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6 similar compounds to monomer 168104

Wt: 469.4
BDBM155257
Wt: 469.4
BDBM155258
Wt: 499.5
BDBM168094
Wt: 499.5
BDBM168095
Wt: 445.5
BDBM168105
Wt: 483.5
BDBM168108

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 155257,155258,168094,168095,168105,168108   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168108
PNG
(US9073931, E21)
Show SMILES CC(C)[C@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1ncc(C)c(n1)C(F)(F)F
Show InChI InChI=1S/C21H24F3N5O3S/c1-11(2)17-19-26-14-7-13(10-30)16(33(4,31)32)8-15(14)28(19)5-6-29(17)20-25-9-12(3)18(27-20)21(22,23)24/h7-9,11,17,30H,5-6,10H2,1-4H3/t17-/m1/s1
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US Patent
10 -10.9n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168094
PNG
(US9073931, E13a)
Show SMILES CC(C)[C@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1ncc(CO)c(n1)C(F)(F)F
Show InChI InChI=1S/C21H24F3N5O4S/c1-11(2)17-19-26-14-6-12(9-30)16(34(3,32)33)7-15(14)28(19)4-5-29(17)20-25-8-13(10-31)18(27-20)21(22,23)24/h6-8,11,17,30-31H,4-5,9-10H2,1-3H3/t17-/m1/s1
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17 -10.6n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM155257
PNG
(US9006244, E2a)
Show SMILES CC(C)[C@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1nccc(n1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N5O3S/c1-11(2)17-18-25-13-8-12(10-29)15(32(3,30)31)9-14(13)27(18)6-7-28(17)19-24-5-4-16(26-19)20(21,22)23/h4-5,8-9,11,17,29H,6-7,10H2,1-3H3/t17-/m1/s1
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20n/an/an/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9006244 (2015)


BindingDB Entry DOI: 10.7270/Q2X92911
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (human))
BDBM168108
PNG
(US9073931, E21)
Show SMILES CC(C)[C@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1ncc(C)c(n1)C(F)(F)F
Show InChI InChI=1S/C21H24F3N5O3S/c1-11(2)17-19-26-14-7-13(10-30)16(33(4,31)32)8-15(14)28(19)5-6-29(17)20-25-9-12(3)18(27-20)21(22,23)24/h7-9,11,17,30H,5-6,10H2,1-4H3/t17-/m1/s1
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83 -9.65n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (human))
BDBM155257
PNG
(US9006244, E2a)
Show SMILES CC(C)[C@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1nccc(n1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N5O3S/c1-11(2)17-18-25-13-8-12(10-29)15(32(3,30)31)9-14(13)27(18)6-7-28(17)19-24-5-4-16(26-19)20(21,22)23/h4-5,8-9,11,17,29H,6-7,10H2,1-3H3/t17-/m1/s1
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318n/an/an/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9006244 (2015)


BindingDB Entry DOI: 10.7270/Q2X92911
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (human))
BDBM168094
PNG
(US9073931, E13a)
Show SMILES CC(C)[C@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1ncc(CO)c(n1)C(F)(F)F
Show InChI InChI=1S/C21H24F3N5O4S/c1-11(2)17-19-26-14-6-12(9-30)16(34(3,32)33)7-15(14)28(19)4-5-29(17)20-25-8-13(10-31)18(27-20)21(22,23)24/h6-8,11,17,30-31H,4-5,9-10H2,1-3H3/t17-/m1/s1
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409 -8.71n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168095
PNG
(US9073931, E13b)
Show SMILES CC(C)[C@@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1ncc(CO)c(n1)C(F)(F)F
Show InChI InChI=1S/C21H24F3N5O4S/c1-11(2)17-19-26-14-6-12(9-30)16(34(3,32)33)7-15(14)28(19)4-5-29(17)20-25-8-13(10-31)18(27-20)21(22,23)24/h6-8,11,17,30-31H,4-5,9-10H2,1-3H3/t17-/m0/s1
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1.04E+3 -8.16n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM168105
PNG
(US9073931, E19)
Show SMILES CC(C)[C@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1ncc(CO)c(C)n1
Show InChI InChI=1S/C21H27N5O4S/c1-12(2)19-20-24-16-7-14(10-27)18(31(4,29)30)8-17(16)25(20)5-6-26(19)21-22-9-15(11-28)13(3)23-21/h7-9,12,19,27-28H,5-6,10-11H2,1-4H3/t19-/m1/s1
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>2.50E+3>-7.64n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (Human))
BDBM155258
PNG
(US9006244, E2b)
Show SMILES CC(C)[C@@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1nccc(n1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N5O3S/c1-11(2)17-18-25-13-8-12(10-29)15(32(3,30)31)9-14(13)27(18)6-7-28(17)19-24-5-4-16(26-19)20(21,22)23/h4-5,8-9,11,17,29H,6-7,10H2,1-3H3/t17-/m0/s1
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>2.50E+3n/an/an/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9006244 (2015)


BindingDB Entry DOI: 10.7270/Q2X92911
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (human))
BDBM168105
PNG
(US9073931, E19)
Show SMILES CC(C)[C@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1ncc(CO)c(C)n1
Show InChI InChI=1S/C21H27N5O4S/c1-12(2)19-20-24-16-7-14(10-27)18(31(4,29)30)8-17(16)25(20)5-6-26(19)21-22-9-15(11-28)13(3)23-21/h7-9,12,19,27-28H,5-6,10-11H2,1-4H3/t19-/m1/s1
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>3.33E+3>-7.47n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (human))
BDBM155258
PNG
(US9006244, E2b)
Show SMILES CC(C)[C@@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1nccc(n1)C(F)(F)F
Show InChI InChI=1S/C20H22F3N5O3S/c1-11(2)17-18-25-13-8-12(10-29)15(32(3,30)31)9-14(13)27(18)6-7-28(17)19-24-5-4-16(26-19)20(21,22)23/h4-5,8-9,11,17,29H,6-7,10H2,1-3H3/t17-/m0/s1
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>3.33E+3n/an/an/an/an/an/an/an/a



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9006244 (2015)


BindingDB Entry DOI: 10.7270/Q2X92911
More data for this
Ligand-Target Pair
Liver X receptor (LXR alpha AND LXR beta)


(Homo sapiens (human))
BDBM168095
PNG
(US9073931, E13b)
Show SMILES CC(C)[C@@H]1N(CCn2c1nc1cc(CO)c(cc21)S(C)(=O)=O)c1ncc(CO)c(n1)C(F)(F)F
Show InChI InChI=1S/C21H24F3N5O4S/c1-11(2)17-19-26-14-6-12(9-30)16(34(3,32)33)7-15(14)28(19)4-5-29(17)20-25-8-13(10-31)18(27-20)21(22,23)24/h6-8,11,17,30-31H,4-5,9-10H2,1-3H3/t17-/m0/s1
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>3.33E+3>-7.47n/an/an/an/an/an/a25



Vitae Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds of the invention were assessed in a competition binding assay where different concentrations of compounds were incubated with the LXR ligan...


US Patent US9073931 (2015)


BindingDB Entry DOI: 10.7270/Q26W98VC
More data for this
Ligand-Target Pair