BindingDB logo
myBDB logout

72 molecules are shown

Compile data set for download or QSAR
Wt: 419.8
BDBM145394
Wt: 417.9
BDBM145599
Wt: 403.8
BDBM145602
Wt: 459.9
BDBM145293
Wt: 433.8
BDBM145397
Wt: 469.8
BDBM145403
Wt: 484.9
BDBM145408
Wt: 433.8
BDBM145510
Wt: 377.8
BDBM145250
Wt: 363.8
BDBM47138
Wt: 460.0
BDBM145260
Wt: 403.8
BDBM145246
<<  First   |  Previous   |  Displayed 61 to 72 (of 72 total )

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 145394,145599,145602,145293,145397,145403,145408,145510,145250,47138,145260,145246   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM47138
PNG
(US8952169, 268 | US8952169, 30 | US9771376, Exampl...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCCC2)cc1F
Show InChI InChI=1S/C15H19ClFNO4S/c1-23(20,21)18-15(19)11-7-12(16)14(8-13(11)17)22-9-10-5-3-2-4-6-10/h7-8,10H,2-6,9H2,1H3,(H,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 210n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145293
PNG
(US8952169, 72 | US9771376, Example 72)
Show SMILES COCCS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C21H27ClFNO5S/c1-28-2-3-30(26,27)24-20(25)16-7-17(22)19(8-18(16)23)29-12-21-9-13-4-14(10-21)6-15(5-13)11-21/h7-8,13-15H,2-6,9-12H2,1H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 15.4n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145250
PNG
(US8952169, 29 | US8952169, 90)
Show SMILES CC1(C)C(COc2cc(F)c(cc2Cl)C(=O)NS(C)(=O)=O)C1(C)C
Show InChI InChI=1S/C16H21ClFNO4S/c1-15(2)13(16(15,3)4)8-23-12-7-11(18)9(6-10(12)17)14(20)19-24(5,21)22/h6-7,13H,8H2,1-5H3,(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.00E+4n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM47138
PNG
(US8952169, 268 | US8952169, 30 | US9771376, Exampl...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCCC2)cc1F
Show InChI InChI=1S/C15H19ClFNO4S/c1-23(20,21)18-15(19)11-7-12(16)14(8-13(11)17)22-9-10-5-3-2-4-6-10/h7-8,10H,2-6,9H2,1H3,(H,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 140n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145260
PNG
(US8952169, 115 | US8952169, 39)
Show SMILES CCCCCC12CCC(COc3cc(F)c(cc3Cl)C(=O)NS(C)(=O)=O)(CC1)CC2
Show InChI InChI=1S/C22H31ClFNO4S/c1-3-4-5-6-21-7-10-22(11-8-21,12-9-21)15-29-19-14-18(24)16(13-17(19)23)20(26)25-30(2,27)28/h13-14H,3-12,15H2,1-2H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145293
PNG
(US8952169, 72 | US9771376, Example 72)
Show SMILES COCCS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C21H27ClFNO5S/c1-28-2-3-30(26,27)24-20(25)16-7-17(22)19(8-18(16)23)29-12-21-9-13-4-14(10-21)6-15(5-13)11-21/h7-8,13-15H,2-6,9-12H2,1H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 76n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145250
PNG
(US8952169, 29 | US8952169, 90)
Show SMILES CC1(C)C(COc2cc(F)c(cc2Cl)C(=O)NS(C)(=O)=O)C1(C)C
Show InChI InChI=1S/C16H21ClFNO4S/c1-15(2)13(16(15,3)4)8-23-12-7-11(18)9(6-10(12)17)14(20)19-24(5,21)22/h6-7,13H,8H2,1-5H3,(H,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 94n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145260
PNG
(US8952169, 115 | US8952169, 39)
Show SMILES CCCCCC12CCC(COc3cc(F)c(cc3Cl)C(=O)NS(C)(=O)=O)(CC1)CC2
Show InChI InChI=1S/C22H31ClFNO4S/c1-3-4-5-6-21-7-10-22(11-8-21,12-9-21)15-29-19-14-18(24)16(13-17(19)23)20(26)25-30(2,27)28/h13-14H,3-12,15H2,1-2H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145394
PNG
(US8952169, 173)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(O[C@H]2C3CC4CC2C[C@@](F)(C4)C3)cc1F
Show InChI InChI=1S/C18H20ClF2NO4S/c1-27(24,25)22-17(23)12-4-13(19)15(5-14(12)20)26-16-10-2-9-3-11(16)8-18(21,6-9)7-10/h4-5,9-11,16H,2-3,6-8H2,1H3,(H,22,23)/t9?,10?,11?,16-,18+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 290n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145397
PNG
(US8952169, 176)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2(F)C3CC4CC(C3)CC2C4)cc1F
Show InChI InChI=1S/C19H22ClF2NO4S/c1-28(25,26)23-18(24)14-7-15(20)17(8-16(14)21)27-9-19(22)12-3-10-2-11(5-12)6-13(19)4-10/h7-8,10-13H,2-6,9H2,1H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 50n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145403
PNG
(US8952169, 182)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4(F)CC(F)(CC(F)(C4)C2)C3)cc1F
Show InChI InChI=1S/C19H20ClF4NO4S/c1-30(27,28)25-15(26)11-2-12(20)14(3-13(11)21)29-10-16-4-17(22)7-18(23,5-16)9-19(24,6-16)8-17/h2-3H,4-10H2,1H3,(H,25,26)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 890n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145408
PNG
(US8952169, 187)
Show SMILES COCCS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2(C#N)C3CC4CC(C3)CC2C4)cc1F
Show InChI InChI=1S/C22H26ClFN2O5S/c1-30-2-3-32(28,29)26-21(27)17-9-18(23)20(10-19(17)24)31-12-22(11-25)15-5-13-4-14(7-15)8-16(22)6-13/h9-10,13-16H,2-8,12H2,1H3,(H,26,27)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 990n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145510
PNG
(US8952169, 306)
Show SMILES CS(=O)(=O)NC(=O)c1cc(F)c(OCC23CC4CC(CC(C4)C2)C3)c(Cl)c1F
Show InChI InChI=1S/C19H22ClF2NO4S/c1-28(25,26)23-18(24)13-5-14(21)17(15(20)16(13)22)27-9-19-6-10-2-11(7-19)4-12(3-10)8-19/h5,10-12H,2-4,6-9H2,1H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.30E+3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145599
PNG
(US8952169, 397)
Show SMILES CC1CCCC(C)C1COc1cc(F)c(cc1Cl)C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C19H25ClFNO4S/c1-11-4-3-5-12(2)15(11)10-26-18-9-17(21)14(8-16(18)20)19(23)22-27(24,25)13-6-7-13/h8-9,11-13,15H,3-7,10H2,1-2H3,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 32n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145602
PNG
(US8952169, 400)
Show SMILES CCS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCC3(CC3)CC2)cc1F
Show InChI InChI=1S/C18H23ClFNO4S/c1-2-26(23,24)21-17(22)13-9-14(19)16(10-15(13)20)25-11-12-3-5-18(6-4-12)7-8-18/h9-10,12H,2-8,11H2,1H3,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 20n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145246
PNG
(BDBM342437 | US8952169, 25)
Show SMILES CC1(C)[C@@H]2CC[C@@]1(C)[C@H](C2)Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C18H23ClFNO4S/c1-17(2)10-5-6-18(17,3)15(7-10)25-14-9-13(20)11(8-12(14)19)16(22)21-26(4,23)24/h8-10,15H,5-7H2,1-4H3,(H,21,22)/t10-,15+,18+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 27n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM47138
PNG
(US8952169, 268 | US8952169, 30 | US9771376, Exampl...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCCC2)cc1F
Show InChI InChI=1S/C15H19ClFNO4S/c1-23(20,21)18-15(19)11-7-12(16)14(8-13(11)17)22-9-10-5-3-2-4-6-10/h7-8,10H,2-6,9H2,1H3,(H,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.90n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145293
PNG
(US8952169, 72 | US9771376, Example 72)
Show SMILES COCCS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C21H27ClFNO5S/c1-28-2-3-30(26,27)24-20(25)16-7-17(22)19(8-18(16)23)29-12-21-9-13-4-14(10-21)6-15(5-13)11-21/h7-8,13-15H,2-6,9-12H2,1H3,(H,24,25)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 15.4n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145510
PNG
(US8952169, 306)
Show SMILES CS(=O)(=O)NC(=O)c1cc(F)c(OCC23CC4CC(CC(C4)C2)C3)c(Cl)c1F
Show InChI InChI=1S/C19H22ClF2NO4S/c1-28(25,26)23-18(24)13-5-14(21)17(15(20)16(13)22)27-9-19-6-10-2-11(7-19)4-12(3-10)8-19/h5,10-12H,2-4,6-9H2,1H3,(H,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.60E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145599
PNG
(US8952169, 397)
Show SMILES CC1CCCC(C)C1COc1cc(F)c(cc1Cl)C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C19H25ClFNO4S/c1-11-4-3-5-12(2)15(11)10-26-18-9-17(21)14(8-16(18)20)19(23)22-27(24,25)13-6-7-13/h8-9,11-13,15H,3-7,10H2,1-2H3,(H,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 200n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145602
PNG
(US8952169, 400)
Show SMILES CCS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCC3(CC3)CC2)cc1F
Show InChI InChI=1S/C18H23ClFNO4S/c1-2-26(23,24)21-17(22)13-9-14(19)16(10-15(13)20)25-11-12-3-5-18(6-4-12)7-8-18/h9-10,12H,2-8,11H2,1H3,(H,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 97n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145246
PNG
(BDBM342437 | US8952169, 25)
Show SMILES CC1(C)[C@@H]2CC[C@@]1(C)[C@H](C2)Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C18H23ClFNO4S/c1-17(2)10-5-6-18(17,3)15(7-10)25-14-9-13(20)11(8-12(14)19)16(22)21-26(4,23)24/h8-10,15H,5-7H2,1-4H3,(H,21,22)/t10-,15+,18+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 27n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM47138
PNG
(US8952169, 268 | US8952169, 30 | US9771376, Exampl...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCCC2)cc1F
Show InChI InChI=1S/C15H19ClFNO4S/c1-23(20,21)18-15(19)11-7-12(16)14(8-13(11)17)22-9-10-5-3-2-4-6-10/h7-8,10H,2-6,9H2,1H3,(H,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.90n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145246
PNG
(BDBM342437 | US8952169, 25)
Show SMILES CC1(C)[C@@H]2CC[C@@]1(C)[C@H](C2)Oc1cc(F)c(cc1Cl)C(=O)NS(C)(=O)=O
Show InChI InChI=1S/C18H23ClFNO4S/c1-17(2)10-5-6-18(17,3)15(7-10)25-14-9-13(20)11(8-12(14)19)16(22)21-26(4,23)24/h8-10,15H,5-7H2,1-4H3,(H,21,22)/t10-,15+,18+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 220n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair