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59 similar compounds to monomer 15067

Compile data set for download or QSAR
Wt: 420.5
BDBM15029
Wt: 344.4
BDBM15037
Wt: 368.4
BDBM15039
Wt: 361.4
BDBM15040
Wt: 388.4
BDBM15041
Wt: 358.4
BDBM15042
Wt: 387.4
BDBM15043
Wt: 386.4
BDBM15044
Wt: 385.4
BDBM15045
Wt: 401.4
BDBM15046
Wt: 422.5
BDBM15047
Wt: 400.4
BDBM15049
Wt: 400.4
BDBM15050
Wt: 400.4
BDBM15051
Wt: 414.4
BDBM15052
Displayed 1 to 15 (of 59 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 15029,15037,15039,15040,15041,15042,15043,15044,15045,15046,15047,15049,15050,15051,15052   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15029
PNG
(3-[(2S)-2-amino-3-({5-[2-(pyridin-4-yl)phenyl]pyri...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccccc1-c1ccncc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C27H24N4O/c28-22(13-20-16-31-27-8-4-3-7-26(20)27)18-32-23-14-21(15-30-17-23)25-6-2-1-5-24(25)19-9-11-29-12-10-19/h1-12,14-17,22,31H,13,18,28H2/t22-/m0/s1
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n/an/an/an/an/an/an/a7.522



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15050
PNG
(N-(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...)
Show SMILES CC(=O)Nc1ccc(cc1)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C24H24N4O2/c1-16(29)28-21-8-6-17(7-9-21)18-11-22(14-26-12-18)30-15-20(25)10-19-13-27-24-5-3-2-4-23(19)24/h2-9,11-14,20,27H,10,15,25H2,1H3,(H,28,29)/t20-/m0/s1
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n/an/a 227n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of Akt


Eur J Med Chem 44: 4090-7 (2009)


Article DOI: 10.1016/j.ejmech.2009.04.050
BindingDB Entry DOI: 10.7270/Q2GT5N74
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15039
PNG
(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)C#N)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H20N4O/c24-11-16-5-7-17(8-6-16)18-10-21(14-26-12-18)28-15-20(25)9-19-13-27-23-4-2-1-3-22(19)23/h1-8,10,12-14,20,27H,9,15,25H2/t20-/m0/s1
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n/an/a 1.83E+3n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15040
PNG
(3-[(2S)-2-amino-3-{[5-(4-fluorophenyl)pyridin-3-yl...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(F)cc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C22H20FN3O/c23-18-7-5-15(6-8-18)16-10-20(13-25-11-16)27-14-19(24)9-17-12-26-22-4-2-1-3-21(17)22/h1-8,10-13,19,26H,9,14,24H2/t19-/m0/s1
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n/an/a 1.56E+3n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15041
PNG
(3-[(2S)-2-amino-3-{[5-(4-nitrophenyl)pyridin-3-yl]...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)N(=O)=O)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C22H20N4O3/c23-18(9-17-12-25-22-4-2-1-3-21(17)22)14-29-20-10-16(11-24-13-20)15-5-7-19(8-6-15)26(27)28/h1-8,10-13,18,25H,9,14,23H2/t18-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15042
PNG
(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(N)cc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C22H22N4O/c23-18-7-5-15(6-8-18)16-10-20(13-25-11-16)27-14-19(24)9-17-12-26-22-4-2-1-3-21(17)22/h1-8,10-13,19,26H,9,14,23-24H2/t19-/m0/s1
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n/an/a 6.94E+3n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15043
PNG
(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)C(O)=O)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H21N3O3/c24-19(9-18-12-26-22-4-2-1-3-21(18)22)14-29-20-10-17(11-25-13-20)15-5-7-16(8-6-15)23(27)28/h1-8,10-13,19,26H,9,14,24H2,(H,27,28)/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15044
PNG
(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)C(N)=O)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O2/c24-19(9-18-12-27-22-4-2-1-3-21(18)22)14-29-20-10-17(11-26-13-20)15-5-7-16(8-6-15)23(25)28/h1-8,10-13,19,27H,9,14,24H2,(H2,25,28)/t19-/m0/s1
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n/an/a 9.31E+3n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15045
PNG
(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)C(N)=N)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H23N5O/c24-19(9-18-12-28-22-4-2-1-3-21(18)22)14-29-20-10-17(11-27-13-20)15-5-7-16(8-6-15)23(25)26/h1-8,10-13,19,28H,9,14,24H2,(H3,25,26)/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15046
PNG
(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)C(=N)NO)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H23N5O2/c24-19(9-18-12-27-22-4-2-1-3-21(18)22)14-30-20-10-17(11-26-13-20)15-5-7-16(8-6-15)23(25)28-29/h1-8,10-13,19,27,29H,9,14,24H2,(H2,25,28)/t19-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15047
PNG
(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)S(N)(=O)=O)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C22H22N4O3S/c23-18(9-17-12-26-22-4-2-1-3-21(17)22)14-29-19-10-16(11-25-13-19)15-5-7-20(8-6-15)30(24,27)28/h1-8,10-13,18,26H,9,14,23H2,(H2,24,27,28)/t18-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15049
PNG
(2-(3-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...)
Show SMILES N[C@H](COc1cncc(c1)-c1cccc(CC(N)=O)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C24H24N4O2/c25-20(10-19-13-28-23-7-2-1-6-22(19)23)15-30-21-11-18(12-27-14-21)17-5-3-4-16(8-17)9-24(26)29/h1-8,11-14,20,28H,9-10,15,25H2,(H2,26,29)/t20-/m0/s1
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n/an/a 1.39E+3n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15050
PNG
(N-(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...)
Show SMILES CC(=O)Nc1ccc(cc1)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C24H24N4O2/c1-16(29)28-21-8-6-17(7-9-21)18-11-22(14-26-12-18)30-15-20(25)10-19-13-27-24-5-3-2-4-23(19)24/h2-9,11-14,20,27H,10,15,25H2,1H3,(H,28,29)/t20-/m0/s1
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n/an/a 227n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15051
PNG
(N-(3-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...)
Show SMILES CC(=O)Nc1cccc(c1)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C24H24N4O2/c1-16(29)28-21-6-4-5-17(10-21)18-11-22(14-26-12-18)30-15-20(25)9-19-13-27-24-8-3-2-7-23(19)24/h2-8,10-14,20,27H,9,15,25H2,1H3,(H,28,29)/t20-/m0/s1
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n/an/a 1.20E+4n/an/an/an/an/an/a



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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15052
PNG
(N-[(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]py...)
Show SMILES CC(=O)NCc1ccc(cc1)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1
Show InChI InChI=1S/C25H26N4O2/c1-17(30)28-12-18-6-8-19(9-7-18)20-11-23(15-27-13-20)31-16-22(26)10-21-14-29-25-5-3-2-4-24(21)25/h2-9,11,13-15,22,29H,10,12,16,26H2,1H3,(H,28,30)/t22-/m0/s1
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Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15037
PNG
(3-[(2S)-2-amino-3-{[5-(pyridin-4-yl)pyridin-3-yl]o...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccncc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C21H20N4O/c22-18(9-17-12-25-21-4-2-1-3-20(17)21)14-26-19-10-16(11-24-13-19)15-5-7-23-8-6-15/h1-8,10-13,18,25H,9,14,22H2/t18-/m0/s1
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n/an/a 245n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of Akt


Eur J Med Chem 44: 4090-7 (2009)


Article DOI: 10.1016/j.ejmech.2009.04.050
BindingDB Entry DOI: 10.7270/Q2GT5N74
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15043
PNG
(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)C(O)=O)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H21N3O3/c24-19(9-18-12-26-22-4-2-1-3-21(18)22)14-29-20-10-17(11-25-13-20)15-5-7-16(8-6-15)23(27)28/h1-8,10-13,19,26H,9,14,24H2,(H,27,28)/t19-/m0/s1
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n/an/a 3.13E+4n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of Akt


Eur J Med Chem 44: 4090-7 (2009)


Article DOI: 10.1016/j.ejmech.2009.04.050
BindingDB Entry DOI: 10.7270/Q2GT5N74
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM15049
PNG
(2-(3-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...)
Show SMILES N[C@H](COc1cncc(c1)-c1cccc(CC(N)=O)c1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C24H24N4O2/c25-20(10-19-13-28-23-7-2-1-6-22(19)23)15-30-21-11-18(12-27-14-21)17-5-3-4-16(8-17)9-24(26)29/h1-8,11-14,20,28H,9-10,15,25H2,(H2,26,29)/t20-/m0/s1
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n/an/a 1.39E+3n/an/an/an/an/an/a



Zhejiang University

Curated by ChEMBL


Assay Description
Inhibition of Akt


Eur J Med Chem 44: 4090-7 (2009)


Article DOI: 10.1016/j.ejmech.2009.04.050
BindingDB Entry DOI: 10.7270/Q2GT5N74
More data for this
Ligand-Target Pair
Protein kinase B (Akt 1)


(Homo sapiens (Human))
BDBM15037
PNG
(3-[(2S)-2-amino-3-{[5-(pyridin-4-yl)pyridin-3-yl]o...)
Show SMILES N[C@H](COc1cncc(c1)-c1ccncc1)Cc1c[nH]c2ccccc12
Show InChI InChI=1S/C21H20N4O/c22-18(9-17-12-25-21-4-2-1-3-20(17)21)14-26-19-10-16(11-24-13-19)15-5-7-23-8-6-15/h1-8,10-13,18,25H,9,14,22H2/t18-/m0/s1
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PubMed
n/an/a 260n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...


Bioorg Med Chem Lett 16: 2000-7 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.065
BindingDB Entry DOI: 10.7270/Q2765CKX
More data for this
Ligand-Target Pair