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10 molecules are shown

Wt: 401.8
BDBM17446
Purchase
Wt: 401.8
BDBM36588
Wt: 296.3
BDBM36589
Wt: 417.8
BDBM36595
Wt: 298.3
BDBM36596
Wt: 402.9
BDBM36597
Wt: 282.3
BDBM36591
Wt: 298.3
BDBM50131563
Wt: 387.8
BDBM50137403
Wt: 325.4
BDBM50137405

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 17446,36588,36589,36595,36596,36597,36591,50131563,50137403,50137405   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17446
PNG
((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
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1n/an/an/an/an/an/an/an/a



GSK



Assay Description
MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...


J Med Chem 50: 3777-85 (2007)


Article DOI: 10.1021/jm061182w
BindingDB Entry DOI: 10.7270/Q2B856D7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36589
PNG
(Ovalicin)
Show SMILES CO[C@@H]1C(=O)CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H24O5/c1-10(2)5-6-12-14(3,21-12)16(18)13(19-4)11(17)7-8-15(16)9-20-15/h5,12-13,18H,6-9H2,1-4H3/t12?,13-,14-,15+,16+/m1/s1
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n/an/a 0.400n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36595
PNG
(FOS-68)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO7/c1-11(2)5-6-13-17(3,28-13)19(24)15(25-4)12(7-8-18(19)10-26-18)27-16(23)21-14(22)9-20/h5,12-13,15,24H,6-10H2,1-4H3,(H,21,22,23)/t12-,13?,15-,17-,18+,19+/m1/s1
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n/an/a 2n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36597
PNG
(FOS-69)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C)OC(=O)CCCCl
Show InChI InChI=1S/C20H31ClO6/c1-13(2)7-8-15-18(3,27-15)20(23)17(24-4)14(9-10-19(20)12-25-19)26-16(22)6-5-11-21/h7,14-15,17,23H,5-6,8-12H2,1-4H3/t14-,15?,17-,18-,19+,20+/m1/s1
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n/an/a 0.100n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36591
PNG
(FOS-37)
Show SMILES CO[C@@H]1[C@H](O)CC[C@]2(CO2)C1[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H26O4/c1-10(2)5-6-12-15(3,20-12)14-13(18-4)11(17)7-8-16(14)9-19-16/h5,11-14,17H,6-9H2,1-4H3/t11-,12?,13-,14?,15-,16+/m1/s1
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n/an/a 8n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36596
PNG
(FOS-34)
Show SMILES CO[C@@H]1[C@H](O)CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H26O5/c1-10(2)5-6-12-14(3,21-12)16(18)13(19-4)11(17)7-8-15(16)9-20-15/h5,11-13,17-18H,6-9H2,1-4H3/t11-,12?,13-,14-,15+,16+/m1/s1
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n/an/a 4n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase Type 2 (MetAP2)


(Mus musculus (Mouse))
BDBM36588
PNG
(AGM-1470)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)C1[C@]1(C)OC1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13?,15-,16?,18-,19+/m1/s1
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n/an/an/an/a 0.0370n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase Type 2 (MetAP2)


(Mus musculus (Mouse))
BDBM36589
PNG
(Ovalicin)
Show SMILES CO[C@@H]1C(=O)CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H24O5/c1-10(2)5-6-12-14(3,21-12)16(18)13(19-4)11(17)7-8-15(16)9-20-15/h5,12-13,18H,6-9H2,1-4H3/t12?,13-,14-,15+,16+/m1/s1
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n/an/an/an/a 0.0180n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase Type 2 (MetAP2)


(Mus musculus (Mouse))
BDBM36595
PNG
(FOS-68)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO7/c1-11(2)5-6-13-17(3,28-13)19(24)15(25-4)12(7-8-18(19)10-26-18)27-16(23)21-14(22)9-20/h5,12-13,15,24H,6-10H2,1-4H3,(H,21,22,23)/t12-,13?,15-,17-,18+,19+/m1/s1
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n/an/an/an/a 0.460n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase Type 2 (MetAP2)


(Mus musculus (Mouse))
BDBM36597
PNG
(FOS-69)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C)OC(=O)CCCCl
Show InChI InChI=1S/C20H31ClO6/c1-13(2)7-8-15-18(3,27-15)20(23)17(24-4)14(9-10-19(20)12-25-19)26-16(22)6-5-11-21/h7,14-15,17,23H,5-6,8-12H2,1-4H3/t14-,15?,17-,18-,19+,20+/m1/s1
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n/an/an/an/a 0.310n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase Type 2 (MetAP2)


(Mus musculus (Mouse))
BDBM36591
PNG
(FOS-37)
Show SMILES CO[C@@H]1[C@H](O)CC[C@]2(CO2)C1[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H26O4/c1-10(2)5-6-12-15(3,20-12)14-13(18-4)11(17)7-8-16(14)9-19-16/h5,11-14,17H,6-9H2,1-4H3/t11-,12?,13-,14?,15-,16+/m1/s1
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n/an/an/an/a 9.5n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase Type 2 (MetAP2)


(Mus musculus (Mouse))
BDBM36596
PNG
(FOS-34)
Show SMILES CO[C@@H]1[C@H](O)CC[C@]2(CO2)[C@@]1(O)[C@]1(C)OC1CC=C(C)C
Show InChI InChI=1S/C16H26O5/c1-10(2)5-6-12-14(3,21-12)16(18)13(19-4)11(17)7-8-15(16)9-20-15/h5,11-13,17-18H,6-9H2,1-4H3/t11-,12?,13-,14-,15+,16+/m1/s1
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n/an/an/an/a 2.20n/an/a7.5n/a



Massachusetts Institute of Technology



Assay Description
Proliferation assay using bovine aortic endothelial cell (BAEC) line.


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
Methionine aminopeptidase (MetAP2)


(Plasmodium falciparum)
BDBM17446
PNG
((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
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n/an/a 2.00E+3n/an/an/an/an/an/a



Johns Hopkins School of Medicine



Assay Description
Enzyme affinity assay using Fumarranol analogs with plasmodium falciparum methionine aminopeptidases (PfMetAPs).


Chem Biol 16: 193-202 (2009)


Article DOI: 10.1016/j.chembiol.2009.01.006
BindingDB Entry DOI: 10.7270/Q2WS8RQ5
More data for this
Ligand-Target Pair
Methionine aminopeptidase (MetAP1)


(Plasmodium falciparum)
BDBM17446
PNG
((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Johns Hopkins School of Medicine



Assay Description
Enzyme affinity assay using Fumarranol analogs with plasmodium falciparum methionine aminopeptidases (PfMetAPs).


Chem Biol 16: 193-202 (2009)


Article DOI: 10.1016/j.chembiol.2009.01.006
BindingDB Entry DOI: 10.7270/Q2WS8RQ5
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM50137403
PNG
(Acetyl-carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(R...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)NC(Cl)=O
Show InChI InChI=1S/C18H26ClNO6/c1-10(2)5-6-12-17(3,26-12)14-13(23-4)11(7-8-18(14)9-24-18)25-16(22)20-15(19)21/h5,11-14H,6-9H2,1-4H3,(H,20,21,22)/t11-,12-,13-,14-,17+,18+/m1/s1
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n/an/a 0.430n/an/an/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Methionine aminopeptidase 2


Bioorg Med Chem Lett 14: 91-4 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.008
BindingDB Entry DOI: 10.7270/Q27P8ZXD
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM50137405
PNG
(CHEMBL176975 | Carbamic acid (3R,4S,5S,6R)-5-metho...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(N)=O
Show InChI InChI=1S/C17H27NO5/c1-10(2)5-6-12-16(3,23-12)14-13(20-4)11(22-15(18)19)7-8-17(14)9-21-17/h5,11-14H,6-9H2,1-4H3,(H2,18,19)/t11-,12-,13-,14-,16+,17+/m1/s1
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n/an/a 0.390n/an/an/an/an/an/a



Gilead Sciences

Curated by ChEMBL


Assay Description
Inhibitory activity against Methionine aminopeptidase 2


Bioorg Med Chem Lett 14: 91-4 (2003)


Article DOI: 10.1016/j.bmcl.2003.10.008
BindingDB Entry DOI: 10.7270/Q27P8ZXD
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM50131563
PNG
(1,4-Dihydroxy-3-methoxy-2-[2-methyl-3-(3-methyl-bu...)
Show SMILES CO[C@@H]1[C@H](O)CC[C@](O)(C=O)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C
Show InChI InChI=1S/C16H26O5/c1-10(2)5-6-12-15(3,21-12)14-13(20-4)11(18)7-8-16(14,19)9-17/h5,9,11-14,18-19H,6-8H2,1-4H3/t11-,12-,13-,14-,15+,16+/m1/s1
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n/an/a 5.36E+4n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against purified recombinant human Methionine Aminopeptidase 2 (MetAP2)


J Med Chem 46: 3452-4 (2003)


Article DOI: 10.1021/jm0341103
BindingDB Entry DOI: 10.7270/Q2NG4Q0J
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17446
PNG
((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
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n/an/a 1n/an/an/an/an/an/a



The Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of human MetAP2


J Med Chem 49: 5645-8 (2006)


Article DOI: 10.1021/jm060559v
BindingDB Entry DOI: 10.7270/Q2PN959W
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17446
PNG
((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
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n/an/a 1.05E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 after 4 hrs


Bioorg Med Chem 19: 5948-54 (2011)


Article DOI: 10.1016/j.bmc.2011.08.063
BindingDB Entry DOI: 10.7270/Q28P60XC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17446
PNG
((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
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n/an/a 1.32E+3n/an/an/an/an/an/a



Nanjing University

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 (unknown origin) after 4 hrs


Bioorg Med Chem Lett 23: 2876-9 (2013)


Article DOI: 10.1016/j.bmcl.2013.03.068
BindingDB Entry DOI: 10.7270/Q2G44RPX
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM17446
PNG
((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1[C@@]1(C)O[C@@H]1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
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n/an/a 1n/an/an/an/an/an/a



University of California Santa Cruz

Curated by ChEMBL


Assay Description
Inhibition of methionine aminopeptidase 2


J Nat Prod 72: 588-603 (2010)


Article DOI: 10.1021/np800817y
BindingDB Entry DOI: 10.7270/Q2765G84
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine aminopeptidase 2


(Homo sapiens (human))
BDBM36588
PNG
(AGM-1470)
Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)C1[C@]1(C)OC1CC=C(C)C)OC(=O)NC(=O)CCl
Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13?,15-,16?,18-,19+/m1/s1
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n/an/a 1n/an/an/an/a7.3537



Massachusetts Institute of Technology



Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2).


Chem Biol 4: 461-71 (1997)


Article DOI: 10.1124/jpet.103.062398
BindingDB Entry DOI: 10.7270/Q2NG4P04
More data for this
Ligand-Target Pair
3D
3D Structure (docked)