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2 similar compounds to monomer 140570

Compile data set for download or QSAR
Wt: 557.9
BDBM140550
Wt: 574.9
BDBM140561

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 140550,140561   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM140550
PNG
(US8912221, 23)
Show SMILES C[C@@H](NC(=O)C1(COC1)NC(=O)c1cc(C)no1)c1ccc(cc1F)-c1cc(Cl)cc(F)c1-c1nnn(C)n1
Show InChI InChI=1/C25H22ClF2N7O4/c1-12-6-20(39-33-12)23(36)30-25(10-38-11-25)24(37)29-13(2)16-5-4-14(7-18(16)27)17-8-15(26)9-19(28)21(17)22-31-34-35(3)32-22/h4-9,13H,10-11H2,1-3H3,(H,29,37)(H,30,36)/t13-/s2
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
1n/an/an/an/an/an/a7.4n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...


US Patent US8912221 (2014)


BindingDB Entry DOI: 10.7270/Q2668BWC
More data for this
Ligand-Target Pair
Bradykinin B1 receptor


(Homo sapiens (Human))
BDBM140561
PNG
(US8912221, 34)
Show SMILES COc1cc(on1)C(=O)NC1(COC1)C(=O)N[C@H](C)c1ncc(cc1F)-c1cc(Cl)cc(F)c1-c1nnn(C)n1
Show InChI InChI=1/C24H21ClF2N8O5/c1-11(29-23(37)24(9-39-10-24)30-22(36)17-7-18(38-3)33-40-17)20-16(27)4-12(8-28-20)14-5-13(25)6-15(26)19(14)21-31-34-35(2)32-21/h4-8,11H,9-10H2,1-3H3,(H,29,37)(H,30,36)/t11-/s2
KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
2.20n/an/an/an/an/an/a7.4n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For binding, Bradykinin-1 receptor antagonist compounds were added in various concentrations in 50 mM Tris pH 7.4, 5 mM MgCl2 together with 6 nM Kall...


US Patent US8912221 (2014)


BindingDB Entry DOI: 10.7270/Q2668BWC
More data for this
Ligand-Target Pair