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7 similar compounds to monomer 176503

Compile data set for download or QSAR
Wt: 395.3
BDBM176508
Wt: 436.4
BDBM176511
Wt: 379.3
BDBM176498
Wt: 422.4
BDBM176499
Wt: 395.3
BDBM176500
Wt: 421.4
BDBM176504
Wt: 407.4
BDBM176507

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 176508,176511,176498,176499,176500,176504,176507   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176498
PNG
(US9120752, 38 | US9765029, 38)
Show SMILES C[C@H](NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1)C(N)=O
Show InChI InChI=1S/C21H18FN3O3/c1-13(20(23)26)24-21(27)19-4-2-3-18(25-19)14-5-9-16(10-6-14)28-17-11-7-15(22)8-12-17/h2-13H,1H3,(H2,23,26)(H,24,27)/t13-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 310n/an/an/an/an/a37



Purdue Pharma, L.P.

US Patent


Assay Description
Cells were prepared by plating the recombinant HEK293 cells or other host cells expressing either recombinant or non-recombinant, native, Nav1.7 alph...


US Patent US9120752 (2015)


BindingDB Entry DOI: 10.7270/Q2B56HHN
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176499
PNG
(US9120752, 39 | US9765029, 39)
Show SMILES NC(=O)C[C@H](NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1)C(N)=O
Show InChI InChI=1S/C22H19FN4O4/c23-14-6-10-16(11-7-14)31-15-8-4-13(5-9-15)17-2-1-3-18(26-17)22(30)27-19(21(25)29)12-20(24)28/h1-11,19H,12H2,(H2,24,28)(H2,25,29)(H,27,30)/t19-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 750n/an/an/an/an/a37



Purdue Pharma, L.P.

US Patent


Assay Description
Cells were prepared by plating the recombinant HEK293 cells or other host cells expressing either recombinant or non-recombinant, native, Nav1.7 alph...


US Patent US9120752 (2015)


BindingDB Entry DOI: 10.7270/Q2B56HHN
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176500
PNG
(US9120752, 40 | US9765029, 40)
Show SMILES NC(=O)[C@@H](CO)NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C21H18FN3O4/c22-14-6-10-16(11-7-14)29-15-8-4-13(5-9-15)17-2-1-3-18(24-17)21(28)25-19(12-26)20(23)27/h1-11,19,26H,12H2,(H2,23,27)(H,25,28)/t19-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.32E+3n/an/an/an/an/a37



Purdue Pharma, L.P.

US Patent


Assay Description
Cells were prepared by plating the recombinant HEK293 cells or other host cells expressing either recombinant or non-recombinant, native, Nav1.7 alph...


US Patent US9120752 (2015)


BindingDB Entry DOI: 10.7270/Q2B56HHN
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176504
PNG
(US9120752, 44 | US9765029, 44)
Show SMILES CC(C)C[C@H](NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1)C(N)=O
Show InChI InChI=1S/C24H24FN3O3/c1-15(2)14-22(23(26)29)28-24(30)21-5-3-4-20(27-21)16-6-10-18(11-7-16)31-19-12-8-17(25)9-13-19/h3-13,15,22H,14H2,1-2H3,(H2,26,29)(H,28,30)/t22-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 340n/an/an/an/an/a37



Purdue Pharma, L.P.

US Patent


Assay Description
Cells were prepared by plating the recombinant HEK293 cells or other host cells expressing either recombinant or non-recombinant, native, Nav1.7 alph...


US Patent US9120752 (2015)


BindingDB Entry DOI: 10.7270/Q2B56HHN
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176507
PNG
(US9120752, 46 | US9765029, 46)
Show SMILES CC(C)[C@H](NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1)C(N)=O
Show InChI InChI=1S/C23H22FN3O3/c1-14(2)21(22(25)28)27-23(29)20-5-3-4-19(26-20)15-6-10-17(11-7-15)30-18-12-8-16(24)9-13-18/h3-14,21H,1-2H3,(H2,25,28)(H,27,29)/t21-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 610n/an/an/an/an/a37



Purdue Pharma, L.P.

US Patent


Assay Description
Cells were prepared by plating the recombinant HEK293 cells or other host cells expressing either recombinant or non-recombinant, native, Nav1.7 alph...


US Patent US9120752 (2015)


BindingDB Entry DOI: 10.7270/Q2B56HHN
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176508
PNG
(US9120752, 47 | US9765029, 47)
Show SMILES NC(=O)[C@H](CO)NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C21H18FN3O4/c22-14-6-10-16(11-7-14)29-15-8-4-13(5-9-15)17-2-1-3-18(24-17)21(28)25-19(12-26)20(23)27/h1-11,19,26H,12H2,(H2,23,27)(H,25,28)/t19-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.53E+3n/an/an/an/an/a37



Purdue Pharma, L.P.

US Patent


Assay Description
Cells were prepared by plating the recombinant HEK293 cells or other host cells expressing either recombinant or non-recombinant, native, Nav1.7 alph...


US Patent US9120752 (2015)


BindingDB Entry DOI: 10.7270/Q2B56HHN
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176508
PNG
(US9120752, 47 | US9765029, 47)
Show SMILES NC(=O)[C@H](CO)NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C21H18FN3O4/c22-14-6-10-16(11-7-14)29-15-8-4-13(5-9-15)17-2-1-3-18(24-17)21(28)25-19(12-26)20(23)27/h1-11,19,26H,12H2,(H2,23,27)(H,25,28)/t19-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.53E+3n/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL of 10×HBSS th...


US Patent US9765029 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176498
PNG
(US9120752, 38 | US9765029, 38)
Show SMILES C[C@H](NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1)C(N)=O
Show InChI InChI=1S/C21H18FN3O3/c1-13(20(23)26)24-21(27)19-4-2-3-18(25-19)14-5-9-16(10-6-14)28-17-11-7-15(22)8-12-17/h2-13H,1H3,(H2,23,26)(H,24,27)/t13-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 310n/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL of 10×HBSS th...


US Patent US9765029 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176499
PNG
(US9120752, 39 | US9765029, 39)
Show SMILES NC(=O)C[C@H](NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1)C(N)=O
Show InChI InChI=1S/C22H19FN4O4/c23-14-6-10-16(11-7-14)31-15-8-4-13(5-9-15)17-2-1-3-18(26-17)22(30)27-19(21(25)29)12-20(24)28/h1-11,19H,12H2,(H2,24,28)(H2,25,29)(H,27,30)/t19-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 750n/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL of 10×HBSS th...


US Patent US9765029 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176500
PNG
(US9120752, 40 | US9765029, 40)
Show SMILES NC(=O)[C@@H](CO)NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C21H18FN3O4/c22-14-6-10-16(11-7-14)29-15-8-4-13(5-9-15)17-2-1-3-18(24-17)21(28)25-19(12-26)20(23)27/h1-11,19,26H,12H2,(H2,23,27)(H,25,28)/t19-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.32E+3n/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL of 10×HBSS th...


US Patent US9765029 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176504
PNG
(US9120752, 44 | US9765029, 44)
Show SMILES CC(C)C[C@H](NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1)C(N)=O
Show InChI InChI=1S/C24H24FN3O3/c1-15(2)14-22(23(26)29)28-24(30)21-5-3-4-20(27-21)16-6-10-18(11-7-16)31-19-12-8-17(25)9-13-19/h3-13,15,22H,14H2,1-2H3,(H2,26,29)(H,28,30)/t22-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 340n/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL of 10×HBSS th...


US Patent US9765029 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176507
PNG
(US9120752, 46 | US9765029, 46)
Show SMILES CC(C)[C@H](NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1)C(N)=O
Show InChI InChI=1S/C23H22FN3O3/c1-14(2)21(22(25)28)27-23(29)20-5-3-4-19(26-20)15-6-10-17(11-7-15)30-18-12-8-16(24)9-13-18/h3-14,21H,1-2H3,(H2,25,28)(H,27,29)/t21-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 610n/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL of 10×HBSS th...


US Patent US9765029 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176511
PNG
(US9120752, 51)
Show SMILES NCCCC[C@H](NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1)C(N)=O
Show InChI InChI=1S/C24H25FN4O3/c25-17-9-13-19(14-10-17)32-18-11-7-16(8-12-18)20-5-3-6-22(28-20)24(31)29-21(23(27)30)4-1-2-15-26/h3,5-14,21H,1-2,4,15,26H2,(H2,27,30)(H,29,31)/t21-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.89E+3n/an/an/an/an/a37



Purdue Pharma, L.P.

US Patent


Assay Description
Cells were prepared by plating the recombinant HEK293 cells or other host cells expressing either recombinant or non-recombinant, native, Nav1.7 alph...


US Patent US9120752 (2015)


BindingDB Entry DOI: 10.7270/Q2B56HHN
More data for this
Ligand-Target Pair