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31 similar compounds to monomer 181418

Compile data set for download or QSAR
Wt: 517.4
BDBM181488
Wt: 543.5
BDBM181486
Wt: 516.9
BDBM181571
Wt: 523.5
BDBM181656
Wt: 513.5
BDBM181577
Wt: 531.0
BDBM181587
Wt: 486.4
BDBM181591
Wt: 500.5
BDBM181593
Wt: 529.4
BDBM181594
Wt: 482.5
BDBM181597
Wt: 500.5
BDBM181600
Wt: 516.9
BDBM181606
Wt: 500.5
BDBM181607
Wt: 489.5
BDBM181608
Wt: 498.5
BDBM181609
Displayed 1 to 15 (of 31 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 181488,181486,181571,181656,181577,181587,181591,181593,181594,181597,181600,181606,181607,181608,181609   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181486
PNG
(US9139577, 3.047 | US9708274, 3.047)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C23H22F5N5O3S/c1-13(22(34)29-11-23(26,27)28)36-19-8-14(24)4-5-17(19)32-21-20-16(25)9-15(10-18(20)30-12-31-21)33-37(35)6-2-3-7-37/h4-5,8-10,12-13H,2-3,6-7,11H2,1H3,(H,29,34)(H,30,31,32)/t13-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM181594
PNG
(US9139577, 4.100 | US9708274, 4.100)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C22H20F5N5O3S/c1-12(21(33)28-10-22(25,26)27)35-18-7-13(23)3-4-16(18)31-20-19-15(24)8-14(9-17(19)29-11-30-20)32-36(34)5-2-6-36/h3-4,7-9,11-12H,2,5-6,10H2,1H3,(H,28,33)(H,29,30,31)/t12-/m1/s1
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n/an/a 14n/an/an/an/a7.5n/a



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK1a was assessed using pre-activated GST-MNK1a. The 2xMKNK1 (MNK1) mixture is prepared in 50 mM HEPES pH 7.5, ...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181571
PNG
(US9139577, 4.077 | US9708274, 4.077)
Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22ClFN6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14+/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181577
PNG
(US9139577, 4.083 | US9708274, 4.083)
Show SMILES CC(NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S(C)(C)=O)C(F)F
Show InChI InChI=1S/C22H23F4N5O3S/c1-11(20(25)26)29-22(32)12(2)34-18-7-13(23)5-6-16(18)30-21-19-15(24)8-14(31-35(3,4)33)9-17(19)27-10-28-21/h5-12,20H,1-4H3,(H,29,32)(H,27,28,30)/t11?,12-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181587
PNG
(US9139577, 4.093 | US9708274, 4.093)
Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCCC1)C#N
Show InChI InChI=1S/C24H24ClFN6O3S/c1-14(12-27)30-24(33)15(2)35-21-9-16(25)5-6-19(21)31-23-22-18(26)10-17(11-20(22)28-13-29-23)32-36(34)7-3-4-8-36/h5-6,9-11,13-15H,3-4,7-8H2,1-2H3,(H,30,33)(H,28,29,31)/t14-,15+/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181591
PNG
(US9139577, 4.097 | US9708274, 4.097)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC#N
Show InChI InChI=1S/C22H20F2N6O3S/c1-13(22(31)26-6-5-25)33-19-9-14(23)3-4-17(19)29-21-20-16(24)10-15(11-18(20)27-12-28-21)30-34(32)7-2-8-34/h3-4,9-13H,2,6-8H2,1H3,(H,26,31)(H,27,28,29)/t13-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181593
PNG
(US9139577, 4.099 | US9708274, 4.099)
Show SMILES CC(NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22F2N6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13?,14-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181594
PNG
(US9139577, 4.100 | US9708274, 4.100)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C22H20F5N5O3S/c1-12(21(33)28-10-22(25,26)27)35-18-7-13(23)3-4-16(18)31-20-19-15(24)8-14(9-17(19)29-11-30-20)32-36(34)5-2-6-36/h3-4,7-9,11-12H,2,5-6,10H2,1H3,(H,28,33)(H,29,30,31)/t12-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181597
PNG
(US9139577, 4.103 | US9708274, 4.103)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCC#N
Show InChI InChI=1S/C23H23FN6O3S/c1-14-10-17(30-34(32)8-3-9-34)12-19-21(14)22(28-13-27-19)29-18-5-4-16(24)11-20(18)33-15(2)23(31)26-7-6-25/h4-5,10-13,15H,3,7-9H2,1-2H3,(H,26,31)(H,27,28,29)/t15-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181600
PNG
(US9139577, 4.106 | US9708274, 4.106)
Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22F2N6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14+/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181606
PNG
(US9139577, 4.112 | US9708274, 4.112)
Show SMILES C[C@@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22ClFN6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(25)4-5-18(20)30-22-21-17(24)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181607
PNG
(US9139577, 4.113 | US9708274, 4.113)
Show SMILES C[C@@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22F2N6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181608
PNG
(US9139577, 4.114 | US9708274, 4.114)
Show SMILES CC(C)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C23H25F2N5O3S/c1-13(2)28-23(31)14(3)33-20-9-15(24)5-6-18(20)29-22-21-17(25)10-16(11-19(21)26-12-27-22)30-34(32)7-4-8-34/h5-6,9-14H,4,7-8H2,1-3H3,(H,28,31)(H,26,27,29)/t14-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181609
PNG
(US9139577, 4.115 | US9708274, 4.115)
Show SMILES COc1cc(cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC#N)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C23H23FN6O4S/c1-14(23(31)26-7-6-25)34-19-10-15(24)4-5-17(19)29-22-21-18(27-13-28-22)11-16(12-20(21)33-2)30-35(32)8-3-9-35/h4-5,10-14H,3,7-9H2,1-2H3,(H,26,31)(H,27,28,29)/t14-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181656
PNG
(US9139577, 6.002 | US9708274, 6.002)
Show SMILES COc1cc(cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)F)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C23H24F3N5O4S/c1-13(23(32)27-11-20(25)26)35-18-8-14(24)4-5-16(18)30-22-21-17(28-12-29-22)9-15(10-19(21)34-2)31-36(33)6-3-7-36/h4-5,8-10,12-13,20H,3,6-7,11H2,1-2H3,(H,27,32)(H,28,29,30)/t13-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM181488
PNG
(US9139577, 3.049 | US9708274, 3.049)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S(C)(C)=O)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C21H20F5N5O3S/c1-11(20(32)27-9-21(24,25)26)34-17-6-12(22)4-5-15(17)30-19-18-14(23)7-13(31-35(2,3)33)8-16(18)28-10-29-19/h4-8,10-11H,9H2,1-3H3,(H,27,32)(H,28,29,30)/t11-/m1/s1
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n/an/a 68n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM181594
PNG
(US9139577, 4.100 | US9708274, 4.100)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C22H20F5N5O3S/c1-12(21(33)28-10-22(25,26)27)35-18-7-13(23)3-4-16(18)31-20-19-15(24)8-14(9-17(19)29-11-30-20)32-36(34)5-2-6-36/h3-4,7-9,11-12H,2,5-6,10H2,1H3,(H,28,33)(H,29,30,31)/t12-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181486
PNG
(US9139577, 3.047 | US9708274, 3.047)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C23H22F5N5O3S/c1-13(22(34)29-11-23(26,27)28)36-19-8-14(24)4-5-17(19)32-21-20-16(25)9-15(10-18(20)30-12-31-21)33-37(35)6-2-3-7-37/h4-5,8-10,12-13H,2-3,6-7,11H2,1H3,(H,29,34)(H,30,31,32)/t13-/m1/s1
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n/an/a 1n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181488
PNG
(US9139577, 3.049 | US9708274, 3.049)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S(C)(C)=O)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C21H20F5N5O3S/c1-11(20(32)27-9-21(24,25)26)34-17-6-12(22)4-5-15(17)30-19-18-14(23)7-13(31-35(2,3)33)8-16(18)28-10-29-19/h4-8,10-11H,9H2,1-3H3,(H,27,32)(H,28,29,30)/t11-/m1/s1
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n/an/a 2n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181571
PNG
(US9139577, 4.077 | US9708274, 4.077)
Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22ClFN6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14+/m0/s1
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n/an/a 2n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181577
PNG
(US9139577, 4.083 | US9708274, 4.083)
Show SMILES CC(NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S(C)(C)=O)C(F)F
Show InChI InChI=1S/C22H23F4N5O3S/c1-11(20(25)26)29-22(32)12(2)34-18-7-13(23)5-6-16(18)30-21-19-15(24)8-14(31-35(3,4)33)9-17(19)27-10-28-21/h5-12,20H,1-4H3,(H,29,32)(H,27,28,30)/t11?,12-/m1/s1
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n/an/a 8n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181587
PNG
(US9139577, 4.093 | US9708274, 4.093)
Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCCC1)C#N
Show InChI InChI=1S/C24H24ClFN6O3S/c1-14(12-27)30-24(33)15(2)35-21-9-16(25)5-6-19(21)31-23-22-18(26)10-17(11-20(22)28-13-29-23)32-36(34)7-3-4-8-36/h5-6,9-11,13-15H,3-4,7-8H2,1-2H3,(H,30,33)(H,28,29,31)/t14-,15+/m0/s1
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n/an/a 1n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181591
PNG
(US9139577, 4.097 | US9708274, 4.097)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC#N
Show InChI InChI=1S/C22H20F2N6O3S/c1-13(22(31)26-6-5-25)33-19-9-14(23)3-4-17(19)29-21-20-16(24)10-15(11-18(20)27-12-28-21)30-34(32)7-2-8-34/h3-4,9-13H,2,6-8H2,1H3,(H,26,31)(H,27,28,29)/t13-/m1/s1
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n/an/a 1n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181593
PNG
(US9139577, 4.099 | US9708274, 4.099)
Show SMILES CC(NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22F2N6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13?,14-/m1/s1
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n/an/a 2n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181594
PNG
(US9139577, 4.100 | US9708274, 4.100)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C22H20F5N5O3S/c1-12(21(33)28-10-22(25,26)27)35-18-7-13(23)3-4-16(18)31-20-19-15(24)8-14(9-17(19)29-11-30-20)32-36(34)5-2-6-36/h3-4,7-9,11-12H,2,5-6,10H2,1H3,(H,28,33)(H,29,30,31)/t12-/m1/s1
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n/an/a 2n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181597
PNG
(US9139577, 4.103 | US9708274, 4.103)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(C)c12)N=S1(=O)CCC1)C(=O)NCC#N
Show InChI InChI=1S/C23H23FN6O3S/c1-14-10-17(30-34(32)8-3-9-34)12-19-21(14)22(28-13-27-19)29-18-5-4-16(24)11-20(18)33-15(2)23(31)26-7-6-25/h4-5,10-13,15H,3,7-9H2,1-2H3,(H,26,31)(H,27,28,29)/t15-/m1/s1
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n/an/a 1n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181600
PNG
(US9139577, 4.106 | US9708274, 4.106)
Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22F2N6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14+/m0/s1
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n/an/a 2n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181606
PNG
(US9139577, 4.112 | US9708274, 4.112)
Show SMILES C[C@@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22ClFN6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(25)4-5-18(20)30-22-21-17(24)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14-/m1/s1
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n/an/a 2n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181607
PNG
(US9139577, 4.113 | US9708274, 4.113)
Show SMILES C[C@@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22F2N6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14-/m1/s1
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n/an/a 1n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181608
PNG
(US9139577, 4.114 | US9708274, 4.114)
Show SMILES CC(C)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C23H25F2N5O3S/c1-13(2)28-23(31)14(3)33-20-9-15(24)5-6-18(20)29-22-21-17(25)10-16(11-19(21)26-12-27-22)30-34(32)7-4-8-34/h5-6,9-14H,4,7-8H2,1-3H3,(H,28,31)(H,26,27,29)/t14-/m1/s1
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n/an/a 5n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181609
PNG
(US9139577, 4.115 | US9708274, 4.115)
Show SMILES COc1cc(cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC#N)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C23H23FN6O4S/c1-14(23(31)26-7-6-25)34-19-10-15(24)4-5-17(19)29-22-21-18(27-13-28-22)11-16(12-20(21)33-2)30-35(32)8-3-9-35/h4-5,10-14H,3,7-9H2,1-2H3,(H,26,31)(H,27,28,29)/t14-/m1/s1
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n/an/a 2n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181656
PNG
(US9139577, 6.002 | US9708274, 6.002)
Show SMILES COc1cc(cc2ncnc(Nc3ccc(F)cc3O[C@H](C)C(=O)NCC(F)F)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C23H24F3N5O4S/c1-13(23(32)27-11-20(25)26)35-18-8-14(24)4-5-16(18)30-22-21-17(28-12-29-22)9-15(10-19(21)34-2)31-36(33)6-3-7-36/h4-5,8-10,12-13,20H,3,6-7,11H2,1-2H3,(H,27,32)(H,28,29,30)/t13-/m1/s1
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n/an/a 2n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM181488
PNG
(US9139577, 3.049 | US9708274, 3.049)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S(C)(C)=O)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C21H20F5N5O3S/c1-11(20(32)27-9-21(24,25)26)34-17-6-12(22)4-5-15(17)30-19-18-14(23)7-13(31-35(2,3)33)8-16(18)28-10-29-19/h4-8,10-11H,9H2,1-3H3,(H,27,32)(H,28,29,30)/t11-/m1/s1
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n/an/a 68n/an/an/an/a7.5n/a



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK1a was assessed using pre-activated GST-MNK1a. The 2xMKNK1 (MNK1) mixture is prepared in 50 mM HEPES pH 7.5, ...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181488
PNG
(US9139577, 3.049 | US9708274, 3.049)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S(C)(C)=O)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C21H20F5N5O3S/c1-11(20(32)27-9-21(24,25)26)34-17-6-12(22)4-5-15(17)30-19-18-14(23)7-13(31-35(2,3)33)8-16(18)28-10-29-19/h4-8,10-11H,9H2,1-3H3,(H,27,32)(H,28,29,30)/t11-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair