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14 similar compounds to monomer 181229

Compile data set for download or QSAR
Wt: 483.9
BDBM181226
Wt: 467.4
BDBM181227
Wt: 467.9
BDBM181228
Wt: 483.9
BDBM181230
Wt: 485.4
BDBM181231
Wt: 437.4
BDBM181217
Wt: 467.4
BDBM181218
Wt: 467.4
BDBM181219
Wt: 451.4
BDBM181220
Wt: 419.4
BDBM181221
Wt: 455.4
BDBM181222
Wt: 471.8
BDBM181223
Wt: 517.4
BDBM181224
Wt: 503.4
BDBM181225

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 181226,181227,181228,181230,181231,181217,181218,181219,181220,181221,181222,181223,181224,181225   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181217
PNG
(US9139529, 60 | US9783501, Compound 60)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(F)cc2)c1
Show InChI InChI=1S/C22H16FN3O4S/c23-15-8-10-17(11-9-15)30-22-19(12-14-4-1-2-7-20(14)26-22)21(27)25-16-5-3-6-18(13-16)31(24,28)29/h1-13H,(H,25,27)(H2,24,28,29)
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n/an/a 17n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181231
PNG
(US9139529, 74 | US9783501, Compound 74)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccccc2OC(F)F)c1
Show InChI InChI=1S/C23H17F2N3O5S/c24-23(25)33-20-11-4-3-10-19(20)32-22-17(12-14-6-1-2-9-18(14)28-22)21(29)27-15-7-5-8-16(13-15)34(26,30)31/h1-13,23H,(H,27,29)(H2,26,30,31)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181219
PNG
(US9139529, 62 | US9783501, Compound 62)
Show SMILES COc1ccc(Oc2nc3ccccc3cc2C(=O)Nc2cccc(c2)S(N)(=O)=O)cc1F
Show InChI InChI=1S/C23H18FN3O5S/c1-31-21-10-9-16(13-19(21)24)32-23-18(11-14-5-2-3-8-20(14)27-23)22(28)26-15-6-4-7-17(12-15)33(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181220
PNG
(US9139529, 63 | US9783501, Compound 63)
Show SMILES Cc1cc(F)ccc1Oc1nc2ccccc2cc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C23H18FN3O4S/c1-14-11-16(24)9-10-21(14)31-23-19(12-15-5-2-3-8-20(15)27-23)22(28)26-17-6-4-7-18(13-17)32(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181221
PNG
(US9139529, 64 | US9783501, Compound 64)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccccc2)c1
Show InChI InChI=1S/C22H17N3O4S/c23-30(27,28)18-11-6-8-16(14-18)24-21(26)19-13-15-7-4-5-12-20(15)25-22(19)29-17-9-2-1-3-10-17/h1-14H,(H,24,26)(H2,23,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181222
PNG
(US9139529, 65 | US9783501, Compound 65)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(F)cc2F)c1
Show InChI InChI=1S/C22H15F2N3O4S/c23-14-8-9-20(18(24)11-14)31-22-17(10-13-4-1-2-7-19(13)27-22)21(28)26-15-5-3-6-16(12-15)32(25,29)30/h1-12H,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181223
PNG
(US9139529, 66 | US9783501, Compound 66)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(F)cc2Cl)c1
Show InChI InChI=1S/C22H15ClFN3O4S/c23-18-11-14(24)8-9-20(18)31-22-17(10-13-4-1-2-7-19(13)27-22)21(28)26-15-5-3-6-16(12-15)32(25,29)30/h1-12H,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181224
PNG
(US9139529, 67 | US9783501, Compound 67)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(OCC(F)(F)F)cc2)c1
Show InChI InChI=1S/C24H18F3N3O5S/c25-24(26,27)14-34-17-8-10-18(11-9-17)35-23-20(12-15-4-1-2-7-21(15)30-23)22(31)29-16-5-3-6-19(13-16)36(28,32)33/h1-13H,14H2,(H,29,31)(H2,28,32,33)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181225
PNG
(US9139529, 68 | US9783501, Compound 68)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)c1
Show InChI InChI=1S/C23H16F3N3O5S/c24-23(25,26)34-17-10-8-16(9-11-17)33-22-19(12-14-4-1-2-7-20(14)29-22)21(30)28-15-5-3-6-18(13-15)35(27,31)32/h1-13H,(H,28,30)(H2,27,31,32)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181226
PNG
(US9139529, 69 | US9783501, Compound 69)
Show SMILES COc1ccc(Oc2nc3ccccc3cc2C(=O)Nc2cccc(c2)S(N)(=O)=O)c(Cl)c1
Show InChI InChI=1S/C23H18ClN3O5S/c1-31-16-9-10-21(19(24)13-16)32-23-18(11-14-5-2-3-8-20(14)27-23)22(28)26-15-6-4-7-17(12-15)33(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181227
PNG
(US9139529, 70 | US9783501, Compound 70)
Show SMILES COc1ccc(Oc2nc3ccccc3cc2C(=O)Nc2cccc(c2)S(N)(=O)=O)c(F)c1
Show InChI InChI=1S/C23H18FN3O5S/c1-31-16-9-10-21(19(24)13-16)32-23-18(11-14-5-2-3-8-20(14)27-23)22(28)26-15-6-4-7-17(12-15)33(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181228
PNG
(US9139529, 71 | US9783501, Compound 71)
Show SMILES Cc1cc(Cl)ccc1Oc1nc2ccccc2cc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C23H18ClN3O4S/c1-14-11-16(24)9-10-21(14)31-23-19(12-15-5-2-3-8-20(15)27-23)22(28)26-17-6-4-7-18(13-17)32(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181230
PNG
(US9139529, 73 | US9783501, Compound 73)
Show SMILES COc1cc(Cl)ccc1Oc1nc2ccccc2cc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C23H18ClN3O5S/c1-31-21-12-15(24)9-10-20(21)32-23-18(11-14-5-2-3-8-19(14)27-23)22(28)26-16-6-4-7-17(13-16)33(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181231
PNG
(US9139529, 74 | US9783501, Compound 74)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccccc2OC(F)F)c1
Show InChI InChI=1S/C23H17F2N3O5S/c24-23(25)33-20-11-4-3-10-19(20)32-22-17(12-14-6-1-2-9-18(14)28-22)21(29)27-15-7-5-8-16(13-15)34(26,30)31/h1-13,23H,(H,27,29)(H2,26,30,31)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181217
PNG
(US9139529, 60 | US9783501, Compound 60)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(F)cc2)c1
Show InChI InChI=1S/C22H16FN3O4S/c23-15-8-10-17(11-9-15)30-22-19(12-14-4-1-2-7-20(14)26-22)21(27)25-16-5-3-6-18(13-16)31(24,28)29/h1-13H,(H,25,27)(H2,24,28,29)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181218
PNG
(US9139529, 61 | US9783501, Compound 61)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2cc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C23H18FN3O5S/c1-31-21-12-15(24)9-10-20(21)32-23-18(11-14-5-2-3-8-19(14)27-23)22(28)26-16-6-4-7-17(13-16)33(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181219
PNG
(US9139529, 62 | US9783501, Compound 62)
Show SMILES COc1ccc(Oc2nc3ccccc3cc2C(=O)Nc2cccc(c2)S(N)(=O)=O)cc1F
Show InChI InChI=1S/C23H18FN3O5S/c1-31-21-10-9-16(13-19(21)24)32-23-18(11-14-5-2-3-8-20(14)27-23)22(28)26-15-6-4-7-17(12-15)33(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181220
PNG
(US9139529, 63 | US9783501, Compound 63)
Show SMILES Cc1cc(F)ccc1Oc1nc2ccccc2cc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C23H18FN3O4S/c1-14-11-16(24)9-10-21(14)31-23-19(12-15-5-2-3-8-20(15)27-23)22(28)26-17-6-4-7-18(13-17)32(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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n/an/a 8n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181221
PNG
(US9139529, 64 | US9783501, Compound 64)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccccc2)c1
Show InChI InChI=1S/C22H17N3O4S/c23-30(27,28)18-11-6-8-16(14-18)24-21(26)19-13-15-7-4-5-12-20(15)25-22(19)29-17-9-2-1-3-10-17/h1-14H,(H,24,26)(H2,23,27,28)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181222
PNG
(US9139529, 65 | US9783501, Compound 65)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(F)cc2F)c1
Show InChI InChI=1S/C22H15F2N3O4S/c23-14-8-9-20(18(24)11-14)31-22-17(10-13-4-1-2-7-19(13)27-22)21(28)26-15-5-3-6-16(12-15)32(25,29)30/h1-12H,(H,26,28)(H2,25,29,30)
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VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181223
PNG
(US9139529, 66 | US9783501, Compound 66)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(F)cc2Cl)c1
Show InChI InChI=1S/C22H15ClFN3O4S/c23-18-11-14(24)8-9-20(18)31-22-17(10-13-4-1-2-7-19(13)27-22)21(28)26-15-5-3-6-16(12-15)32(25,29)30/h1-12H,(H,26,28)(H2,25,29,30)
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n/an/a 2n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181224
PNG
(US9139529, 67 | US9783501, Compound 67)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(OCC(F)(F)F)cc2)c1
Show InChI InChI=1S/C24H18F3N3O5S/c25-24(26,27)14-34-17-8-10-18(11-9-17)35-23-20(12-15-4-1-2-7-21(15)30-23)22(31)29-16-5-3-6-19(13-16)36(28,32)33/h1-13H,14H2,(H,29,31)(H2,28,32,33)
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n/an/a 61n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181225
PNG
(US9139529, 68 | US9783501, Compound 68)
Show SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc3ccccc3nc2Oc2ccc(OC(F)(F)F)cc2)c1
Show InChI InChI=1S/C23H16F3N3O5S/c24-23(25,26)34-17-10-8-16(9-11-17)33-22-19(12-14-4-1-2-7-20(14)29-22)21(30)28-15-5-3-6-18(13-15)35(27,31)32/h1-13H,(H,28,30)(H2,27,31,32)
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n/an/a 13n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181226
PNG
(US9139529, 69 | US9783501, Compound 69)
Show SMILES COc1ccc(Oc2nc3ccccc3cc2C(=O)Nc2cccc(c2)S(N)(=O)=O)c(Cl)c1
Show InChI InChI=1S/C23H18ClN3O5S/c1-31-16-9-10-21(19(24)13-16)32-23-18(11-14-5-2-3-8-20(14)27-23)22(28)26-15-6-4-7-17(12-15)33(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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n/an/a 15n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181227
PNG
(US9139529, 70 | US9783501, Compound 70)
Show SMILES COc1ccc(Oc2nc3ccccc3cc2C(=O)Nc2cccc(c2)S(N)(=O)=O)c(F)c1
Show InChI InChI=1S/C23H18FN3O5S/c1-31-16-9-10-21(19(24)13-16)32-23-18(11-14-5-2-3-8-20(14)27-23)22(28)26-15-6-4-7-17(12-15)33(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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n/an/a 34n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181228
PNG
(US9139529, 71 | US9783501, Compound 71)
Show SMILES Cc1cc(Cl)ccc1Oc1nc2ccccc2cc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C23H18ClN3O4S/c1-14-11-16(24)9-10-21(14)31-23-19(12-15-5-2-3-8-20(15)27-23)22(28)26-17-6-4-7-18(13-17)32(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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n/an/a 14n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 10 subunit alpha


(Homo sapiens (Human))
BDBM181230
PNG
(US9139529, 73 | US9783501, Compound 73)
Show SMILES COc1cc(Cl)ccc1Oc1nc2ccccc2cc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C23H18ClN3O5S/c1-31-21-12-15(24)9-10-20(21)32-23-18(11-14-5-2-3-8-19(14)27-23)22(28)26-16-6-4-7-17(13-16)33(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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n/an/a 31n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9783501 (2017)

More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.8


(Rattus norvegicus (Rat))
BDBM181218
PNG
(US9139529, 61 | US9783501, Compound 61)
Show SMILES COc1cc(F)ccc1Oc1nc2ccccc2cc1C(=O)Nc1cccc(c1)S(N)(=O)=O
Show InChI InChI=1S/C23H18FN3O5S/c1-31-21-12-15(24)9-10-20(21)32-23-18(11-14-5-2-3-8-19(14)27-23)22(28)26-16-6-4-7-17(13-16)33(25,29)30/h2-13H,1H3,(H,26,28)(H2,25,29,30)
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n/an/a 11n/an/an/an/an/an/a



VERTEX PHARMACEUTICALS INCORPORATED

US Patent


Assay Description
Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...


US Patent US9139529 (2015)


BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
More data for this
Ligand-Target Pair