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15 similar compounds to monomer 174818

Compile data set for download or QSAR
Wt: 433.8
BDBM174810
Wt: 434.8
BDBM174811
Wt: 434.8
BDBM174815
Wt: 457.8
BDBM174821
Wt: 419.4
BDBM174822
Wt: 424.2
BDBM174823
Wt: 453.8
BDBM174825
Wt: 438.8
BDBM174827
Wt: 421.8
BDBM174831
Wt: 448.8
BDBM174770
Wt: 448.8
BDBM174771
Wt: 448.8
BDBM174772
Wt: 453.8
BDBM174776
Wt: 453.8
BDBM174777
Wt: 453.8
BDBM174778

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 156 hits for monomerid = 174810,174811,174815,174821,174822,174823,174825,174827,174831,174770,174771,174772,174776,174777,174778   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174777
PNG
(US10053462, 8 | US9102686, 8 | US9540388, 8)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m0/s1
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1.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9102686 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DXP
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174777
PNG
(US10053462, 8 | US9102686, 8 | US9540388, 8)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m0/s1
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1.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10053462 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174777
PNG
(US10053462, 8 | US9102686, 8 | US9540388, 8)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m0/s1
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1.30n/a 2.5n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174777
PNG
(US10053462, 8 | US9102686, 8 | US9540388, 8)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m0/s1
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1.30n/a 9.70n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174777
PNG
(US10053462, 8 | US9102686, 8 | US9540388, 8)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m0/s1
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1.30n/a 16n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @−80 C. On the day of the experiment, cell membrane preparations were made according ...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174772
PNG
(US10053462, 3 | US9102686, 3 | US9540388, 3)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(5-2-6-13(15)20(22,23)24)19(31)30-11-4-1-7-14(30)17-27-28-18(29(17)10-11)16-25-8-3-9-26-16/h2-3,5-6,8-9,11,14H,1,4,7,10H2/t11-,14+/m1/s1
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4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9102686 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DXP
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174772
PNG
(US10053462, 3 | US9102686, 3 | US9540388, 3)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(5-2-6-13(15)20(22,23)24)19(31)30-11-4-1-7-14(30)17-27-28-18(29(17)10-11)16-25-8-3-9-26-16/h2-3,5-6,8-9,11,14H,1,4,7,10H2/t11-,14+/m1/s1
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4n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10053462 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174772
PNG
(US10053462, 3 | US9102686, 3 | US9540388, 3)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(5-2-6-13(15)20(22,23)24)19(31)30-11-4-1-7-14(30)17-27-28-18(29(17)10-11)16-25-8-3-9-26-16/h2-3,5-6,8-9,11,14H,1,4,7,10H2/t11-,14+/m1/s1
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4n/a>1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @−80 C. On the day of the experiment, cell membrane preparations were made according ...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174772
PNG
(US10053462, 3 | US9102686, 3 | US9540388, 3)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(5-2-6-13(15)20(22,23)24)19(31)30-11-4-1-7-14(30)17-27-28-18(29(17)10-11)16-25-8-3-9-26-16/h2-3,5-6,8-9,11,14H,1,4,7,10H2/t11-,14+/m1/s1
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4n/a 9.60n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174772
PNG
(US10053462, 3 | US9102686, 3 | US9540388, 3)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@@H]3CCC[C@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(5-2-6-13(15)20(22,23)24)19(31)30-11-4-1-7-14(30)17-27-28-18(29(17)10-11)16-25-8-3-9-26-16/h2-3,5-6,8-9,11,14H,1,4,7,10H2/t11-,14+/m1/s1
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4n/a 8.10n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174831
PNG
(US10053462, 62 | US9102686, 62 | US9540388, 62)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc[nH]4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5O/c20-15-11(3-1-4-12(15)19(21,22)23)18(29)28-10-6-7-14(28)17-26-25-16(27(17)9-10)13-5-2-8-24-13/h1-5,8,10,14,24H,6-7,9H2/t10-,14+/m0/s1
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6.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9102686 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DXP
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174831
PNG
(US10053462, 62 | US9102686, 62 | US9540388, 62)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc[nH]4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5O/c20-15-11(3-1-4-12(15)19(21,22)23)18(29)28-10-6-7-14(28)17-26-25-16(27(17)9-10)13-5-2-8-24-13/h1-5,8,10,14,24H,6-7,9H2/t10-,14+/m0/s1
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6.30n/a>1.00E+4n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174821
PNG
(US10053462, 52 | US9102686, 52 | US9540388, 52)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C18H12ClF4N5OS/c19-14-9(2-3-10(20)13(14)18(21,22)23)17(29)28-8-1-4-12(28)16-26-25-15(27(16)5-8)11-6-30-7-24-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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6.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9102686 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DXP
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174815
PNG
(US10053462, 46 | US9102686, 46 | US9540388, 46)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-14-11(3-1-4-12(14)19(21,22)23)18(30)29-10-5-6-13(29)16-26-27-17(28(16)9-10)15-24-7-2-8-25-15/h1-4,7-8,10,13H,5-6,9H2/t10-,13+/m0/s1
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6.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10053462 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174821
PNG
(US10053462, 52 | US9102686, 52 | US9540388, 52)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C18H12ClF4N5OS/c19-14-9(2-3-10(20)13(14)18(21,22)23)17(29)28-8-1-4-12(28)16-26-25-15(27(16)5-8)11-6-30-7-24-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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6.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10053462 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174831
PNG
(US10053462, 62 | US9102686, 62 | US9540388, 62)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc[nH]4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5O/c20-15-11(3-1-4-12(15)19(21,22)23)18(29)28-10-6-7-14(28)17-26-25-16(27(17)9-10)13-5-2-8-24-13/h1-5,8,10,14,24H,6-7,9H2/t10-,14+/m0/s1
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6.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10053462 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174815
PNG
(US10053462, 46 | US9102686, 46 | US9540388, 46)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-14-11(3-1-4-12(14)19(21,22)23)18(30)29-10-5-6-13(29)16-26-27-17(28(16)9-10)15-24-7-2-8-25-15/h1-4,7-8,10,13H,5-6,9H2/t10-,13+/m0/s1
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6.30n/a 1.58E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @−80 C. On the day of the experiment, cell membrane preparations were made according ...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174815
PNG
(US10053462, 46 | US9102686, 46 | US9540388, 46)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-14-11(3-1-4-12(14)19(21,22)23)18(30)29-10-5-6-13(29)16-26-27-17(28(16)9-10)15-24-7-2-8-25-15/h1-4,7-8,10,13H,5-6,9H2/t10-,13+/m0/s1
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6.30n/a 15n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174815
PNG
(US10053462, 46 | US9102686, 46 | US9540388, 46)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-14-11(3-1-4-12(14)19(21,22)23)18(30)29-10-5-6-13(29)16-26-27-17(28(16)9-10)15-24-7-2-8-25-15/h1-4,7-8,10,13H,5-6,9H2/t10-,13+/m0/s1
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6.30n/a 253n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174821
PNG
(US10053462, 52 | US9102686, 52 | US9540388, 52)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C18H12ClF4N5OS/c19-14-9(2-3-10(20)13(14)18(21,22)23)17(29)28-8-1-4-12(28)16-26-25-15(27(16)5-8)11-6-30-7-24-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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6.30n/a 4.10E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @−80 C. On the day of the experiment, cell membrane preparations were made according ...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174821
PNG
(US10053462, 52 | US9102686, 52 | US9540388, 52)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C18H12ClF4N5OS/c19-14-9(2-3-10(20)13(14)18(21,22)23)17(29)28-8-1-4-12(28)16-26-25-15(27(16)5-8)11-6-30-7-24-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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6.30n/a 10n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174821
PNG
(US10053462, 52 | US9102686, 52 | US9540388, 52)
Show SMILES Fc1ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c(Cl)c1C(F)(F)F
Show InChI InChI=1S/C18H12ClF4N5OS/c19-14-9(2-3-10(20)13(14)18(21,22)23)17(29)28-8-1-4-12(28)16-26-25-15(27(16)5-8)11-6-30-7-24-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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6.30n/a 131n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174831
PNG
(US10053462, 62 | US9102686, 62 | US9540388, 62)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc[nH]4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5O/c20-15-11(3-1-4-12(15)19(21,22)23)18(29)28-10-6-7-14(28)17-26-25-16(27(17)9-10)13-5-2-8-24-13/h1-5,8,10,14,24H,6-7,9H2/t10-,14+/m0/s1
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6.30n/a 1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @−80 C. On the day of the experiment, cell membrane preparations were made according ...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174831
PNG
(US10053462, 62 | US9102686, 62 | US9540388, 62)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccc[nH]4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5O/c20-15-11(3-1-4-12(15)19(21,22)23)18(29)28-10-6-7-14(28)17-26-25-16(27(17)9-10)13-5-2-8-24-13/h1-5,8,10,14,24H,6-7,9H2/t10-,14+/m0/s1
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6.30n/a 20n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174815
PNG
(US10053462, 46 | US9102686, 46 | US9540388, 46)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ncccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-14-11(3-1-4-12(14)19(21,22)23)18(30)29-10-5-6-13(29)16-26-27-17(28(16)9-10)15-24-7-2-8-25-15/h1-4,7-8,10,13H,5-6,9H2/t10-,13+/m0/s1
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6.30n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9102686 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DXP
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174810
PNG
(US10053462, 41 | US9102686, 41 | US9540388, 41)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H15ClF3N5O/c21-16-12(4-3-5-13(16)20(22,23)24)19(30)29-11-7-8-15(29)18-27-26-17(28(18)10-11)14-6-1-2-9-25-14/h1-6,9,11,15H,7-8,10H2/t11-,15+/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9102686 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DXP
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174823
PNG
(US10053462, 54 | US9102686, 54 | US9540388, 54)
Show SMILES Fc1c(Cl)ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5OS/c18-10-3-2-9(13(19)14(10)20)17(26)25-8-1-4-12(25)16-23-22-15(24(16)5-8)11-6-27-7-21-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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7.90n/a 8.91E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174822
PNG
(US10053462, 53 | US9102686, 53 | US9540388, 53)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CC[C@@H]1c1nnc(-c3cscn3)n1C2
Show InChI InChI=1S/C19H16F3N5OS/c1-10-12(3-2-4-13(10)19(20,21)22)18(28)27-11-5-6-15(27)17-25-24-16(26(17)7-11)14-8-29-9-23-14/h2-4,8-9,11,15H,5-7H2,1H3/t11-,15+/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9102686 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DXP
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174823
PNG
(US10053462, 54 | US9102686, 54 | US9540388, 54)
Show SMILES Fc1c(Cl)ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5OS/c18-10-3-2-9(13(19)14(10)20)17(26)25-8-1-4-12(25)16-23-22-15(24(16)5-8)11-6-27-7-21-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9102686 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DXP
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174810
PNG
(US10053462, 41 | US9102686, 41 | US9540388, 41)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H15ClF3N5O/c21-16-12(4-3-5-13(16)20(22,23)24)19(30)29-11-7-8-15(29)18-27-26-17(28(18)10-11)14-6-1-2-9-25-14/h1-6,9,11,15H,7-8,10H2/t11-,15+/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10053462 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174811
PNG
(US10053462, 42 | US9102686, 42 | US9540388, 42)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cnccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-15-11(2-1-3-12(15)19(21,22)23)18(30)29-10-4-5-14(29)17-27-26-16(28(17)9-10)13-8-24-6-7-25-13/h1-3,6-8,10,14H,4-5,9H2/t10-,14+/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10053462 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174822
PNG
(US10053462, 53 | US9102686, 53 | US9540388, 53)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CC[C@@H]1c1nnc(-c3cscn3)n1C2
Show InChI InChI=1S/C19H16F3N5OS/c1-10-12(3-2-4-13(10)19(20,21)22)18(28)27-11-5-6-15(27)17-25-24-16(26(17)7-11)14-8-29-9-23-14/h2-4,8-9,11,15H,5-7H2,1H3/t11-,15+/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10053462 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Mus musculus)
BDBM174823
PNG
(US10053462, 54 | US9102686, 54 | US9540388, 54)
Show SMILES Fc1c(Cl)ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5OS/c18-10-3-2-9(13(19)14(10)20)17(26)25-8-1-4-12(25)16-23-22-15(24(16)5-8)11-6-27-7-21-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10053462 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174810
PNG
(US10053462, 41 | US9102686, 41 | US9540388, 41)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H15ClF3N5O/c21-16-12(4-3-5-13(16)20(22,23)24)19(30)29-11-7-8-15(29)18-27-26-17(28(18)10-11)14-6-1-2-9-25-14/h1-6,9,11,15H,7-8,10H2/t11-,15+/m0/s1
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7.90n/a 1.00E+4n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @−80 C. On the day of the experiment, cell membrane preparations were made according ...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174810
PNG
(US10053462, 41 | US9102686, 41 | US9540388, 41)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H15ClF3N5O/c21-16-12(4-3-5-13(16)20(22,23)24)19(30)29-11-7-8-15(29)18-27-26-17(28(18)10-11)14-6-1-2-9-25-14/h1-6,9,11,15H,7-8,10H2/t11-,15+/m0/s1
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7.90n/a 6.30n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174810
PNG
(US10053462, 41 | US9102686, 41 | US9540388, 41)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
Show InChI InChI=1S/C20H15ClF3N5O/c21-16-12(4-3-5-13(16)20(22,23)24)19(30)29-11-7-8-15(29)18-27-26-17(28(18)10-11)14-6-1-2-9-25-14/h1-6,9,11,15H,7-8,10H2/t11-,15+/m0/s1
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7.90n/a 1.59E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174811
PNG
(US10053462, 42 | US9102686, 42 | US9540388, 42)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cnccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-15-11(2-1-3-12(15)19(21,22)23)18(30)29-10-4-5-14(29)17-27-26-16(28(17)9-10)13-8-24-6-7-25-13/h1-3,6-8,10,14H,4-5,9H2/t10-,14+/m0/s1
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7.90n/a 1.59E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @−80 C. On the day of the experiment, cell membrane preparations were made according ...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174811
PNG
(US10053462, 42 | US9102686, 42 | US9540388, 42)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cnccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-15-11(2-1-3-12(15)19(21,22)23)18(30)29-10-4-5-14(29)17-27-26-16(28(17)9-10)13-8-24-6-7-25-13/h1-3,6-8,10,14H,4-5,9H2/t10-,14+/m0/s1
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7.90n/a 20n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174811
PNG
(US10053462, 42 | US9102686, 42 | US9540388, 42)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cnccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-15-11(2-1-3-12(15)19(21,22)23)18(30)29-10-4-5-14(29)17-27-26-16(28(17)9-10)13-8-24-6-7-25-13/h1-3,6-8,10,14H,4-5,9H2/t10-,14+/m0/s1
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7.90n/a 251n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174822
PNG
(US10053462, 53 | US9102686, 53 | US9540388, 53)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CC[C@@H]1c1nnc(-c3cscn3)n1C2
Show InChI InChI=1S/C19H16F3N5OS/c1-10-12(3-2-4-13(10)19(20,21)22)18(28)27-11-5-6-15(27)17-25-24-16(26(17)7-11)14-8-29-9-23-14/h2-4,8-9,11,15H,5-7H2,1H3/t11-,15+/m0/s1
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7.90n/a 131n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @−80 C. On the day of the experiment, cell membrane preparations were made according ...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174822
PNG
(US10053462, 53 | US9102686, 53 | US9540388, 53)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CC[C@@H]1c1nnc(-c3cscn3)n1C2
Show InChI InChI=1S/C19H16F3N5OS/c1-10-12(3-2-4-13(10)19(20,21)22)18(28)27-11-5-6-15(27)17-25-24-16(26(17)7-11)14-8-29-9-23-14/h2-4,8-9,11,15H,5-7H2,1H3/t11-,15+/m0/s1
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7.90n/a 3.10n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174822
PNG
(US10053462, 53 | US9102686, 53 | US9540388, 53)
Show SMILES Cc1c(cccc1C(F)(F)F)C(=O)N1[C@H]2CC[C@@H]1c1nnc(-c3cscn3)n1C2
Show InChI InChI=1S/C19H16F3N5OS/c1-10-12(3-2-4-13(10)19(20,21)22)18(28)27-11-5-6-15(27)17-25-24-16(26(17)7-11)14-8-29-9-23-14/h2-4,8-9,11,15H,5-7H2,1H3/t11-,15+/m0/s1
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7.90n/a 3.86E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174823
PNG
(US10053462, 54 | US9102686, 54 | US9540388, 54)
Show SMILES Fc1c(Cl)ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5OS/c18-10-3-2-9(13(19)14(10)20)17(26)25-8-1-4-12(25)16-23-22-15(24(16)5-8)11-6-27-7-21-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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7.90n/a 3.86E+3n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @−80 C. On the day of the experiment, cell membrane preparations were made according ...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174823
PNG
(US10053462, 54 | US9102686, 54 | US9540388, 54)
Show SMILES Fc1c(Cl)ccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C17H12Cl2FN5OS/c18-10-3-2-9(13(19)14(10)20)17(26)25-8-1-4-12(25)16-23-22-15(24(16)5-8)11-6-27-7-21-11/h2-3,6-8,12H,1,4-5H2/t8-,12+/m0/s1
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7.90n/a 6.10n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
P2X purinoceptor 7 (P2X7)


(Rattus norvegicus (Rat))
BDBM174811
PNG
(US10053462, 42 | US9102686, 42 | US9540388, 42)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4cnccn4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N6O/c20-15-11(2-1-3-12(15)19(21,22)23)18(30)29-10-4-5-14(29)17-27-26-16(28(17)9-10)13-8-24-6-7-25-13/h1-3,6-8,10,14H,4-5,9H2/t10-,14+/m0/s1
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7.90n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9102686 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DXP
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174777
PNG
(US10053462, 8 | US9102686, 8 | US9540388, 8)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m0/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9102686 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DXP
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174827
PNG
(US10053462, 58 | US9102686, 58 | US9540388, 58)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccsc4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N4OS/c20-15-12(2-1-3-13(15)19(21,22)23)18(28)27-11-4-5-14(27)17-25-24-16(26(17)8-11)10-6-7-29-9-10/h1-3,6-7,9,11,14H,4-5,8H2/t11-,14+/m0/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according...


US Patent US9102686 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DXP
More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174777
PNG
(US10053462, 8 | US9102686, 8 | US9540388, 8)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m0/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10053462 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174827
PNG
(US10053462, 58 | US9102686, 58 | US9540388, 58)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccsc4)n2C3)c1Cl
Show InChI InChI=1S/C19H14ClF3N4OS/c20-15-12(2-1-3-13(15)19(21,22)23)18(28)27-11-4-5-14(27)17-25-24-16(26(17)8-11)10-6-7-29-9-10/h1-3,6-7,9,11,14H,4-5,8H2/t11-,14+/m0/s1
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10n/an/an/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @ −80 C. On the day of the experiment, cell membrane preparations were made according...


US Patent US10053462 (2018)

More data for this
Ligand-Target Pair
P2X purinoceptor 7


(Homo sapiens (Human))
BDBM174777
PNG
(US10053462, 8 | US9102686, 8 | US9540388, 8)
Show SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4cscn4)n2C3)c1Cl
Show InChI InChI=1S/C19H15ClF3N5OS/c20-15-11(4-2-5-12(15)19(21,22)23)18(29)28-10-3-1-6-14(28)17-26-25-16(27(17)7-10)13-8-30-9-24-13/h2,4-5,8-10,14H,1,3,6-7H2/t10-,14+/m0/s1
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10n/a 16n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
human or rat P2X7-1321N1 cells were collected and frozen @−80 C. On the day of the experiment, cell membrane preparations were made according ...


US Patent US9540388 (2017)


BindingDB Entry DOI: 10.7270/Q20V8B0D
More data for this
Ligand-Target Pair
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