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16 similar compounds to monomer 181170

Compile data set for download or QSAR
Wt: 438.4
BDBM181158
Wt: 468.4
BDBM181159
Wt: 504.4
BDBM181160
Wt: 484.9
BDBM181161
Wt: 456.4
BDBM181162
Wt: 472.8
BDBM181163
Wt: 468.4
BDBM181164
Wt: 480.4
BDBM181165
Wt: 468.9
BDBM181166
Wt: 486.4
BDBM181167
Wt: 484.9
BDBM181168
Wt: 468.4
BDBM181169
Wt: 452.4
BDBM181171
Wt: 518.4
BDBM181172
Wt: 482.4
BDBM181173
Displayed 1 to 15 (of 16 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 181158,181159,181160,181161,181162,181163,181164,181165,181166,181167,181168,181169,181171,181172,181173   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181158
PNG
(US9139529, 1 | US9783501, Compound 1)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2)c1
Show InChI InChI=1S/C21H15FN4O4S/c22-13-8-10-15(11-9-13)30-21-19(25-17-6-1-2-7-18(17)26-21)20(27)24-14-4-3-5-16(12-14)31(23,28)29/h1-12H,(H,24,27)(H2,23,28,29)
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n/an/a 27n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181173
PNG
(US9139529, 16 | US9783501, Compound 16)
Show SMILES CNS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2OC)c1
Show InChI InChI=1S/C23H19FN4O5S/c1-25-34(30,31)16-7-5-6-15(13-16)26-22(29)21-23(28-18-9-4-3-8-17(18)27-21)33-19-11-10-14(24)12-20(19)32-2/h3-13,25H,1-2H3,(H,26,29)
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n/an/a 22n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181160
PNG
(US9139529, 3 | US9783501, Compound 3)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)c1
Show InChI InChI=1S/C22H15F3N4O5S/c23-22(24,25)34-15-10-8-14(9-11-15)33-21-19(28-17-6-1-2-7-18(17)29-21)20(30)27-13-4-3-5-16(12-13)35(26,31)32/h1-12H,(H,27,30)(H2,26,31,32)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181161
PNG
(US9139529, 4 | US9783501, Compound 4)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2cccc(c2)S(N)(=O)=O)c(Cl)c1
Show InChI InChI=1S/C22H17ClN4O5S/c1-31-14-9-10-19(16(23)12-14)32-22-20(26-17-7-2-3-8-18(17)27-22)21(28)25-13-5-4-6-15(11-13)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181162
PNG
(US9139529, 5 | US9783501, Compound 5)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2F)c1
Show InChI InChI=1S/C21H14F2N4O4S/c22-12-8-9-18(15(23)10-12)31-21-19(26-16-6-1-2-7-17(16)27-21)20(28)25-13-4-3-5-14(11-13)32(24,29)30/h1-11H,(H,25,28)(H2,24,29,30)
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n/an/a 13n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181163
PNG
(US9139529, 6 | US9783501, Compound 6)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2Cl)c1
Show InChI InChI=1S/C21H14ClFN4O4S/c22-15-10-12(23)8-9-18(15)31-21-19(26-16-6-1-2-7-17(16)27-21)20(28)25-13-4-3-5-14(11-13)32(24,29)30/h1-11H,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181164
PNG
(US9139529, 7 | US9783501, Compound 7)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2cccc(c2)S(N)(=O)=O)cc1F
Show InChI InChI=1S/C22H17FN4O5S/c1-31-19-10-9-14(12-16(19)23)32-22-20(26-17-7-2-3-8-18(17)27-22)21(28)25-13-5-4-6-15(11-13)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181165
PNG
(US9139529, 8 | US9783501, Compound 8)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2cccc(c2)S(N)(=O)=O)c(OC)c1
Show InChI InChI=1S/C23H20N4O6S/c1-31-15-10-11-19(20(13-15)32-2)33-23-21(26-17-8-3-4-9-18(17)27-23)22(28)25-14-6-5-7-16(12-14)34(24,29)30/h3-13H,1-2H3,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181166
PNG
(US9139529, 9 | US9783501, Compound 9)
Show SMILES Cc1cc(Cl)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C22H17ClN4O4S/c1-13-11-14(23)9-10-19(13)31-22-20(26-17-7-2-3-8-18(17)27-22)21(28)25-15-5-4-6-16(12-15)32(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181167
PNG
(US9139529, 10 | US9783501, Compound 10)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccccc2OC(F)F)c1
Show InChI InChI=1S/C22H16F2N4O5S/c23-22(24)33-18-11-4-3-10-17(18)32-21-19(27-15-8-1-2-9-16(15)28-21)20(29)26-13-6-5-7-14(12-13)34(25,30)31/h1-12,22H,(H,26,29)(H2,25,30,31)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181168
PNG
(US9139529, 11 | US9783501, Compound 11)
Show SMILES COc1cc(Cl)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C22H17ClN4O5S/c1-31-19-11-13(23)9-10-18(19)32-22-20(26-16-7-2-3-8-17(16)27-22)21(28)25-14-5-4-6-15(12-14)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181169
PNG
(US9139529, 12 | US9783501, Compound 12)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2cccc(c2)S(N)(=O)=O)c(F)c1
Show InChI InChI=1S/C22H17FN4O5S/c1-31-14-9-10-19(16(23)12-14)32-22-20(26-17-7-2-3-8-18(17)27-22)21(28)25-13-5-4-6-15(11-13)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181171
PNG
(US9139529, 14 | US9783501, Compound 14)
Show SMILES Cc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C22H17FN4O4S/c1-13-11-14(23)9-10-19(13)31-22-20(26-17-7-2-3-8-18(17)27-22)21(28)25-15-5-4-6-16(12-15)32(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181172
PNG
(US9139529, 15 | US9783501, Compound 15)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OCC(F)(F)F)cc2)c1
Show InChI InChI=1S/C23H17F3N4O5S/c24-23(25,26)13-34-15-8-10-16(11-9-15)35-22-20(29-18-6-1-2-7-19(18)30-22)21(31)28-14-4-3-5-17(12-14)36(27,32)33/h1-12H,13H2,(H,28,31)(H2,27,32,33)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181173
PNG
(US9139529, 16 | US9783501, Compound 16)
Show SMILES CNS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2OC)c1
Show InChI InChI=1S/C23H19FN4O5S/c1-25-34(30,31)16-7-5-6-15(13-16)26-22(29)21-23(28-18-9-4-3-8-17(18)27-21)33-19-11-10-14(24)12-20(19)32-2/h3-13,25H,1-2H3,(H,26,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181158
PNG
(US9139529, 1 | US9783501, Compound 1)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2)c1
Show InChI InChI=1S/C21H15FN4O4S/c22-13-8-10-15(11-9-13)30-21-19(25-17-6-1-2-7-18(17)26-21)20(27)24-14-4-3-5-16(12-14)31(23,28)29/h1-12H,(H,24,27)(H2,23,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181159
PNG
(US9139529, 2 | US9783501, Compound 2)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C22H17FN4O5S/c1-31-19-11-13(23)9-10-18(19)32-22-20(26-16-7-2-3-8-17(16)27-22)21(28)25-14-5-4-6-15(12-14)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181160
PNG
(US9139529, 3 | US9783501, Compound 3)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)c1
Show InChI InChI=1S/C22H15F3N4O5S/c23-22(24,25)34-15-10-8-14(9-11-15)33-21-19(28-17-6-1-2-7-18(17)29-21)20(30)27-13-4-3-5-16(12-13)35(26,31)32/h1-12H,(H,27,30)(H2,26,31,32)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181161
PNG
(US9139529, 4 | US9783501, Compound 4)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2cccc(c2)S(N)(=O)=O)c(Cl)c1
Show InChI InChI=1S/C22H17ClN4O5S/c1-31-14-9-10-19(16(23)12-14)32-22-20(26-17-7-2-3-8-18(17)27-22)21(28)25-13-5-4-6-15(11-13)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181162
PNG
(US9139529, 5 | US9783501, Compound 5)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2F)c1
Show InChI InChI=1S/C21H14F2N4O4S/c22-12-8-9-18(15(23)10-12)31-21-19(26-16-6-1-2-7-17(16)27-21)20(28)25-13-4-3-5-14(11-13)32(24,29)30/h1-11H,(H,25,28)(H2,24,29,30)
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n/an/a 13n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181163
PNG
(US9139529, 6 | US9783501, Compound 6)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2Cl)c1
Show InChI InChI=1S/C21H14ClFN4O4S/c22-15-10-12(23)8-9-18(15)31-21-19(26-16-6-1-2-7-17(16)27-21)20(28)25-13-4-3-5-14(11-13)32(24,29)30/h1-11H,(H,25,28)(H2,24,29,30)
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n/an/a 3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181164
PNG
(US9139529, 7 | US9783501, Compound 7)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2cccc(c2)S(N)(=O)=O)cc1F
Show InChI InChI=1S/C22H17FN4O5S/c1-31-19-10-9-14(12-16(19)23)32-22-20(26-17-7-2-3-8-18(17)27-22)21(28)25-13-5-4-6-15(11-13)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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n/an/a 42n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181165
PNG
(US9139529, 8 | US9783501, Compound 8)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2cccc(c2)S(N)(=O)=O)c(OC)c1
Show InChI InChI=1S/C23H20N4O6S/c1-31-15-10-11-19(20(13-15)32-2)33-23-21(26-17-8-3-4-9-18(17)27-23)22(28)25-14-6-5-7-16(12-14)34(24,29)30/h3-13H,1-2H3,(H,25,28)(H2,24,29,30)
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n/an/a 6n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181166
PNG
(US9139529, 9 | US9783501, Compound 9)
Show SMILES Cc1cc(Cl)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C22H17ClN4O4S/c1-13-11-14(23)9-10-19(13)31-22-20(26-17-7-2-3-8-18(17)27-22)21(28)25-15-5-4-6-16(12-15)32(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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n/an/a 14n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181167
PNG
(US9139529, 10 | US9783501, Compound 10)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccccc2OC(F)F)c1
Show InChI InChI=1S/C22H16F2N4O5S/c23-22(24)33-18-11-4-3-10-17(18)32-21-19(27-15-8-1-2-9-16(15)28-21)20(29)26-13-6-5-7-14(12-13)34(25,30)31/h1-12,22H,(H,26,29)(H2,25,30,31)
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n/an/a 36n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181168
PNG
(US9139529, 11 | US9783501, Compound 11)
Show SMILES COc1cc(Cl)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C22H17ClN4O5S/c1-31-19-11-13(23)9-10-18(19)32-22-20(26-16-7-2-3-8-17(16)27-22)21(28)25-14-5-4-6-15(12-14)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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n/an/a 5n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181169
PNG
(US9139529, 12 | US9783501, Compound 12)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2cccc(c2)S(N)(=O)=O)c(F)c1
Show InChI InChI=1S/C22H17FN4O5S/c1-31-14-9-10-19(16(23)12-14)32-22-20(26-17-7-2-3-8-18(17)27-22)21(28)25-13-5-4-6-15(11-13)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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n/an/a 22n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181171
PNG
(US9139529, 14 | US9783501, Compound 14)
Show SMILES Cc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C22H17FN4O4S/c1-13-11-14(23)9-10-19(13)31-22-20(26-17-7-2-3-8-18(17)27-22)21(28)25-15-5-4-6-16(12-15)32(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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n/an/a 7n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181172
PNG
(US9139529, 15 | US9783501, Compound 15)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OCC(F)(F)F)cc2)c1
Show InChI InChI=1S/C23H17F3N4O5S/c24-23(25,26)13-34-15-8-10-16(11-9-15)35-22-20(29-18-6-1-2-7-19(18)30-22)21(31)28-14-4-3-5-17(12-14)36(27,32)33/h1-12H,13H2,(H,28,31)(H2,27,32,33)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181159
PNG
(US9139529, 2 | US9783501, Compound 2)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C22H17FN4O5S/c1-31-19-11-13(23)9-10-18(19)32-22-20(26-16-7-2-3-8-17(16)27-22)21(28)25-14-5-4-6-15(12-14)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair