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6 similar compounds to monomer 185519

Compile data set for download or QSAR
Wt: 294.3
BDBM185522
Wt: 293.3
BDBM185381
Wt: 302.7
BDBM185382
Wt: 286.3
BDBM185529
Wt: 286.3
BDBM185535
Wt: 310.3
BDBM185450

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 185522,185381,185382,185529,185535,185450   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185381
PNG
(US9156845, 24)
Show SMILES COc1ccc(cc1-c1c[nH]c2ncnc(N(C)C)c12)[N+]#[C-]
Show InChI InChI=1S/C16H15N5O/c1-17-10-5-6-13(22-4)11(7-10)12-8-18-15-14(12)16(21(2)3)20-9-19-15/h5-9H,2-4H3,(H,18,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 24n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185382
PNG
(US9156845, 25)
Show SMILES COc1ccc(Cl)cc1-c1c[nH]c2ncnc(N(C)C)c12
Show InChI InChI=1S/C15H15ClN4O/c1-20(2)15-13-11(7-17-14(13)18-8-19-15)10-6-9(16)4-5-12(10)21-3/h4-8H,1-3H3,(H,17,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 22n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185450
PNG
(US9156845, 101)
Show SMILES COc1ccccc1-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C17H18N4O2/c1-22-14-5-3-2-4-12(14)13-10-18-16-15(13)17(20-11-19-16)21-6-8-23-9-7-21/h2-5,10-11H,6-9H2,1H3,(H,18,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 14n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185522
PNG
(US9156845, 176)
Show SMILES COc1ccccc1-c1c[nH]c2ncnc(N3CCCC3)c12
Show InChI InChI=1S/C17H18N4O/c1-22-14-7-3-2-6-12(14)13-10-18-16-15(13)17(20-11-19-16)21-8-4-5-9-21/h2-3,6-7,10-11H,4-5,8-9H2,1H3,(H,18,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 54n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185529
PNG
(US9156845, 183)
Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N(C)C)c12
Show InChI InChI=1S/C15H15FN4O/c1-20(2)15-13-11(7-17-14(13)18-8-19-15)10-6-9(16)4-5-12(10)21-3/h4-8H,1-3H3,(H,17,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 13n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185535
PNG
(US9156845, 189)
Show SMILES COc1cccc(F)c1-c1c[nH]c2ncnc(N(C)C)c12
Show InChI InChI=1S/C15H15FN4O/c1-20(2)15-13-9(7-17-14(13)18-8-19-15)12-10(16)5-4-6-11(12)21-3/h4-8H,1-3H3,(H,17,18,19)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 27n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185381
PNG
(US9156845, 24)
Show SMILES COc1ccc(cc1-c1c[nH]c2ncnc(N(C)C)c12)[N+]#[C-]
Show InChI InChI=1S/C16H15N5O/c1-17-10-5-6-13(22-4)11(7-10)12-8-18-15-14(12)16(21(2)3)20-9-19-15/h5-9H,2-4H3,(H,18,19,20)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 30n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185382
PNG
(US9156845, 25)
Show SMILES COc1ccc(Cl)cc1-c1c[nH]c2ncnc(N(C)C)c12
Show InChI InChI=1S/C15H15ClN4O/c1-20(2)15-13-11(7-17-14(13)18-8-19-15)10-6-9(16)4-5-12(10)21-3/h4-8H,1-3H3,(H,17,18,19)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 19n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185450
PNG
(US9156845, 101)
Show SMILES COc1ccccc1-c1c[nH]c2ncnc(N3CCOCC3)c12
Show InChI InChI=1S/C17H18N4O2/c1-22-14-5-3-2-4-12(14)13-10-18-16-15(13)17(20-11-19-16)21-6-8-23-9-7-21/h2-5,10-11H,6-9H2,1H3,(H,18,19,20)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 23n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185522
PNG
(US9156845, 176)
Show SMILES COc1ccccc1-c1c[nH]c2ncnc(N3CCCC3)c12
Show InChI InChI=1S/C17H18N4O/c1-22-14-7-3-2-6-12(14)13-10-18-16-15(13)17(20-11-19-16)21-8-4-5-9-21/h2-3,6-7,10-11H,4-5,8-9H2,1H3,(H,18,19,20)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 68n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185529
PNG
(US9156845, 183)
Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N(C)C)c12
Show InChI InChI=1S/C15H15FN4O/c1-20(2)15-13-11(7-17-14(13)18-8-19-15)10-6-9(16)4-5-12(10)21-3/h4-8H,1-3H3,(H,17,18,19)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 11n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185535
PNG
(US9156845, 189)
Show SMILES COc1cccc(F)c1-c1c[nH]c2ncnc(N(C)C)c12
Show InChI InChI=1S/C15H15FN4O/c1-20(2)15-13-9(7-17-14(13)18-8-19-15)12-10(16)5-4-6-11(12)21-3/h4-8H,1-3H3,(H,17,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 40n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair