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20 similar compounds to monomer 161235

Compile data set for download or QSAR
Wt: 324.3
BDBM161216
Wt: 358.7
BDBM161230
Wt: 376.7
BDBM161228
Wt: 393.1
BDBM161229
Wt: 393.1
BDBM161233
Wt: 388.7
BDBM161231
Wt: 372.7
BDBM161232
Wt: 376.7
BDBM161234
Wt: 363.3
BDBM161238
Wt: 376.7
BDBM161284
Wt: 358.7
BDBM161282
Wt: 372.7
BDBM161283
Wt: 388.7
BDBM161318
Wt: 354.3
BDBM161319
Wt: 423.2
BDBM161330
Displayed 1 to 15 (of 20 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 161216,161230,161228,161229,161233,161231,161232,161234,161238,161284,161282,161283,161318,161319,161330   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM161216
PNG
(US10087143, Compound 1 | US9051270, 1)
Show SMILES Fc1ccc(Oc2ccccc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C18H13FN2O3/c19-12-5-7-14(8-6-12)24-16-4-2-1-3-15(16)18(23)21-13-9-10-20-17(22)11-13/h1-11H,(H2,20,21,22,23)
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n/an/a 1.09E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9051270 (2015)


BindingDB Entry DOI: 10.7270/Q2B27T1F
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161330
PNG
(US10087143, Compound 115 | US9051270, 115)
Show SMILES COc1ccc(Oc2cc(Cl)c(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1F
Show InChI InChI=1S/C19H13Cl2FN2O4/c1-27-16-3-2-11(7-15(16)22)28-17-9-14(21)13(20)8-12(17)19(26)24-10-4-5-23-18(25)6-10/h2-9H,1H3,(H2,23,24,25,26)
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n/an/a 7n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM161229
PNG
(US10087143, Compound 14 | US9051270, 14)
Show SMILES Fc1ccc(Oc2cc(Cl)ccc2C(=O)Nc2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C18H11Cl2FN2O3/c19-10-1-3-13(18(25)23-12-5-6-22-17(24)9-12)16(7-10)26-15-4-2-11(21)8-14(15)20/h1-9H,(H2,22,23,24,25)
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n/an/a 65n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9051270 (2015)


BindingDB Entry DOI: 10.7270/Q2B27T1F
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM161230
PNG
(US10087143, Compound 15 | US9051270, 15)
Show SMILES Fc1ccc(Oc2cc(Cl)ccc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C18H12ClFN2O3/c19-11-1-6-15(18(24)22-13-7-8-21-17(23)10-13)16(9-11)25-14-4-2-12(20)3-5-14/h1-10H,(H2,21,22,23,24)
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n/an/a 76n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9051270 (2015)


BindingDB Entry DOI: 10.7270/Q2B27T1F
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM161231
PNG
(US10087143, Compound 16 | US9051270, 16)
Show SMILES COc1cc(F)ccc1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O4/c1-26-17-9-12(21)3-5-15(17)27-16-8-11(20)2-4-14(16)19(25)23-13-6-7-22-18(24)10-13/h2-10H,1H3,(H2,22,23,24,25)
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n/an/a 14n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9051270 (2015)


BindingDB Entry DOI: 10.7270/Q2B27T1F
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM161232
PNG
(US10087143, Compound 17 | US9051270, 17)
Show SMILES Cc1cccc(F)c1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O3/c1-11-3-2-4-15(21)18(11)26-16-9-12(20)5-6-14(16)19(25)23-13-7-8-22-17(24)10-13/h2-10H,1H3,(H2,22,23,24,25)
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n/an/a 1.80E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9051270 (2015)


BindingDB Entry DOI: 10.7270/Q2B27T1F
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM161233
PNG
(US10087143, Compound 18 | US9051270, 18)
Show SMILES Fc1cccc(Cl)c1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C18H11Cl2FN2O3/c19-10-4-5-12(18(25)23-11-6-7-22-16(24)9-11)15(8-10)26-17-13(20)2-1-3-14(17)21/h1-9H,(H2,22,23,24,25)
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n/an/a 1.20E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9051270 (2015)


BindingDB Entry DOI: 10.7270/Q2B27T1F
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM161234
PNG
(US10087143, Compound 19 | US9051270, 19)
Show SMILES Fc1cccc(F)c1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C18H11ClF2N2O3/c19-10-4-5-12(18(25)23-11-6-7-22-16(24)9-11)15(8-10)26-17-13(20)2-1-3-14(17)21/h1-9H,(H2,22,23,24,25)
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n/an/a 6.00E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9051270 (2015)


BindingDB Entry DOI: 10.7270/Q2B27T1F
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM161238
PNG
(US10087143, Compound 23 | US9051270, 23)
Show SMILES Cc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C#N
Show InChI InChI=1S/C20H14FN3O3/c1-12-8-14(21)3-5-17(12)27-18-9-13(11-22)2-4-16(18)20(26)24-15-6-7-23-19(25)10-15/h2-10H,1H3,(H2,23,24,25,26)
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n/an/a 1.50E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9051270 (2015)


BindingDB Entry DOI: 10.7270/Q2B27T1F
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM161282
PNG
(US10087143, Compound 67 | US9051270, 67)
Show SMILES Fc1ccc(Oc2ccc(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C18H12ClFN2O3/c19-11-1-6-16(25-14-4-2-12(20)3-5-14)15(9-11)18(24)22-13-7-8-21-17(23)10-13/h1-10H,(H2,21,22,23,24)
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n/an/a 69n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9051270 (2015)


BindingDB Entry DOI: 10.7270/Q2B27T1F
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM161283
PNG
(US10087143, Compound 68 | US9051270, 68 | US916304...)
Show SMILES Cc1cc(F)ccc1Oc1ccc(Cl)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O3/c1-11-8-13(21)3-5-16(11)26-17-4-2-12(20)9-15(17)19(25)23-14-6-7-22-18(24)10-14/h2-10H,1H3,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9051270 (2015)


BindingDB Entry DOI: 10.7270/Q2B27T1F
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM161284
PNG
(US10087143, Compound 69 | US9051270, 69)
Show SMILES Fc1ccc(Oc2ccc(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)c(F)c1
Show InChI InChI=1S/C18H11ClF2N2O3/c19-10-1-3-15(26-16-4-2-11(20)8-14(16)21)13(7-10)18(25)23-12-5-6-22-17(24)9-12/h1-9H,(H2,22,23,24,25)
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n/an/a 112n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9051270 (2015)


BindingDB Entry DOI: 10.7270/Q2B27T1F
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM161318
PNG
(US10087143, Compound 103 | US9051270, 103)
Show SMILES COc1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C19H14ClFN2O4/c1-26-13-3-5-17(15(20)10-13)27-16-4-2-11(21)8-14(16)19(25)23-12-6-7-22-18(24)9-12/h2-10H,1H3,(H2,22,23,24,25)
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n/an/a 330n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9051270 (2015)


BindingDB Entry DOI: 10.7270/Q2B27T1F
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM161319
PNG
(US10087143, Compound 104 | US9051270, 104)
Show SMILES COc1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C19H15FN2O4/c1-25-14-3-5-15(6-4-14)26-17-7-2-12(20)10-16(17)19(24)22-13-8-9-21-18(23)11-13/h2-11H,1H3,(H2,21,22,23,24)
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n/an/a 1.15E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9051270 (2015)


BindingDB Entry DOI: 10.7270/Q2B27T1F
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM161330
PNG
(US10087143, Compound 115 | US9051270, 115)
Show SMILES COc1ccc(Oc2cc(Cl)c(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1F
Show InChI InChI=1S/C19H13Cl2FN2O4/c1-27-16-3-2-11(7-15(16)22)28-17-9-14(21)13(20)8-12(17)19(26)24-10-4-5-23-18(25)6-10/h2-9H,1H3,(H2,23,24,25,26)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9051270 (2015)


BindingDB Entry DOI: 10.7270/Q2B27T1F
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM161283
PNG
(US10087143, Compound 68 | US9051270, 68 | US916304...)
Show SMILES Cc1cc(F)ccc1Oc1ccc(Cl)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O3/c1-11-8-13(21)3-5-16(11)26-17-4-2-12(20)9-15(17)19(25)23-14-6-7-22-18(24)10-14/h2-10H,1H3,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9163042 (2015)


BindingDB Entry DOI: 10.7270/Q21Z4361
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161216
PNG
(US10087143, Compound 1 | US9051270, 1)
Show SMILES Fc1ccc(Oc2ccccc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C18H13FN2O3/c19-12-5-7-14(8-6-12)24-16-4-2-1-3-15(16)18(23)21-13-9-10-20-17(22)11-13/h1-11H,(H2,20,21,22,23)
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n/an/a 1.09E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161228
PNG
(US10087143, Compound 13 | US9051270, 13)
Show SMILES Fc1ccc(Oc2cc(Cl)ccc2C(=O)Nc2cc[nH]c(=O)c2)c(F)c1
Show InChI InChI=1S/C18H11ClF2N2O3/c19-10-1-3-13(18(25)23-12-5-6-22-17(24)9-12)16(7-10)26-15-4-2-11(20)8-14(15)21/h1-9H,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161229
PNG
(US10087143, Compound 14 | US9051270, 14)
Show SMILES Fc1ccc(Oc2cc(Cl)ccc2C(=O)Nc2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C18H11Cl2FN2O3/c19-10-1-3-13(18(25)23-12-5-6-22-17(24)9-12)16(7-10)26-15-4-2-11(21)8-14(15)20/h1-9H,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161230
PNG
(US10087143, Compound 15 | US9051270, 15)
Show SMILES Fc1ccc(Oc2cc(Cl)ccc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C18H12ClFN2O3/c19-11-1-6-15(18(24)22-13-7-8-21-17(23)10-13)16(9-11)25-14-4-2-12(20)3-5-14/h1-10H,(H2,21,22,23,24)
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n/an/a 76n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161231
PNG
(US10087143, Compound 16 | US9051270, 16)
Show SMILES COc1cc(F)ccc1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O4/c1-26-17-9-12(21)3-5-15(17)27-16-8-11(20)2-4-14(16)19(25)23-13-6-7-22-18(24)10-13/h2-10H,1H3,(H2,22,23,24,25)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161232
PNG
(US10087143, Compound 17 | US9051270, 17)
Show SMILES Cc1cccc(F)c1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O3/c1-11-3-2-4-15(21)18(11)26-16-9-12(20)5-6-14(16)19(25)23-13-7-8-22-17(24)10-13/h2-10H,1H3,(H2,22,23,24,25)
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n/an/a 1.80E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161233
PNG
(US10087143, Compound 18 | US9051270, 18)
Show SMILES Fc1cccc(Cl)c1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C18H11Cl2FN2O3/c19-10-4-5-12(18(25)23-11-6-7-22-16(24)9-11)15(8-10)26-17-13(20)2-1-3-14(17)21/h1-9H,(H2,22,23,24,25)
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n/an/a 1.20E+4n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161234
PNG
(US10087143, Compound 19 | US9051270, 19)
Show SMILES Fc1cccc(F)c1Oc1cc(Cl)ccc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C18H11ClF2N2O3/c19-10-4-5-12(18(25)23-11-6-7-22-16(24)9-11)15(8-10)26-17-13(20)2-1-3-14(17)21/h1-9H,(H2,22,23,24,25)
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n/an/a 6.00E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161238
PNG
(US10087143, Compound 23 | US9051270, 23)
Show SMILES Cc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1cc[nH]c(=O)c1)C#N
Show InChI InChI=1S/C20H14FN3O3/c1-12-8-14(21)3-5-17(12)27-18-9-13(11-22)2-4-16(18)20(26)24-15-6-7-23-19(25)10-15/h2-10H,1H3,(H2,23,24,25,26)
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n/an/a 1.50E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161282
PNG
(US10087143, Compound 67 | US9051270, 67)
Show SMILES Fc1ccc(Oc2ccc(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C18H12ClFN2O3/c19-11-1-6-16(25-14-4-2-12(20)3-5-14)15(9-11)18(24)22-13-7-8-21-17(23)10-13/h1-10H,(H2,21,22,23,24)
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n/an/a 69n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161283
PNG
(US10087143, Compound 68 | US9051270, 68 | US916304...)
Show SMILES Cc1cc(F)ccc1Oc1ccc(Cl)cc1C(=O)Nc1cc[nH]c(=O)c1
Show InChI InChI=1S/C19H14ClFN2O3/c1-11-8-13(21)3-5-16(11)26-17-4-2-12(20)9-15(17)19(25)23-14-6-7-22-18(24)10-14/h2-10H,1H3,(H2,22,23,24,25)
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n/an/a 30n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161284
PNG
(US10087143, Compound 69 | US9051270, 69)
Show SMILES Fc1ccc(Oc2ccc(Cl)cc2C(=O)Nc2cc[nH]c(=O)c2)c(F)c1
Show InChI InChI=1S/C18H11ClF2N2O3/c19-10-1-3-15(26-16-4-2-11(20)8-14(16)21)13(7-10)18(25)23-12-5-6-22-17(24)9-12/h1-9H,(H2,22,23,24,25)
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n/an/a 112n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161318
PNG
(US10087143, Compound 103 | US9051270, 103)
Show SMILES COc1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)c(Cl)c1
Show InChI InChI=1S/C19H14ClFN2O4/c1-26-13-3-5-17(15(20)10-13)27-16-4-2-11(21)8-14(16)19(25)23-12-6-7-22-18(24)9-12/h2-10H,1H3,(H2,22,23,24,25)
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n/an/a 330n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM161319
PNG
(US10087143, Compound 104 | US9051270, 104)
Show SMILES COc1ccc(Oc2ccc(F)cc2C(=O)Nc2cc[nH]c(=O)c2)cc1
Show InChI InChI=1S/C19H15FN2O4/c1-25-14-3-5-15(6-4-14)26-17-7-2-12(20)10-16(17)19(24)22-13-8-9-21-18(23)11-13/h2-11H,1H3,(H2,21,22,23,24)
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n/an/a 1.15E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Sodium channels are voltage-dependent proteins that can be activated by inducing membrane voltage changes by applying electric fields. The electrical...


US Patent US10087143 (2018)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM161228
PNG
(US10087143, Compound 13 | US9051270, 13)
Show SMILES Fc1ccc(Oc2cc(Cl)ccc2C(=O)Nc2cc[nH]c(=O)c2)c(F)c1
Show InChI InChI=1S/C18H11ClF2N2O3/c19-10-1-3-13(18(25)23-12-5-6-22-17(24)9-12)16(7-10)26-15-4-2-11(20)8-14(15)21/h1-9H,(H2,22,23,24,25)
PDB

KEGG

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n/an/a 106n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9051270 (2015)


BindingDB Entry DOI: 10.7270/Q2B27T1F
More data for this
Ligand-Target Pair