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2 similar compounds to monomer 154565

Wt: 302.3
BDBM154566
Wt: 259.2
BDBM50331561

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 154566,50331561   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methyl-lysine binding protein (53BP1)


(Homo sapiens)
BDBM154566
PNG
(N-(3-(Tert-butylamino)propyl)-4-(trifluoromethyl)b...)
Show SMILES CC(C)(C)NCCCNC(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H21F3N2O/c1-14(2,3)20-10-4-9-19-13(21)11-5-7-12(8-6-11)15(16,17)18/h5-8,20H,4,9-10H2,1-3H3,(H,19,21)
PDB
MMDB

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PubMed
n/an/a>1.00E+5n/an/an/an/a8.01,117.6



University of North Carolina at Chapel Hill



Assay Description
In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...


ACS Chem Biol 10: 1072-81 (2015)

More data for this
Ligand-Target Pair
Chromobox protein homolog 7 (CBX7)


(Homo sapiens (Human))
BDBM154566
PNG
(N-(3-(Tert-butylamino)propyl)-4-(trifluoromethyl)b...)
Show SMILES CC(C)(C)NCCCNC(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H21F3N2O/c1-14(2,3)20-10-4-9-19-13(21)11-5-7-12(8-6-11)15(16,17)18/h5-8,20H,4,9-10H2,1-3H3,(H,19,21)
PDB

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PubMed
n/an/a>1.00E+5n/an/an/an/a8.01,117.6



University of North Carolina at Chapel Hill



Assay Description
In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...


ACS Chem Biol 10: 1072-81 (2015)

More data for this
Ligand-Target Pair
Histone demethylase JARID1A


(Homo sapiens (Human))
BDBM154566
PNG
(N-(3-(Tert-butylamino)propyl)-4-(trifluoromethyl)b...)
Show SMILES CC(C)(C)NCCCNC(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H21F3N2O/c1-14(2,3)20-10-4-9-19-13(21)11-5-7-12(8-6-11)15(16,17)18/h5-8,20H,4,9-10H2,1-3H3,(H,19,21)
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PubMed
n/an/a>1.00E+5n/an/an/an/a8.01,117.6



University of North Carolina at Chapel Hill



Assay Description
In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...


ACS Chem Biol 10: 1072-81 (2015)

More data for this
Ligand-Target Pair
PHD finger protein 1 (PHF1)


(Homo sapiens (Human))
BDBM154566
PNG
(N-(3-(Tert-butylamino)propyl)-4-(trifluoromethyl)b...)
Show SMILES CC(C)(C)NCCCNC(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H21F3N2O/c1-14(2,3)20-10-4-9-19-13(21)11-5-7-12(8-6-11)15(16,17)18/h5-8,20H,4,9-10H2,1-3H3,(H,19,21)
PDB

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UniProtKB/SwissProt

GoogleScholar
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.0844.45



University of North Carolina at Chapel Hill



Assay Description
In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...


ACS Chem Biol 10: 1072-81 (2015)

More data for this
Ligand-Target Pair
PHD finger protein 19 (PHF19)


(Homo sapiens (Human))
BDBM154566
PNG
(N-(3-(Tert-butylamino)propyl)-4-(trifluoromethyl)b...)
Show SMILES CC(C)(C)NCCCNC(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H21F3N2O/c1-14(2,3)20-10-4-9-19-13(21)11-5-7-12(8-6-11)15(16,17)18/h5-8,20H,4,9-10H2,1-3H3,(H,19,21)
PDB

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PC sid
UniChem

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Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.0844.45



University of North Carolina at Chapel Hill



Assay Description
In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...


ACS Chem Biol 10: 1072-81 (2015)

More data for this
Ligand-Target Pair
Cathepsin (S and K)


(Homo sapiens (Human))
BDBM50331561
PNG
(CHEMBL1288588 | N-(1-oxobutan-2-yl)-3-(trifluorome...)
Show SMILES CCC(NC(=O)c1cccc(c1)C(F)(F)F)C=O
Show InChI InChI=1S/C12H12F3NO2/c1-2-10(7-17)16-11(18)8-4-3-5-9(6-8)12(13,14)15/h3-7,10H,2H2,1H3,(H,16,18)
PDB
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PubMed
n/an/a 1.07E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human cathepsin S by fluorescence assay


Bioorg Med Chem Lett 20: 6890-4 (2010)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase (UHRF1)


(Homo sapiens (Human))
BDBM154566
PNG
(N-(3-(Tert-butylamino)propyl)-4-(trifluoromethyl)b...)
Show SMILES CC(C)(C)NCCCNC(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H21F3N2O/c1-14(2,3)20-10-4-9-19-13(21)11-5-7-12(8-6-11)15(16,17)18/h5-8,20H,4,9-10H2,1-3H3,(H,19,21)
PDB

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UniChem

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Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.0571.3



University of North Carolina at Chapel Hill



Assay Description
In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...


ACS Chem Biol 10: 1072-81 (2015)

More data for this
Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM154566
PNG
(N-(3-(Tert-butylamino)propyl)-4-(trifluoromethyl)b...)
Show SMILES CC(C)(C)NCCCNC(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H21F3N2O/c1-14(2,3)20-10-4-9-19-13(21)11-5-7-12(8-6-11)15(16,17)18/h5-8,20H,4,9-10H2,1-3H3,(H,19,21)
PDB

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UniChem

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Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.0571.3



University of North Carolina at Chapel Hill



Assay Description
In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...


ACS Chem Biol 10: 1072-81 (2015)

More data for this
Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3)


(Homo sapiens (Human))
BDBM154566
PNG
(N-(3-(Tert-butylamino)propyl)-4-(trifluoromethyl)b...)
Show SMILES CC(C)(C)NCCCNC(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H21F3N2O/c1-14(2,3)20-10-4-9-19-13(21)11-5-7-12(8-6-11)15(16,17)18/h5-8,20H,4,9-10H2,1-3H3,(H,19,21)
PDB

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UniChem

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Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.0571.3



University of North Carolina at Chapel Hill



Assay Description
In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...


ACS Chem Biol 10: 1072-81 (2015)

More data for this
Ligand-Target Pair
MBT domain-containing protein 1 (MBTD1)


(Homo sapiens (Human))
BDBM154566
PNG
(N-(3-(Tert-butylamino)propyl)-4-(trifluoromethyl)b...)
Show SMILES CC(C)(C)NCCCNC(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H21F3N2O/c1-14(2,3)20-10-4-9-19-13(21)11-5-7-12(8-6-11)15(16,17)18/h5-8,20H,4,9-10H2,1-3H3,(H,19,21)
PDB

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UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
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PC sid
UniChem

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Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.0571.3



University of North Carolina at Chapel Hill



Assay Description
In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...


ACS Chem Biol 10: 1072-81 (2015)

More data for this
Ligand-Target Pair
PHD finger protein 23 (PHF23)


(Homo sapiens (Human))
BDBM154566
PNG
(N-(3-(Tert-butylamino)propyl)-4-(trifluoromethyl)b...)
Show SMILES CC(C)(C)NCCCNC(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H21F3N2O/c1-14(2,3)20-10-4-9-19-13(21)11-5-7-12(8-6-11)15(16,17)18/h5-8,20H,4,9-10H2,1-3H3,(H,19,21)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/a8.0844.45



University of North Carolina at Chapel Hill



Assay Description
In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...


ACS Chem Biol 10: 1072-81 (2015)

More data for this
Ligand-Target Pair