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4 similar compounds to monomer 184349

Compile data set for download or QSAR
Wt: 435.4
BDBM167976
Wt: 436.5
BDBM184346
Wt: 434.4
BDBM184347
Wt: 448.5
BDBM184348

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 167976,184346,184347,184348   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM167976
PNG
(US9073926, 10)
Show SMILES Cn1cc(NC(=O)c2ccc3nc4C(=O)NCCCn4c3c2)nc1C(=O)NC1CCCC1
Show InChI InChI=1S/C22H25N7O3/c1-28-12-17(26-18(28)22(32)24-14-5-2-3-6-14)27-20(30)13-7-8-15-16(11-13)29-10-4-9-23-21(31)19(29)25-15/h7-8,11-12,14H,2-6,9-10H2,1H3,(H,23,31)(H,24,32)(H,27,30)
PDB
MMDB

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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 69n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 2


(Homo sapiens (Human))
BDBM184348
PNG
(US9150577, 233)
Show SMILES Cn1cc(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)n4c3c2)nc1C(=O)NC1CCCC1
Show InChI InChI=1S/C24H28N6O3/c1-24(2)13-25-22(32)18-10-14-8-9-15(11-17(14)30(18)24)21(31)28-19-12-29(3)20(27-19)23(33)26-16-6-4-5-7-16/h8-12,16H,4-7,13H2,1-3H3,(H,25,32)(H,26,33)(H,28,31)
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PC cid
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US Patent
n/an/a 3.70n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9150577 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22V6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 2


(Homo sapiens (Human))
BDBM184347
PNG
(US9150577, 232)
Show SMILES Cn1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc1C(=O)NC1CCCC1
Show InChI InChI=1S/C23H26N6O3/c1-28-13-19(26-20(28)23(32)25-16-5-2-3-6-16)27-21(30)15-8-7-14-11-18-22(31)24-9-4-10-29(18)17(14)12-15/h7-8,11-13,16H,2-6,9-10H2,1H3,(H,24,31)(H,25,32)(H,27,30)
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9150577 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22V6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha 2


(Homo sapiens (Human))
BDBM184346
PNG
(US9150577, 231)
Show SMILES Cn1cc(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)n4c3c2)nc1C(=O)NC(C)(C)C
Show InChI InChI=1S/C23H28N6O3/c1-22(2,3)27-21(32)18-25-17(11-28(18)6)26-19(30)14-8-7-13-9-16-20(31)24-12-23(4,5)29(16)15(13)10-14/h7-11H,12H2,1-6H3,(H,24,31)(H,26,30)(H,27,32)
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9150577 (2015)


BindingDB Entry DOI: 10.7270/Q2GB22V6
More data for this
Ligand-Target Pair