BindingDB logo
myBDB logout

41 similar compounds to monomer 17227

Compile data set for download or QSAR
Wt: 438.9
BDBM17084
Wt: 455.3
BDBM17226
Wt: 489.8
BDBM17229
Wt: 489.8
BDBM17230
Wt: 489.8
BDBM17231
Wt: 532.8
BDBM17233
Wt: 587.9
BDBM17235
Wt: 631.9
BDBM17236
Wt: 510.4
BDBM50404097
Wt: 475.7
BDBM50404098
Wt: 449.9
BDBM50404099
Wt: 455.3
BDBM50404100
Wt: 459.3
BDBM50404102
Wt: 539.4
BDBM50404103
Wt: 450.9
BDBM50404104
Displayed 1 to 15 (of 41 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 49 hits for monomerid = 17084,17226,17229,17230,17231,17233,17235,17236,50404097,50404098,50404099,50404100,50404102,50404103,50404104   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor X


(Homo sapiens (human))
BDBM17226
PNG
(3-chloro-N-{2-[(4-chlorophenyl)carbamoyl]-4-methyl...)
Show SMILES Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C23H16Cl2N2O2S/c1-13-6-11-18(17(12-13)22(28)26-15-9-7-14(24)8-10-15)27-23(29)21-20(25)16-4-2-3-5-19(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.320n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of factor 10a


J Med Chem 53: 6243-74 (2010)


Article DOI: 10.1021/jm100146h
BindingDB Entry DOI: 10.7270/Q2CR5VBB
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM17226
PNG
(3-chloro-N-{2-[(4-chlorophenyl)carbamoyl]-4-methyl...)
Show SMILES Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C23H16Cl2N2O2S/c1-13-6-11-18(17(12-13)22(28)26-15-9-7-14(24)8-10-15)27-23(29)21-20(25)16-4-2-3-5-19(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.320n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human factor Xa


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM17226
PNG
(3-chloro-N-{2-[(4-chlorophenyl)carbamoyl]-4-methyl...)
Show SMILES Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C23H16Cl2N2O2S/c1-13-6-11-18(17(12-13)22(28)26-15-9-7-14(24)8-10-15)27-23(29)21-20(25)16-4-2-3-5-19(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.330 -12.8n/an/an/an/an/a7.522



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM17231
PNG
(3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]...)
Show SMILES Cc1ccc2c(Cl)c(sc2c1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C23H15Cl3N2O2S/c1-12-2-8-16-19(10-12)31-21(20(16)26)23(30)28-18-9-5-14(25)11-17(18)22(29)27-15-6-3-13(24)4-7-15/h2-11H,1H3,(H,27,29)(H,28,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.950 -12.2n/an/an/an/an/a7.522



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM17236
PNG
(2-(4-{[3-chloro-2-({4-chloro-2-[(4-chlorophenyl)ca...)
Show SMILES OC(=O)CN1CCN(Cc2ccc3c(Cl)c(sc3c2)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C29H25Cl3N4O4S/c30-18-2-5-20(6-3-18)33-28(39)22-14-19(31)4-8-23(22)34-29(40)27-26(32)21-7-1-17(13-24(21)41-27)15-35-9-11-36(12-10-35)16-25(37)38/h1-8,13-14H,9-12,15-16H2,(H,33,39)(H,34,40)(H,37,38)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
9.5 -10.8n/an/an/an/an/a7.522



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM17084
PNG
(3-chloro-N-{2-[(4-fluorophenyl)carbamoyl]-4-methyl...)
Show SMILES Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C23H16ClFN2O2S/c1-13-6-11-18(17(12-13)22(28)26-15-9-7-14(25)8-10-15)27-23(29)21-20(24)16-4-2-3-5-19(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
10 -10.8n/an/an/an/an/a7.522



Berlex Biosciences



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


J Med Chem 50: 2967-80 (2007)


Article DOI: 10.1021/jm070125f
BindingDB Entry DOI: 10.7270/Q2J101F5
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM17084
PNG
(3-chloro-N-{2-[(4-fluorophenyl)carbamoyl]-4-methyl...)
Show SMILES Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C23H16ClFN2O2S/c1-13-6-11-18(17(12-13)22(28)26-15-9-7-14(25)8-10-15)27-23(29)21-20(24)16-4-2-3-5-19(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
11n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of factor 10a


J Med Chem 53: 6243-74 (2010)


Article DOI: 10.1021/jm100146h
BindingDB Entry DOI: 10.7270/Q2CR5VBB
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM17084
PNG
(3-chloro-N-{2-[(4-fluorophenyl)carbamoyl]-4-methyl...)
Show SMILES Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C23H16ClFN2O2S/c1-13-6-11-18(17(12-13)22(28)26-15-9-7-14(25)8-10-15)27-23(29)21-20(24)16-4-2-3-5-19(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
11n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human factor Xa


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM17233
PNG
(3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]...)
Show SMILES CN(C)Cc1ccc2c(Cl)c(sc2c1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C25H20Cl3N3O2S/c1-31(2)13-14-3-9-18-21(11-14)34-23(22(18)28)25(33)30-20-10-6-16(27)12-19(20)24(32)29-17-7-4-15(26)5-8-17/h3-12H,13H2,1-2H3,(H,29,32)(H,30,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
14 -10.6n/an/an/an/an/a7.522



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM50404104
PNG
(CHEMBL53011)
Show SMILES COc1ccc(NC(=O)c2cc(C)ccc2NC(=O)c2sc3ccccc3c2Cl)cc1
Show InChI InChI=1S/C24H19ClN2O3S/c1-14-7-12-19(18(13-14)23(28)26-15-8-10-16(30-2)11-9-15)27-24(29)22-21(25)17-5-3-4-6-20(17)31-22/h3-13H,1-2H3,(H,26,28)(H,27,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
16n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human factor Xa


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM17235
PNG
(3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]...)
Show SMILES CN1CCN(Cc2ccc3c(Cl)c(sc3c2)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C28H25Cl3N4O2S/c1-34-10-12-35(13-11-34)16-17-2-8-21-24(14-17)38-26(25(21)31)28(37)33-23-9-5-19(30)15-22(23)27(36)32-20-6-3-18(29)4-7-20/h2-9,14-15H,10-13,16H2,1H3,(H,32,36)(H,33,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
21 -10.4n/an/an/an/an/a7.522



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM50404102
PNG
(CHEMBL359219)
Show SMILES Fc1cccc(NC(=O)c2sc3ccccc3c2Cl)c1C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C22H13Cl2FN2O2S/c23-12-8-10-13(11-9-12)26-21(28)18-15(25)5-3-6-16(18)27-22(29)20-19(24)14-4-1-2-7-17(14)30-20/h1-11H,(H,26,28)(H,27,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
26n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human factor Xa


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM17230
PNG
(3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]...)
Show SMILES Cc1ccc2sc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cc3)c(Cl)c2c1
Show InChI InChI=1S/C23H15Cl3N2O2S/c1-12-2-9-19-17(10-12)20(26)21(31-19)23(30)28-18-8-5-14(25)11-16(18)22(29)27-15-6-3-13(24)4-7-15/h2-11H,1H3,(H,27,29)(H,28,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
54 -9.81n/an/an/an/an/a7.522



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM50404100
PNG
(CHEMBL358135)
Show SMILES Cc1cccc(C(=O)Nc2ccc(Cl)cc2)c1NC(=O)c1sc2ccccc2c1Cl
Show InChI InChI=1S/C23H16Cl2N2O2S/c1-13-5-4-7-17(22(28)26-15-11-9-14(24)10-12-15)20(13)27-23(29)21-19(25)16-6-2-3-8-18(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
58n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human factor Xa


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM50404103
PNG
(CHEMBL422134)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C27H24Cl2N4O2S/c1-32-12-14-33(15-13-32)19-10-11-22(21(16-19)26(34)30-18-8-6-17(28)7-9-18)31-27(35)25-24(29)20-4-2-3-5-23(20)36-25/h2-11,16H,12-15H2,1H3,(H,30,34)(H,31,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
470n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human factor Xa


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM50404099
PNG
(CHEMBL148036)
Show SMILES Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(CN)cc1
Show InChI InChI=1S/C24H20ClN3O2S/c1-14-6-11-19(18(12-14)23(29)27-16-9-7-15(13-26)8-10-16)28-24(30)22-21(25)17-4-2-3-5-20(17)31-22/h2-12H,13,26H2,1H3,(H,27,29)(H,28,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.40E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human factor Xa


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Trypsin


(Bos taurus (bovine))
BDBM17233
PNG
(3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]...)
Show SMILES CN(C)Cc1ccc2c(Cl)c(sc2c1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C25H20Cl3N3O2S/c1-31(2)13-14-3-9-18-21(11-14)34-23(22(18)28)25(33)30-20-10-6-16(27)12-19(20)24(32)29-17-7-4-15(26)5-8-17/h3-12H,13H2,1-2H3,(H,29,32)(H,30,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Trypsin


(Bos taurus (bovine))
BDBM17235
PNG
(3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]...)
Show SMILES CN1CCN(Cc2ccc3c(Cl)c(sc3c2)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C28H25Cl3N4O2S/c1-34-10-12-35(13-11-34)16-17-2-8-21-24(14-17)38-26(25(21)31)28(37)33-23-9-5-19(30)15-22(23)27(36)32-20-6-3-18(29)4-7-20/h2-9,14-15H,10-13,16H2,1H3,(H,32,36)(H,33,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Trypsin


(Bos taurus (bovine))
BDBM17236
PNG
(2-(4-{[3-chloro-2-({4-chloro-2-[(4-chlorophenyl)ca...)
Show SMILES OC(=O)CN1CCN(Cc2ccc3c(Cl)c(sc3c2)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C29H25Cl3N4O4S/c30-18-2-5-20(6-3-18)33-28(39)22-14-19(31)4-8-23(22)34-29(40)27-26(32)21-7-1-17(13-24(21)41-27)15-35-9-11-36(12-10-35)16-25(37)38/h1-8,13-14H,9-12,15-16H2,(H,33,39)(H,34,40)(H,37,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Trypsin


(Homo sapiens (human))
BDBM17226
PNG
(3-chloro-N-{2-[(4-chlorophenyl)carbamoyl]-4-methyl...)
Show SMILES Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C23H16Cl2N2O2S/c1-13-6-11-18(17(12-13)22(28)26-15-9-7-14(24)8-10-15)27-23(29)21-20(25)16-4-2-3-5-19(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against bovine trypsin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Trypsin


(Homo sapiens (human))
BDBM50404098
PNG
(CHEMBL146160)
Show SMILES Clc1c(sc2ccccc12)C(=O)Nc1cccc(Cl)c1C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C22H13Cl3N2O2S/c23-12-8-10-13(11-9-12)26-21(28)18-15(24)5-3-6-16(18)27-22(29)20-19(25)14-4-1-2-7-17(14)30-20/h1-11H,(H,26,28)(H,27,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against bovine trypsin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Trypsin


(Homo sapiens (human))
BDBM50404102
PNG
(CHEMBL359219)
Show SMILES Fc1cccc(NC(=O)c2sc3ccccc3c2Cl)c1C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C22H13Cl2FN2O2S/c23-12-8-10-13(11-9-12)26-21(28)18-15(25)5-3-6-16(18)27-22(29)20-19(24)14-4-1-2-7-17(14)30-20/h1-11H,(H,26,28)(H,27,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against bovine trypsin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Trypsin


(Homo sapiens (human))
BDBM17084
PNG
(3-chloro-N-{2-[(4-fluorophenyl)carbamoyl]-4-methyl...)
Show SMILES Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C23H16ClFN2O2S/c1-13-6-11-18(17(12-13)22(28)26-15-9-7-14(25)8-10-15)27-23(29)21-20(24)16-4-2-3-5-19(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against bovine trypsin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Trypsin


(Homo sapiens (human))
BDBM50404103
PNG
(CHEMBL422134)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C27H24Cl2N4O2S/c1-32-12-14-33(15-13-32)19-10-11-22(21(16-19)26(34)30-18-8-6-17(28)7-9-18)31-27(35)25-24(29)20-4-2-3-5-23(20)36-25/h2-11,16H,12-15H2,1H3,(H,30,34)(H,31,35)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against bovine trypsin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Trypsin


(Homo sapiens (human))
BDBM50404099
PNG
(CHEMBL148036)
Show SMILES Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(CN)cc1
Show InChI InChI=1S/C24H20ClN3O2S/c1-14-6-11-19(18(12-14)23(29)27-16-9-7-15(13-26)8-10-16)28-24(30)22-21(25)17-4-2-3-5-20(17)31-22/h2-12H,13,26H2,1H3,(H,27,29)(H,28,30)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against bovine trypsin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Trypsin


(Homo sapiens (human))
BDBM50404100
PNG
(CHEMBL358135)
Show SMILES Cc1cccc(C(=O)Nc2ccc(Cl)cc2)c1NC(=O)c1sc2ccccc2c1Cl
Show InChI InChI=1S/C23H16Cl2N2O2S/c1-13-5-4-7-17(22(28)26-15-11-9-14(24)10-12-15)20(13)27-23(29)21-19(25)16-6-2-3-8-18(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against bovine trypsin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Trypsin


(Homo sapiens (human))
BDBM50404097
PNG
(CHEMBL342964)
Show SMILES Clc1c(sc2ccccc12)C(=O)Nc1ccc(cc1C(=O)Nc1ccc(Cl)cc1)N1CCCC1
Show InChI InChI=1S/C26H21Cl2N3O2S/c27-16-7-9-17(10-8-16)29-25(32)20-15-18(31-13-3-4-14-31)11-12-21(20)30-26(33)24-23(28)19-5-1-2-6-22(19)34-24/h1-2,5-12,15H,3-4,13-14H2,(H,29,32)(H,30,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against bovine trypsin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Trypsin


(Homo sapiens (human))
BDBM50404104
PNG
(CHEMBL53011)
Show SMILES COc1ccc(NC(=O)c2cc(C)ccc2NC(=O)c2sc3ccccc3c2Cl)cc1
Show InChI InChI=1S/C24H19ClN2O3S/c1-14-7-12-19(18(13-14)23(28)26-15-8-10-16(30-2)11-9-15)27-24(29)22-21(25)17-5-3-4-6-20(17)31-22/h3-13H,1-2H3,(H,26,28)(H,27,29)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against bovine trypsin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM50404097
PNG
(CHEMBL342964)
Show SMILES Clc1c(sc2ccccc12)C(=O)Nc1ccc(cc1C(=O)Nc1ccc(Cl)cc1)N1CCCC1
Show InChI InChI=1S/C26H21Cl2N3O2S/c27-16-7-9-17(10-8-16)29-25(32)20-15-18(31-13-3-4-14-31)11-12-21(20)30-26(33)24-23(28)19-5-1-2-6-22(19)34-24/h1-2,5-12,15H,3-4,13-14H2,(H,29,32)(H,30,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human factor Xa


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM50404098
PNG
(CHEMBL146160)
Show SMILES Clc1c(sc2ccccc12)C(=O)Nc1cccc(Cl)c1C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C22H13Cl3N2O2S/c23-12-8-10-13(11-9-12)26-21(28)18-15(24)5-3-6-16(18)27-22(29)20-19(25)14-4-1-2-7-17(14)30-20/h1-11H,(H,26,28)(H,27,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human factor Xa


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM50404103
PNG
(CHEMBL422134)
Show SMILES CN1CCN(CC1)c1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C27H24Cl2N4O2S/c1-32-12-14-33(15-13-32)19-10-11-22(21(16-19)26(34)30-18-8-6-17(28)7-9-18)31-27(35)25-24(29)20-4-2-3-5-23(20)36-25/h2-11,16H,12-15H2,1H3,(H,30,34)(H,31,35)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human thrombin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM50404104
PNG
(CHEMBL53011)
Show SMILES COc1ccc(NC(=O)c2cc(C)ccc2NC(=O)c2sc3ccccc3c2Cl)cc1
Show InChI InChI=1S/C24H19ClN2O3S/c1-14-7-12-19(18(13-14)23(28)26-15-8-10-16(30-2)11-9-15)27-24(29)22-21(25)17-5-3-4-6-20(17)31-22/h3-13H,1-2H3,(H,26,28)(H,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human thrombin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (human))
BDBM17229
PNG
(3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]...)
Show SMILES Cc1cccc2sc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cc3)c(Cl)c12
Show InChI InChI=1S/C23H15Cl3N2O2S/c1-12-3-2-4-18-19(12)20(26)21(31-18)23(30)28-17-10-7-14(25)11-16(17)22(29)27-15-8-5-13(24)6-9-15/h2-11H,1H3,(H,27,29)(H,28,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3>-7.15n/an/an/an/an/a7.522



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM50404100
PNG
(CHEMBL358135)
Show SMILES Cc1cccc(C(=O)Nc2ccc(Cl)cc2)c1NC(=O)c1sc2ccccc2c1Cl
Show InChI InChI=1S/C23H16Cl2N2O2S/c1-13-5-4-7-17(22(28)26-15-11-9-14(24)10-12-15)20(13)27-23(29)21-19(25)16-6-2-3-8-18(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human thrombin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM17084
PNG
(3-chloro-N-{2-[(4-fluorophenyl)carbamoyl]-4-methyl...)
Show SMILES Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C23H16ClFN2O2S/c1-13-6-11-18(17(12-13)22(28)26-15-9-7-14(25)8-10-15)27-23(29)21-20(24)16-4-2-3-5-19(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human thrombin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM50404102
PNG
(CHEMBL359219)
Show SMILES Fc1cccc(NC(=O)c2sc3ccccc3c2Cl)c1C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C22H13Cl2FN2O2S/c23-12-8-10-13(11-9-12)26-21(28)18-15(25)5-3-6-16(18)27-22(29)20-19(24)14-4-1-2-7-17(14)30-20/h1-11H,(H,26,28)(H,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human thrombin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM17226
PNG
(3-chloro-N-{2-[(4-chlorophenyl)carbamoyl]-4-methyl...)
Show SMILES Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C23H16Cl2N2O2S/c1-13-6-11-18(17(12-13)22(28)26-15-9-7-14(24)8-10-15)27-23(29)21-20(25)16-4-2-3-5-19(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human thrombin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM50404097
PNG
(CHEMBL342964)
Show SMILES Clc1c(sc2ccccc12)C(=O)Nc1ccc(cc1C(=O)Nc1ccc(Cl)cc1)N1CCCC1
Show InChI InChI=1S/C26H21Cl2N3O2S/c27-16-7-9-17(10-8-16)29-25(32)20-15-18(31-13-3-4-14-31)11-12-21(20)30-26(33)24-23(28)19-5-1-2-6-22(19)34-24/h1-2,5-12,15H,3-4,13-14H2,(H,29,32)(H,30,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human thrombin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM50404099
PNG
(CHEMBL148036)
Show SMILES Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(CN)cc1
Show InChI InChI=1S/C24H20ClN3O2S/c1-14-6-11-19(18(12-14)23(29)27-16-9-7-15(13-26)8-10-16)28-24(30)22-21(25)17-4-2-3-5-20(17)31-22/h2-12H,13,26H2,1H3,(H,27,29)(H,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human thrombin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM50404098
PNG
(CHEMBL146160)
Show SMILES Clc1c(sc2ccccc12)C(=O)Nc1cccc(Cl)c1C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C22H13Cl3N2O2S/c23-12-8-10-13(11-9-12)26-21(28)18-15(24)5-3-6-16(18)27-22(29)20-19(25)14-4-1-2-7-17(14)30-20/h1-11H,(H,26,28)(H,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition constant against human thrombin


Bioorg Med Chem Lett 13: 507-11 (2003)


Article DOI: 10.1016/s0960-894x(02)00938-1
BindingDB Entry DOI: 10.7270/Q21N829C
More data for this
Ligand-Target Pair
Trypsin


(Bos taurus (bovine))
BDBM17229
PNG
(3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]...)
Show SMILES Cc1cccc2sc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cc3)c(Cl)c12
Show InChI InChI=1S/C23H15Cl3N2O2S/c1-12-3-2-4-18-19(12)20(26)21(31-18)23(30)28-17-10-7-14(25)11-16(17)22(29)27-15-8-5-13(24)6-9-15/h2-11H,1H3,(H,27,29)(H,28,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Trypsin


(Bos taurus (bovine))
BDBM17226
PNG
(3-chloro-N-{2-[(4-chlorophenyl)carbamoyl]-4-methyl...)
Show SMILES Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C23H16Cl2N2O2S/c1-13-6-11-18(17(12-13)22(28)26-15-9-7-14(24)8-10-15)27-23(29)21-20(25)16-4-2-3-5-19(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM17236
PNG
(2-(4-{[3-chloro-2-({4-chloro-2-[(4-chlorophenyl)ca...)
Show SMILES OC(=O)CN1CCN(Cc2ccc3c(Cl)c(sc3c2)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C29H25Cl3N4O4S/c30-18-2-5-20(6-3-18)33-28(39)22-14-19(31)4-8-23(22)34-29(40)27-26(32)21-7-1-17(13-24(21)41-27)15-35-9-11-36(12-10-35)16-25(37)38/h1-8,13-14H,9-12,15-16H2,(H,33,39)(H,34,40)(H,37,38)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM17235
PNG
(3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]...)
Show SMILES CN1CCN(Cc2ccc3c(Cl)c(sc3c2)C(=O)Nc2ccc(Cl)cc2C(=O)Nc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C28H25Cl3N4O2S/c1-34-10-12-35(13-11-34)16-17-2-8-21-24(14-17)38-26(25(21)31)28(37)33-23-9-5-19(30)15-22(23)27(36)32-20-6-3-18(29)4-7-20/h2-9,14-15H,10-13,16H2,1H3,(H,32,36)(H,33,37)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM17233
PNG
(3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]...)
Show SMILES CN(C)Cc1ccc2c(Cl)c(sc2c1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C25H20Cl3N3O2S/c1-31(2)13-14-3-9-18-21(11-14)34-23(22(18)28)25(33)30-20-10-6-16(27)12-19(20)24(32)29-17-7-4-15(26)5-8-17/h3-12H,13H2,1-2H3,(H,29,32)(H,30,33)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM17231
PNG
(3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]...)
Show SMILES Cc1ccc2c(Cl)c(sc2c1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C23H15Cl3N2O2S/c1-12-2-8-16-19(10-12)31-21(20(16)26)23(30)28-18-9-5-14(25)11-17(18)22(29)27-15-6-3-13(24)4-7-15/h2-11H,1H3,(H,27,29)(H,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM17230
PNG
(3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]...)
Show SMILES Cc1ccc2sc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cc3)c(Cl)c2c1
Show InChI InChI=1S/C23H15Cl3N2O2S/c1-12-2-9-19-17(10-12)20(26)21(31-19)23(30)28-18-8-5-14(25)11-16(18)22(29)27-15-6-3-13(24)4-7-15/h2-11H,1H3,(H,27,29)(H,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM17226
PNG
(3-chloro-N-{2-[(4-chlorophenyl)carbamoyl]-4-methyl...)
Show SMILES Cc1ccc(NC(=O)c2sc3ccccc3c2Cl)c(c1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C23H16Cl2N2O2S/c1-13-6-11-18(17(12-13)22(28)26-15-9-7-14(24)8-10-15)27-23(29)21-20(25)16-4-2-3-5-19(16)30-21/h2-12H,1H3,(H,26,28)(H,27,29)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair
Prothrombin


(Homo sapiens (Human))
BDBM17229
PNG
(3-chloro-N-{4-chloro-2-[(4-chlorophenyl)carbamoyl]...)
Show SMILES Cc1cccc2sc(C(=O)Nc3ccc(Cl)cc3C(=O)Nc3ccc(Cl)cc3)c(Cl)c12
Show InChI InChI=1S/C23H15Cl3N2O2S/c1-12-3-2-4-18-19(12)20(26)21(31-18)23(30)28-17-10-7-14(25)11-16(17)22(29)27-15-8-5-13(24)6-9-15/h2-11H,1H3,(H,27,29)(H,28,30)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+3n/an/an/an/an/an/an/an/a



Berlex



Assay Description
The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...


Bioorg Med Chem 15: 2127-46 (2007)


Article DOI: 10.1016/j.bmc.2006.12.019
BindingDB Entry DOI: 10.7270/Q2MS3R1T
More data for this
Ligand-Target Pair