BindingDB logo
myBDB logout

5 similar compounds to monomer 167992

Compile data set for download or QSAR
Wt: 386.4
BDBM168071
Wt: 371.3
BDBM167989
Wt: 338.3
BDBM167991
Wt: 321.3
BDBM167993
Wt: 399.4
BDBM168005

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 168071,167989,167991,167993,168005   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM167989
PNG
(US9073926, 23)
Show SMILES O=C(Nc1cnc2ccccc2c1)c1ccc2cc3C(=O)NCCCn3c2n1
Show InChI InChI=1S/C21H17N5O2/c27-20(24-15-10-13-4-1-2-5-16(13)23-12-15)17-7-6-14-11-18-21(28)22-8-3-9-26(18)19(14)25-17/h1-2,4-7,10-12H,3,8-9H2,(H,22,28)(H,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.20n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM167991
PNG
(US9073926, 25)
Show SMILES Fc1cccc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)c1
Show InChI InChI=1S/C18H15FN4O2/c19-12-3-1-4-13(10-12)21-17(24)14-6-5-11-9-15-18(25)20-7-2-8-23(15)16(11)22-14/h1,3-6,9-10H,2,7-8H2,(H,20,25)(H,21,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 20n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168071
PNG
(US9073926, 105)
Show SMILES O=C(Nc1cccc(c1)-c1c[nH]cn1)c1ccc2cc3C(=O)NCCCn3c2n1
Show InChI InChI=1S/C21H18N6O2/c28-20(25-15-4-1-3-13(9-15)17-11-22-12-24-17)16-6-5-14-10-18-21(29)23-7-2-8-27(18)19(14)26-16/h1,3-6,9-12H,2,7-8H2,(H,22,24)(H,23,29)(H,25,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 17n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168005
PNG
(US9073926, 39)
Show SMILES CC1(C)CNC(=O)c2cc3ccc(nc3n2C1)C(=O)Nc1cnc2ccccc2c1
Show InChI InChI=1S/C23H21N5O2/c1-23(2)12-25-22(30)19-10-15-7-8-18(27-20(15)28(19)13-23)21(29)26-16-9-14-5-3-4-6-17(14)24-11-16/h3-11H,12-13H2,1-2H3,(H,25,30)(H,26,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 91n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM167993
PNG
(US9073926, 27)
Show SMILES O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCCCn3c2n1
Show InChI InChI=1S/C17H15N5O2/c23-16(20-12-3-1-6-18-10-12)13-5-4-11-9-14-17(24)19-7-2-8-22(14)15(11)21-13/h1,3-6,9-10H,2,7-8H2,(H,19,24)(H,20,23)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 37n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair