...)
Show SMILES N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C46H67N17O9/c47-28(12-6-19-55-45(50)51)39(67)59-31-14-7-18-54-37(65)17-16-30(38(49)66)58-43(71)34(22-26-24-57-29-13-5-4-11-27(26)29)62-41(69)32(15-8-20-56-46(52)53)60-42(70)33(21-25-9-2-1-3-10-25)61-44(72)35(23-36(48)64)63-40(31)68/h1-5,9-11,13,24,28,30-35,57H,6-8,12,14-23,47H2,(H2,48,64)(H2,49,66)(H,54,65)(H,58,71)(H,59,67)(H,60,70)(H,61,72)(H,62,69)(H,63,68)(H4,50,51,55)(H4,52,53,56)/t28-,30-,31-,32-,33+,34-,35-/m0/s1
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42n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135773
PNG
(US10179804, Example 158 | US8846601, 158 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCN)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C47H67N15O10/c1-26(63)56-32(14-7-19-48)41(67)58-33-15-8-20-53-39(65)18-17-31(40(50)66)57-45(71)36(23-28-25-55-30-13-6-5-12-29(28)30)61-42(68)34(16-9-21-54-47(51)52)59-44(70)35(22-27-10-3-2-4-11-27)60-46(72)37(24-38(49)64)62-43(33)69/h2-6,10-13,25,31-37,55H,7-9,14-24,48H2,1H3,(H2,49,64)(H2,50,66)(H,53,65)(H,56,63)(H,57,71)(H,58,67)(H,59,70)(H,60,72)(H,61,68)(H,62,69)(H4,51,52,54)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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50n/an/an/an/an/an/an/an/a



Palatin Technologies, Inc.

US Patent


Assay Description
Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...


US Patent US10179804 (2019)

More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135773
PNG
(US10179804, Example 158 | US8846601, 158 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCN)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C47H67N15O10/c1-26(63)56-32(14-7-19-48)41(67)58-33-15-8-20-53-39(65)18-17-31(40(50)66)57-45(71)36(23-28-25-55-30-13-6-5-12-29(28)30)61-42(68)34(16-9-21-54-47(51)52)59-44(70)35(22-27-10-3-2-4-11-27)60-46(72)37(24-38(49)64)62-43(33)69/h2-6,10-13,25,31-37,55H,7-9,14-24,48H2,1H3,(H2,49,64)(H2,50,66)(H,53,65)(H,56,63)(H,57,71)(H,58,67)(H,59,70)(H,60,72)(H,61,68)(H,62,69)(H4,51,52,54)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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50 -10.4n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))
BDBM135773
PNG
(US10179804, Example 158 | US8846601, 158 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCN)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C47H67N15O10/c1-26(63)56-32(14-7-19-48)41(67)58-33-15-8-20-53-39(65)18-17-31(40(50)66)57-45(71)36(23-28-25-55-30-13-6-5-12-29(28)30)61-42(68)34(16-9-21-54-47(51)52)59-44(70)35(22-27-10-3-2-4-11-27)60-46(72)37(24-38(49)64)62-43(33)69/h2-6,10-13,25,31-37,55H,7-9,14-24,48H2,1H3,(H2,49,64)(H2,50,66)(H,53,65)(H,56,63)(H,57,71)(H,58,67)(H,59,70)(H,60,72)(H,61,68)(H,62,69)(H4,51,52,54)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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50n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135767
PNG
(US10179804, Example 152 | US8846601, 152 | US94582...)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33+,34-,35-,36-,37+,38-/m0/s1
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120 -9.81n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135767
PNG
(US10179804, Example 152 | US8846601, 152 | US94582...)
Show SMILES CC(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33+,34-,35-,36-,37+,38-/m0/s1
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120n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135765
PNG
(US10179804, Example 150 | US8846601, 150 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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130n/an/an/an/an/an/a7.5n/a



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US8846601 (2014)


BindingDB Entry DOI: 10.7270/Q2SF2TWK
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135765
PNG
(US10179804, Example 150 | US8846601, 150 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCCNC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C49H71N17O10/c1-27(67)60-33(14-8-22-57-48(52)53)42(71)62-34-15-7-21-56-40(69)20-18-32(41(51)70)61-47(76)38(25-29-26-59-31-13-6-5-12-30(29)31)66-44(73)35(16-9-23-58-49(54)55)63-46(75)37(24-28-10-3-2-4-11-28)65-45(74)36(64-43(34)72)17-19-39(50)68/h2-6,10-13,26,32-38,59H,7-9,14-25H2,1H3,(H2,50,68)(H2,51,70)(H,56,69)(H,60,67)(H,61,76)(H,62,71)(H,63,75)(H,64,72)(H,65,74)(H,66,73)(H4,52,53,57)(H4,54,55,58)/t32-,33-,34-,35-,36-,37+,38-/m0/s1
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130 -9.77n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
Melanocyte-stimulating hormone receptor


(Homo sapiens (Human))
BDBM135776
PNG
(US10179804, Example 161 | US8846601, 161 | US94582...)
Show SMILES CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCC(=O)NCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C48H69N17O10/c1-26(66)59-32(15-8-20-56-47(51)52)41(70)62-34-17-18-39(68)55-19-7-14-31(40(50)69)60-45(74)36(23-28-25-58-30-13-6-5-12-29(28)30)64-42(71)33(16-9-21-57-48(53)54)61-44(73)35(22-27-10-3-2-4-11-27)63-46(75)37(24-38(49)67)65-43(34)72/h2-6,10-13,25,31-37,58H,7-9,14-24H2,1H3,(H2,49,67)(H2,50,69)(H,55,68)(H,59,66)(H,60,74)(H,61,73)(H,62,70)(H,63,75)(H,64,71)(H,65,72)(H4,51,52,56)(H4,53,54,57)/t31-,32-,33-,34-,35+,36-,37-/m0/s1
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155 -9.66n/an/an/an/an/a7.537



Palatin Technologies, Inc.

US Patent


Assay Description
A competitive inhibition binding assay is performed using membrane homogenates prepared from HEK-293 cells that express recombinant hMC4-R, hMC3-R, o...


US Patent US9458201 (2016)


BindingDB Entry DOI: 10.7270/Q2HT2N79
More data for this
Ligand-Target Pair
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