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4 similar compounds to monomer 19033

Compile data set for download or QSAR
Wt: 548.5
BDBM19029
Wt: 553.5
BDBM19032
Wt: 513.5
BDBM19034
Wt: 541.5
BDBM19035

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 19029,19032,19034,19035   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor X


(Homo sapiens (Human))
BDBM19032
PNG
(1-(3-amino-1,2-benzoxazol-5-yl)-N-{1-[2-(pyrrolidi...)
Show SMILES Nc1noc2ccc(cc12)-n1nc(cc1C(=O)NC1CCN(CC1)c1ccccc1CN1CCCC1)C(F)(F)F
Show InChI InChI=1S/C28H30F3N7O2/c29-28(30,31)25-16-23(38(34-25)20-7-8-24-21(15-20)26(32)35-40-24)27(39)33-19-9-13-37(14-10-19)22-6-2-1-5-18(22)17-36-11-3-4-12-36/h1-2,5-8,15-16,19H,3-4,9-14,17H2,(H2,32,35)(H,33,39)
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Article
PubMed
0.610 -12.4n/an/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...


Bioorg Med Chem Lett 17: 1432-7 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.071
BindingDB Entry DOI: 10.7270/Q2KD1W5D
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM19034
PNG
(1-(3-amino-1,2-benzoxazol-5-yl)-N-(1-{2-[(methylam...)
Show SMILES CNCc1ccccc1N1CCC(CC1)NC(=O)c1cc(nn1-c1ccc2onc(N)c2c1)C(F)(F)F
Show InChI InChI=1S/C25H26F3N7O2/c1-30-14-15-4-2-3-5-19(15)34-10-8-16(9-11-34)31-24(36)20-13-22(25(26,27)28)32-35(20)17-6-7-21-18(12-17)23(29)33-37-21/h2-7,12-13,16,30H,8-11,14H2,1H3,(H2,29,33)(H,31,36)
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Article
PubMed
0.670 -12.4n/an/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...


Bioorg Med Chem Lett 17: 1432-7 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.071
BindingDB Entry DOI: 10.7270/Q2KD1W5D
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM19035
PNG
(1-(3-amino-1,2-benzoxazol-5-yl)-N-[1-(2-{[ethyl(me...)
Show SMILES CCN(C)Cc1ccccc1N1CCC(CC1)NC(=O)c1cc(nn1-c1ccc2onc(N)c2c1)C(F)(F)F
Show InChI InChI=1S/C27H30F3N7O2/c1-3-35(2)16-17-6-4-5-7-21(17)36-12-10-18(11-13-36)32-26(38)22-15-24(27(28,29)30)33-37(22)19-8-9-23-20(14-19)25(31)34-39-23/h4-9,14-15,18H,3,10-13,16H2,1-2H3,(H2,31,34)(H,32,38)
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Article
PubMed
0.700 -12.4n/an/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...


Bioorg Med Chem Lett 17: 1432-7 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.071
BindingDB Entry DOI: 10.7270/Q2KD1W5D
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM19029
PNG
(1-(3-amino-1,2-benzoxazol-5-yl)-N-[1-(2-methanesul...)
Show SMILES CS(=O)(=O)c1ccccc1N1CCC(CC1)NC(=O)c1cc(nn1-c1ccc2onc(N)c2c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N6O4S/c1-38(35,36)20-5-3-2-4-17(20)32-10-8-14(9-11-32)29-23(34)18-13-21(24(25,26)27)30-33(18)15-6-7-19-16(12-15)22(28)31-37-19/h2-7,12-14H,8-11H2,1H3,(H2,28,31)(H,29,34)
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Article
PubMed
1.70 -11.8n/an/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
Ki values were obtained from human purified enzyme. All assays were run in microtiter plates. Plates were read for 30 min at 405 nm. Rates were deter...


Bioorg Med Chem Lett 17: 1432-7 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.071
BindingDB Entry DOI: 10.7270/Q2KD1W5D
More data for this
Ligand-Target Pair