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13 molecules are shown

Wt: 274.3
BDBM14794
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Wt: 259.3
BDBM14796
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Wt: 278.7
BDBM14797
Wt: 289.2
BDBM14798
Wt: 244.2
BDBM14785
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Wt: 326.7
BDBM14786
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Wt: 295.3
BDBM14787
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Wt: 380.2
BDBM14789
Wt: 334.2
BDBM14790
Wt: 328.2
BDBM14791
Wt: 300.3
BDBM14792
Wt: 323.3
BDBM14793
Wt: 289.2
BDBM14795
Purchase

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 14794,14796,14797,14798,14785,14786,14787,14789,14790,14791,14792,14793,14795   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase Type 4 (PDE4B)


(Homo sapiens (human))
BDBM14785
PNG
(Pyrazole carboxylic ester 8 | ethyl 3,5-dimethyl-1...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccccc1
Show InChI InChI=1S/C14H16N2O2/c1-4-18-14(17)13-10(2)15-16(11(13)3)12-8-6-5-7-9-12/h5-9H,4H2,1-3H3
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n/an/a 310n/an/an/an/a7.530



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4D)


(Homo sapiens (human))
BDBM14798
PNG
(Pyrazole carboxylic ester 21 | ethyl 3,5-dimethyl-...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C14H15N3O4/c1-4-21-14(18)13-9(2)15-16(10(13)3)11-6-5-7-12(8-11)17(19)20/h5-8H,4H2,1-3H3
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Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 4 (PDE4B)


(Homo sapiens (human))
BDBM14787
PNG
(Pyrazole carboxylic ester 10 | ethyl 3,5-dimethyl-...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1cccc2cccnc12
Show InChI InChI=1S/C17H17N3O2/c1-4-22-17(21)15-11(2)19-20(12(15)3)14-9-5-7-13-8-6-10-18-16(13)14/h5-10H,4H2,1-3H3
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n/an/a 1.70E+4n/an/an/an/a7.530



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4B)


(Homo sapiens (human))
BDBM14789
PNG
(Pyrazole carboxylic ester 12 | ethyl 1-[3,5-bis(tr...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H14F6N2O2/c1-4-26-14(25)13-8(2)23-24(9(13)3)12-6-10(15(17,18)19)5-11(7-12)16(20,21)22/h5-7H,4H2,1-3H3
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Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4B)


(Homo sapiens (human))
BDBM14790
PNG
(Pyrazole carboxylic ester 13 | ethyl 1-(2,4-dinitr...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccc(cc1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C14H14N4O6/c1-4-24-14(19)13-8(2)15-16(9(13)3)11-6-5-10(17(20)21)7-12(11)18(22)23/h5-7H,4H2,1-3H3
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Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4B)


(Homo sapiens (human))
BDBM14791
PNG
(Pyrazole carboxylic ester 14 | ethyl 3,5-dimethyl-...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C15H15F3N2O3/c1-4-22-14(21)13-9(2)19-20(10(13)3)11-5-7-12(8-6-11)23-15(16,17)18/h5-8H,4H2,1-3H3
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n/an/a 3.20E+4n/an/an/an/a7.530



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4B)


(Homo sapiens (human))
BDBM14792
PNG
(Pyrazole carboxylic ester 15 | ethyl 1-(4-tert-but...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C18H24N2O2/c1-7-22-17(21)16-12(2)19-20(13(16)3)15-10-8-14(9-11-15)18(4,5)6/h8-11H,7H2,1-6H3
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n/an/a 1.90E+4n/an/an/an/a7.530



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4B)


(Homo sapiens (human))
BDBM14793
PNG
(Pyrazole carboxylic ester 16 | ethyl 3,5-dimethyl-...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H17N3O4S/c1-4-21-14(18)13-9(2)16-17(10(13)3)11-5-7-12(8-6-11)22(15,19)20/h5-8H,4H2,1-3H3,(H2,15,19,20)
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n/an/a 1.30E+4n/an/an/an/a7.530



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4B)


(Homo sapiens (human))
BDBM14794
PNG
(Pyrazole carboxylic ester 17 | ethyl 1-(4-methoxyp...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccc(OC)cc1
Show InChI InChI=1S/C15H18N2O3/c1-5-20-15(18)14-10(2)16-17(11(14)3)12-6-8-13(19-4)9-7-12/h6-9H,5H2,1-4H3
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n/an/a 5.90E+3n/an/an/an/a7.530



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 4 (PDE4B)


(Homo sapiens (human))
BDBM14795
PNG
(Pyrazole carboxylic ester 18 | ethyl 3,5-dimethyl-...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C14H15N3O4/c1-4-21-14(18)13-9(2)15-16(10(13)3)11-5-7-12(8-6-11)17(19)20/h5-8H,4H2,1-3H3
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n/an/a 840n/an/an/an/a7.530



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4B)


(Homo sapiens (human))
BDBM14796
PNG
(Pyrazole carboxylic ester 19 | ethyl 1-(4-aminophe...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccc(N)cc1
Show InChI InChI=1S/C14H17N3O2/c1-4-19-14(18)13-9(2)16-17(10(13)3)12-7-5-11(15)6-8-12/h5-8H,4,15H2,1-3H3
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n/an/a 350n/an/an/an/a7.530



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 4 (PDE4B)


(Homo sapiens (human))
BDBM14797
PNG
(Pyrazole carboxylic ester 20 | ethyl 1-(2-chloroph...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccccc1Cl
Show InChI InChI=1S/C14H15ClN2O2/c1-4-19-14(18)13-9(2)16-17(10(13)3)12-8-6-5-7-11(12)15/h5-8H,4H2,1-3H3
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n/an/a 56n/an/an/an/a7.530



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 4 (PDE4B)


(Homo sapiens (human))
BDBM14798
PNG
(Pyrazole carboxylic ester 21 | ethyl 3,5-dimethyl-...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C14H15N3O4/c1-4-21-14(18)13-9(2)15-16(10(13)3)11-6-5-7-12(8-11)17(19)20/h5-8H,4H2,1-3H3
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n/an/a 33n/an/an/an/a7.530



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 4 (PDE4D)


(Homo sapiens (human))
BDBM14785
PNG
(Pyrazole carboxylic ester 8 | ethyl 3,5-dimethyl-1...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccccc1
Show InChI InChI=1S/C14H16N2O2/c1-4-18-14(17)13-10(2)15-16(11(13)3)12-8-6-5-7-9-12/h5-9H,4H2,1-3H3
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n/an/a 270n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4D)


(Homo sapiens (human))
BDBM14786
PNG
(Pyrazole carboxylic ester 9 | ethyl 3-(4-chlorophe...)
Show SMILES CCOC(=O)c1cn(nc1-c1ccc(Cl)cc1)-c1ccccc1
Show InChI InChI=1S/C18H15ClN2O2/c1-2-23-18(22)16-12-21(15-6-4-3-5-7-15)20-17(16)13-8-10-14(19)11-9-13/h3-12H,2H2,1H3
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n/an/a 880n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4D)


(Homo sapiens (human))
BDBM14787
PNG
(Pyrazole carboxylic ester 10 | ethyl 3,5-dimethyl-...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1cccc2cccnc12
Show InChI InChI=1S/C17H17N3O2/c1-4-22-17(21)15-11(2)19-20(12(15)3)14-9-5-7-13-8-6-10-18-16(13)14/h5-10H,4H2,1-3H3
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n/an/a 1.90E+4n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4D)


(Homo sapiens (human))
BDBM14789
PNG
(Pyrazole carboxylic ester 12 | ethyl 1-[3,5-bis(tr...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H14F6N2O2/c1-4-26-14(25)13-8(2)23-24(9(13)3)12-6-10(15(17,18)19)5-11(7-12)16(20,21)22/h5-7H,4H2,1-3H3
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n/an/a 9.70E+4n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4D)


(Homo sapiens (human))
BDBM14790
PNG
(Pyrazole carboxylic ester 13 | ethyl 1-(2,4-dinitr...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccc(cc1[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C14H14N4O6/c1-4-24-14(19)13-8(2)15-16(9(13)3)11-6-5-10(17(20)21)7-12(11)18(22)23/h5-7H,4H2,1-3H3
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n/an/a 4.60E+3n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4D)


(Homo sapiens (human))
BDBM14791
PNG
(Pyrazole carboxylic ester 14 | ethyl 3,5-dimethyl-...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C15H15F3N2O3/c1-4-22-14(21)13-9(2)19-20(10(13)3)11-5-7-12(8-6-11)23-15(16,17)18/h5-8H,4H2,1-3H3
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n/an/a 2.10E+4n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4D)


(Homo sapiens (human))
BDBM14792
PNG
(Pyrazole carboxylic ester 15 | ethyl 1-(4-tert-but...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C18H24N2O2/c1-7-22-17(21)16-12(2)19-20(13(16)3)15-10-8-14(9-11-15)18(4,5)6/h8-11H,7H2,1-6H3
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n/an/a 1.40E+4n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4D)


(Homo sapiens (human))
BDBM14793
PNG
(Pyrazole carboxylic ester 16 | ethyl 3,5-dimethyl-...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H17N3O4S/c1-4-21-14(18)13-9(2)16-17(10(13)3)11-5-7-12(8-6-11)22(15,19)20/h5-8H,4H2,1-3H3,(H2,15,19,20)
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UniChem
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n/an/a 9.10E+3n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4D)


(Homo sapiens (human))
BDBM14794
PNG
(Pyrazole carboxylic ester 17 | ethyl 1-(4-methoxyp...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccc(OC)cc1
Show InChI InChI=1S/C15H18N2O3/c1-5-20-15(18)14-10(2)16-17(11(14)3)12-6-8-13(19-4)9-7-12/h6-9H,5H2,1-4H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 4 (PDE4D)


(Homo sapiens (human))
BDBM14795
PNG
(Pyrazole carboxylic ester 18 | ethyl 3,5-dimethyl-...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C14H15N3O4/c1-4-21-14(18)13-9(2)15-16(10(13)3)11-5-7-12(8-6-11)17(19)20/h5-8H,4H2,1-3H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4D)


(Homo sapiens (human))
BDBM14796
PNG
(Pyrazole carboxylic ester 19 | ethyl 1-(4-aminophe...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccc(N)cc1
Show InChI InChI=1S/C14H17N3O2/c1-4-19-14(18)13-9(2)16-17(10(13)3)12-7-5-11(15)6-8-12/h5-8H,4,15H2,1-3H3
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n/an/a 160n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 4 (PDE4D)


(Homo sapiens (human))
BDBM14797
PNG
(Pyrazole carboxylic ester 20 | ethyl 1-(2-chloroph...)
Show SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccccc1Cl
Show InChI InChI=1S/C14H15ClN2O2/c1-4-19-14(18)13-9(2)16-17(10(13)3)12-8-6-5-7-11(12)15/h5-8H,4H2,1-3H3
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n/an/a 19n/an/an/an/an/an/a



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 4 (PDE4B)


(Homo sapiens (human))
BDBM14786
PNG
(Pyrazole carboxylic ester 9 | ethyl 3-(4-chlorophe...)
Show SMILES CCOC(=O)c1cn(nc1-c1ccc(Cl)cc1)-c1ccccc1
Show InChI InChI=1S/C18H15ClN2O2/c1-2-23-18(22)16-12-21(15-6-4-3-5-7-15)20-17(16)13-8-10-14(19)11-9-13/h3-12H,2H2,1H3
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n/an/a 1.50E+3n/an/an/an/a7.530



Plexxikon



Assay Description
Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...


Nat Biotechnol 23: 201-7 (2005)


Article DOI: 10.1038/nbt1059
BindingDB Entry DOI: 10.7270/Q21N7ZCN
More data for this
Ligand-Target Pair
3D
3D Structure (docked)