BindingDB logo
myBDB logout

5 similar compounds to monomer 185379

Compile data set for download or QSAR
Wt: 296.3
BDBM185374
Wt: 300.3
BDBM185433
Wt: 298.3
BDBM185467
Wt: 300.3
BDBM185470
Wt: 268.3
BDBM185474

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 185374,185433,185467,185470,185474   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185374
PNG
(US9156845, 17)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12
Show InChI InChI=1S/C16H20N6/c1-11-4-3-5-22(8-11)16-14-13(12-6-20-21(2)9-12)7-17-15(14)18-10-19-16/h6-7,9-11H,3-5,8H2,1-2H3,(H,17,18,19)/t11-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 14n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185433
PNG
(US9156845, 81)
Show SMILES Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCC(F)CC3)c12
Show InChI InChI=1S/C15H17FN6/c1-21-8-10(6-20-21)12-7-17-14-13(12)15(19-9-18-14)22-4-2-11(16)3-5-22/h6-9,11H,2-5H2,1H3,(H,17,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 36n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185467
PNG
(US9156845, 120)
Show SMILES Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCCC(O)C3)c12
Show InChI InChI=1S/C15H18N6O/c1-20-7-10(5-19-20)12-6-16-14-13(12)15(18-9-17-14)21-4-2-3-11(22)8-21/h5-7,9,11,22H,2-4,8H2,1H3,(H,16,17,18)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 44n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185470
PNG
(US9156845, 123)
Show SMILES Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCCC(F)C3)c12
Show InChI InChI=1S/C15H17FN6/c1-21-7-10(5-20-21)12-6-17-14-13(12)15(19-9-18-14)22-4-2-3-11(16)8-22/h5-7,9,11H,2-4,8H2,1H3,(H,17,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 31n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185474
PNG
(US9156845, 127)
Show SMILES CN(C1CC1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12
Show InChI InChI=1S/C14H16N6/c1-19-7-9(5-18-19)11-6-15-13-12(11)14(17-8-16-13)20(2)10-3-4-10/h5-8,10H,3-4H2,1-2H3,(H,15,16,17)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 37n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185374
PNG
(US9156845, 17)
Show SMILES C[C@H]1CCCN(C1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12
Show InChI InChI=1S/C16H20N6/c1-11-4-3-5-22(8-11)16-14-13(12-6-20-21(2)9-12)7-17-15(14)18-10-19-16/h6-7,9-11H,3-5,8H2,1-2H3,(H,17,18,19)/t11-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 12n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185433
PNG
(US9156845, 81)
Show SMILES Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCC(F)CC3)c12
Show InChI InChI=1S/C15H17FN6/c1-21-8-10(6-20-21)12-7-17-14-13(12)15(19-9-18-14)22-4-2-11(16)3-5-22/h6-9,11H,2-5H2,1H3,(H,17,18,19)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 50n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185467
PNG
(US9156845, 120)
Show SMILES Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCCC(O)C3)c12
Show InChI InChI=1S/C15H18N6O/c1-20-7-10(5-19-20)12-6-16-14-13(12)15(18-9-17-14)21-4-2-3-11(22)8-21/h5-7,9,11,22H,2-4,8H2,1H3,(H,16,17,18)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 34n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185470
PNG
(US9156845, 123)
Show SMILES Cn1cc(cn1)-c1c[nH]c2ncnc(N3CCCC(F)C3)c12
Show InChI InChI=1S/C15H17FN6/c1-21-7-10(5-20-21)12-6-17-14-13(12)15(19-9-18-14)22-4-2-3-11(16)8-22/h5-7,9,11H,2-4,8H2,1H3,(H,17,18,19)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 27n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185474
PNG
(US9156845, 127)
Show SMILES CN(C1CC1)c1ncnc2[nH]cc(-c3cnn(C)c3)c12
Show InChI InChI=1S/C14H16N6/c1-19-7-9(5-18-19)11-6-15-13-12(11)14(17-8-16-13)20(2)10-3-4-10/h5-8,10H,3-4H2,1-2H3,(H,15,16,17)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 37n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair