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10 similar compounds to monomer 168007

Compile data set for download or QSAR
Wt: 321.3
BDBM167993
Wt: 338.3
BDBM168006
Wt: 352.3
BDBM168008
Wt: 380.4
BDBM168009
Wt: 366.4
BDBM168010
Wt: 394.4
BDBM168011
Wt: 414.4
BDBM168012
Wt: 400.4
BDBM168013
Wt: 428.4
BDBM168014
Wt: 415.4
BDBM168034

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 167993,168006,168008,168009,168010,168011,168012,168013,168014,168034   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM167993
PNG
(US9073926, 27)
Show SMILES O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCCCn3c2n1
Show InChI InChI=1S/C17H15N5O2/c23-16(20-12-3-1-6-18-10-12)13-5-4-11-9-14-17(24)19-7-2-8-22(14)15(11)21-13/h1,3-6,9-10H,2,7-8H2,(H,19,24)(H,20,23)
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US Patent
n/an/a 37n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168006
PNG
(US9073926, 40)
Show SMILES CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(C)c1
Show InChI InChI=1S/C17H18N6O2/c1-10-5-6-18-17(25)14-7-11-3-4-13(21-15(11)23(10)14)16(24)20-12-8-19-22(2)9-12/h3-4,7-10H,5-6H2,1-2H3,(H,18,25)(H,20,24)
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n/an/a 0.780n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168008
PNG
(US9073926, 42)
Show SMILES Cn1cc(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)cn1
Show InChI InChI=1S/C18H20N6O2/c1-18(2)9-19-17(26)14-6-11-4-5-13(22-15(11)24(14)10-18)16(25)21-12-7-20-23(3)8-12/h4-8H,9-10H2,1-3H3,(H,19,26)(H,21,25)
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n/an/a 72n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168009
PNG
(US9073926, 43)
Show SMILES CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(c1)C(C)(C)C
Show InChI InChI=1S/C20H24N6O2/c1-12-7-8-21-19(28)16-9-13-5-6-15(24-17(13)26(12)16)18(27)23-14-10-22-25(11-14)20(2,3)4/h5-6,9-12H,7-8H2,1-4H3,(H,21,28)(H,23,27)
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n/an/a 1.10n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168034
PNG
(US9073926, 68)
Show SMILES CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccncc2)c1
Show InChI InChI=1S/C22H21N7O2/c1-14-4-9-24-22(31)19-10-16-2-3-18(27-20(16)29(14)19)21(30)26-17-11-25-28(13-17)12-15-5-7-23-8-6-15/h2-3,5-8,10-11,13-14H,4,9,12H2,1H3,(H,24,31)(H,26,30)
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US Patent
n/an/a 0.270n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168011
PNG
(US9073926, 45)
Show SMILES CC(C)(C)n1cc(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)cn1
Show InChI InChI=1S/C21H26N6O2/c1-20(2,3)27-10-14(9-23-27)24-18(28)15-7-6-13-8-16-19(29)22-11-21(4,5)12-26(16)17(13)25-15/h6-10H,11-12H2,1-5H3,(H,22,29)(H,24,28)
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n/an/a 50n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168012
PNG
(US9073926, 46)
Show SMILES CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C23H22N6O2/c1-15-9-10-24-23(31)20-11-17-7-8-19(27-21(17)29(15)20)22(30)26-18-12-25-28(14-18)13-16-5-3-2-4-6-16/h2-8,11-12,14-15H,9-10,13H2,1H3,(H,24,31)(H,26,30)
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n/an/a 0.390n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168013
PNG
(US9073926, 47)
Show SMILES O=C(Nc1cnn(Cc2ccccc2)c1)c1ccc2cc3C(=O)NCCCn3c2n1
Show InChI InChI=1S/C22H20N6O2/c29-21(25-17-12-24-27(14-17)13-15-5-2-1-3-6-15)18-8-7-16-11-19-22(30)23-9-4-10-28(19)20(16)26-18/h1-3,5-8,11-12,14H,4,9-10,13H2,(H,23,30)(H,25,29)
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n/an/a 3.80n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168014
PNG
(US9073926, 48)
Show SMILES CC1(C)CNC(=O)c2cc3ccc(nc3n2C1)C(=O)Nc1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C24H24N6O2/c1-24(2)14-25-23(32)20-10-17-8-9-19(28-21(17)30(20)15-24)22(31)27-18-11-26-29(13-18)12-16-6-4-3-5-7-16/h3-11,13H,12,14-15H2,1-2H3,(H,25,32)(H,27,31)
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n/an/a 12n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168010
PNG
(US9073926, 44)
Show SMILES CC(C)(C)n1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)cn1
Show InChI InChI=1S/C19H22N6O2/c1-19(2,3)25-11-13(10-21-25)22-17(26)14-6-5-12-9-15-18(27)20-7-4-8-24(15)16(12)23-14/h5-6,9-11H,4,7-8H2,1-3H3,(H,20,27)(H,22,26)
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n/an/a 9.70n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair