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3 similar compounds to monomer 162469

Compile data set for download or QSAR
Wt: 395.3
BDBM176508
Wt: 379.3
BDBM176498
Wt: 395.3
BDBM176500

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 176508,176498,176500   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176498
PNG
(US9120752, 38 | US9765029, 38)
Show SMILES C[C@H](NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1)C(N)=O
Show InChI InChI=1S/C21H18FN3O3/c1-13(20(23)26)24-21(27)19-4-2-3-18(25-19)14-5-9-16(10-6-14)28-17-11-7-15(22)8-12-17/h2-13H,1H3,(H2,23,26)(H,24,27)/t13-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 310n/an/an/an/an/a37



Purdue Pharma, L.P.

US Patent


Assay Description
Cells were prepared by plating the recombinant HEK293 cells or other host cells expressing either recombinant or non-recombinant, native, Nav1.7 alph...


US Patent US9120752 (2015)


BindingDB Entry DOI: 10.7270/Q2B56HHN
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176500
PNG
(US9120752, 40 | US9765029, 40)
Show SMILES NC(=O)[C@@H](CO)NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C21H18FN3O4/c22-14-6-10-16(11-7-14)29-15-8-4-13(5-9-15)17-2-1-3-18(24-17)21(28)25-19(12-26)20(23)27/h1-11,19,26H,12H2,(H2,23,27)(H,25,28)/t19-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.32E+3n/an/an/an/an/a37



Purdue Pharma, L.P.

US Patent


Assay Description
Cells were prepared by plating the recombinant HEK293 cells or other host cells expressing either recombinant or non-recombinant, native, Nav1.7 alph...


US Patent US9120752 (2015)


BindingDB Entry DOI: 10.7270/Q2B56HHN
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176508
PNG
(US9120752, 47 | US9765029, 47)
Show SMILES NC(=O)[C@H](CO)NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C21H18FN3O4/c22-14-6-10-16(11-7-14)29-15-8-4-13(5-9-15)17-2-1-3-18(24-17)21(28)25-19(12-26)20(23)27/h1-11,19,26H,12H2,(H2,23,27)(H,25,28)/t19-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.53E+3n/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL of 10×HBSS th...


US Patent US9765029 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176498
PNG
(US9120752, 38 | US9765029, 38)
Show SMILES C[C@H](NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1)C(N)=O
Show InChI InChI=1S/C21H18FN3O3/c1-13(20(23)26)24-21(27)19-4-2-3-18(25-19)14-5-9-16(10-6-14)28-17-11-7-15(22)8-12-17/h2-13H,1H3,(H2,23,26)(H,24,27)/t13-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 310n/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL of 10×HBSS th...


US Patent US9765029 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176500
PNG
(US9120752, 40 | US9765029, 40)
Show SMILES NC(=O)[C@@H](CO)NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C21H18FN3O4/c22-14-6-10-16(11-7-14)29-15-8-4-13(5-9-15)17-2-1-3-18(24-17)21(28)25-19(12-26)20(23)27/h1-11,19,26H,12H2,(H2,23,27)(H,25,28)/t19-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.32E+3n/an/an/an/an/an/a



Purdue Pharma L.P.

US Patent


Assay Description
The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL of 10×HBSS th...


US Patent US9765029 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM176508
PNG
(US9120752, 47 | US9765029, 47)
Show SMILES NC(=O)[C@H](CO)NC(=O)c1cccc(n1)-c1ccc(Oc2ccc(F)cc2)cc1
Show InChI InChI=1S/C21H18FN3O4/c22-14-6-10-16(11-7-14)29-15-8-4-13(5-9-15)17-2-1-3-18(24-17)21(28)25-19(12-26)20(23)27/h1-11,19,26H,12H2,(H2,23,27)(H,25,28)/t19-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.53E+3n/an/an/an/an/a37



Purdue Pharma, L.P.

US Patent


Assay Description
Cells were prepared by plating the recombinant HEK293 cells or other host cells expressing either recombinant or non-recombinant, native, Nav1.7 alph...


US Patent US9120752 (2015)


BindingDB Entry DOI: 10.7270/Q2B56HHN
More data for this
Ligand-Target Pair