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44 molecules are shown

Wt: 330.4
BDBM17443
Wt: 314.4
BDBM17444
Wt: 314.4
BDBM17445
Wt: 301.3
BDBM17364
Wt: 296.3
BDBM17365
Wt: 310.4
BDBM17366
Wt: 314.3
BDBM17368
Wt: 332.3
BDBM17369
Wt: 297.3
BDBM17370
Wt: 302.4
BDBM17376
Wt: 316.8
BDBM17377
Wt: 330.8
BDBM17378
Wt: 346.8
BDBM17379
Wt: 334.7
BDBM17380
Wt: 352.7
BDBM17381
Displayed 1 to 15 (of 44 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 17443,17444,17445,17364,17365,17366,17368,17369,17370,17376,17377,17378,17379,17380,17381   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17365
PNG
(1,2,4-Triazole Compound, 23 | 5-(benzylsulfanyl)-N...)
Show SMILES Cc1ccc(Nc2nnc(SCc3ccccc3)[nH]2)cc1
Show InChI InChI=1S/C16H16N4S/c1-12-7-9-14(10-8-12)17-15-18-16(20-19-15)21-11-13-5-3-2-4-6-13/h2-10H,11H2,1H3,(H2,17,18,19,20)
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0.0700 -13.7n/an/an/an/an/a7.522



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17377
PNG
(1,2,4-Triazole Compound, 35 | 5-(benzylsulfanyl)-N...)
Show SMILES Clc1ccc(Nc2nnc(SCc3ccccc3)[nH]2)cc1
Show InChI InChI=1S/C15H13ClN4S/c16-12-6-8-13(9-7-12)17-14-18-15(20-19-14)21-10-11-4-2-1-3-5-11/h1-9H,10H2,(H2,17,18,19,20)
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0.430n/an/an/an/an/an/an/an/a



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17380
PNG
(1,2,4-Triazole Compound, 38 | N-(4-chlorophenyl)-5...)
Show SMILES Fc1ccccc1CSc1nnc(Nc2ccc(Cl)cc2)[nH]1
Show InChI InChI=1S/C15H12ClFN4S/c16-11-5-7-12(8-6-11)18-14-19-15(21-20-14)22-9-10-3-1-2-4-13(10)17/h1-8H,9H2,(H2,18,19,20,21)
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0.610n/an/an/an/an/an/an/an/a



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17368
PNG
(1,2,4-Triazole Compound, 26 | 5-{[(2-fluorophenyl)...)
Show SMILES Cc1ccc(Nc2nnc(SCc3ccccc3F)[nH]2)cc1
Show InChI InChI=1S/C16H15FN4S/c1-11-6-8-13(9-7-11)18-15-19-16(21-20-15)22-10-12-4-2-3-5-14(12)17/h2-9H,10H2,1H3,(H2,18,19,20,21)
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0.650 -12.4n/an/an/an/an/a7.522



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17381
PNG
(1,2,4-Triazole Compound, 39 | N-(4-chlorophenyl)-5...)
Show SMILES Fc1ccc(CSc2nnc(Nc3ccc(Cl)cc3)[nH]2)cc1F
Show InChI InChI=1S/C15H11ClF2N4S/c16-10-2-4-11(5-3-10)19-14-20-15(22-21-14)23-8-9-1-6-12(17)13(18)7-9/h1-7H,8H2,(H2,19,20,21,22)
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1.5n/an/an/an/an/an/an/an/a



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17443
PNG
(1,2,4-Triazole Compound, 102 | N-[2-(propan-2-yl)p...)
Show SMILES CC(C)c1ccccc1Nc1nnc(SCc2cccs2)[nH]1
Show InChI InChI=1S/C16H18N4S2/c1-11(2)13-7-3-4-8-14(13)17-15-18-16(20-19-15)22-10-12-6-5-9-21-12/h3-9,11H,10H2,1-2H3,(H2,17,18,19,20)
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2n/an/an/an/an/an/an/an/a



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17444
PNG
(1,2,4-Triazole Compound, 103 | 5-[(furan-2-ylmethy...)
Show SMILES CC(C)c1ccccc1Nc1nnc(SCc2ccco2)[nH]1
Show InChI InChI=1S/C16H18N4OS/c1-11(2)13-7-3-4-8-14(13)17-15-18-16(20-19-15)22-10-12-6-5-9-21-12/h3-9,11H,10H2,1-2H3,(H2,17,18,19,20)
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3n/an/an/an/an/an/an/an/a



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17369
PNG
(1,2,4-Triazole Compound, 27 | 5-{[(3,4-difluorophe...)
Show SMILES Cc1ccc(Nc2nnc(SCc3ccc(F)c(F)c3)[nH]2)cc1
Show InChI InChI=1S/C16H14F2N4S/c1-10-2-5-12(6-3-10)19-15-20-16(22-21-15)23-9-11-4-7-13(17)14(18)8-11/h2-8H,9H2,1H3,(H2,19,20,21,22)
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3.30 -11.4n/an/an/an/an/a7.522



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17364
PNG
(1,2,4-Triazole Compound, 22 | 5-{[(5-methyl-1,2-ox...)
Show SMILES Cc1cc(CSc2nnc(Nc3ccccc3C)[nH]2)no1
Show InChI InChI=1S/C14H15N5OS/c1-9-5-3-4-6-12(9)15-13-16-14(18-17-13)21-8-11-7-10(2)20-19-11/h3-7H,8H2,1-2H3,(H2,15,16,17,18)
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3.60 -11.4n/an/an/an/an/a7.522



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17376
PNG
(1,2,4-Triazole Compound, 34 | N-(4-methylphenyl)-5...)
Show SMILES Cc1ccc(Nc2nnc(SCc3cccs3)[nH]2)cc1
Show InChI InChI=1S/C14H14N4S2/c1-10-4-6-11(7-5-10)15-13-16-14(18-17-13)20-9-12-3-2-8-19-12/h2-8H,9H2,1H3,(H2,15,16,17,18)
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5.20n/an/an/an/an/an/an/an/a



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17366
PNG
(1,2,4-Triazole Compound, 24 | N-(4-methylphenyl)-5...)
Show SMILES Cc1ccc(Nc2nnc(SCc3ccccc3C)[nH]2)cc1
Show InChI InChI=1S/C17H18N4S/c1-12-7-9-15(10-8-12)18-16-19-17(21-20-16)22-11-14-6-4-3-5-13(14)2/h3-10H,11H2,1-2H3,(H2,18,19,20,21)
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6.5 -11.0n/an/an/an/an/a7.522



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17370
PNG
(1,2,4-Triazole Compound, 28 | N-(4-methylphenyl)-5...)
Show SMILES Cc1ccc(Nc2nnc(SCc3ccccn3)[nH]2)cc1
Show InChI InChI=1S/C15H15N5S/c1-11-5-7-12(8-6-11)17-14-18-15(20-19-14)21-10-13-4-2-3-9-16-13/h2-9H,10H2,1H3,(H2,17,18,19,20)
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7.80 -10.9n/an/an/an/an/a7.522



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17378
PNG
(1,2,4-Triazole Compound, 36 | N-(4-chlorophenyl)-5...)
Show SMILES Cc1ccccc1CSc1nnc(Nc2ccc(Cl)cc2)[nH]1
Show InChI InChI=1S/C16H15ClN4S/c1-11-4-2-3-5-12(11)10-22-16-19-15(20-21-16)18-14-8-6-13(17)7-9-14/h2-9H,10H2,1H3,(H2,18,19,20,21)
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23n/an/an/an/an/an/an/an/a



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17445
PNG
(1,2,4-Triazole Compound, 104 | 5-[(furan-3-ylmethy...)
Show SMILES CC(C)c1ccccc1Nc1nnc(SCc2ccoc2)[nH]1
Show InChI InChI=1S/C16H18N4OS/c1-11(2)13-5-3-4-6-14(13)17-15-18-16(20-19-15)22-10-12-7-8-21-9-12/h3-9,11H,10H2,1-2H3,(H2,17,18,19,20)
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24n/an/an/an/an/an/an/an/a



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17379
PNG
(1,2,4-Triazole Compound, 37 | N-(4-chlorophenyl)-5...)
Show SMILES COc1ccccc1CSc1nnc(Nc2ccc(Cl)cc2)[nH]1
Show InChI InChI=1S/C16H15ClN4OS/c1-22-14-5-3-2-4-11(14)10-23-16-19-15(20-21-16)18-13-8-6-12(17)7-9-13/h2-9H,10H2,1H3,(H2,18,19,20,21)
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>1.00E+4n/an/an/an/an/an/an/an/a



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair