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4 similar compounds to monomer 185404

Compile data set for download or QSAR
Wt: 292.3
BDBM185373
Wt: 332.4
BDBM185401
Wt: 293.3
BDBM185407
Wt: 332.4
BDBM185411

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 185373,185401,185407,185411   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185373
PNG
(US9156845, 15)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
Show InChI InChI=1S/C18H20N4/c1-13-6-5-9-22(11-13)18-16-15(14-7-3-2-4-8-14)10-19-17(16)20-12-21-18/h2-4,7-8,10,12-13H,5-6,9,11H2,1H3,(H,19,20,21)/t13-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 91n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185401
PNG
(US9156845, 45)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3ccc4[nH]ncc4c3)c12
Show InChI InChI=1S/C19H18N6/c1-12-3-2-6-25(10-12)19-17-15(9-20-18(17)21-11-22-19)13-4-5-16-14(7-13)8-23-24-16/h4-5,7-9,11-12H,2-3,6,10H2,1H3/b15-13+/t12-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 67n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185407
PNG
(US9156845, 51)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccnc3)c12
Show InChI InChI=1S/C17H19N5/c1-12-4-3-7-22(10-12)17-15-14(13-5-2-6-18-8-13)9-19-16(15)20-11-21-17/h2,5-6,8-9,11-12H,3-4,7,10H2,1H3,(H,19,20,21)/t12-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 56n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185411
PNG
(US9156845, 55)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cnc4cc[nH]c4c3)c12
Show InChI InChI=1S/C19H18N6/c1-12-3-2-6-25(10-12)19-17-14(9-22-18(17)23-11-24-19)13-7-16-15(21-8-13)4-5-20-16/h4-5,7-9,11-12H,2-3,6,10H2,1H3/b14-13-/t12-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 50n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185373
PNG
(US9156845, 15)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3ccccc3)c12
Show InChI InChI=1S/C18H20N4/c1-13-6-5-9-22(11-13)18-16-15(14-7-3-2-4-8-14)10-19-17(16)20-12-21-18/h2-4,7-8,10,12-13H,5-6,9,11H2,1H3,(H,19,20,21)/t13-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 92n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185401
PNG
(US9156845, 45)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3ccc4[nH]ncc4c3)c12
Show InChI InChI=1S/C19H18N6/c1-12-3-2-6-25(10-12)19-17-15(9-20-18(17)21-11-22-19)13-4-5-16-14(7-13)8-23-24-16/h4-5,7-9,11-12H,2-3,6,10H2,1H3/b15-13+/t12-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 66n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185407
PNG
(US9156845, 51)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cccnc3)c12
Show InChI InChI=1S/C17H19N5/c1-12-4-3-7-22(10-12)17-15-14(13-5-2-6-18-8-13)9-19-16(15)20-11-21-17/h2,5-6,8-9,11-12H,3-4,7,10H2,1H3,(H,19,20,21)/t12-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 95n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185411
PNG
(US9156845, 55)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cnc4cc[nH]c4c3)c12
Show InChI InChI=1S/C19H18N6/c1-12-3-2-6-25(10-12)19-17-14(9-22-18(17)23-11-24-19)13-7-16-15(21-8-13)4-5-20-16/h4-5,7-9,11-12H,2-3,6,10H2,1H3/b14-13-/t12-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 53n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair