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25 similar compounds to monomer 182602

Wt: 547.5
BDBM182395
Wt: 519.5
BDBM182396
Wt: 514.0
BDBM182588
Wt: 528.0
BDBM182589
Wt: 533.5
BDBM182401
Wt: 587.5
BDBM182402
Wt: 535.5
BDBM182473
Wt: 533.5
BDBM182474
Wt: 521.5
BDBM182590
Wt: 535.5
BDBM182591
Wt: 467.5
BDBM182592
Wt: 481.6
BDBM182593
Wt: 519.5
BDBM182475
Wt: 479.5
BDBM182476
Wt: 493.6
BDBM182477
Displayed 1 to 15 (of 25 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 182395,182396,182588,182589,182401,182402,182473,182474,182590,182591,182592,182593,182475,182476,182477   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (human))
BDBM182395
PNG
(US9145392, 96)
Show SMILES CC(C)Oc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCC1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C27H33F4N7O/c1-17(2)39-23-24(32)33-16-34-26(23)37-10-6-18(7-11-37)25-35-22(15-38(25)13-12-36-8-3-9-36)19-4-5-21(28)20(14-19)27(29,30)31/h4-5,14-18H,3,6-13H2,1-2H3,(H2,32,33,34)
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US Patent
n/an/a 5.30n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM182593
PNG
(US9145392, 294)
Show SMILES CC(C)Oc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN(C)C)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C26H36FN7O/c1-17(2)35-23-24(28)29-16-30-26(23)33-10-8-19(9-11-33)25-31-22(15-34(25)13-12-32(4)5)20-6-7-21(27)18(3)14-20/h6-7,14-17,19H,8-13H2,1-5H3,(H2,28,29,30)
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n/an/a 1.90n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (human))
BDBM182401
PNG
(US9145392, 102)
Show SMILES CCOc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCC1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H31F4N7O/c1-2-38-22-23(31)32-16-33-25(22)36-10-6-17(7-11-36)24-34-21(15-37(24)13-12-35-8-3-9-35)18-4-5-20(27)19(14-18)26(28,29)30/h4-5,14-17H,2-3,6-13H2,1H3,(H2,31,32,33)
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n/an/a 2.40n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (human))
BDBM182402
PNG
(US9145392, 103)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCC2)-c2ccc(F)c(c2)C(F)(F)F)c1OCC(F)(F)F
Show InChI InChI=1S/C26H28F7N7O/c27-19-3-2-17(12-18(19)26(31,32)33)20-13-40(11-10-38-6-1-7-38)23(37-20)16-4-8-39(9-5-16)24-21(22(34)35-15-36-24)41-14-25(28,29)30/h2-3,12-13,15-16H,1,4-11,14H2,(H2,34,35,36)
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US Patent
n/an/a 4.20n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (human))
BDBM182473
PNG
(US9145392, 174)
Show SMILES CCNCCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1OC(C)C)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H33F4N7O/c1-4-32-9-12-37-14-21(18-5-6-20(27)19(13-18)26(28,29)30)35-24(37)17-7-10-36(11-8-17)25-22(38-16(2)3)23(31)33-15-34-25/h5-6,13-17,32H,4,7-12H2,1-3H3,(H2,31,33,34)
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US Patent
n/an/a 0.440n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (human))
BDBM182474
PNG
(US9145392, 175)
Show SMILES CC(C)Oc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CC1CNC1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H31F4N7O/c1-15(2)38-22-23(31)33-14-34-25(22)36-7-5-17(6-8-36)24-35-21(13-37(24)12-16-10-32-11-16)18-3-4-20(27)19(9-18)26(28,29)30/h3-4,9,13-17,32H,5-8,10-12H2,1-2H3,(H2,31,33,34)
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US Patent
n/an/a 5.90n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (human))
BDBM182475
PNG
(US9145392, 176)
Show SMILES CCOc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CC1CNC1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H29F4N7O/c1-2-37-21-22(30)32-14-33-24(21)35-7-5-16(6-8-35)23-34-20(13-36(23)12-15-10-31-11-15)17-3-4-19(26)18(9-17)25(27,28)29/h3-4,9,13-16,31H,2,5-8,10-12H2,1H3,(H2,30,32,33)
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n/an/a 5.5n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (human))
BDBM182476
PNG
(US9145392, 177)
Show SMILES CCOc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCC1)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C26H34FN7O/c1-3-35-23-24(28)29-17-30-26(23)33-11-7-19(8-12-33)25-31-22(20-5-6-21(27)18(2)15-20)16-34(25)14-13-32-9-4-10-32/h5-6,15-17,19H,3-4,7-14H2,1-2H3,(H2,28,29,30)
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n/an/a 1.20n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (human))
BDBM182477
PNG
(US9145392, 178)
Show SMILES CC(C)Oc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCC1)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C27H36FN7O/c1-18(2)36-24-25(29)30-17-31-27(24)34-11-7-20(8-12-34)26-32-23(21-5-6-22(28)19(3)15-21)16-35(26)14-13-33-9-4-10-33/h5-6,15-18,20H,4,7-14H2,1-3H3,(H2,29,30,31)
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US Patent
n/an/a 3.90n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (human))
BDBM182588
PNG
(US9145392, 289)
Show SMILES CCOc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCCC1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C26H33ClFN7O/c1-2-36-23-24(29)30-17-31-26(23)34-11-7-18(8-12-34)25-32-22(19-5-6-21(28)20(27)15-19)16-35(25)14-13-33-9-3-4-10-33/h5-6,15-18H,2-4,7-14H2,1H3,(H2,29,30,31)
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US Patent
n/an/a 0.800n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (human))
BDBM182589
PNG
(US9145392, 290)
Show SMILES CC(C)Oc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCCC1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C27H35ClFN7O/c1-18(2)37-24-25(30)31-17-32-27(24)35-11-7-19(8-12-35)26-33-23(20-5-6-22(29)21(28)15-20)16-36(26)14-13-34-9-3-4-10-34/h5-6,15-19H,3-4,7-14H2,1-2H3,(H2,30,31,32)
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n/an/a 1.30n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (human))
BDBM182590
PNG
(US9145392, 291)
Show SMILES CCOc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN(C)C)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H31F4N7O/c1-4-37-21-22(30)31-15-32-24(21)35-9-7-16(8-10-35)23-33-20(14-36(23)12-11-34(2)3)17-5-6-19(26)18(13-17)25(27,28)29/h5-6,13-16H,4,7-12H2,1-3H3,(H2,30,31,32)
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US Patent
n/an/a 2.60n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (human))
BDBM182591
PNG
(US9145392, 292)
Show SMILES CC(C)Oc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN(C)C)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H33F4N7O/c1-16(2)38-22-23(31)32-15-33-25(22)36-9-7-17(8-10-36)24-34-21(14-37(24)12-11-35(3)4)18-5-6-20(27)19(13-18)26(28,29)30/h5-6,13-17H,7-12H2,1-4H3,(H2,31,32,33)
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US Patent
n/an/a 3.40n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (human))
BDBM182592
PNG
(US9145392, 293)
Show SMILES CCOc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN(C)C)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C25H34FN7O/c1-5-34-22-23(27)28-16-29-25(22)32-10-8-18(9-11-32)24-30-21(15-33(24)13-12-31(3)4)19-6-7-20(26)17(2)14-19/h6-7,14-16,18H,5,8-13H2,1-4H3,(H2,27,28,29)
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n/an/a 1n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (human))
BDBM182593
PNG
(US9145392, 294)
Show SMILES CC(C)Oc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN(C)C)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C26H36FN7O/c1-17(2)35-23-24(28)29-16-30-26(23)33-10-8-19(9-11-33)25-31-22(15-34(25)13-12-32(4)5)20-6-7-21(27)18(3)14-20/h6-7,14-17,19H,8-13H2,1-5H3,(H2,28,29,30)
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n/an/a 1.30n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM182395
PNG
(US9145392, 96)
Show SMILES CC(C)Oc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCC1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C27H33F4N7O/c1-17(2)39-23-24(32)33-16-34-26(23)37-10-6-18(7-11-37)25-35-22(15-38(25)13-12-36-8-3-9-36)19-4-5-21(28)20(14-19)27(29,30)31/h4-5,14-18H,3,6-13H2,1-2H3,(H2,32,33,34)
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n/an/a 7.90n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM182396
PNG
(US9145392, 97)
Show SMILES COc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCC1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H29F4N7O/c1-37-21-22(30)31-15-32-24(21)35-9-5-16(6-10-35)23-33-20(14-36(23)12-11-34-7-2-8-34)17-3-4-19(26)18(13-17)25(27,28)29/h3-4,13-16H,2,5-12H2,1H3,(H2,30,31,32)
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n/an/a 6.10n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM182401
PNG
(US9145392, 102)
Show SMILES CCOc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCC1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H31F4N7O/c1-2-38-22-23(31)32-16-33-25(22)36-10-6-17(7-11-36)24-34-21(15-37(24)13-12-35-8-3-9-35)18-4-5-20(27)19(14-18)26(28,29)30/h4-5,14-17H,2-3,6-13H2,1H3,(H2,31,32,33)
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n/an/a 4.10n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM182402
PNG
(US9145392, 103)
Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCC2)-c2ccc(F)c(c2)C(F)(F)F)c1OCC(F)(F)F
Show InChI InChI=1S/C26H28F7N7O/c27-19-3-2-17(12-18(19)26(31,32)33)20-13-40(11-10-38-6-1-7-38)23(37-20)16-4-8-39(9-5-16)24-21(22(34)35-15-36-24)41-14-25(28,29)30/h2-3,12-13,15-16H,1,4-11,14H2,(H2,34,35,36)
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n/an/a 6.60n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM182473
PNG
(US9145392, 174)
Show SMILES CCNCCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1OC(C)C)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H33F4N7O/c1-4-32-9-12-37-14-21(18-5-6-20(27)19(13-18)26(28,29)30)35-24(37)17-7-10-36(11-8-17)25-22(38-16(2)3)23(31)33-15-34-25/h5-6,13-17,32H,4,7-12H2,1-3H3,(H2,31,33,34)
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n/an/a 0.520n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM182474
PNG
(US9145392, 175)
Show SMILES CC(C)Oc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CC1CNC1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H31F4N7O/c1-15(2)38-22-23(31)33-14-34-25(22)36-7-5-17(6-8-36)24-35-21(13-37(24)12-16-10-32-11-16)18-3-4-20(27)19(9-18)26(28,29)30/h3-4,9,13-17,32H,5-8,10-12H2,1-2H3,(H2,31,33,34)
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n/an/a 4.5n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM182475
PNG
(US9145392, 176)
Show SMILES CCOc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CC1CNC1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H29F4N7O/c1-2-37-21-22(30)32-14-33-24(21)35-7-5-16(6-8-35)23-34-20(13-36(23)12-15-10-31-11-15)17-3-4-19(26)18(9-17)25(27,28)29/h3-4,9,13-16,31H,2,5-8,10-12H2,1H3,(H2,30,32,33)
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n/an/a 5n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM182476
PNG
(US9145392, 177)
Show SMILES CCOc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCC1)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C26H34FN7O/c1-3-35-23-24(28)29-17-30-26(23)33-11-7-19(8-12-33)25-31-22(20-5-6-21(27)18(2)15-20)16-34(25)14-13-32-9-4-10-32/h5-6,15-17,19H,3-4,7-14H2,1-2H3,(H2,28,29,30)
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n/an/a 2.10n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM182477
PNG
(US9145392, 178)
Show SMILES CC(C)Oc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCC1)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C27H36FN7O/c1-18(2)36-24-25(29)30-17-31-27(24)34-11-7-20(8-12-34)26-32-23(21-5-6-22(28)19(3)15-21)16-35(26)14-13-33-9-4-10-33/h5-6,15-18,20H,4,7-14H2,1-3H3,(H2,29,30,31)
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n/an/a 2.70n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM182588
PNG
(US9145392, 289)
Show SMILES CCOc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCCC1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C26H33ClFN7O/c1-2-36-23-24(29)30-17-31-26(23)34-11-7-18(8-12-34)25-32-22(19-5-6-21(28)20(27)15-19)16-35(25)14-13-33-9-3-4-10-33/h5-6,15-18H,2-4,7-14H2,1H3,(H2,29,30,31)
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n/an/a 2.10n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM182589
PNG
(US9145392, 290)
Show SMILES CC(C)Oc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCCC1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C27H35ClFN7O/c1-18(2)37-24-25(30)31-17-32-27(24)35-11-7-19(8-12-35)26-33-23(20-5-6-22(29)21(28)15-20)16-36(26)14-13-34-9-3-4-10-34/h5-6,15-19H,3-4,7-14H2,1-2H3,(H2,30,31,32)
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n/an/a 2n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM182590
PNG
(US9145392, 291)
Show SMILES CCOc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN(C)C)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H31F4N7O/c1-4-37-21-22(30)31-15-32-24(21)35-9-7-16(8-10-35)23-33-20(14-36(23)12-11-34(2)3)17-5-6-19(26)18(13-17)25(27,28)29/h5-6,13-16H,4,7-12H2,1-3H3,(H2,30,31,32)
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n/an/a 8n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM182591
PNG
(US9145392, 292)
Show SMILES CC(C)Oc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN(C)C)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C26H33F4N7O/c1-16(2)38-22-23(31)32-15-33-25(22)36-9-7-17(8-10-36)24-34-21(14-37(24)12-11-35(3)4)18-5-6-20(27)19(13-18)26(28,29)30/h5-6,13-17H,7-12H2,1-4H3,(H2,31,32,33)
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n/an/a 7.60n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
AKT/p21CIP1


(Homo sapiens (human))
BDBM182592
PNG
(US9145392, 293)
Show SMILES CCOc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN(C)C)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C25H34FN7O/c1-5-34-22-23(27)28-16-29-25(22)32-10-8-18(9-11-32)24-30-21(15-33(24)13-12-31(3)4)19-6-7-20(26)17(2)14-19/h6-7,14-16,18H,5,8-13H2,1-4H3,(H2,27,28,29)
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n/an/a 1.70n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (human))
BDBM182396
PNG
(US9145392, 97)
Show SMILES COc1c(N)ncnc1N1CCC(CC1)c1nc(cn1CCN1CCC1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C25H29F4N7O/c1-37-21-22(30)31-15-32-24(21)35-9-5-16(6-10-35)23-33-20(14-36(23)12-11-34-7-2-8-34)17-3-4-19(26)18(13-17)25(27,28)29/h3-4,13-16H,2,5-12H2,1H3,(H2,30,31,32)
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n/an/a 2.20n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...


US Patent US9145392 (2015)

More data for this
Ligand-Target Pair