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20 similar compounds to monomer 181212

Compile data set for download or QSAR
Wt: 468.4
BDBM181159
Wt: 434.3
BDBM181189
Wt: 434.3
BDBM181191
Wt: 433.3
BDBM181193
Wt: 430.3
BDBM181199
Wt: 379.3
BDBM181200
Wt: 459.4
BDBM181201
Wt: 457.4
BDBM181202
Wt: 467.4
BDBM181203
Wt: 429.4
BDBM181204
Wt: 429.4
BDBM181205
Wt: 429.4
BDBM181206
Wt: 415.3
BDBM181208
Wt: 415.3
BDBM181209
Wt: 390.3
BDBM181210
Displayed 1 to 15 (of 20 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 181159,181189,181191,181193,181199,181200,181201,181202,181203,181204,181205,181206,181208,181209,181210   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181159
PNG
(US9139529, 2 | US9783501, Compound 2)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C22H17FN4O5S/c1-31-19-11-13(23)9-10-18(19)32-22-20(26-16-7-2-3-8-17(16)27-22)21(28)25-14-5-4-6-15(12-14)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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n/an/a 6n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181210
PNG
(US9139529, 53 | US9783501, Compound 53)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccncc1
Show InChI InChI=1S/C21H15FN4O3/c1-28-18-12-13(22)6-7-17(18)29-21-19(20(27)24-14-8-10-23-11-9-14)25-15-4-2-3-5-16(15)26-21/h2-12H,1H3,(H,23,24,27)
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n/an/a 22n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181191
PNG
(US9139529, 34 | US9783501, Compound 34)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccnc(c1)C(O)=O
Show InChI InChI=1S/C22H15FN4O5/c1-31-18-10-12(23)6-7-17(18)32-21-19(26-14-4-2-3-5-15(14)27-21)20(28)25-13-8-9-24-16(11-13)22(29)30/h2-11H,1H3,(H,29,30)(H,24,25,28)
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n/an/a 16n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181193
PNG
(US9139529, 36 | US9783501, Compound 36)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C23H16FN3O5/c1-31-19-12-14(24)9-10-18(19)32-22-20(26-16-7-2-3-8-17(16)27-22)21(28)25-15-6-4-5-13(11-15)23(29)30/h2-12H,1H3,(H,25,28)(H,29,30)
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n/an/a 460n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181199
PNG
(US9139529, 42 | US9783501, Compound 42)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc2[nH]nnc2c1
Show InChI InChI=1S/C22H15FN6O3/c1-31-19-10-12(23)6-9-18(19)32-22-20(25-14-4-2-3-5-15(14)26-22)21(30)24-13-7-8-16-17(11-13)28-29-27-16/h2-11H,1H3,(H,24,30)(H,27,28,29)
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n/an/a 96n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181200
PNG
(US9139529, 43 | US9783501, Compound 43)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cn[nH]c1
Show InChI InChI=1S/C19H14FN5O3/c1-27-16-8-11(20)6-7-15(16)28-19-17(18(26)23-12-9-21-22-10-12)24-13-4-2-3-5-14(13)25-19/h2-10H,1H3,(H,21,22)(H,23,26)
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n/an/a 220n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181201
PNG
(US9139529, 44 | US9783501, Compound 44)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc2[nH]c(CO)nc2c1
Show InChI InChI=1S/C24H18FN5O4/c1-33-20-10-13(25)6-9-19(20)34-24-22(29-15-4-2-3-5-16(15)30-24)23(32)26-14-7-8-17-18(11-14)28-21(12-31)27-17/h2-11,31H,12H2,1H3,(H,26,32)(H,27,28)
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n/an/a 425n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181202
PNG
(US9139529, 45 | US9783501, Compound 45)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C23H16FN7O3/c1-33-19-12-14(24)9-10-18(19)34-23-20(26-16-7-2-3-8-17(16)27-23)22(32)25-15-6-4-5-13(11-15)21-28-30-31-29-21/h2-12H,1H3,(H,25,32)(H,28,29,30,31)
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n/an/a 1.65E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181203
PNG
(US9139529, 46 | US9783501, Compound 46)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C23H18FN3O5S/c1-31-20-12-14(24)10-11-19(20)32-23-21(26-17-8-3-4-9-18(17)27-23)22(28)25-15-6-5-7-16(13-15)33(2,29)30/h3-13H,1-2H3,(H,25,28)
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n/an/a 1n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181204
PNG
(US9139529, 47 | US9783501, Compound 47)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc2cn[nH]c2c1
Show InChI InChI=1S/C23H16FN5O3/c1-31-20-10-14(24)7-9-19(20)32-23-21(27-16-4-2-3-5-17(16)28-23)22(30)26-15-8-6-13-12-25-29-18(13)11-15/h2-12H,1H3,(H,25,29)(H,26,30)
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n/an/a 130n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181205
PNG
(US9139529, 48 | US9783501, Compound 48)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C23H16FN5O3/c1-31-20-11-14(24)6-9-19(20)32-23-21(27-17-4-2-3-5-18(17)28-23)22(30)26-15-7-8-16-13(10-15)12-25-29-16/h2-12H,1H3,(H,25,29)(H,26,30)
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n/an/a 86n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181206
PNG
(US9139529, 49 | US9783501, Compound 49)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc2nc[nH]c2c1
Show InChI InChI=1S/C23H16FN5O3/c1-31-20-10-13(24)6-9-19(20)32-23-21(28-16-4-2-3-5-17(16)29-23)22(30)27-14-7-8-15-18(11-14)26-12-25-15/h2-12H,1H3,(H,25,26)(H,27,30)
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n/an/a 585n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181208
PNG
(US9139529, 51 | US9783501, Compound 51)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C#N
Show InChI InChI=1S/C22H14FN5O3/c1-30-19-10-13(23)6-9-18(19)31-22-20(27-16-4-2-3-5-17(16)28-22)21(29)26-15-8-7-14(11-24)25-12-15/h2-10,12H,1H3,(H,26,29)
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n/an/a 37n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181209
PNG
(US9139529, 52 | US9783501, Compound 52)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(cn1)C#N
Show InChI InChI=1S/C22H14FN5O3/c1-30-18-10-14(23)7-8-17(18)31-22-20(26-15-4-2-3-5-16(15)27-22)21(29)28-19-9-6-13(11-24)12-25-19/h2-10,12H,1H3,(H,25,28,29)
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n/an/a 2.40E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181210
PNG
(US9139529, 53 | US9783501, Compound 53)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccncc1
Show InChI InChI=1S/C21H15FN4O3/c1-28-18-12-13(22)6-7-17(18)29-21-19(20(27)24-14-8-10-23-11-9-14)25-15-4-2-3-5-16(15)26-21/h2-12H,1H3,(H,23,24,27)
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n/an/a 22n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181159
PNG
(US9139529, 2 | US9783501, Compound 2)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C22H17FN4O5S/c1-31-19-11-13(23)9-10-18(19)32-22-20(26-16-7-2-3-8-17(16)27-22)21(28)25-14-5-4-6-15(12-14)33(24,29)30/h2-12H,1H3,(H,25,28)(H2,24,29,30)
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n/an/a 6n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181189
PNG
(US9139529, 32 | US9783501, Compound 32)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C22H15FN4O5/c1-31-18-10-12(23)6-9-17(18)32-21-19(26-14-4-2-3-5-15(14)27-21)20(28)25-13-7-8-16(22(29)30)24-11-13/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 83n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181191
PNG
(US9139529, 34 | US9783501, Compound 34)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccnc(c1)C(O)=O
Show InChI InChI=1S/C22H15FN4O5/c1-31-18-10-12(23)6-7-17(18)32-21-19(26-14-4-2-3-5-15(14)27-21)20(28)25-13-8-9-24-16(11-13)22(29)30/h2-11H,1H3,(H,29,30)(H,24,25,28)
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n/an/a 16n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181193
PNG
(US9139529, 36 | US9783501, Compound 36)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)C(O)=O
Show InChI InChI=1S/C23H16FN3O5/c1-31-19-12-14(24)9-10-18(19)32-22-20(26-16-7-2-3-8-17(16)27-22)21(28)25-15-6-4-5-13(11-15)23(29)30/h2-12H,1H3,(H,25,28)(H,29,30)
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n/an/a 460n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181199
PNG
(US9139529, 42 | US9783501, Compound 42)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc2[nH]nnc2c1
Show InChI InChI=1S/C22H15FN6O3/c1-31-19-10-12(23)6-9-18(19)32-22-20(25-14-4-2-3-5-15(14)26-22)21(30)24-13-7-8-16-17(11-13)28-29-27-16/h2-11H,1H3,(H,24,30)(H,27,28,29)
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n/an/a 96n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181200
PNG
(US9139529, 43 | US9783501, Compound 43)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cn[nH]c1
Show InChI InChI=1S/C19H14FN5O3/c1-27-16-8-11(20)6-7-15(16)28-19-17(18(26)23-12-9-21-22-10-12)24-13-4-2-3-5-14(13)25-19/h2-10H,1H3,(H,21,22)(H,23,26)
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n/an/a 220n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181201
PNG
(US9139529, 44 | US9783501, Compound 44)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc2[nH]c(CO)nc2c1
Show InChI InChI=1S/C24H18FN5O4/c1-33-20-10-13(25)6-9-19(20)34-24-22(29-15-4-2-3-5-16(15)30-24)23(32)26-14-7-8-17-18(11-14)28-21(12-31)27-17/h2-11,31H,12H2,1H3,(H,26,32)(H,27,28)
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n/an/a 425n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181202
PNG
(US9139529, 45 | US9783501, Compound 45)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)-c1nnn[nH]1
Show InChI InChI=1S/C23H16FN7O3/c1-33-19-12-14(24)9-10-18(19)34-23-20(26-16-7-2-3-8-17(16)27-23)22(32)25-15-6-4-5-13(11-15)21-28-30-31-29-21/h2-12H,1H3,(H,25,32)(H,28,29,30,31)
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n/an/a 1.65E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181203
PNG
(US9139529, 46 | US9783501, Compound 46)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C23H18FN3O5S/c1-31-20-12-14(24)10-11-19(20)32-23-21(26-17-8-3-4-9-18(17)27-23)22(28)25-15-6-5-7-16(13-15)33(2,29)30/h3-13H,1-2H3,(H,25,28)
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n/an/a 1n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181204
PNG
(US9139529, 47 | US9783501, Compound 47)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc2cn[nH]c2c1
Show InChI InChI=1S/C23H16FN5O3/c1-31-20-10-14(24)7-9-19(20)32-23-21(27-16-4-2-3-5-17(16)28-23)22(30)26-15-8-6-13-12-25-29-18(13)11-15/h2-12H,1H3,(H,25,29)(H,26,30)
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n/an/a 130n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181205
PNG
(US9139529, 48 | US9783501, Compound 48)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc2[nH]ncc2c1
Show InChI InChI=1S/C23H16FN5O3/c1-31-20-11-14(24)6-9-19(20)32-23-21(27-17-4-2-3-5-18(17)28-23)22(30)26-15-7-8-16-13(10-15)12-25-29-16/h2-12H,1H3,(H,25,29)(H,26,30)
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n/an/a 86n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181206
PNG
(US9139529, 49 | US9783501, Compound 49)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc2nc[nH]c2c1
Show InChI InChI=1S/C23H16FN5O3/c1-31-20-10-13(24)6-9-19(20)32-23-21(28-16-4-2-3-5-17(16)29-23)22(30)27-14-7-8-15-18(11-14)26-12-25-15/h2-12H,1H3,(H,25,26)(H,27,30)
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n/an/a 585n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181208
PNG
(US9139529, 51 | US9783501, Compound 51)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C#N
Show InChI InChI=1S/C22H14FN5O3/c1-30-19-10-13(23)6-9-18(19)31-22-20(27-16-4-2-3-5-17(16)28-22)21(29)26-15-8-7-14(11-24)25-12-15/h2-10,12H,1H3,(H,26,29)
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n/an/a 37n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181209
PNG
(US9139529, 52 | US9783501, Compound 52)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(cn1)C#N
Show InChI InChI=1S/C22H14FN5O3/c1-30-18-10-14(23)7-8-17(18)31-22-20(26-15-4-2-3-5-16(15)27-22)21(29)28-19-9-6-13(11-24)12-25-19/h2-10,12H,1H3,(H,25,28,29)
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n/an/a 2.40E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181189
PNG
(US9139529, 32 | US9783501, Compound 32)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C22H15FN4O5/c1-31-18-10-12(23)6-9-17(18)32-21-19(26-14-4-2-3-5-15(14)27-21)20(28)25-13-7-8-16(22(29)30)24-11-13/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 83n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair