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21 similar compounds to monomer 161637

Compile data set for download or QSAR
Wt: 679.2
BDBM161494
Wt: 594.1
BDBM161473
Wt: 675.2
BDBM161487
Wt: 591.0
BDBM161497
Wt: 606.1
BDBM161507
Wt: 631.6
BDBM161517
Wt: 716.7
BDBM161519
Wt: 644.1
BDBM161532
Wt: 729.2
BDBM161538
Wt: 757.3
BDBM161578
Wt: 707.2
BDBM161582
Wt: 700.2
BDBM161583
Wt: 703.2
BDBM161577
Wt: 693.2
BDBM161595
Wt: 745.3
BDBM161596
Displayed 1 to 15 (of 21 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 161494,161473,161487,161497,161507,161517,161519,161532,161538,161578,161582,161583,161577,161595,161596   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161473
PNG
(US9108983, Example 1)
Show SMILES C[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(Cl)cc1-c1cc(C(=O)N(c2cnn(C)c2)c2ccc(O)cc2)c(C)n1C
Show InChI InChI=1S/C34H32ClN5O3/c1-21-15-23-7-5-6-8-24(23)19-39(21)33(42)29-14-9-25(35)16-31(29)32-17-30(22(2)38(32)4)34(43)40(27-18-36-37(3)20-27)26-10-12-28(41)13-11-26/h5-14,16-18,20-21,41H,15,19H2,1-4H3/t21-/m1/s1
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n/an/a 5n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161494
PNG
(US9108983, Example 25 | US9108983, Example 416)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1cnn(C)c1)c1ccc(O)cc1
Show InChI InChI=1S/C38H39ClN6O4/c1-25-34(38(48)45(31-21-40-41(2)23-31)29-9-11-32(46)12-10-29)20-36(42(25)3)35-19-28(39)8-13-33(35)37(47)44-22-27-7-5-4-6-26(27)18-30(44)24-43-14-16-49-17-15-43/h4-13,19-21,23,30,46H,14-18,22,24H2,1-3H3/t30-/m0/s1
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n/an/a 2.90n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161494
PNG
(US9108983, Example 25 | US9108983, Example 416)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1cnn(C)c1)c1ccc(O)cc1
Show InChI InChI=1S/C38H39ClN6O4/c1-25-34(38(48)45(31-21-40-41(2)23-31)29-9-11-32(46)12-10-29)20-36(42(25)3)35-19-28(39)8-13-33(35)37(47)44-22-27-7-5-4-6-26(27)18-30(44)24-43-14-16-49-17-15-43/h4-13,19-21,23,30,46H,14-18,22,24H2,1-3H3/t30-/m0/s1
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n/an/a 4n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161497
PNG
(US9108983, Example 28)
Show SMILES C[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(Cl)cc1-c1cc(C(=O)N(c2ccncc2)c2ccc(O)cc2)c(C)n1C
Show InChI InChI=1S/C35H31ClN4O3/c1-22-18-24-6-4-5-7-25(24)21-39(22)34(42)30-13-8-26(36)19-32(30)33-20-31(23(2)38(33)3)35(43)40(28-14-16-37-17-15-28)27-9-11-29(41)12-10-27/h4-17,19-20,22,41H,18,21H2,1-3H3/t22-/m1/s1
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n/an/a 7.5n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161507
PNG
(US9108983, Example 38)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CO)n1C)C(=O)N(c1ccccc1)c1ccc(O)cc1
Show InChI InChI=1S/C36H32ClN3O4/c1-23-32(36(44)40(27-10-4-3-5-11-27)28-13-15-30(42)16-14-28)20-34(38(23)2)33-19-26(37)12-17-31(33)35(43)39-21-25-9-7-6-8-24(25)18-29(39)22-41/h3-17,19-20,29,41-42H,18,21-22H2,1-2H3/t29-/m0/s1
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n/an/a 7.5n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161517
PNG
(US9108983, Example 48)
Show SMILES COc1ncc(cn1)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2C)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C36H33N5O6/c1-21-13-23-7-5-6-8-24(23)19-40(21)34(43)30-16-33-32(46-20-47-33)15-29(30)31-14-28(22(2)39(31)3)35(44)41(25-9-11-27(42)12-10-25)26-17-37-36(45-4)38-18-26/h5-12,14-18,21,42H,13,19-20H2,1-4H3/t21-/m1/s1
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n/an/a 4.40n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161519
PNG
(US9108983, Example 50)
Show SMILES COc1ncc(cn1)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C40H40N6O7/c1-25-32(39(49)46(28-8-10-31(47)11-9-28)30-20-41-40(50-3)42-21-30)17-35(43(25)2)33-18-36-37(53-24-52-36)19-34(33)38(48)45-22-27-7-5-4-6-26(27)16-29(45)23-44-12-14-51-15-13-44/h4-11,17-21,29,47H,12-16,22-24H2,1-3H3/t29-/m0/s1
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n/an/a 5.90n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161532
PNG
(US9108983, Example 63)
Show SMILES C[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(Cl)cc1-c1cc(C(=O)N(c2ccc(O)cc2)c2cnc3n(C)ccc3c2)c(C)n1C
Show InChI InChI=1S/C38H34ClN5O3/c1-23-17-25-7-5-6-8-27(25)22-43(23)37(46)32-14-9-28(39)19-34(32)35-20-33(24(2)42(35)4)38(47)44(29-10-12-31(45)13-11-29)30-18-26-15-16-41(3)36(26)40-21-30/h5-16,18-21,23,45H,17,22H2,1-4H3/t23-/m1/s1
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n/an/a 5.10n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161538
PNG
(US9108983, Example 74)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1ccc(O)cc1)c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C42H41ClN6O4/c1-27-37(42(52)49(32-9-11-35(50)12-10-32)33-21-29-14-15-45(2)40(29)44-24-33)23-39(46(27)3)38-22-31(43)8-13-36(38)41(51)48-25-30-7-5-4-6-28(30)20-34(48)26-47-16-18-53-19-17-47/h4-15,21-24,34,50H,16-20,25-26H2,1-3H3/t34-/m0/s1
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n/an/a 6.10n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161577
PNG
(US9108983, Example 392)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CCCN2CCOCC2)n1C)C(=O)N(c1ccccc1)c1ccc(O)cc1
Show InChI InChI=1S/C42H43ClN4O4/c1-29-38(42(50)47(33-11-4-3-5-12-33)34-15-17-36(48)18-16-34)27-40(44(29)2)39-26-32(43)14-19-37(39)41(49)46-28-31-10-7-6-9-30(31)25-35(46)13-8-20-45-21-23-51-24-22-45/h3-7,9-12,14-19,26-27,35,48H,8,13,20-25,28H2,1-2H3/t35-/m1/s1
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n/an/a 3.80n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161578
PNG
(US9108983, Example 393)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CCCN2CCOCC2)n1C)C(=O)N(c1ccc(O)cc1)c1cnc2n(C)ccc2c1
Show InChI InChI=1S/C44H45ClN6O4/c1-29-39(44(54)51(34-11-13-37(52)14-12-34)36-24-31-16-18-47(2)42(31)46-27-36)26-41(48(29)3)40-25-33(45)10-15-38(40)43(53)50-28-32-8-5-4-7-30(32)23-35(50)9-6-17-49-19-21-55-22-20-49/h4-5,7-8,10-16,18,24-27,35,52H,6,9,17,19-23,28H2,1-3H3/t35-/m1/s1
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n/an/a 2.10n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161582
PNG
(US9108983, Example 397)
Show SMILES COc1ncc(cn1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C39H39ClN6O5/c1-25-34(38(49)46(29-9-11-32(47)12-10-29)31-21-41-39(50-3)42-22-31)20-36(43(25)2)35-19-28(40)8-13-33(35)37(48)45-23-27-7-5-4-6-26(27)18-30(45)24-44-14-16-51-17-15-44/h4-13,19-22,30,47H,14-18,23-24H2,1-3H3/t30-/m0/s1
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n/an/a 4.5n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161583
PNG
(US9108983, Example 398)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1ccc(O)cc1)c1cccc(c1)C#N
Show InChI InChI=1S/C41H38ClN5O4/c1-27-37(41(50)47(32-11-13-35(48)14-12-32)33-9-5-6-28(20-33)24-43)23-39(44(27)2)38-22-31(42)10-15-36(38)40(49)46-25-30-8-4-3-7-29(30)21-34(46)26-45-16-18-51-19-17-45/h3-15,20,22-23,34,48H,16-19,21,25-26H2,1-2H3/t34-/m0/s1
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n/an/a 3.90n/an/an/an/a7.4n/a



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US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161595
PNG
(US9108983, Example 411)
Show SMILES C[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(Cl)cc1-c1cc(C(=O)N(c2cnn(C)c2)c2ccc(O)cc2)c(C)n1CCN1CCOCC1
Show InChI InChI=1S/C39H41ClN6O4/c1-26-20-28-6-4-5-7-29(28)24-45(26)38(48)34-13-8-30(40)21-36(34)37-22-35(27(2)44(37)15-14-43-16-18-50-19-17-43)39(49)46(32-23-41-42(3)25-32)31-9-11-33(47)12-10-31/h4-13,21-23,25-26,47H,14-20,24H2,1-3H3/t26-/m1/s1
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n/an/a 5.5n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161596
PNG
(US9108983, Example 412)
Show SMILES Cc1c(cc(C#N)n1C)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CCCN2CCOCC2)n(C)c1C)c1ccc(O)cc1
Show InChI InChI=1S/C43H45ClN6O4/c1-28-38(43(53)50(33-12-14-36(51)15-13-33)40-24-35(26-45)46(3)29(40)2)25-41(47(28)4)39-23-32(44)11-16-37(39)42(52)49-27-31-9-6-5-8-30(31)22-34(49)10-7-17-48-18-20-54-21-19-48/h5-6,8-9,11-16,23-25,34,51H,7,10,17-22,27H2,1-4H3/t34-/m1/s1
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n/an/a 3.10n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair
Apoptosis regulator Bcl-2


(Homo sapiens (Human))
BDBM161487
PNG
(US9108983, Example 17)
Show SMILES Cc1c(cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n1C)C(=O)N(c1ccccc1)c1ccc(O)cc1
Show InChI InChI=1S/C40H39ClN4O4/c1-27-36(40(48)45(31-10-4-3-5-11-31)32-13-15-34(46)16-14-32)24-38(42(27)2)37-23-30(41)12-17-35(37)39(47)44-25-29-9-7-6-8-28(29)22-33(44)26-43-18-20-49-21-19-43/h3-17,23-24,33,46H,18-22,25-26H2,1-2H3/t33-/m0/s1
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n/an/a 8n/an/an/an/a7.4n/a



LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD

US Patent


Assay Description
The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 correspond...


US Patent US9108983 (2015)


BindingDB Entry DOI: 10.7270/Q2PC314Z
More data for this
Ligand-Target Pair