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15 molecules are shown

Wt: 258.2
BDBM14217
Wt: 308.3
BDBM14230
Wt: 342.7
BDBM14231
Wt: 342.7
BDBM14232
Wt: 419.5
BDBM14233
Wt: 419.5
BDBM14234
Wt: 405.4
BDBM14235
Wt: 405.4
BDBM14236
Wt: 407.4
BDBM14237
Wt: 498.5
BDBM14238
Wt: 560.6
BDBM14239
Wt: 643.9
BDBM50219576
Wt: 544.6
BDBM50219589
Wt: 565.0
BDBM50219599
Wt: 530.6
BDBM50219602

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 14217,14230,14231,14232,14233,14234,14235,14236,14237,14238,14239,50219576,50219589,50219599,50219602   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50219599
PNG
(5-(3-{[1-(benzylsulfonyl)piperidin-4-yl]amino}phen...)
Show SMILES OC(=O)COc1c(Cl)c(sc1C(O)=O)-c1cccc(NC2CCN(CC2)S(=O)(=O)Cc2ccccc2)c1
Show InChI InChI=1S/C25H25ClN2O7S2/c26-21-22(35-14-20(29)30)24(25(31)32)36-23(21)17-7-4-8-19(13-17)27-18-9-11-28(12-10-18)37(33,34)15-16-5-2-1-3-6-16/h1-8,13,18,27H,9-12,14-15H2,(H,29,30)(H,31,32)
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0.680n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PTP1B


J Med Chem 50: 4681-98 (2007)


Article DOI: 10.1021/jm0702478
BindingDB Entry DOI: 10.7270/Q2TX3F37
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50219589
PNG
(5-(3-{[1-(benzylsulfonyl)piperidin-4-yl]amino}phen...)
Show SMILES Cc1c(OCC(O)=O)c(sc1-c1cccc(NC2CCN(CC2)S(=O)(=O)Cc2ccccc2)c1)C(O)=O
Show InChI InChI=1S/C26H28N2O7S2/c1-17-23(35-15-22(29)30)25(26(31)32)36-24(17)19-8-5-9-21(14-19)27-20-10-12-28(13-11-20)37(33,34)16-18-6-3-2-4-7-18/h2-9,14,20,27H,10-13,15-16H2,1H3,(H,29,30)(H,31,32)
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8n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PTP1B


J Med Chem 50: 4681-98 (2007)


Article DOI: 10.1021/jm0702478
BindingDB Entry DOI: 10.7270/Q2TX3F37
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))
BDBM50219576
PNG
(4-bromo-3-(carboxymethoxy)-5-(3-(1-(3-chlorobenzyl...)
Show SMILES OC(=O)COc1c(Br)c(sc1C(O)=O)-c1cccc(NC2CCN(CC2)S(=O)(=O)Cc2cccc(Cl)c2)c1
Show InChI InChI=1S/C25H24BrClN2O7S2/c26-21-22(36-13-20(30)31)24(25(32)33)37-23(21)16-4-2-6-19(12-16)28-18-7-9-29(10-8-18)38(34,35)14-15-3-1-5-17(27)11-15/h1-6,11-12,18,28H,7-10,13-14H2,(H,30,31)(H,32,33)
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9n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TCPTP


J Med Chem 50: 4681-98 (2007)


Article DOI: 10.1021/jm0702478
BindingDB Entry DOI: 10.7270/Q2TX3F37
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50219576
PNG
(4-bromo-3-(carboxymethoxy)-5-(3-(1-(3-chlorobenzyl...)
Show SMILES OC(=O)COc1c(Br)c(sc1C(O)=O)-c1cccc(NC2CCN(CC2)S(=O)(=O)Cc2cccc(Cl)c2)c1
Show InChI InChI=1S/C25H24BrClN2O7S2/c26-21-22(36-13-20(30)31)24(25(32)33)37-23(21)16-4-2-6-19(12-16)28-18-7-9-29(10-8-18)38(34,35)14-15-3-1-5-17(27)11-15/h1-6,11-12,18,28H,7-10,13-14H2,(H,30,31)(H,32,33)
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10n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PTP1B


J Med Chem 50: 4681-98 (2007)


Article DOI: 10.1021/jm0702478
BindingDB Entry DOI: 10.7270/Q2TX3F37
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Protein-Tyrosine Phosphatase 1B (PTP1B)


(Homo sapiens (human))
BDBM14239
PNG
(5-(carboxymethoxy)-10-{[1-(phenylmethane)sulfonylp...)
Show SMILES OC(=O)COc1c(sc2c1sc1cc(NC3CCN(CC3)S(=O)(=O)Cc3ccccc3)ccc21)C(O)=O
Show InChI InChI=1S/C25H24N2O7S3/c28-20(29)13-34-21-23-22(36-24(21)25(30)31)18-7-6-17(12-19(18)35-23)26-16-8-10-27(11-9-16)37(32,33)14-15-4-2-1-3-5-15/h1-7,12,16,26H,8-11,13-14H2,(H,28,29)(H,30,31)
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370 -8.77n/an/an/an/an/an/a25



Wyeth Research



Assay Description
The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...


Bioorg Med Chem 14: 2162-77 (2006)


Article DOI: 10.1016/j.bmc.2005.11.005
BindingDB Entry DOI: 10.7270/Q289143K
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))
BDBM14239
PNG
(5-(carboxymethoxy)-10-{[1-(phenylmethane)sulfonylp...)
Show SMILES OC(=O)COc1c(sc2c1sc1cc(NC3CCN(CC3)S(=O)(=O)Cc3ccccc3)ccc21)C(O)=O
Show InChI InChI=1S/C25H24N2O7S3/c28-20(29)13-34-21-23-22(36-24(21)25(30)31)18-7-6-17(12-19(18)35-23)26-16-8-10-27(11-9-16)37(32,33)14-15-4-2-1-3-5-15/h1-7,12,16,26H,8-11,13-14H2,(H,28,29)(H,30,31)
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380 -8.75n/an/an/an/an/an/a25



Wyeth Research



Assay Description
The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...


Bioorg Med Chem 14: 2162-77 (2006)


Article DOI: 10.1016/j.bmc.2005.11.005
BindingDB Entry DOI: 10.7270/Q289143K
More data for this
Ligand-Target Pair
Protein-Tyrosine Phosphatase 1B (PTP1B)


(Homo sapiens (human))
BDBM14234
PNG
(5-(carboxymethoxy)-10-[(cyclohexylmethyl)amino]-3,...)
Show SMILES OC(=O)COc1c(sc2c1sc1cc(NCC3CCCCC3)ccc21)C(O)=O
Show InChI InChI=1S/C20H21NO5S2/c22-15(23)10-26-16-18-17(28-19(16)20(24)25)13-7-6-12(8-14(13)27-18)21-9-11-4-2-1-3-5-11/h6-8,11,21H,1-5,9-10H2,(H,22,23)(H,24,25)
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680 -8.41n/an/an/an/an/an/a25



Wyeth Research



Assay Description
The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...


Bioorg Med Chem 14: 2162-77 (2006)


Article DOI: 10.1016/j.bmc.2005.11.005
BindingDB Entry DOI: 10.7270/Q289143K
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Protein-Tyrosine Phosphatase 1B (PTP1B)


(Homo sapiens (human))
BDBM14236
PNG
(5-(carboxymethoxy)-10-(cyclohexylamino)-3,7-dithia...)
Show SMILES OC(=O)COc1c(sc2c1sc1cc(NC3CCCCC3)ccc21)C(O)=O
Show InChI InChI=1S/C19H19NO5S2/c21-14(22)9-25-15-17-16(27-18(15)19(23)24)12-7-6-11(8-13(12)26-17)20-10-4-2-1-3-5-10/h6-8,10,20H,1-5,9H2,(H,21,22)(H,23,24)
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740 -8.36n/an/an/an/an/an/a25



Wyeth Research



Assay Description
The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...


Bioorg Med Chem 14: 2162-77 (2006)


Article DOI: 10.1016/j.bmc.2005.11.005
BindingDB Entry DOI: 10.7270/Q289143K
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Protein-Tyrosine Phosphatase 1B (PTP1B)


(Homo sapiens (human))
BDBM14233
PNG
(5-(carboxymethoxy)-9-[(cyclohexylmethyl)amino]-3,7...)
Show SMILES OC(=O)COc1c(sc2c1sc1c(NCC3CCCCC3)cccc21)C(O)=O
Show InChI InChI=1S/C20H21NO5S2/c22-14(23)10-26-15-18-17(28-19(15)20(24)25)12-7-4-8-13(16(12)27-18)21-9-11-5-2-1-3-6-11/h4,7-8,11,21H,1-3,5-6,9-10H2,(H,22,23)(H,24,25)
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920 -8.23n/an/an/an/an/an/a25



Wyeth Research



Assay Description
The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...


Bioorg Med Chem 14: 2162-77 (2006)


Article DOI: 10.1016/j.bmc.2005.11.005
BindingDB Entry DOI: 10.7270/Q289143K
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Protein-Tyrosine Phosphatase 1B (PTP1B)


(Homo sapiens (human))
BDBM14238
PNG
(5-(carboxymethoxy)-10-{[1-(ethanesulfonyl)piperidi...)
Show SMILES CCS(=O)(=O)N1CCC(CC1)Nc1ccc2c(c1)sc1c(OCC(O)=O)c(sc21)C(O)=O
Show InChI InChI=1S/C20H22N2O7S3/c1-2-32(27,28)22-7-5-11(6-8-22)21-12-3-4-13-14(9-12)30-18-16(29-10-15(23)24)19(20(25)26)31-17(13)18/h3-4,9,11,21H,2,5-8,10H2,1H3,(H,23,24)(H,25,26)
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1.60E+3 -7.90n/an/an/an/an/an/a25



Wyeth Research



Assay Description
The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...


Bioorg Med Chem 14: 2162-77 (2006)


Article DOI: 10.1016/j.bmc.2005.11.005
BindingDB Entry DOI: 10.7270/Q289143K
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Protein-Tyrosine Phosphatase 1B (PTP1B)


(Homo sapiens (human))
BDBM14235
PNG
(5-(carboxymethoxy)-9-(cyclohexylamino)-3,7-dithiat...)
Show SMILES OC(=O)COc1c(sc2c1sc1c(NC3CCCCC3)cccc21)C(O)=O
Show InChI InChI=1S/C19H19NO5S2/c21-13(22)9-25-14-17-16(27-18(14)19(23)24)11-7-4-8-12(15(11)26-17)20-10-5-2-1-3-6-10/h4,7-8,10,20H,1-3,5-6,9H2,(H,21,22)(H,23,24)
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1.70E+3 -7.87n/an/an/an/an/an/a25



Wyeth Research



Assay Description
The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...


Bioorg Med Chem 14: 2162-77 (2006)


Article DOI: 10.1016/j.bmc.2005.11.005
BindingDB Entry DOI: 10.7270/Q289143K
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM50219602
PNG
(5-(3-{[1-(benzylsulfonyl)piperidin-4-yl]amino}phen...)
Show SMILES OC(=O)COc1cc(sc1C(O)=O)-c1cccc(NC2CCN(CC2)S(=O)(=O)Cc2ccccc2)c1
Show InChI InChI=1S/C25H26N2O7S2/c28-23(29)15-34-21-14-22(35-24(21)25(30)31)18-7-4-8-20(13-18)26-19-9-11-27(12-10-19)36(32,33)16-17-5-2-1-3-6-17/h1-8,13-14,19,26H,9-12,15-16H2,(H,28,29)(H,30,31)
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2.00E+3n/an/an/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PTP1B


J Med Chem 50: 4681-98 (2007)


Article DOI: 10.1021/jm0702478
BindingDB Entry DOI: 10.7270/Q2TX3F37
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Protein-Tyrosine Phosphatase 1B (PTP1B)


(Homo sapiens (human))
BDBM14237
PNG
(5-(carboxymethoxy)-10-(oxan-4-ylamino)-3,7-dithiat...)
Show SMILES OC(=O)COc1c(sc2c3ccc(NC4CCOCC4)cc3sc12)C(O)=O
Show InChI InChI=1S/C18H17NO6S2/c20-13(21)8-25-14-16-15(27-17(14)18(22)23)11-2-1-10(7-12(11)26-16)19-9-3-5-24-6-4-9/h1-2,7,9,19H,3-6,8H2,(H,20,21)(H,22,23)
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2.40E+3 -7.66n/an/an/an/an/an/a25



Wyeth Research



Assay Description
The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...


Bioorg Med Chem 14: 2162-77 (2006)


Article DOI: 10.1016/j.bmc.2005.11.005
BindingDB Entry DOI: 10.7270/Q289143K
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Protein-Tyrosine Phosphatase 1B (PTP1B)


(Homo sapiens (human))
BDBM14232
PNG
(5-(carboxymethoxy)-10-chloro-3,7-dithiatricyclo[6....)
Show SMILES OC(=O)COc1c(sc2c1sc1cc(Cl)ccc21)C(O)=O
Show InChI InChI=1S/C13H7ClO5S2/c14-5-1-2-6-7(3-5)20-11-9(19-4-8(15)16)12(13(17)18)21-10(6)11/h1-3H,4H2,(H,15,16)(H,17,18)
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3.50E+3 -7.44n/an/an/an/an/an/a25



Wyeth Research



Assay Description
The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...


Bioorg Med Chem 14: 2162-77 (2006)


Article DOI: 10.1016/j.bmc.2005.11.005
BindingDB Entry DOI: 10.7270/Q289143K
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))
BDBM14230
PNG
(5-(carboxymethoxy)-3,7-dithiatricyclo[6.4.0.0^{2,6...)
Show SMILES OC(=O)COc1c(sc2c1sc1ccccc21)C(O)=O
Show InChI InChI=1S/C13H8O5S2/c14-8(15)5-18-9-11-10(20-12(9)13(16)17)6-3-1-2-4-7(6)19-11/h1-4H,5H2,(H,14,15)(H,16,17)
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4.10E+3 -7.34n/an/an/an/an/an/a25



Wyeth Research



Assay Description
The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...


Bioorg Med Chem 14: 2162-77 (2006)


Article DOI: 10.1016/j.bmc.2005.11.005
BindingDB Entry DOI: 10.7270/Q289143K
More data for this
Ligand-Target Pair
Protein-tyrosine phosphatase 1B


(Homo sapiens (human))
BDBM14230
PNG
(5-(carboxymethoxy)-3,7-dithiatricyclo[6.4.0.0^{2,6...)
Show SMILES OC(=O)COc1c(sc2c1sc1ccccc21)C(O)=O
Show InChI InChI=1S/C13H8O5S2/c14-8(15)5-18-9-11-10(20-12(9)13(16)17)6-3-1-2-4-7(6)19-11/h1-4H,5H2,(H,14,15)(H,16,17)
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4.10E+3n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPN1


J Med Chem 52: 6649-59 (2009)


Article DOI: 10.1021/jm9008899
BindingDB Entry DOI: 10.7270/Q29023T5
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Protein-Tyrosine Phosphatase 1B (PTP1B)


(Homo sapiens (human))
BDBM14230
PNG
(5-(carboxymethoxy)-3,7-dithiatricyclo[6.4.0.0^{2,6...)
Show SMILES OC(=O)COc1c(sc2c1sc1ccccc21)C(O)=O
Show InChI InChI=1S/C13H8O5S2/c14-8(15)5-18-9-11-10(20-12(9)13(16)17)6-3-1-2-4-7(6)19-11/h1-4H,5H2,(H,14,15)(H,16,17)
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9.20E+3 -6.87n/an/an/an/an/an/a25



Wyeth Research



Assay Description
The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...


Bioorg Med Chem 14: 2162-77 (2006)


Article DOI: 10.1016/j.bmc.2005.11.005
BindingDB Entry DOI: 10.7270/Q289143K
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Tyrosine-protein phosphatase non-receptor type 2


(Homo sapiens (Human))
BDBM14230
PNG
(5-(carboxymethoxy)-3,7-dithiatricyclo[6.4.0.0^{2,6...)
Show SMILES OC(=O)COc1c(sc2c1sc1ccccc21)C(O)=O
Show InChI InChI=1S/C13H8O5S2/c14-8(15)5-18-9-11-10(20-12(9)13(16)17)6-3-1-2-4-7(6)19-11/h1-4H,5H2,(H,14,15)(H,16,17)
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9.20E+3n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPN2


J Med Chem 52: 6649-59 (2009)


Article DOI: 10.1021/jm9008899
BindingDB Entry DOI: 10.7270/Q29023T5
More data for this
Ligand-Target Pair
Protein-Tyrosine Phosphatase 1B (PTP1B)


(Homo sapiens (human))
BDBM14231
PNG
(5-(carboxymethoxy)-9-chloro-3,7-dithiatricyclo[6.4...)
Show SMILES OC(=O)COc1c(sc2c1sc1c(Cl)cccc21)C(O)=O
Show InChI InChI=1S/C13H7ClO5S2/c14-6-3-1-2-5-9(6)20-11-8(19-4-7(15)16)12(13(17)18)21-10(5)11/h1-3H,4H2,(H,15,16)(H,17,18)
PDB
MMDB

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UniChem

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Article
PubMed
1.00E+4 -6.82n/an/an/an/an/an/a25



Wyeth Research



Assay Description
The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...


Bioorg Med Chem 14: 2162-77 (2006)


Article DOI: 10.1016/j.bmc.2005.11.005
BindingDB Entry DOI: 10.7270/Q289143K
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Protein-Tyrosine Phosphatase 1B (PTP1B)


(Homo sapiens (human))
BDBM14217
PNG
(3-(carboxymethoxy)thieno[3,2-b]thiophene-2-carboxy...)
Show SMILES OC(=O)COc1c(sc2ccsc12)C(O)=O
Show InChI InChI=1S/C9H6O5S2/c10-5(11)3-14-6-7-4(1-2-15-7)16-8(6)9(12)13/h1-2H,3H2,(H,10,11)(H,12,13)
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Article
PubMed
2.80E+5 -4.79n/an/an/an/an/a7.022



Wyeth Research



Assay Description
The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...


Bioorg Med Chem 14: 2162-77 (2006)


Article DOI: 10.1016/j.bmc.2005.11.005
BindingDB Entry DOI: 10.7270/Q289143K
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Receptor-type tyrosine-protein phosphatase F (LAR)


(Homo sapiens (Human))
BDBM14230
PNG
(5-(carboxymethoxy)-3,7-dithiatricyclo[6.4.0.0^{2,6...)
Show SMILES OC(=O)COc1c(sc2c1sc1ccccc21)C(O)=O
Show InChI InChI=1S/C13H8O5S2/c14-8(15)5-18-9-11-10(20-12(9)13(16)17)6-3-1-2-4-7(6)19-11/h1-4H,5H2,(H,14,15)(H,16,17)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
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Article
PubMed
1.10E+6n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRF


J Med Chem 52: 6649-59 (2009)


Article DOI: 10.1021/jm9008899
BindingDB Entry DOI: 10.7270/Q29023T5
More data for this
Ligand-Target Pair
Tyrosine-Protein Phosphatase (CD45)


(Homo sapiens (Human))
BDBM14230
PNG
(5-(carboxymethoxy)-3,7-dithiatricyclo[6.4.0.0^{2,6...)
Show SMILES OC(=O)COc1c(sc2c1sc1ccccc21)C(O)=O
Show InChI InChI=1S/C13H8O5S2/c14-8(15)5-18-9-11-10(20-12(9)13(16)17)6-3-1-2-4-7(6)19-11/h1-4H,5H2,(H,14,15)(H,16,17)
PDB
MMDB

Reactome pathway
KEGG

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.25E+6n/an/an/an/an/an/an/an/a



University of Miami

Curated by ChEMBL


Assay Description
Inhibition of PTPRC


J Med Chem 52: 6649-59 (2009)


Article DOI: 10.1021/jm9008899
BindingDB Entry DOI: 10.7270/Q29023T5
More data for this
Ligand-Target Pair