BindingDB logo
myBDB logout

7 similar compounds to monomer 181190

Compile data set for download or QSAR
Wt: 469.3
BDBM181174
Wt: 404.3
BDBM181175
Wt: 386.3
BDBM181177
Wt: 484.3
BDBM181179
Wt: 452.3
BDBM181181
Wt: 470.3
BDBM181188
Wt: 434.3
BDBM181191

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 181174,181175,181177,181179,181181,181188,181191   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181174
PNG
(US9139529, 17 | US9783501, Compound 17)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C23H14F3N3O5/c24-23(25,26)34-16-11-9-15(10-12-16)33-21-19(28-17-3-1-2-4-18(17)29-21)20(30)27-14-7-5-13(6-8-14)22(31)32/h1-12H,(H,27,30)(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 44n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181175
PNG
(US9139529, 18 | US9783501, Compound 18)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2)cn1
Show InChI InChI=1S/C21H13FN4O4/c22-12-5-8-14(9-6-12)30-20-18(25-15-3-1-2-4-16(15)26-20)19(27)24-13-7-10-17(21(28)29)23-11-13/h1-11H,(H,24,27)(H,28,29)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 250n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181177
PNG
(US9139529, 20 | US9783501, Compound 20)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccccc2)cn1
Show InChI InChI=1S/C21H14N4O4/c26-19(23-13-10-11-17(21(27)28)22-12-13)18-20(29-14-6-2-1-3-7-14)25-16-9-5-4-8-15(16)24-18/h1-12H,(H,23,26)(H,27,28)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.08E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181179
PNG
(US9139529, 22 | US9783501, Compound 22)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OCC(F)(F)F)cc2)cn1
Show InChI InChI=1S/C23H15F3N4O5/c24-23(25,26)12-34-14-6-8-15(9-7-14)35-21-19(29-16-3-1-2-4-17(16)30-21)20(31)28-13-5-10-18(22(32)33)27-11-13/h1-11H,12H2,(H,28,31)(H,32,33)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 180n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181181
PNG
(US9139529, 24 | US9783501, Compound 24)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccccc2OC(F)F)cn1
Show InChI InChI=1S/C22H14F2N4O5/c23-22(24)33-17-8-4-3-7-16(17)32-20-18(27-13-5-1-2-6-14(13)28-20)19(29)26-12-9-10-15(21(30)31)25-11-12/h1-11,22H,(H,26,29)(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 340n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181188
PNG
(US9139529, 31 | US9783501, Compound 31)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)cn1
Show InChI InChI=1S/C22H13F3N4O5/c23-22(24,25)34-14-8-6-13(7-9-14)33-20-18(28-15-3-1-2-4-16(15)29-20)19(30)27-12-5-10-17(21(31)32)26-11-12/h1-11H,(H,27,30)(H,31,32)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 15n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181191
PNG
(US9139529, 34 | US9783501, Compound 34)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccnc(c1)C(O)=O
Show InChI InChI=1S/C22H15FN4O5/c1-31-18-10-12(23)6-7-17(18)32-21-19(26-14-4-2-3-5-15(14)27-21)20(28)25-13-8-9-24-16(11-13)22(29)30/h2-11H,1H3,(H,29,30)(H,24,25,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 16n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181174
PNG
(US9139529, 17 | US9783501, Compound 17)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)cc1
Show InChI InChI=1S/C23H14F3N3O5/c24-23(25,26)34-16-11-9-15(10-12-16)33-21-19(28-17-3-1-2-4-18(17)29-21)20(30)27-14-7-5-13(6-8-14)22(31)32/h1-12H,(H,27,30)(H,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 44n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181175
PNG
(US9139529, 18 | US9783501, Compound 18)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(F)cc2)cn1
Show InChI InChI=1S/C21H13FN4O4/c22-12-5-8-14(9-6-12)30-20-18(25-15-3-1-2-4-16(15)26-20)19(27)24-13-7-10-17(21(28)29)23-11-13/h1-11H,(H,24,27)(H,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 250n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181177
PNG
(US9139529, 20 | US9783501, Compound 20)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccccc2)cn1
Show InChI InChI=1S/C21H14N4O4/c26-19(23-13-10-11-17(21(27)28)22-12-13)18-20(29-14-6-2-1-3-7-14)25-16-9-5-4-8-15(16)24-18/h1-12H,(H,23,26)(H,27,28)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.08E+3n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181179
PNG
(US9139529, 22 | US9783501, Compound 22)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OCC(F)(F)F)cc2)cn1
Show InChI InChI=1S/C23H15F3N4O5/c24-23(25,26)12-34-14-6-8-15(9-7-14)35-21-19(29-16-3-1-2-4-17(16)30-21)20(31)28-13-5-10-18(22(32)33)27-11-13/h1-11H,12H2,(H,28,31)(H,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 180n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181181
PNG
(US9139529, 24 | US9783501, Compound 24)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccccc2OC(F)F)cn1
Show InChI InChI=1S/C22H14F2N4O5/c23-22(24)33-17-8-4-3-7-16(17)32-20-18(27-13-5-1-2-6-14(13)28-20)19(29)26-12-9-10-15(21(30)31)25-11-12/h1-11,22H,(H,26,29)(H,30,31)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 340n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181188
PNG
(US9139529, 31 | US9783501, Compound 31)
Show SMILES OC(=O)c1ccc(NC(=O)c2nc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)cn1
Show InChI InChI=1S/C22H13F3N4O5/c23-22(24,25)34-14-8-6-13(7-9-14)33-20-18(28-15-3-1-2-4-16(15)29-20)19(30)27-12-5-10-17(21(31)32)26-11-12/h1-11H,(H,27,30)(H,31,32)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 15n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181191
PNG
(US9139529, 34 | US9783501, Compound 34)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2nc1C(=O)Nc1ccnc(c1)C(O)=O
Show InChI InChI=1S/C22H15FN4O5/c1-31-18-10-12(23)6-7-17(18)32-21-19(26-14-4-2-3-5-15(14)27-21)20(28)25-13-8-9-24-16(11-13)22(29)30/h2-11H,1H3,(H,29,30)(H,24,25,28)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 16n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair