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5 similar compounds to monomer 168032

Compile data set for download or QSAR
Wt: 321.3
BDBM168067
Wt: 417.4
BDBM167995
Wt: 403.4
BDBM167996
Wt: 431.4
BDBM167997
Wt: 403.4
BDBM168029

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 168067,167995,167996,167997,168029   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM167995
PNG
(US9073926, 29)
Show SMILES CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NCCC(C)n5c4n3)cnc12
Show InChI InChI=1S/C22H23N7O2/c1-12(2)29-19-15(10-25-29)8-16(11-24-19)26-21(30)17-5-4-14-9-18-22(31)23-7-6-13(3)28(18)20(14)27-17/h4-5,8-13H,6-7H2,1-3H3,(H,23,31)(H,26,30)
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US Patent
n/an/a 2.10n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM167996
PNG
(US9073926, 30)
Show SMILES CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NCCCn5c4n3)cnc12
Show InChI InChI=1S/C21H21N7O2/c1-12(2)28-18-14(10-24-28)8-15(11-23-18)25-20(29)16-5-4-13-9-17-21(30)22-6-3-7-27(17)19(13)26-16/h4-5,8-12H,3,6-7H2,1-2H3,(H,22,30)(H,25,29)
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US Patent
n/an/a 25n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168067
PNG
(US9073926, 101)
Show SMILES CC1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cccnc1
Show InChI InChI=1S/C17H15N5O2/c1-10-8-19-17(24)14-7-11-4-5-13(21-15(11)22(10)14)16(23)20-12-3-2-6-18-9-12/h2-7,9-10H,8H2,1H3,(H,19,24)(H,20,23)
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US Patent
n/an/a 120n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168029
PNG
(US9073926, 63)
Show SMILES CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NC[C@H](C)n5c4n3)cnc12
Show InChI InChI=1S/C21H21N7O2/c1-11(2)28-18-14(9-24-28)6-15(10-22-18)25-20(29)16-5-4-13-7-17-21(30)23-8-12(3)27(17)19(13)26-16/h4-7,9-12H,8H2,1-3H3,(H,23,30)(H,25,29)/t12-/m0/s1
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US Patent
n/an/a 84n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM167997
PNG
(US9073926, 31)
Show SMILES CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NCC(C)(C)Cn5c4n3)cnc12
Show InChI InChI=1S/C23H25N7O2/c1-13(2)30-19-15(9-26-30)7-16(10-24-19)27-21(31)17-6-5-14-8-18-22(32)25-11-23(3,4)12-29(18)20(14)28-17/h5-10,13H,11-12H2,1-4H3,(H,25,32)(H,27,31)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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US Patent
n/an/a 105n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair