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12 similar compounds to monomer 50313368

Compile data set for download or QSAR
Wt: 414.4
BDBM159393
Wt: 372.4
BDBM50313364
Wt: 384.4
BDBM50313367
Wt: 368.4
BDBM50313374
Wt: 370.4
BDBM50313375
Wt: 372.4
BDBM50313380
Wt: 372.4
BDBM50313382
Wt: 388.4
BDBM50346264
Wt: 428.5
BDBM50345022
Wt: 442.5
BDBM50345023
Wt: 388.4
BDBM50442476
Wt: 464.5
BDBM159443

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 159393,50313364,50313367,50313374,50313375,50313380,50313382,50346264,50345022,50345023,50442476,159443   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM159393
PNG
(US9034921, E007 | US9034921, E009 | US9340521, E00...)
Show SMILES COc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3CCCc3c2C)cc1
Show InChI InChI=1S/C24H30O6/c1-13-15(10-14-6-8-16(29-2)9-7-14)11-19(18-5-3-4-17(13)18)24-23(28)22(27)21(26)20(12-25)30-24/h6-9,11,20-28H,3-5,10,12H2,1-2H3/t20-,21-,22+,23-,24+/m1/s1
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US Patent
n/an/a 0.793n/an/an/an/a7.437



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9034921 (2015)


BindingDB Entry DOI: 10.7270/Q2QF8RMT
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50442476
PNG
(CHEMBL2440365)
Show SMILES CCOc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H28O6/c1-3-27-17-8-5-14(6-9-17)10-16-11-15(7-4-13(16)2)21-19(25)20(26)22(28-21)18(24)12-23/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20-,21+,22-/m1/s1
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n/an/an/an/a 3.40E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM159443
PNG
(US9034921, E077)
Show SMILES CCOc1ccc(Cc2cc(cc(c2C)-c2ccccc2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C28H32O6/c1-3-33-22-11-9-18(10-12-22)13-20-14-21(15-23(17(20)2)19-7-5-4-6-8-19)28-27(32)26(31)25(30)24(16-29)34-28/h4-12,14-15,24-32H,3,13,16H2,1-2H3/t24-,25-,26+,27-,28+/m1/s1
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US Patent
n/an/a 3.84n/an/an/an/a7.437



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9034921 (2015)


BindingDB Entry DOI: 10.7270/Q2QF8RMT
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM159393
PNG
(US9034921, E007 | US9034921, E009 | US9340521, E00...)
Show SMILES COc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3CCCc3c2C)cc1
Show InChI InChI=1S/C24H30O6/c1-13-15(10-14-6-8-16(29-2)9-7-14)11-19(18-5-3-4-17(13)18)24-23(28)22(27)21(26)20(12-25)30-24/h6-9,11,20-28H,3-5,10,12H2,1-2H3/t20-,21-,22+,23-,24+/m1/s1
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US Patent
n/an/a 0.790n/an/an/an/a7.437



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5×104 cells/well...


US Patent US9340521 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60CH
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM159393
PNG
(US9034921, E007 | US9034921, E009 | US9340521, E00...)
Show SMILES COc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3CCCc3c2C)cc1
Show InChI InChI=1S/C24H30O6/c1-13-15(10-14-6-8-16(29-2)9-7-14)11-19(18-5-3-4-17(13)18)24-23(28)22(27)21(26)20(12-25)30-24/h6-9,11,20-28H,3-5,10,12H2,1-2H3/t20-,21-,22+,23-,24+/m1/s1
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n/an/a 26.8n/an/an/an/a7.437



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT1 were seeded into a 96-well culture plate at a density of 5×104 cells/well...


US Patent US9340521 (2016)


BindingDB Entry DOI: 10.7270/Q2TQ60CH
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50313364
PNG
((2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H28O5/c1-3-14-5-7-15(8-6-14)10-17-11-16(9-4-13(17)2)22-21(26)20(25)19(24)18(12-23)27-22/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20+,21-,22+/m1/s1
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n/an/a 1.5n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs


Bioorg Med Chem Lett 20: 1569-72 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.075
BindingDB Entry DOI: 10.7270/Q2DF6RBP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50313367
PNG
((6S,7R,8R,9S)-6-(3-(4-ethylbenzyl)-4-methylphenyl)...)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2OC3(COC3)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C23H28O5/c1-3-15-5-7-16(8-6-15)10-18-11-17(9-4-14(18)2)21-19(24)20(25)22(26)23(28-21)12-27-13-23/h4-9,11,19-22,24-26H,3,10,12-13H2,1-2H3/t19-,20-,21+,22+/m1/s1
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n/an/a 3.40n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs


Bioorg Med Chem Lett 20: 1569-72 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.075
BindingDB Entry DOI: 10.7270/Q2DF6RBP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50313374
PNG
((5S,6R,7R,8S)-5-(3-(4-ethylbenzyl)-4-methylphenyl)...)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2OC3(CC3)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C23H28O4/c1-3-15-5-7-16(8-6-15)12-18-13-17(9-4-14(18)2)21-19(24)20(25)22(26)23(27-21)10-11-23/h4-9,13,19-22,24-26H,3,10-12H2,1-2H3/t19-,20-,21+,22+/m1/s1
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n/an/a 190n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs


Bioorg Med Chem Lett 20: 1569-72 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.075
BindingDB Entry DOI: 10.7270/Q2DF6RBP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50313375
PNG
((5S,6R,7R,8S)-5-(3-(4-methoxybenzyl)-4-methylpheny...)
Show SMILES COc1ccc(Cc2cc(ccc2C)[C@@H]2OC3(CC3)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H26O5/c1-13-3-6-15(12-16(13)11-14-4-7-17(26-2)8-5-14)20-18(23)19(24)21(25)22(27-20)9-10-22/h3-8,12,18-21,23-25H,9-11H2,1-2H3/t18-,19-,20+,21+/m1/s1
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n/an/a 370n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs


Bioorg Med Chem Lett 20: 1569-72 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.075
BindingDB Entry DOI: 10.7270/Q2DF6RBP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50313367
PNG
((6S,7R,8R,9S)-6-(3-(4-ethylbenzyl)-4-methylphenyl)...)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2OC3(COC3)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C23H28O5/c1-3-15-5-7-16(8-6-15)10-18-11-17(9-4-14(18)2)21-19(24)20(25)22(26)23(28-21)12-27-13-23/h4-9,11,19-22,24-26H,3,10,12-13H2,1-2H3/t19-,20-,21+,22+/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs


Bioorg Med Chem Lett 20: 1569-72 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.075
BindingDB Entry DOI: 10.7270/Q2DF6RBP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50313380
PNG
((2S,3R,4S,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H28O5/c1-3-14-5-7-15(8-6-14)10-17-11-16(9-4-13(17)2)22-21(26)20(25)19(24)18(12-23)27-22/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20-,21-,22+/m1/s1
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n/an/a 3.70E+3n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs


Bioorg Med Chem Lett 20: 1569-72 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.075
BindingDB Entry DOI: 10.7270/Q2DF6RBP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50313382
PNG
((2S,3R,4R,5R,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H28O5/c1-3-14-5-7-15(8-6-14)10-17-11-16(9-4-13(17)2)22-21(26)20(25)19(24)18(12-23)27-22/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19+,20+,21-,22+/m1/s1
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n/an/a 139n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs


Bioorg Med Chem Lett 20: 1569-72 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.075
BindingDB Entry DOI: 10.7270/Q2DF6RBP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50313374
PNG
((5S,6R,7R,8S)-5-(3-(4-ethylbenzyl)-4-methylphenyl)...)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2OC3(CC3)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C23H28O4/c1-3-15-5-7-16(8-6-15)12-18-13-17(9-4-14(18)2)21-19(24)20(25)22(26)23(27-21)10-11-23/h4-9,13,19-22,24-26H,3,10-12H2,1-2H3/t19-,20-,21+,22+/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs


Bioorg Med Chem Lett 20: 1569-72 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.075
BindingDB Entry DOI: 10.7270/Q2DF6RBP
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50313375
PNG
((5S,6R,7R,8S)-5-(3-(4-methoxybenzyl)-4-methylpheny...)
Show SMILES COc1ccc(Cc2cc(ccc2C)[C@@H]2OC3(CC3)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H26O5/c1-13-3-6-15(12-16(13)11-14-4-7-17(26-2)8-5-14)20-18(23)19(24)21(25)22(27-20)9-10-22/h3-8,12,18-21,23-25H,9-11H2,1-2H3/t18-,19-,20+,21+/m1/s1
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n/an/a 7.90n/an/an/an/an/an/a



Pfizer Global Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs


Bioorg Med Chem Lett 20: 1569-72 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.075
BindingDB Entry DOI: 10.7270/Q2DF6RBP
More data for this
Ligand-Target Pair
Bcl-2-related protein A1


(Homo sapiens (Human))
BDBM50313374
PNG
((5S,6R,7R,8S)-5-(3-(4-ethylbenzyl)-4-methylphenyl)...)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2OC3(CC3)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C23H28O4/c1-3-15-5-7-16(8-6-15)12-18-13-17(9-4-14(18)2)21-19(24)20(25)22(26)23(27-21)10-11-23/h4-9,13,19-22,24-26H,3,10-12H2,1-2H3/t19-,20-,21+,22+/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Human BioMolecular Research Institute

Curated by ChEMBL


Assay Description
Inhibition of N-terminal FITC BH3 peptide binding to GST-tagged Bfl1 by fluorescence polarization assay


Bioorg Med Chem Lett 20: 6560-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.046
BindingDB Entry DOI: 10.7270/Q27D2VCZ
More data for this
Ligand-Target Pair
Bcl-2-related protein A1


(Homo sapiens (Human))
BDBM50313364
PNG
((2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H28O5/c1-3-14-5-7-15(8-6-14)10-17-11-16(9-4-13(17)2)22-21(26)20(25)19(24)18(12-23)27-22/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20+,21-,22+/m1/s1
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n/an/a 250n/an/an/an/an/an/a



Human BioMolecular Research Institute

Curated by ChEMBL


Assay Description
Inhibition of N-terminal FITC BH3 peptide binding to GST-tagged Bfl1 by fluorescence polarization assay


Bioorg Med Chem Lett 20: 6560-4 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.046
BindingDB Entry DOI: 10.7270/Q27D2VCZ
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens (Human))
BDBM50345022
PNG
((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(15-oxa-tricycl...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc2CCCCCCOc3ccc(Cc2c1)cc3
Show InChI InChI=1S/C25H32O6/c26-15-21-22(27)23(28)24(29)25(31-21)18-9-8-17-5-3-1-2-4-12-30-20-10-6-16(7-11-20)13-19(17)14-18/h6-11,14,21-29H,1-5,12-13,15H2/t21-,22-,23+,24-,25+/m1/s1
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n/an/a 81.9n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation counting


Bioorg Med Chem Lett 21: 3759-63 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.063
BindingDB Entry DOI: 10.7270/Q2NC61KM
More data for this
Ligand-Target Pair
Low affinity sodium-glucose cotransporter


(Homo sapiens (Human))
BDBM50345023
PNG
((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(16-oxa-tricycl...)
Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc2CCCCCCCOc3ccc(Cc2c1)cc3
Show InChI InChI=1S/C26H34O6/c27-16-22-23(28)24(29)25(30)26(32-22)19-10-9-18-6-4-2-1-3-5-13-31-21-11-7-17(8-12-21)14-20(18)15-19/h7-12,15,22-30H,1-6,13-14,16H2/t22-,23-,24+,25-,26+/m1/s1
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n/an/a 99.7n/an/an/an/an/an/a



Green Cross Corporation

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation counting


Bioorg Med Chem Lett 21: 3759-63 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.063
BindingDB Entry DOI: 10.7270/Q2NC61KM
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50346264
PNG
((2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzyl)-4-methylphe...)
Show SMILES CCOc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H28O6/c1-3-27-17-8-5-14(6-9-17)10-16-11-15(7-4-13(16)2)22-21(26)20(25)19(24)18(12-23)28-22/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20+,21-,22+/m1/s1
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Article
PubMed
n/an/an/an/a 1.10n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...


J Med Chem 53: 8770-4 (2010)


Article DOI: 10.1021/jm101080v
BindingDB Entry DOI: 10.7270/Q2N29X9T
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM50313364
PNG
((2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)
Show SMILES CCc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H28O5/c1-3-14-5-7-15(8-6-14)10-17-11-16(9-4-13(17)2)22-21(26)20(25)19(24)18(12-23)27-22/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20+,21-,22+/m1/s1
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Article
PubMed
n/an/an/an/a 12n/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]-alpha-methylglucopyranoside uptake after 2 hrs by liquid scintilla...


J Med Chem 53: 8770-4 (2010)


Article DOI: 10.1021/jm101080v
BindingDB Entry DOI: 10.7270/Q2N29X9T
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 1 (SGLT1)


(Homo sapiens (Human))
BDBM50442476
PNG
(CHEMBL2440365)
Show SMILES CCOc1ccc(Cc2cc(ccc2C)[C@@H]2O[C@H]([C@H](O)CO)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C22H28O6/c1-3-27-17-8-5-14(6-9-17)10-16-11-15(7-4-13(16)2)21-19(25)20(26)22(28-21)18(24)12-23/h4-9,11,18-26H,3,10,12H2,1-2H3/t18-,19-,20-,21+,22-/m1/s1
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Article
PubMed
n/an/an/an/a>5.00E+4n/an/an/an/a



National Taiwan University

Curated by ChEMBL


Assay Description
Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as inhibition of [14C]-AMG uptake up to 120 mins by scintillation counting method


Bioorg Med Chem 21: 6282-91 (2013)


Article DOI: 10.1016/j.bmc.2013.08.067
BindingDB Entry DOI: 10.7270/Q29G5P80
More data for this
Ligand-Target Pair
Sodium/glucose cotransporter 2 (SGLT2)


(Homo sapiens (Human))
BDBM159393
PNG
(US9034921, E007 | US9034921, E009 | US9340521, E00...)
Show SMILES COc1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3CCCc3c2C)cc1
Show InChI InChI=1S/C24H30O6/c1-13-15(10-14-6-8-16(29-2)9-7-14)11-19(18-5-3-4-17(13)18)24-23(28)22(27)21(26)20(12-25)30-24/h6-9,11,20-28H,3-5,10,12H2,1-2H3/t20-,21-,22+,23-,24+/m1/s1
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US Patent
n/an/a 1.18n/an/an/an/a7.437



GREEN CROSS CORPORATION

US Patent


Assay Description
For sodium-dependent glucose transport assay, cells expressing hSGLT2 were seeded into a 96-well culture plate at a density of 5x104 cells/well in RP...


US Patent US9034921 (2015)


BindingDB Entry DOI: 10.7270/Q2QF8RMT
More data for this
Ligand-Target Pair