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9 similar compounds to monomer 184960

Compile data set for download or QSAR
Wt: 358.2
BDBM184919
Wt: 265.3
BDBM184641
Wt: 358.2
BDBM184653
Wt: 344.2
BDBM184657
Wt: 399.0
BDBM184949
Wt: 358.2
BDBM184950
Wt: 372.2
BDBM185110
Wt: 330.2
BDBM184954
Wt: 316.1
BDBM184955

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 184919,184641,184653,184657,184949,184950,185110,184954,184955   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-myristoyltransferase (NMT1)


(Trypanosoma brucei)
BDBM184641
PNG
(US9156811, DDD48025)
Show SMILES Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccccc1
Show InChI InChI=1S/C12H15N3O2S/c1-9-12(10(2)15(3)13-9)14-18(16,17)11-7-5-4-6-8-11/h4-8H,1-3H3,(H-,14,16,17)
UniProtKB/TrEMBL

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PC sid
UniChem

Similars

US Patent
n/an/a 1.18E+4n/an/an/an/a7.425



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SGM
More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Leishmania major)
BDBM185110
PNG
(US9156811, DDD100871)
Show SMILES CCCc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C14H18BrN3O2S/c1-4-5-13-14(10(2)18(3)16-13)17-21(19,20)12-8-6-11(15)7-9-12/h6-9H,4-5H2,1-3H3,(H-,17,19,20)
PDB

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US Patent
n/an/a>1.00E+3n/an/an/an/a7.425



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SGM
More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Trypanosoma brucei)
BDBM184657
PNG
(US9156811, DDD71240)
Show SMILES Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1cccc(Br)c1
Show InChI InChI=1S/C12H14BrN3O2S/c1-8-12(9(2)16(3)14-8)15-19(17,18)11-6-4-5-10(13)7-11/h4-7H,1-3H3,(H-,15,17,18)
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US Patent
n/an/a 8.00E+3n/an/an/an/a7.425



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SGM
More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Trypanosoma brucei)
BDBM184919
PNG
(US9156811, DDD87766)
Show SMILES CN(c1c(C)nn(C)c1C)[S+]([O-])(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C13H16BrN3O2S/c1-9-13(10(2)16(3)15-9)17(4)20(18,19)12-7-5-11(14)6-8-12/h5-8H,1-4H3
UniProtKB/TrEMBL

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US Patent
n/an/a 1.00E+4n/an/an/an/a7.425



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SGM
More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Trypanosoma brucei)
BDBM184949
PNG
(US9156811, DDD88315)
Show SMILES Cc1c(N[S+]([O-])(=O)c2c(Cl)cc(Br)cc2Cl)cnn1C
Show InChI InChI=1S/C11H10BrCl2N3O2S/c1-6-10(5-15-17(6)2)16-20(18,19)11-8(13)3-7(12)4-9(11)14/h3-5H,1-2H3,(H-,16,18,19)
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US Patent
n/an/a 2.00E+4n/an/an/an/a7.425



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SGM
More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Trypanosoma brucei)
BDBM184950
PNG
(US9156811, DDD88316)
Show SMILES Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(Br)cc1C
Show InChI InChI=1S/C13H16BrN3O2S/c1-8-7-11(14)5-6-12(8)20(18,19)16-13-9(2)15-17(4)10(13)3/h5-7H,1-4H3,(H-,16,18,19)
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US Patent
n/an/a 1.27E+4n/an/an/an/a7.425



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SGM
More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Trypanosoma brucei)
BDBM184954
PNG
(US9156811, DDD88320)
Show SMILES Cc1nn(C)cc1N[S+]([O-])(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C11H12BrN3O2S/c1-8-11(7-15(2)13-8)14-18(16,17)10-5-3-9(12)4-6-10/h3-7H,1-2H3,(H-,14,16,17)
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US Patent
n/an/a 4.41E+4n/an/an/an/a7.425



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SGM
More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Trypanosoma brucei)
BDBM184955
PNG
(US9156811, DDD88321)
Show SMILES Cn1cc(N[S+]([O-])(=O)c2ccc(Br)cc2)cn1
Show InChI InChI=1S/C10H10BrN3O2S/c1-14-7-9(6-12-14)13-17(15,16)10-4-2-8(11)3-5-10/h2-7H,1H3,(H-,13,15,16)
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US Patent
n/an/a>1.00E+5n/an/an/an/a7.425



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SGM
More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Trypanosoma brucei)
BDBM185110
PNG
(US9156811, DDD100871)
Show SMILES CCCc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C14H18BrN3O2S/c1-4-5-13-14(10(2)18(3)16-13)17-21(19,20)12-8-6-11(15)7-9-12/h6-9H,4-5H2,1-3H3,(H-,17,19,20)
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US Patent
n/an/a 7.95E+3n/an/an/an/a7.425



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SGM
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM184949
PNG
(US9156811, DDD88315)
Show SMILES Cc1c(N[S+]([O-])(=O)c2c(Cl)cc(Br)cc2Cl)cnn1C
Show InChI InChI=1S/C11H10BrCl2N3O2S/c1-6-10(5-15-17(6)2)16-20(18,19)11-8(13)3-7(12)4-9(11)14/h3-5H,1-2H3,(H-,16,18,19)
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US Patent
n/an/a 7.08E+4n/an/an/an/a7.425



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SGM
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM184950
PNG
(US9156811, DDD88316)
Show SMILES Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(Br)cc1C
Show InChI InChI=1S/C13H16BrN3O2S/c1-8-7-11(14)5-6-12(8)20(18,19)16-13-9(2)15-17(4)10(13)3/h5-7H,1-4H3,(H-,16,18,19)
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US Patent
n/an/a 1.07E+5n/an/an/an/a7.425



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SGM
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM184954
PNG
(US9156811, DDD88320)
Show SMILES Cc1nn(C)cc1N[S+]([O-])(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C11H12BrN3O2S/c1-8-11(7-15(2)13-8)14-18(16,17)10-5-3-9(12)4-6-10/h3-7H,1-2H3,(H-,14,16,17)
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n/an/a>1.00E+5n/an/an/an/a7.425



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SGM
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM184955
PNG
(US9156811, DDD88321)
Show SMILES Cn1cc(N[S+]([O-])(=O)c2ccc(Br)cc2)cn1
Show InChI InChI=1S/C10H10BrN3O2S/c1-14-7-9(6-12-14)13-17(15,16)10-4-2-8(11)3-5-10/h2-7H,1H3,(H-,13,15,16)
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n/an/a>1.00E+5n/an/an/an/a7.425



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SGM
More data for this
Ligand-Target Pair
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)


(Homo sapiens (Human))
BDBM185110
PNG
(US9156811, DDD100871)
Show SMILES CCCc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C14H18BrN3O2S/c1-4-5-13-14(10(2)18(3)16-13)17-21(19,20)12-8-6-11(15)7-9-12/h6-9H,4-5H2,1-3H3,(H-,17,19,20)
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n/an/a>1.00E+3n/an/an/an/a7.425



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SGM
More data for this
Ligand-Target Pair
N-myristoyltransferase (NMT1)


(Trypanosoma brucei)
BDBM184653
PNG
(US9156811, DDD71235)
Show SMILES Cc1nn(C)c(C)c1N[S+]([O-])(=O)c1ccc(Br)c(C)c1
Show InChI InChI=1S/C13H16BrN3O2S/c1-8-7-11(5-6-12(8)14)20(18,19)16-13-9(2)15-17(4)10(13)3/h5-7H,1-4H3,(H-,16,18,19)
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n/an/a 5.40E+3n/an/an/an/a7.425



Univeristy of Dundee

US Patent


Assay Description
Measurement of the ability of compounds to inhibit the NMT-1 and/or NMT-2 enzyme isoforms of human, trypanosome (T. brucei), leishmanial (L. major) a...


US Patent US9156811 (2015)


BindingDB Entry DOI: 10.7270/Q2K35SGM
More data for this
Ligand-Target Pair