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14 similar compounds to monomer 168048

Compile data set for download or QSAR
Wt: 395.4
BDBM168053
Wt: 367.4
BDBM168054
Wt: 381.4
BDBM168055
Wt: 379.4
BDBM168056
Wt: 353.3
BDBM168057
Wt: 415.4
BDBM168058
Wt: 429.4
BDBM168059
Wt: 415.4
BDBM168060
Wt: 367.4
BDBM168045
Wt: 325.3
BDBM168046
Wt: 325.3
BDBM168049
Wt: 325.3
BDBM168050
Wt: 339.3
BDBM168051
Wt: 339.3
BDBM168052

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 168053,168054,168055,168056,168057,168058,168059,168060,168045,168046,168049,168050,168051,168052   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168045
PNG
(US9073926, 79)
Show SMILES CC(C)(C)c1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)no1
Show InChI InChI=1S/C19H21N5O3/c1-19(2,3)14-10-15(23-27-14)22-17(25)12-6-5-11-9-13-18(26)20-7-4-8-24(13)16(11)21-12/h5-6,9-10H,4,7-8H2,1-3H3,(H,20,26)(H,22,23,25)
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n/an/a 19n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168046
PNG
(US9073926, 80)
Show SMILES Cc1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)no1
Show InChI InChI=1S/C16H15N5O3/c1-9-7-13(20-24-9)19-15(22)11-4-3-10-8-12-16(23)17-5-2-6-21(12)14(10)18-11/h3-4,7-8H,2,5-6H2,1H3,(H,17,23)(H,19,20,22)
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n/an/a 19n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168049
PNG
(US9073926, 83)
Show SMILES C[C@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(C)on1
Show InChI InChI=1S/C16H15N5O3/c1-8-7-17-16(23)12-6-10-3-4-11(18-14(10)21(8)12)15(22)19-13-5-9(2)24-20-13/h3-6,8H,7H2,1-2H3,(H,17,23)(H,19,20,22)/t8-/m0/s1
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n/an/a 380n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168050
PNG
(US9073926, 84)
Show SMILES C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(C)on1
Show InChI InChI=1S/C16H15N5O3/c1-8-7-17-16(23)12-6-10-3-4-11(18-14(10)21(8)12)15(22)19-13-5-9(2)24-20-13/h3-6,8H,7H2,1-2H3,(H,17,23)(H,19,20,22)/t8-/m1/s1
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n/an/a 6.60n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168051
PNG
(US9073926, 85)
Show SMILES C[C@H]1NC(=O)c2cc3ccc(nc3n2[C@H]1C)C(=O)Nc1cc(C)on1
Show InChI InChI=1S/C17H17N5O3/c1-8-6-14(21-25-8)20-16(23)12-5-4-11-7-13-17(24)18-9(2)10(3)22(13)15(11)19-12/h4-7,9-10H,1-3H3,(H,18,24)(H,20,21,23)/t9-,10+/m1/s1
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n/an/a 2.60n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168052
PNG
(US9073926, 86)
Show SMILES C[C@@H]1NC(=O)c2cc3ccc(nc3n2[C@H]1C)C(=O)Nc1cc(C)on1
Show InChI InChI=1S/C17H17N5O3/c1-8-6-14(21-25-8)20-16(23)12-5-4-11-7-13-17(24)18-9(2)10(3)22(13)15(11)19-12/h4-7,9-10H,1-3H3,(H,18,24)(H,20,21,23)/t9-,10-/m0/s1
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n/an/a 110n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168060
PNG
(US9073926, 94)
Show SMILES CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(Cc2ccccc2)on1
Show InChI InChI=1S/C23H21N5O3/c1-14-9-10-24-23(30)19-12-16-7-8-18(25-21(16)28(14)19)22(29)26-20-13-17(31-27-20)11-15-5-3-2-4-6-15/h2-8,12-14H,9-11H2,1H3,(H,24,30)(H,26,27,29)
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n/an/a 3.30n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168054
PNG
(US9073926, 88)
Show SMILES CCc1cc(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)no1
Show InChI InChI=1S/C19H21N5O3/c1-4-12-8-15(23-27-12)22-17(25)13-6-5-11-7-14-18(26)20-9-19(2,3)10-24(14)16(11)21-13/h5-8H,4,9-10H2,1-3H3,(H,20,26)(H,22,23,25)
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n/an/a 109n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168055
PNG
(US9073926, 89)
Show SMILES CC(C)c1cc(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)no1
Show InChI InChI=1S/C20H23N5O3/c1-11(2)15-8-16(24-28-15)23-18(26)13-6-5-12-7-14-19(27)21-9-20(3,4)10-25(14)17(12)22-13/h5-8,11H,9-10H2,1-4H3,(H,21,27)(H,23,24,26)
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n/an/a 125n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168056
PNG
(US9073926, 90)
Show SMILES CC1(C)CNC(=O)c2cc3ccc(nc3n2C1)C(=O)Nc1cc(on1)C1CC1
Show InChI InChI=1S/C20H21N5O3/c1-20(2)9-21-19(27)14-7-12-5-6-13(22-17(12)25(14)10-20)18(26)23-16-8-15(28-24-16)11-3-4-11/h5-8,11H,3-4,9-10H2,1-2H3,(H,21,27)(H,23,24,26)
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n/an/a 43n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168057
PNG
(US9073926, 91)
Show SMILES Cc1cc(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)no1
Show InChI InChI=1S/C18H19N5O3/c1-10-6-14(22-26-10)21-16(24)12-5-4-11-7-13-17(25)19-8-18(2,3)9-23(13)15(11)20-12/h4-7H,8-9H2,1-3H3,(H,19,25)(H,21,22,24)
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n/an/a 395n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168058
PNG
(US9073926, 92)
Show SMILES CC1(C)CNC(=O)c2cc3ccc(nc3n2C1)C(=O)Nc1cc(on1)-c1ccccc1
Show InChI InChI=1S/C23H21N5O3/c1-23(2)12-24-22(30)17-10-15-8-9-16(25-20(15)28(17)13-23)21(29)26-19-11-18(31-27-19)14-6-4-3-5-7-14/h3-11H,12-13H2,1-2H3,(H,24,30)(H,26,27,29)
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n/an/a 502n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168059
PNG
(US9073926, 93)
Show SMILES CC1(C)CNC(=O)c2cc3ccc(nc3n2C1)C(=O)Nc1cc(Cc2ccccc2)on1
Show InChI InChI=1S/C24H23N5O3/c1-24(2)13-25-23(31)19-11-16-8-9-18(26-21(16)29(19)14-24)22(30)27-20-12-17(32-28-20)10-15-6-4-3-5-7-15/h3-9,11-12H,10,13-14H2,1-2H3,(H,25,31)(H,27,28,30)
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n/an/a 360n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase alpha-3


(Homo sapiens (Human))
BDBM168053
PNG
(US9073926, 87)
Show SMILES CC(C)(C)c1cc(NC(=O)c2ccc3cc4C(=O)NCC(C)(C)Cn4c3n2)no1
Show InChI InChI=1S/C21H25N5O3/c1-20(2,3)15-9-16(25-29-15)24-18(27)13-7-6-12-8-14-19(28)22-10-21(4,5)11-26(14)17(12)23-13/h6-9H,10-11H2,1-5H3,(H,22,28)(H,24,25,27)
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n/an/a 175n/an/an/an/a7.5n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...


US Patent US9073926 (2015)


BindingDB Entry DOI: 10.7270/Q2BP01J6
More data for this
Ligand-Target Pair