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3 similar compounds to monomer 185470

Compile data set for download or QSAR
Wt: 296.3
BDBM185374
Wt: 310.3
BDBM185379
Wt: 300.3
BDBM185433

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 185374,185379,185433   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185374
PNG
(US9156845, 17)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12
Show InChI InChI=1S/C16H20N6/c1-11-4-3-5-22(8-11)16-14-13(12-6-20-21(2)9-12)7-17-15(14)18-10-19-16/h6-7,9-11H,3-5,8H2,1-2H3,(H,17,18,19)/t11-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 14n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185379
PNG
(US9156845, 22)
Show SMILES C[C@H]1C[C@@H](C)CN(C1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12
Show InChI InChI=1S/C17H22N6/c1-11-4-12(2)8-23(7-11)17-15-14(13-5-21-22(3)9-13)6-18-16(15)19-10-20-17/h5-6,9-12H,4,7-8H2,1-3H3,(H,18,19,20)/t11-,12+
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 16n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185433
PNG
(US9156845, 81)
Show SMILES Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCC(F)CC3)c12
Show InChI InChI=1S/C15H17FN6/c1-21-8-10(6-20-21)12-7-17-14-13(12)15(19-9-18-14)22-4-2-11(16)3-5-22/h6-9,11H,2-5H2,1H3,(H,17,18,19)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 50n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185374
PNG
(US9156845, 17)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12
Show InChI InChI=1S/C16H20N6/c1-11-4-3-5-22(8-11)16-14-13(12-6-20-21(2)9-12)7-17-15(14)18-10-19-16/h6-7,9-11H,3-5,8H2,1-2H3,(H,17,18,19)/t11-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 12n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185379
PNG
(US9156845, 22)
Show SMILES C[C@H]1C[C@@H](C)CN(C1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12
Show InChI InChI=1S/C17H22N6/c1-11-4-12(2)8-23(7-11)17-15-14(13-5-21-22(3)9-13)6-18-16(15)19-10-20-17/h5-6,9-12H,4,7-8H2,1-3H3,(H,18,19,20)/t11-,12+
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 16n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185433
PNG
(US9156845, 81)
Show SMILES Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCC(F)CC3)c12
Show InChI InChI=1S/C15H17FN6/c1-21-8-10(6-20-21)12-7-17-14-13(12)15(19-9-18-14)22-4-2-11(16)3-5-22/h6-9,11H,2-5H2,1H3,(H,17,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 36n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair