BindingDB logo
myBDB logout

3 similar compounds to monomer 142001

Compile data set for download or QSAR
Wt: 392.5
BDBM141996
Wt: 392.5
BDBM141997
Wt: 392.5
BDBM141998

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 141996,141997,141998   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM141996
PNG
(US8927536, 2)
Show SMILES CC1(CO)Cc2nnc(n2CCS1)C1(CC1)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C22H24N4OS/c1-21(15-27)13-19-24-25-20(26(19)11-12-28-21)22(8-9-22)18-6-4-16(5-7-18)17-3-2-10-23-14-17/h2-7,10,14,27H,8-9,11-13,15H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.60n/an/an/an/a7.425



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A reaction was performed on a 384-well plate (Greiner Bio One) using a reaction volume of 24 ÁL, and all the samples were diluted with an assay buffe...


US Patent US8927536 (2015)


BindingDB Entry DOI: 10.7270/Q2Q23XZP
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM141998
PNG
(US8927536, 4)
Show SMILES C[C@]1(CO)Cc2nnc(n2CCS1)C1(CC1)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C22H24N4OS/c1-21(15-27)13-19-24-25-20(26(19)11-12-28-21)22(8-9-22)18-6-4-16(5-7-18)17-3-2-10-23-14-17/h2-7,10,14,27H,8-9,11-13,15H2,1H3/t21-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.30n/an/an/an/a7.425



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A reaction was performed on a 384-well plate (Greiner Bio One) using a reaction volume of 24 ÁL, and all the samples were diluted with an assay buffe...


US Patent US8927536 (2015)


BindingDB Entry DOI: 10.7270/Q2Q23XZP
More data for this
Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1


(Homo sapiens (Human))
BDBM141997
PNG
(US8927536, 3)
Show SMILES C[C@@]1(CO)Cc2nnc(n2CCS1)C1(CC1)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C22H24N4OS/c1-21(15-27)13-19-24-25-20(26(19)11-12-28-21)22(8-9-22)18-6-4-16(5-7-18)17-3-2-10-23-14-17/h2-7,10,14,27H,8-9,11-13,15H2,1H3/t21-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6.30n/an/an/an/a7.425



Daiichi Sankyo Company, Limited

US Patent


Assay Description
A reaction was performed on a 384-well plate (Greiner Bio One) using a reaction volume of 24 ÁL, and all the samples were diluted with an assay buffe...


US Patent US8927536 (2015)


BindingDB Entry DOI: 10.7270/Q2Q23XZP
More data for this
Ligand-Target Pair