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5 similar compounds to monomer 185531

Compile data set for download or QSAR
Wt: 326.3
BDBM185505
Wt: 344.3
BDBM185509
Wt: 298.3
BDBM185514
Wt: 312.3
BDBM185521
Wt: 344.3
BDBM185527

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 185505,185509,185514,185521,185527   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185505
PNG
(US9156845, 159)
Show SMILES COc1ccccc1-c1c[nH]c2ncnc(N3CCC(F)CC3)c12
Show InChI InChI=1S/C18H19FN4O/c1-24-15-5-3-2-4-13(15)14-10-20-17-16(14)18(22-11-21-17)23-8-6-12(19)7-9-23/h2-5,10-12H,6-9H2,1H3,(H,20,21,22)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 67n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185509
PNG
(US9156845, 163)
Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCC(F)CC3)c12
Show InChI InChI=1S/C18H18F2N4O/c1-25-15-3-2-12(20)8-13(15)14-9-21-17-16(14)18(23-10-22-17)24-6-4-11(19)5-7-24/h2-3,8-11H,4-7H2,1H3,(H,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 25n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185514
PNG
(US9156845, 168)
Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCC3)c12
Show InChI InChI=1S/C16H15FN4O/c1-22-13-4-3-10(17)7-11(13)12-8-18-15-14(12)16(20-9-19-15)21-5-2-6-21/h3-4,7-9H,2,5-6H2,1H3,(H,18,19,20)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 85n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185521
PNG
(US9156845, 175)
Show SMILES COc1ccccc1-c1c[nH]c2ncnc(N3CC[C@H](F)C3)c12
Show InChI InChI=1S/C17H17FN4O/c1-23-14-5-3-2-4-12(14)13-8-19-16-15(13)17(21-10-20-16)22-7-6-11(18)9-22/h2-5,8,10-11H,6-7,9H2,1H3,(H,19,20,21)/t11-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 41n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185527
PNG
(US9156845, 181)
Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCCC(F)C3)c12
Show InChI InChI=1S/C18H18F2N4O/c1-25-15-5-4-11(19)7-13(15)14-8-21-17-16(14)18(23-10-22-17)24-6-2-3-12(20)9-24/h4-5,7-8,10,12H,2-3,6,9H2,1H3,(H,21,22,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 24n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185505
PNG
(US9156845, 159)
Show SMILES COc1ccccc1-c1c[nH]c2ncnc(N3CCC(F)CC3)c12
Show InChI InChI=1S/C18H19FN4O/c1-24-15-5-3-2-4-13(15)14-10-20-17-16(14)18(22-11-21-17)23-8-6-12(19)7-9-23/h2-5,10-12H,6-9H2,1H3,(H,20,21,22)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 74n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185509
PNG
(US9156845, 163)
Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCC(F)CC3)c12
Show InChI InChI=1S/C18H18F2N4O/c1-25-15-3-2-12(20)8-13(15)14-9-21-17-16(14)18(23-10-22-17)24-6-4-11(19)5-7-24/h2-3,8-11H,4-7H2,1H3,(H,21,22,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 29n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185514
PNG
(US9156845, 168)
Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCC3)c12
Show InChI InChI=1S/C16H15FN4O/c1-22-13-4-3-10(17)7-11(13)12-8-18-15-14(12)16(20-9-19-15)21-5-2-6-21/h3-4,7-9H,2,5-6H2,1H3,(H,18,19,20)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 75n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM185521
PNG
(US9156845, 175)
Show SMILES COc1ccccc1-c1c[nH]c2ncnc(N3CC[C@H](F)C3)c12
Show InChI InChI=1S/C17H17FN4O/c1-23-14-5-3-2-4-12(14)13-8-19-16-15(13)17(21-10-20-16)22-7-6-11(18)9-22/h2-5,8,10-11H,6-7,9H2,1H3,(H,19,20,21)/t11-/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 54n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM185527
PNG
(US9156845, 181)
Show SMILES COc1ccc(F)cc1-c1c[nH]c2ncnc(N3CCCC(F)C3)c12
Show InChI InChI=1S/C18H18F2N4O/c1-25-15-5-4-11(19)7-13(15)14-8-21-17-16(14)18(23-10-22-17)24-6-2-3-12(20)9-24/h4-5,7-8,10,12H,2-3,6,9H2,1H3,(H,21,22,23)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 22n/an/an/an/a7.5n/a



Pfizer Inc.

US Patent


Assay Description
LRRK2 kinase activity was measured using Lantha Screen technology from Invitrogen. GST-tagged truncated LRRK2 from Invitrogen (Cat # PV4874) was incu...


US Patent US9156845 (2015)


BindingDB Entry DOI: 10.7270/Q2DB80MW
More data for this
Ligand-Target Pair