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31 similar compounds to monomer 140242

Compile data set for download or QSAR
Wt: 542.0
BDBM140237
Wt: 499.0
BDBM140238
Wt: 525.5
BDBM140205
Wt: 525.5
BDBM140206
Wt: 521.6
BDBM140207
Wt: 525.5
BDBM140208
Wt: 507.5
BDBM140209
Wt: 521.6
BDBM140210
Wt: 492.0
BDBM140211
Wt: 521.6
BDBM140214
Wt: 521.6
BDBM140215
Wt: 525.5
BDBM140216
Wt: 532.5
BDBM140219
Wt: 537.6
BDBM140222
Wt: 532.5
BDBM140227
Displayed 1 to 15 (of 31 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 140237,140238,140205,140206,140207,140208,140209,140210,140211,140214,140215,140216,140219,140222,140227   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM140237
PNG
(US8906911, 46)
Show SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C27H35ClF3N3O3/c1-36-24-15-37-8-6-23(24)32-17-9-16-3-2-7-26(16,12-17)25(35)34-14-19-10-20(34)13-33(19)18-4-5-22(28)21(11-18)27(29,30)31/h4-5,11,16-17,19-20,23-24,32H,2-3,6-10,12-15H2,1H3/t16-,17-,19+,20+,23+,24-,26-/m1/s1
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17 -9.85 17.6n/an/an/an/a7.44



AbbVie Inc.

US Patent


Assay Description
Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...


US Patent US8906911 (2014)


BindingDB Entry DOI: 10.7270/Q2BV7FBV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM140206
PNG
(US8906911, 15)
Show SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C27H35F4N3O3/c1-36-24-15-37-8-6-23(24)32-17-9-16-3-2-7-26(16,12-17)25(35)34-14-19-10-20(34)13-33(19)18-4-5-22(28)21(11-18)27(29,30)31/h4-5,11,16-17,19-20,23-24,32H,2-3,6-10,12-15H2,1H3/t16-,17-,19+,20+,23+,24-,26-/m1/s1
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29 -9.55 34.7n/an/an/an/a7.44



AbbVie Inc.

US Patent


Assay Description
Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...


US Patent US8906911 (2014)


BindingDB Entry DOI: 10.7270/Q2BV7FBV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM140205
PNG
(US8906911, 14)
Show SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C27H35F4N3O3/c1-36-24-15-37-8-6-22(24)32-18-9-16-3-2-7-26(16,12-18)25(35)34-14-19-11-20(34)13-33(19)23-10-17(27(29,30)31)4-5-21(23)28/h4-5,10,16,18-20,22,24,32H,2-3,6-9,11-15H2,1H3/t16-,18-,19+,20+,22+,24-,26-/m1/s1
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31 -9.52 43n/an/an/an/a7.44



AbbVie Inc.

US Patent


Assay Description
Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...


US Patent US8906911 (2014)


BindingDB Entry DOI: 10.7270/Q2BV7FBV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM140219
PNG
(US8906911, 28)
Show SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1cc(ccc1C#N)C(F)(F)F
Show InChI InChI=1S/C28H35F3N4O3/c1-37-25-16-38-8-6-23(25)33-20-9-18-3-2-7-27(18,12-20)26(36)35-15-21-11-22(35)14-34(21)24-10-19(28(29,30)31)5-4-17(24)13-32/h4-5,10,18,20-23,25,33H,2-3,6-9,11-12,14-16H2,1H3/t18-,20-,21+,22+,23+,25-,27-/m1/s1
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32 -9.50 19.8n/an/an/an/a7.44



AbbVie Inc.

US Patent


Assay Description
Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...


US Patent US8906911 (2014)


BindingDB Entry DOI: 10.7270/Q2BV7FBV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM140238
PNG
(US8906911, 47)
Show SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1ccc(Cl)c(c1)C#N
Show InChI InChI=1S/C27H35ClN4O3/c1-34-25-16-35-8-6-24(25)30-19-10-18-3-2-7-27(18,12-19)26(33)32-15-21-11-22(32)14-31(21)20-4-5-23(28)17(9-20)13-29/h4-5,9,18-19,21-22,24-25,30H,2-3,6-8,10-12,14-16H2,1H3/t18-,19-,21+,22+,24+,25-,27-/m1/s1
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77 -9.01 49.8n/an/an/an/a7.44



AbbVie Inc.

US Patent


Assay Description
Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...


US Patent US8906911 (2014)


BindingDB Entry DOI: 10.7270/Q2BV7FBV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM140211
PNG
(US8906911, 20)
Show SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C26H35ClFN3O3/c1-33-24-15-34-8-6-23(24)29-17-9-16-3-2-7-26(16,12-17)25(32)31-14-19-10-20(31)13-30(19)18-4-5-22(28)21(27)11-18/h4-5,11,16-17,19-20,23-24,29H,2-3,6-10,12-15H2,1H3/t16-,17-,19+,20+,23+,24-,26-/m1/s1
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112 -8.81 182n/an/an/an/a7.44



AbbVie Inc.

US Patent


Assay Description
Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...


US Patent US8906911 (2014)


BindingDB Entry DOI: 10.7270/Q2BV7FBV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM140207
PNG
(US8906911, 16)
Show SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1cc(ccc1C)C(F)(F)F
Show InChI InChI=1S/C28H38F3N3O3/c1-17-5-6-19(28(29,30)31)11-24(17)33-14-22-12-21(33)15-34(22)26(35)27-8-3-4-18(27)10-20(13-27)32-23-7-9-37-16-25(23)36-2/h5-6,11,18,20-23,25,32H,3-4,7-10,12-16H2,1-2H3/t18-,20-,21+,22+,23+,25-,27-/m1/s1
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199 -8.49 106n/an/an/an/a7.44



AbbVie Inc.

US Patent


Assay Description
Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...


US Patent US8906911 (2014)


BindingDB Entry DOI: 10.7270/Q2BV7FBV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM140209
PNG
(US8906911, 18)
Show SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C27H36F3N3O3/c1-35-24-16-36-9-7-23(24)31-19-10-17-5-3-8-26(17,13-19)25(34)33-15-21-12-22(33)14-32(21)20-6-2-4-18(11-20)27(28,29)30/h2,4,6,11,17,19,21-24,31H,3,5,7-10,12-16H2,1H3/t17-,19-,21+,22+,23+,24-,26-/m1/s1
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207 -8.47 76.4n/an/an/an/a7.44



AbbVie Inc.

US Patent


Assay Description
Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...


US Patent US8906911 (2014)


BindingDB Entry DOI: 10.7270/Q2BV7FBV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM140216
PNG
(US8906911, 25)
Show SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1S/C27H35F4N3O3/c1-36-24-15-37-6-4-23(24)32-19-8-16-3-2-5-26(16,12-19)25(35)34-14-21-11-22(34)13-33(21)20-9-17(27(29,30)31)7-18(28)10-20/h7,9-10,16,19,21-24,32H,2-6,8,11-15H2,1H3/t16-,19-,21+,22+,23+,24-,26-/m1/s1
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271 -8.32 92.2n/an/an/an/a7.44



AbbVie Inc.

US Patent


Assay Description
Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...


US Patent US8906911 (2014)


BindingDB Entry DOI: 10.7270/Q2BV7FBV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM140210
PNG
(US8906911, 19)
Show SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1ccc(C)c(c1)C(F)(F)F
Show InChI InChI=1S/C28H38F3N3O3/c1-17-5-6-20(12-23(17)28(29,30)31)33-14-22-11-21(33)15-34(22)26(35)27-8-3-4-18(27)10-19(13-27)32-24-7-9-37-16-25(24)36-2/h5-6,12,18-19,21-22,24-25,32H,3-4,7-11,13-16H2,1-2H3/t18-,19-,21+,22+,24+,25-,27-/m1/s1
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306 -8.26 233n/an/an/an/a7.44



AbbVie Inc.

US Patent


Assay Description
Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...


US Patent US8906911 (2014)


BindingDB Entry DOI: 10.7270/Q2BV7FBV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM140227
PNG
(US8906911, 36)
Show SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1cc(ccc1C(F)(F)F)C#N
Show InChI InChI=1S/C28H35F3N4O3/c1-37-25-16-38-8-6-23(25)33-19-10-18-3-2-7-27(18,12-19)26(36)35-15-20-11-21(35)14-34(20)24-9-17(13-32)4-5-22(24)28(29,30)31/h4-5,9,18-21,23,25,33H,2-3,6-8,10-12,14-16H2,1H3/t18-,19-,20+,21+,23+,25-,27-/m1/s1
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1.06E+3 -7.57 305n/an/an/an/a7.44



AbbVie Inc.

US Patent


Assay Description
Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...


US Patent US8906911 (2014)


BindingDB Entry DOI: 10.7270/Q2BV7FBV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM140222
PNG
(US8906911, 31)
Show SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1ccc(OC)c(c1)C(F)(F)F
Show InChI InChI=1S/C28H38F3N3O4/c1-36-24-6-5-19(12-22(24)28(29,30)31)33-14-21-11-20(33)15-34(21)26(35)27-8-3-4-17(27)10-18(13-27)32-23-7-9-38-16-25(23)37-2/h5-6,12,17-18,20-21,23,25,32H,3-4,7-11,13-16H2,1-2H3/t17-,18-,20+,21+,23+,25-,27-/m1/s1
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n/an/a 1.02E+3n/an/an/an/a7.44



AbbVie Inc.

US Patent


Assay Description
Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...


US Patent US8906911 (2014)


BindingDB Entry DOI: 10.7270/Q2BV7FBV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM140214
PNG
(US8906911, 23)
Show SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1cccc(c1C)C(F)(F)F
Show InChI InChI=1S/C28H38F3N3O3/c1-17-22(28(29,30)31)6-3-7-24(17)33-14-21-12-20(33)15-34(21)26(35)27-9-4-5-18(27)11-19(13-27)32-23-8-10-37-16-25(23)36-2/h3,6-7,18-21,23,25,32H,4-5,8-16H2,1-2H3/t18-,19-,20+,21+,23+,25-,27-/m1/s1
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n/an/a 1.11E+3n/an/an/an/a7.44



AbbVie Inc.

US Patent


Assay Description
Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...


US Patent US8906911 (2014)


BindingDB Entry DOI: 10.7270/Q2BV7FBV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM140208
PNG
(US8906911, 17)
Show SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C27H35F4N3O3/c1-36-23-15-37-9-7-21(23)32-17-10-16-4-3-8-26(16,12-17)25(35)34-14-18-11-19(34)13-33(18)22-6-2-5-20(24(22)28)27(29,30)31/h2,5-6,16-19,21,23,32H,3-4,7-15H2,1H3/t16-,17-,18+,19+,21+,23-,26-/m1/s1
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n/an/a 1.29E+3n/an/an/an/a7.44



AbbVie Inc.

US Patent


Assay Description
Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...


US Patent US8906911 (2014)


BindingDB Entry DOI: 10.7270/Q2BV7FBV
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))
BDBM140215
PNG
(US8906911, 24)
Show SMILES CO[C@@H]1COCC[C@@H]1N[C@@H]1C[C@H]2CCC[C@]2(C1)C(=O)N1C[C@@H]2C[C@H]1CN2c1cc(C)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H38F3N3O3/c1-17-8-19(28(29,30)31)11-21(9-17)33-14-23-12-22(33)15-34(23)26(35)27-6-3-4-18(27)10-20(13-27)32-24-5-7-37-16-25(24)36-2/h8-9,11,18,20,22-25,32H,3-7,10,12-16H2,1-2H3/t18-,20-,22+,23+,24+,25-,27-/m1/s1
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n/an/a 1.39E+3n/an/an/an/a7.44



AbbVie Inc.

US Patent


Assay Description
Radioligand binding assays were performed in CHO cells expressing human CCR2B and Galpha±16 coupling protein. All compounds were dissolved in DMSO a...


US Patent US8906911 (2014)


BindingDB Entry DOI: 10.7270/Q2BV7FBV
More data for this
Ligand-Target Pair