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16 similar compounds to monomer 181179

Compile data set for download or QSAR
Wt: 469.3
BDBM181174
Wt: 404.3
BDBM181175
Wt: 418.3
BDBM181176
Wt: 386.3
BDBM181177
Wt: 434.3
BDBM181178
Wt: 450.8
BDBM181180
Wt: 452.3
BDBM181181
Wt: 434.8
BDBM181182
Wt: 446.4
BDBM181183
Wt: 434.3
BDBM181184
Wt: 438.7
BDBM181185
Wt: 422.3
BDBM181186
Wt: 450.8
BDBM181187
Wt: 470.3
BDBM181188
Wt: 434.3
BDBM181189
Displayed 1 to 15 (of 16 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 181174,181175,181176,181177,181178,181180,181181,181182,181183,181184,181185,181186,181187,181188,181189   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181174
PNG
(US9139529, 17 | US9783501, Compound 17)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C23H14F3N3O5/c24-23(25,26)34-16-11-9-15(10-12-16)33-21-19(28-17-3-1-2-4-18(17)29-21)20(30)27-14-7-5-13(6-8-14)22(31)32/h1-12H,(H,27,30)(H,31,32)
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n/an/a 44n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181189
PNG
(US9139529, 32 | US9783501, Compound 32)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C22H15FN4O5/c1-31-18-10-12(23)6-9-17(18)32-21-19(26-14-4-2-3-5-15(14)27-21)20(28)25-13-7-8-16(22(29)30)24-11-13/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 83n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181176
PNG
(US9139529, 19 | US9783501, Compound 19)
Show SMILES Cc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C22H15FN4O4/c1-12-10-13(23)6-9-18(12)31-21-19(26-15-4-2-3-5-16(15)27-21)20(28)25-14-7-8-17(22(29)30)24-11-14/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 86n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181177
PNG
(US9139529, 20 | US9783501, Compound 20)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccccc2)cn1
Show InChI InChI=1S/C21H14N4O4/c26-19(23-13-10-11-17(21(27)28)22-12-13)18-20(29-14-6-2-1-3-7-14)25-16-9-5-4-8-15(16)24-18/h1-12H,(H,23,26)(H,27,28)
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n/an/a 1.08E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181178
PNG
(US9139529, 21 | US9783501, Compound 21)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2ccc(nc2)C(O)=O)c(F)c1
Show InChI InChI=1S/C22H15FN4O5/c1-31-13-7-9-18(14(23)10-13)32-21-19(26-15-4-2-3-5-16(15)27-21)20(28)25-12-6-8-17(22(29)30)24-11-12/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 235n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181180
PNG
(US9139529, 23 | US9783501, Compound 23)
Show SMILES COc1cc(Cl)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C22H15ClN4O5/c1-31-18-10-12(23)6-9-17(18)32-21-19(26-14-4-2-3-5-15(14)27-21)20(28)25-13-7-8-16(22(29)30)24-11-13/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 19n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181181
PNG
(US9139529, 24 | US9783501, Compound 24)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccccc2OC(F)F)cn1
Show InChI InChI=1S/C22H14F2N4O5/c23-22(24)33-17-8-4-3-7-16(17)32-20-18(27-13-5-1-2-6-14(13)28-20)19(29)26-12-9-10-15(21(30)31)25-11-12/h1-11,22H,(H,26,29)(H,30,31)
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n/an/a 340n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181182
PNG
(US9139529, 25 | US9783501, Compound 25)
Show SMILES Cc1cc(Cl)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C22H15ClN4O4/c1-12-10-13(23)6-9-18(12)31-21-19(26-15-4-2-3-5-16(15)27-21)20(28)25-14-7-8-17(22(29)30)24-11-14/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 56n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181183
PNG
(US9139529, 26 | US9783501, Compound 26)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2ccc(nc2)C(O)=O)c(OC)c1
Show InChI InChI=1S/C23H18N4O6/c1-31-14-8-10-18(19(11-14)32-2)33-22-20(26-15-5-3-4-6-16(15)27-22)21(28)25-13-7-9-17(23(29)30)24-12-13/h3-12H,1-2H3,(H,25,28)(H,29,30)
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n/an/a 46n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181184
PNG
(US9139529, 27 | US9783501, Compound 27)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2ccc(nc2)C(O)=O)cc1F
Show InChI InChI=1S/C22H15FN4O5/c1-31-18-9-7-13(10-14(18)23)32-21-19(26-15-4-2-3-5-16(15)27-21)20(28)25-12-6-8-17(22(29)30)24-11-12/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 185n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181185
PNG
(US9139529, 28 | US9783501, Compound 28)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2Cl)cn1
Show InChI InChI=1S/C21H12ClFN4O4/c22-13-9-11(23)5-8-17(13)31-20-18(26-14-3-1-2-4-15(14)27-20)19(28)25-12-6-7-16(21(29)30)24-10-12/h1-10H,(H,25,28)(H,29,30)
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n/an/a 51n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181186
PNG
(US9139529, 29 | US9783501, Compound 29)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2F)cn1
Show InChI InChI=1S/C21H12F2N4O4/c22-11-5-8-17(13(23)9-11)31-20-18(26-14-3-1-2-4-15(14)27-20)19(28)25-12-6-7-16(21(29)30)24-10-12/h1-10H,(H,25,28)(H,29,30)
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n/an/a 185n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181187
PNG
(US9139529, 30 | US9783501, Compound 30)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2ccc(nc2)C(O)=O)c(Cl)c1
Show InChI InChI=1S/C22H15ClN4O5/c1-31-13-7-9-18(14(23)10-13)32-21-19(26-15-4-2-3-5-16(15)27-21)20(28)25-12-6-8-17(22(29)30)24-11-12/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 69n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181188
PNG
(US9139529, 31 | US9783501, Compound 31)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)cn1
Show InChI InChI=1S/C22H13F3N4O5/c23-22(24,25)34-14-8-6-13(7-9-14)33-20-18(28-15-3-1-2-4-16(15)29-20)19(30)27-12-5-10-17(21(31)32)26-11-12/h1-11H,(H,27,30)(H,31,32)
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n/an/a 15n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181189
PNG
(US9139529, 32 | US9783501, Compound 32)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C22H15FN4O5/c1-31-18-10-12(23)6-9-17(18)32-21-19(26-14-4-2-3-5-15(14)27-21)20(28)25-13-7-8-16(22(29)30)24-11-13/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 83n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181174
PNG
(US9139529, 17 | US9783501, Compound 17)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C23H14F3N3O5/c24-23(25,26)34-16-11-9-15(10-12-16)33-21-19(28-17-3-1-2-4-18(17)29-21)20(30)27-14-7-5-13(6-8-14)22(31)32/h1-12H,(H,27,30)(H,31,32)
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n/an/a 44n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181175
PNG
(US9139529, 18 | US9783501, Compound 18)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2)cn1
Show InChI InChI=1S/C21H13FN4O4/c22-12-5-8-14(9-6-12)30-20-18(25-15-3-1-2-4-16(15)26-20)19(27)24-13-7-10-17(21(28)29)23-11-13/h1-11H,(H,24,27)(H,28,29)
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n/an/a 250n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181176
PNG
(US9139529, 19 | US9783501, Compound 19)
Show SMILES Cc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C22H15FN4O4/c1-12-10-13(23)6-9-18(12)31-21-19(26-15-4-2-3-5-16(15)27-21)20(28)25-14-7-8-17(22(29)30)24-11-14/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 86n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181177
PNG
(US9139529, 20 | US9783501, Compound 20)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccccc2)cn1
Show InChI InChI=1S/C21H14N4O4/c26-19(23-13-10-11-17(21(27)28)22-12-13)18-20(29-14-6-2-1-3-7-14)25-16-9-5-4-8-15(16)24-18/h1-12H,(H,23,26)(H,27,28)
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n/an/a 1.08E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181178
PNG
(US9139529, 21 | US9783501, Compound 21)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2ccc(nc2)C(O)=O)c(F)c1
Show InChI InChI=1S/C22H15FN4O5/c1-31-13-7-9-18(14(23)10-13)32-21-19(26-15-4-2-3-5-16(15)27-21)20(28)25-12-6-8-17(22(29)30)24-11-12/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 235n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181180
PNG
(US9139529, 23 | US9783501, Compound 23)
Show SMILES COc1cc(Cl)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C22H15ClN4O5/c1-31-18-10-12(23)6-9-17(18)32-21-19(26-14-4-2-3-5-15(14)27-21)20(28)25-13-7-8-16(22(29)30)24-11-13/h2-11H,1H3,(H,25,28)(H,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181181
PNG
(US9139529, 24 | US9783501, Compound 24)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccccc2OC(F)F)cn1
Show InChI InChI=1S/C22H14F2N4O5/c23-22(24)33-17-8-4-3-7-16(17)32-20-18(27-13-5-1-2-6-14(13)28-20)19(29)26-12-9-10-15(21(30)31)25-11-12/h1-11,22H,(H,26,29)(H,30,31)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181182
PNG
(US9139529, 25 | US9783501, Compound 25)
Show SMILES Cc1cc(Cl)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccc(nc1)C(O)=O
Show InChI InChI=1S/C22H15ClN4O4/c1-12-10-13(23)6-9-18(12)31-21-19(26-15-4-2-3-5-16(15)27-21)20(28)25-14-7-8-17(22(29)30)24-11-14/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 56n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181183
PNG
(US9139529, 26 | US9783501, Compound 26)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2ccc(nc2)C(O)=O)c(OC)c1
Show InChI InChI=1S/C23H18N4O6/c1-31-14-8-10-18(19(11-14)32-2)33-22-20(26-15-5-3-4-6-16(15)27-22)21(28)25-13-7-9-17(23(29)30)24-12-13/h3-12H,1-2H3,(H,25,28)(H,29,30)
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n/an/a 46n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181184
PNG
(US9139529, 27 | US9783501, Compound 27)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2ccc(nc2)C(O)=O)cc1F
Show InChI InChI=1S/C22H15FN4O5/c1-31-18-9-7-13(10-14(18)23)32-21-19(26-15-4-2-3-5-16(15)27-21)20(28)25-12-6-8-17(22(29)30)24-11-12/h2-11H,1H3,(H,25,28)(H,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181185
PNG
(US9139529, 28 | US9783501, Compound 28)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2Cl)cn1
Show InChI InChI=1S/C21H12ClFN4O4/c22-13-9-11(23)5-8-17(13)31-20-18(26-14-3-1-2-4-15(14)27-20)19(28)25-12-6-7-16(21(29)30)24-10-12/h1-10H,(H,25,28)(H,29,30)
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n/an/a 51n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181186
PNG
(US9139529, 29 | US9783501, Compound 29)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2F)cn1
Show InChI InChI=1S/C21H12F2N4O4/c22-11-5-8-17(13(23)9-11)31-20-18(26-14-3-1-2-4-15(14)27-20)19(28)25-12-6-7-16(21(29)30)24-10-12/h1-10H,(H,25,28)(H,29,30)
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n/an/a 185n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181187
PNG
(US9139529, 30 | US9783501, Compound 30)
Show SMILES COc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2ccc(nc2)C(O)=O)c(Cl)c1
Show InChI InChI=1S/C22H15ClN4O5/c1-31-13-7-9-18(14(23)10-13)32-21-19(26-15-4-2-3-5-16(15)27-21)20(28)25-12-6-8-17(22(29)30)24-11-12/h2-11H,1H3,(H,25,28)(H,29,30)
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n/an/a 69n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181188
PNG
(US9139529, 31 | US9783501, Compound 31)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)cn1
Show InChI InChI=1S/C22H13F3N4O5/c23-22(24,25)34-14-8-6-13(7-9-14)33-20-18(28-15-3-1-2-4-16(15)29-20)19(30)27-12-5-10-17(21(31)32)26-11-12/h1-11H,(H,27,30)(H,31,32)
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n/an/a 15n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181175
PNG
(US9139529, 18 | US9783501, Compound 18)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2)cn1
Show InChI InChI=1S/C21H13FN4O4/c22-12-5-8-14(9-6-12)30-20-18(25-15-3-1-2-4-16(15)26-20)19(27)24-13-7-10-17(21(28)29)23-11-13/h1-11H,(H,24,27)(H,28,29)
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n/an/a 250n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair