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19 similar compounds to monomer 181587

Compile data set for download or QSAR
Wt: 543.5
BDBM181486
Wt: 516.9
BDBM181571
Wt: 486.4
BDBM181591
Wt: 500.5
BDBM181593
Wt: 529.4
BDBM181594
Wt: 500.5
BDBM181600
Wt: 516.9
BDBM181606
Wt: 500.5
BDBM181607
Wt: 489.5
BDBM181608
Wt: 493.5
BDBM181611
Wt: 511.4
BDBM181617
Wt: 525.5
BDBM181622
Wt: 579.4
BDBM181623
Wt: 525.5
BDBM181624
Wt: 543.5
BDBM181630
Displayed 1 to 15 (of 19 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 181486,181571,181591,181593,181594,181600,181606,181607,181608,181611,181617,181622,181623,181624,181630   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181486
PNG
(US9139577, 3.047 | US9708274, 3.047)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C23H22F5N5O3S/c1-13(22(34)29-11-23(26,27)28)36-19-8-14(24)4-5-17(19)32-21-20-16(25)9-15(10-18(20)30-12-31-21)33-37(35)6-2-3-7-37/h4-5,8-10,12-13H,2-3,6-7,11H2,1H3,(H,29,34)(H,30,31,32)/t13-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM181594
PNG
(US9139577, 4.100 | US9708274, 4.100)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C22H20F5N5O3S/c1-12(21(33)28-10-22(25,26)27)35-18-7-13(23)3-4-16(18)31-20-19-15(24)8-14(9-17(19)29-11-30-20)32-36(34)5-2-6-36/h3-4,7-9,11-12H,2,5-6,10H2,1H3,(H,28,33)(H,29,30,31)/t12-/m1/s1
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n/an/a 14n/an/an/an/a7.5n/a



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK1a was assessed using pre-activated GST-MNK1a. The 2xMKNK1 (MNK1) mixture is prepared in 50 mM HEPES pH 7.5, ...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181591
PNG
(US9139577, 4.097 | US9708274, 4.097)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC#N
Show InChI InChI=1S/C22H20F2N6O3S/c1-13(22(31)26-6-5-25)33-19-9-14(23)3-4-17(19)29-21-20-16(24)10-15(11-18(20)27-12-28-21)30-34(32)7-2-8-34/h3-4,9-13H,2,6-8H2,1H3,(H,26,31)(H,27,28,29)/t13-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181593
PNG
(US9139577, 4.099 | US9708274, 4.099)
Show SMILES CC(NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22F2N6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13?,14-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181594
PNG
(US9139577, 4.100 | US9708274, 4.100)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C22H20F5N5O3S/c1-12(21(33)28-10-22(25,26)27)35-18-7-13(23)3-4-16(18)31-20-19-15(24)8-14(9-17(19)29-11-30-20)32-36(34)5-2-6-36/h3-4,7-9,11-12H,2,5-6,10H2,1H3,(H,28,33)(H,29,30,31)/t12-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181600
PNG
(US9139577, 4.106 | US9708274, 4.106)
Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22F2N6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14+/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181606
PNG
(US9139577, 4.112 | US9708274, 4.112)
Show SMILES C[C@@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22ClFN6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(25)4-5-18(20)30-22-21-17(24)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181607
PNG
(US9139577, 4.113 | US9708274, 4.113)
Show SMILES C[C@@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22F2N6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181608
PNG
(US9139577, 4.114 | US9708274, 4.114)
Show SMILES CC(C)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C23H25F2N5O3S/c1-13(2)28-23(31)14(3)33-20-9-15(24)5-6-18(20)29-22-21-17(25)10-16(11-19(21)26-12-27-22)30-34(32)7-4-8-34/h5-6,9-14H,4,7-8H2,1-3H3,(H,28,31)(H,26,27,29)/t14-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181611
PNG
(US9139577, 4.117 | US9708274, 4.117)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCCF
Show InChI InChI=1S/C22H22F3N5O3S/c1-13(22(31)26-6-5-23)33-19-9-14(24)3-4-17(19)29-21-20-16(25)10-15(11-18(20)27-12-28-21)30-34(32)7-2-8-34/h3-4,9-13H,2,5-8H2,1H3,(H,26,31)(H,27,28,29)/t13-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181617
PNG
(US9139577, 4.123 | US9708274, 4.123)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC(F)F
Show InChI InChI=1S/C22H21F4N5O3S/c1-12(22(32)27-10-19(25)26)34-18-7-13(23)3-4-16(18)30-21-20-15(24)8-14(9-17(20)28-11-29-21)31-35(33)5-2-6-35/h3-4,7-9,11-12,19H,2,5-6,10H2,1H3,(H,27,32)(H,28,29,30)/t12-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181622
PNG
(US9139577, 4.128 | US9708274, 4.128)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NC(CF)CF
Show InChI InChI=1S/C23H23F4N5O3S/c1-13(23(33)30-16(10-24)11-25)35-20-7-14(26)3-4-18(20)31-22-21-17(27)8-15(9-19(21)28-12-29-22)32-36(34)5-2-6-36/h3-4,7-9,12-13,16H,2,5-6,10-11H2,1H3,(H,30,33)(H,28,29,31)/t13-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181623
PNG
(US9139577, 4.129 | US9708274, 4.129)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)C(F)(F)F
Show InChI InChI=1S/C23H20F7N5O3S/c1-12(21(36)31-10-22(26,27)23(28,29)30)38-18-7-13(24)3-4-16(18)34-20-19-15(25)8-14(9-17(19)32-11-33-20)35-39(37)5-2-6-39/h3-4,7-9,11-12H,2,5-6,10H2,1H3,(H,31,36)(H,32,33,34)/t12-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181624
PNG
(US9139577, 4.130 | US9708274, 4.130)
Show SMILES CC(NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(F)F
Show InChI InChI=1S/C23H23F4N5O3S/c1-12(21(26)27)30-23(33)13(2)35-19-8-14(24)4-5-17(19)31-22-20-16(25)9-15(10-18(20)28-11-29-22)32-36(34)6-3-7-36/h4-5,8-13,21H,3,6-7H2,1-2H3,(H,30,33)(H,28,29,31)/t12?,13-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181630
PNG
(US9139577, 4.136)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)N[C@@H](C)C(F)(F)F
Show InChI InChI=1S/C23H22F5N5O3S/c1-12(22(34)31-13(2)23(26,27)28)36-19-8-14(24)4-5-17(19)32-21-20-16(25)9-15(10-18(20)29-11-30-21)33-37(35)6-3-7-37/h4-5,8-13H,3,6-7H2,1-2H3,(H,31,34)(H,29,30,32)/t12-,13+/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM181594
PNG
(US9139577, 4.100 | US9708274, 4.100)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C22H20F5N5O3S/c1-12(21(33)28-10-22(25,26)27)35-18-7-13(23)3-4-16(18)31-20-19-15(24)8-14(9-17(19)29-11-30-20)32-36(34)5-2-6-36/h3-4,7-9,11-12H,2,5-6,10H2,1H3,(H,28,33)(H,29,30,31)/t12-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (human))
BDBM181630
PNG
(US9139577, 4.136)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)N[C@@H](C)C(F)(F)F
Show InChI InChI=1S/C23H22F5N5O3S/c1-12(22(34)31-13(2)23(26,27)28)36-19-8-14(24)4-5-17(19)32-21-20-16(25)9-15(10-18(20)29-11-30-21)33-37(35)6-3-7-37/h4-5,8-13H,3,6-7H2,1-2H3,(H,31,34)(H,29,30,32)/t12-,13+/m1/s1
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n/an/a 29n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The Z-LYTE biochemical assay employs a fluorescence-based, coupled-enzyme format and is based on the differential sensitivity of phosphorylated and n...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181486
PNG
(US9139577, 3.047 | US9708274, 3.047)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C23H22F5N5O3S/c1-13(22(34)29-11-23(26,27)28)36-19-8-14(24)4-5-17(19)32-21-20-16(25)9-15(10-18(20)30-12-31-21)33-37(35)6-2-3-7-37/h4-5,8-10,12-13H,2-3,6-7,11H2,1H3,(H,29,34)(H,30,31,32)/t13-/m1/s1
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n/an/a 1n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181571
PNG
(US9139577, 4.077 | US9708274, 4.077)
Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22ClFN6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14+/m0/s1
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n/an/a 2n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181591
PNG
(US9139577, 4.097 | US9708274, 4.097)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC#N
Show InChI InChI=1S/C22H20F2N6O3S/c1-13(22(31)26-6-5-25)33-19-9-14(23)3-4-17(19)29-21-20-16(24)10-15(11-18(20)27-12-28-21)30-34(32)7-2-8-34/h3-4,9-13H,2,6-8H2,1H3,(H,26,31)(H,27,28,29)/t13-/m1/s1
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n/an/a 1n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181593
PNG
(US9139577, 4.099 | US9708274, 4.099)
Show SMILES CC(NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22F2N6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13?,14-/m1/s1
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n/an/a 2n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181594
PNG
(US9139577, 4.100 | US9708274, 4.100)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)F
Show InChI InChI=1S/C22H20F5N5O3S/c1-12(21(33)28-10-22(25,26)27)35-18-7-13(23)3-4-16(18)31-20-19-15(24)8-14(9-17(19)29-11-30-20)32-36(34)5-2-6-36/h3-4,7-9,11-12H,2,5-6,10H2,1H3,(H,28,33)(H,29,30,31)/t12-/m1/s1
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n/an/a 2n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181600
PNG
(US9139577, 4.106 | US9708274, 4.106)
Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22F2N6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14+/m0/s1
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n/an/a 2n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181606
PNG
(US9139577, 4.112 | US9708274, 4.112)
Show SMILES C[C@@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(Cl)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22ClFN6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(25)4-5-18(20)30-22-21-17(24)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14-/m1/s1
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n/an/a 2n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181607
PNG
(US9139577, 4.113 | US9708274, 4.113)
Show SMILES C[C@@H](NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22F2N6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14-/m1/s1
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n/an/a 1n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181608
PNG
(US9139577, 4.114 | US9708274, 4.114)
Show SMILES CC(C)NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1
Show InChI InChI=1S/C23H25F2N5O3S/c1-13(2)28-23(31)14(3)33-20-9-15(24)5-6-18(20)29-22-21-17(25)10-16(11-19(21)26-12-27-22)30-34(32)7-4-8-34/h5-6,9-14H,4,7-8H2,1-3H3,(H,28,31)(H,26,27,29)/t14-/m1/s1
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n/an/a 5n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181611
PNG
(US9139577, 4.117 | US9708274, 4.117)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCCF
Show InChI InChI=1S/C22H22F3N5O3S/c1-13(22(31)26-6-5-23)33-19-9-14(24)3-4-17(19)29-21-20-16(25)10-15(11-18(20)27-12-28-21)30-34(32)7-2-8-34/h3-4,9-13H,2,5-8H2,1H3,(H,26,31)(H,27,28,29)/t13-/m1/s1
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n/an/a 3n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181617
PNG
(US9139577, 4.123 | US9708274, 4.123)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC(F)F
Show InChI InChI=1S/C22H21F4N5O3S/c1-12(22(32)27-10-19(25)26)34-18-7-13(23)3-4-16(18)30-21-20-15(24)8-14(9-17(20)28-11-29-21)31-35(33)5-2-6-35/h3-4,7-9,11-12,19H,2,5-6,10H2,1H3,(H,27,32)(H,28,29,30)/t12-/m1/s1
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n/an/a 3n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181622
PNG
(US9139577, 4.128 | US9708274, 4.128)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NC(CF)CF
Show InChI InChI=1S/C23H23F4N5O3S/c1-13(23(33)30-16(10-24)11-25)35-20-7-14(26)3-4-18(20)31-22-21-17(27)8-15(9-19(21)28-12-29-22)32-36(34)5-2-6-36/h3-4,7-9,12-13,16H,2,5-6,10-11H2,1H3,(H,30,33)(H,28,29,31)/t13-/m1/s1
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n/an/a 2n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181623
PNG
(US9139577, 4.129 | US9708274, 4.129)
Show SMILES C[C@@H](Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(=O)NCC(F)(F)C(F)(F)F
Show InChI InChI=1S/C23H20F7N5O3S/c1-12(21(36)31-10-22(26,27)23(28,29)30)38-18-7-13(24)3-4-16(18)34-20-19-15(25)8-14(9-17(19)32-11-33-20)35-39(37)5-2-6-39/h3-4,7-9,11-12H,2,5-6,10H2,1H3,(H,31,36)(H,32,33,34)/t12-/m1/s1
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n/an/a 2n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181624
PNG
(US9139577, 4.130 | US9708274, 4.130)
Show SMILES CC(NC(=O)[C@@H](C)Oc1cc(F)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C(F)F
Show InChI InChI=1S/C23H23F4N5O3S/c1-12(21(26)27)30-23(33)13(2)35-19-8-14(24)4-5-17(19)31-22-20-16(25)9-15(10-18(20)28-11-29-22)32-36(34)6-3-7-36/h4-5,8-13,21H,3,6-7H2,1-2H3,(H,30,33)(H,28,29,31)/t12?,13-/m1/s1
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n/an/a 3n/an/an/an/an/a25



EVOTEC INTERNATIONAL GMBH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9708274 (2017)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM181571
PNG
(US9139577, 4.077 | US9708274, 4.077)
Show SMILES C[C@H](NC(=O)[C@@H](C)Oc1cc(Cl)ccc1Nc1ncnc2cc(cc(F)c12)N=S1(=O)CCC1)C#N
Show InChI InChI=1S/C23H22ClFN6O3S/c1-13(11-26)29-23(32)14(2)34-20-8-15(24)4-5-18(20)30-22-21-17(25)9-16(10-19(21)27-12-28-22)31-35(33)6-3-7-35/h4-5,8-10,12-14H,3,6-7H2,1-2H3,(H,29,32)(H,27,28,30)/t13-,14+/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The inhibition of kinase activity of MNK2a was assessed using pre-activated GST-MNK2a. The white, 384-well OptiPlate F plates were purchased from Per...


US Patent US9139577 (2015)


BindingDB Entry DOI: 10.7270/Q2K64GT1
More data for this
Ligand-Target Pair