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11 similar compounds to monomer 168051

Compile data set for download or QSAR
Wt: 353.3
BDBM168057
Wt: 401.4
BDBM168063
Wt: 401.4
BDBM168064
Wt: 415.4
BDBM168065
Wt: 415.4
BDBM168066
Wt: 367.4
BDBM168045
Wt: 325.3
BDBM168046
Wt: 339.3
BDBM168048
Wt: 325.3
BDBM168049
Wt: 325.3
BDBM168050
Wt: 339.3
BDBM168052

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 168057,168063,168064,168065,168066,168045,168046,168048,168049,168050,168052   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168045
PNG
(US9073926, 79)
Show SMILES CC(C)(C)c1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)no1
Show InChI InChI=1S/C19H21N5O3/c1-19(2,3)14-10-15(23-27-14)22-17(25)12-6-5-11-9-13-18(26)20-7-4-8-24(13)16(11)21-12/h5-6,9-10H,4,7-8H2,1-3H3,(H,20,26)(H,22,23,25)
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US Patent
n/an/a 19n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168046
PNG
(US9073926, 80)
Show SMILES Cc1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)no1
Show InChI InChI=1S/C16H15N5O3/c1-9-7-13(20-24-9)19-15(22)11-4-3-10-8-12-16(23)17-5-2-6-21(12)14(10)18-11/h3-4,7-8H,2,5-6H2,1H3,(H,17,23)(H,19,20,22)
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n/an/a 19n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168048
PNG
(US9073926, 82)
Show SMILES CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(C)on1
Show InChI InChI=1S/C17H17N5O3/c1-9-5-6-18-17(24)13-8-11-3-4-12(19-15(11)22(9)13)16(23)20-14-7-10(2)25-21-14/h3-4,7-9H,5-6H2,1-2H3,(H,18,24)(H,20,21,23)
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n/an/a 5.20n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168049
PNG
(US9073926, 83)
Show SMILES C[C@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(C)on1
Show InChI InChI=1S/C16H15N5O3/c1-8-7-17-16(23)12-6-10-3-4-11(18-14(10)21(8)12)15(22)19-13-5-9(2)24-20-13/h3-6,8H,7H2,1-2H3,(H,17,23)(H,19,20,22)/t8-/m0/s1
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n/an/a 380n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168050
PNG
(US9073926, 84)
Show SMILES C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(C)on1
Show InChI InChI=1S/C16H15N5O3/c1-8-7-17-16(23)12-6-10-3-4-11(18-14(10)21(8)12)15(22)19-13-5-9(2)24-20-13/h3-6,8H,7H2,1-2H3,(H,17,23)(H,19,20,22)/t8-/m1/s1
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n/an/a 6.60n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168066
PNG
(US9073926, 100)
Show SMILES C[C@@H]1NC(=O)c2cc3ccc(nc3n2[C@H]1C)C(=O)Nc1cc(Cc2ccccc2)on1
Show InChI InChI=1S/C23H21N5O3/c1-13-14(2)28-19(23(30)24-13)11-16-8-9-18(25-21(16)28)22(29)26-20-12-17(31-27-20)10-15-6-4-3-5-7-15/h3-9,11-14H,10H2,1-2H3,(H,24,30)(H,26,27,29)/t13-,14-/m0/s1
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n/an/a 57n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168057
PNG
(US9073926, 91)
Show SMILES Cc1cc(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)no1
Show InChI InChI=1S/C18H19N5O3/c1-10-6-14(22-26-10)21-16(24)12-5-4-11-7-13-17(25)19-8-18(2,3)9-23(13)15(11)20-12/h4-7H,8-9H2,1-3H3,(H,19,25)(H,21,22,24)
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n/an/a 395n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168063
PNG
(US9073926, 97)
Show SMILES C[C@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(Cc2ccccc2)on1
Show InChI InChI=1S/C22H19N5O3/c1-13-12-23-22(29)18-10-15-7-8-17(24-20(15)27(13)18)21(28)25-19-11-16(30-26-19)9-14-5-3-2-4-6-14/h2-8,10-11,13H,9,12H2,1H3,(H,23,29)(H,25,26,28)/t13-/m0/s1
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n/an/a 490n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168064
PNG
(US9073926, 98)
Show SMILES C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(Cc2ccccc2)on1
Show InChI InChI=1S/C22H19N5O3/c1-13-12-23-22(29)18-10-15-7-8-17(24-20(15)27(13)18)21(28)25-19-11-16(30-26-19)9-14-5-3-2-4-6-14/h2-8,10-11,13H,9,12H2,1H3,(H,23,29)(H,25,26,28)/t13-/m1/s1
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n/an/a 3.90n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168065
PNG
(US9073926, 99)
Show SMILES C[C@H]1NC(=O)c2cc3ccc(nc3n2[C@H]1C)C(=O)Nc1cc(Cc2ccccc2)on1
Show InChI InChI=1S/C23H21N5O3/c1-13-14(2)28-19(23(30)24-13)11-16-8-9-18(25-21(16)28)22(29)26-20-12-17(31-27-20)10-15-6-4-3-5-7-15/h3-9,11-14H,10H2,1-2H3,(H,24,30)(H,26,27,29)/t13-,14+/m1/s1
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n/an/a 5.10n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168052
PNG
(US9073926, 86)
Show SMILES C[C@@H]1NC(=O)c2cc3ccc(nc3n2[C@H]1C)C(=O)Nc1cc(C)on1
Show InChI InChI=1S/C17H17N5O3/c1-8-6-14(21-25-8)20-16(23)12-5-4-11-7-13-17(24)18-9(2)10(3)22(13)15(11)19-12/h4-7,9-10H,1-3H3,(H,18,24)(H,20,21,23)/t9-,10-/m0/s1
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n/an/a 110n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair