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90 similar compounds to monomer 190906

Compile data set for download or QSAR
Wt: 445.5
BDBM190969		Wt: 445.5
BDBM190936Purchase		Wt: 481.4
BDBM190913		Wt: 481.4
BDBM190918		Wt: 511.5
BDBM190920
Wt: 481.4
BDBM190921		Wt: 511.5
BDBM190923		Wt: 459.5
BDBM190924		Wt: 489.5
BDBM190926		Wt: 507.5
BDBM190927
Wt: 507.5
BDBM190928		Wt: 485.5
BDBM190929		Wt: 517.4
BDBM190930		Wt: 517.4
BDBM190931		Wt: 495.5
BDBM190932
Displayed 1 to 15 (of 90 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 52 hits for monomerid = 190969,190936,190913,190918,190920,190921,190923,190924,190926,190927,190928,190929,190930,190931,190932   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190918
PNG
(US10077266, Example 29 | US9181249, 29 | US9708313...)
Show SMILES CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)C(C)=O
Show InChI InChI=1S/C23H27F4N5O2/c1-13-21-18(7-10-32(13)14(2)33)29-23(22(30-21)28-12-20(26)27)31-8-5-16(6-9-31)34-19-4-3-15(24)11-17(19)25/h3-4,11,13,16,20H,5-10,12H2,1-2H3,(H,28,30)
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n/an/a 0.178n/an/an/an/an/a37



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190969
PNG
(US10077266, Example 156 | US9181249, 156 | US91812...)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-20-13-30(15(3)31)11-8-19(20)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
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n/an/a 9.50E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190921
PNG
(US10077266, Example 32 | US9181249, 32 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H27F4N5O2/c1-13-21-18(7-10-32(13)14(2)33)29-22(28-12-20(26)27)23(30-21)31-8-5-16(6-9-31)34-19-4-3-15(24)11-17(19)25/h3-4,11,13,16,20H,5-10,12H2,1-2H3,(H,28,29)
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n/an/a 0.0760n/an/an/an/an/a37



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190923
PNG
(US10077266, Example 34 | US9181249, 34 | US9708313...)
Show SMILES COCC(=O)N1CCc2nc(NCC(F)F)c(nc2C1C)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C24H29F4N5O3/c1-14-22-18(7-10-33(14)21(34)13-35-2)30-23(29-12-20(27)28)24(31-22)32-8-5-16(6-9-32)36-19-4-3-15(25)11-17(19)26/h3-4,11,14,16,20H,5-10,12-13H2,1-2H3,(H,29,30)
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n/an/a 0.0680n/an/an/an/an/a37



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190924
PNG
(US10077266, Example 35 | US9181249, 35 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H31F2N5O2/c1-14(2)27-23-24(29-22-15(3)31(16(4)32)12-9-20(22)28-23)30-10-7-18(8-11-30)33-21-6-5-17(25)13-19(21)26/h5-6,13-15,18H,7-12H2,1-4H3,(H,27,28)
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n/an/a 0.0880n/an/an/an/an/a37



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190926
PNG
(US10077266, Example 37 | US9181249, 37 | US9708313...)
Show SMILES COCC(=O)N1CCc2nc(NC(C)C)c(nc2C1C)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C25H33F2N5O3/c1-15(2)28-24-25(30-23-16(3)32(22(33)14-34-4)12-9-20(23)29-24)31-10-7-18(8-11-31)35-21-6-5-17(26)13-19(21)27/h5-6,13,15-16,18H,7-12,14H2,1-4H3,(H,28,29)
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n/an/a 0.0910n/an/an/an/an/a37



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190927
PNG
(US10077266, Example 38 | US9181249, 38 | US9708313...)
Show SMILES CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)C(=O)C1CC1
Show InChI InChI=1S/C25H29F4N5O2/c1-14-22-19(8-11-34(14)25(35)15-2-3-15)31-24(23(32-22)30-13-21(28)29)33-9-6-17(7-10-33)36-20-5-4-16(26)12-18(20)27/h4-5,12,14-15,17,21H,2-3,6-11,13H2,1H3,(H,30,32)
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n/an/a 0.0850n/an/an/an/an/a37



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190928
PNG
(US10077266, Example 39 | US9181249, 39 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CC1
Show InChI InChI=1S/C25H29F4N5O2/c1-14-22-19(8-11-34(14)25(35)15-2-3-15)31-23(30-13-21(28)29)24(32-22)33-9-6-17(7-10-33)36-20-5-4-16(26)12-18(20)27/h4-5,12,14-15,17,21H,2-3,6-11,13H2,1H3,(H,30,31)
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n/an/a 0.126n/an/an/an/an/a37



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190929
PNG
(US10077266, Example 40 | US9181249, 40 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CC1
Show InChI InChI=1S/C26H33F2N5O2/c1-15(2)29-24-25(31-23-16(3)33(13-10-21(23)30-24)26(34)17-4-5-17)32-11-8-19(9-12-32)35-22-7-6-18(27)14-20(22)28/h6-7,14-17,19H,4-5,8-13H2,1-3H3,(H,29,30)
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n/an/a 0.259n/an/an/an/an/a37



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190969
PNG
(US10077266, Example 156 | US9181249, 156 | US91812...)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-20-13-30(15(3)31)11-8-19(20)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
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n/an/a 0.00950n/an/an/an/an/a37



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190913
PNG
(US10077266, Example 24 | US9181249, 24 | US9708313...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C23H27F4N5O2/c1-13(2)28-21-22(30-17-7-10-32(12-18(17)29-21)23(33)20(26)27)31-8-5-15(6-9-31)34-19-4-3-14(24)11-16(19)25/h3-4,11,13,15,20H,5-10,12H2,1-2H3,(H,28,29)
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n/an/a 0.129n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190930
PNG
(US10077266, Example 41 | US9181249, 41 | US9708313...)
Show SMILES CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)C(=O)C(F)F
Show InChI InChI=1S/C23H25F6N5O2/c1-12-19-16(6-9-34(12)23(35)20(28)29)31-22(21(32-19)30-11-18(26)27)33-7-4-14(5-8-33)36-17-3-2-13(24)10-15(17)25/h2-3,10,12,14,18,20H,4-9,11H2,1H3,(H,30,32)
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n/an/a 0.212n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190931
PNG
(US10077266, Example 42 | US9181249, 42 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C23H25F6N5O2/c1-12-19-16(6-9-34(12)23(35)20(28)29)31-21(30-11-18(26)27)22(32-19)33-7-4-14(5-8-33)36-17-3-2-13(24)10-15(17)25/h2-3,10,12,14,18,20H,4-9,11H2,1H3,(H,30,31)
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n/an/a 0.193n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190932
PNG
(US10077266, Example 43 | US9181249, 43 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C24H29F4N5O2/c1-13(2)29-22-23(31-20-14(3)33(24(34)21(27)28)11-8-18(20)30-22)32-9-6-16(7-10-32)35-19-5-4-15(25)12-17(19)26/h4-5,12-14,16,21H,6-11H2,1-3H3,(H,29,30)
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n/an/a 0.116n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190936
PNG
(US10077266, Example 141 | US9181249, 141 | US91812...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-19-8-11-30(15(3)31)13-20(19)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
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n/an/a 0.0246n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190969
PNG
(US10077266, Example 156 | US9181249, 156 | US91812...)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-20-13-30(15(3)31)11-8-19(20)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
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n/an/a 0.0737n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190936
PNG
(US10077266, Example 141 | US9181249, 141 | US91812...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-19-8-11-30(15(3)31)13-20(19)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
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n/an/a 0.0337n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190932
PNG
(US10077266, Example 43 | US9181249, 43 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C24H29F4N5O2/c1-13(2)29-22-23(31-20-14(3)33(24(34)21(27)28)11-8-18(20)30-22)32-9-6-16(7-10-32)35-19-5-4-15(25)12-17(19)26/h4-5,12-14,16,21H,6-11H2,1-3H3,(H,29,30)
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n/an/a 1.16E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190936
PNG
(US10077266, Example 141 | US9181249, 141 | US91812...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-19-8-11-30(15(3)31)13-20(19)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
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n/an/a 2.46E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190969
PNG
(US10077266, Example 156 | US9181249, 156 | US91812...)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-20-13-30(15(3)31)11-8-19(20)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
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n/an/a 9.50E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190913
PNG
(US10077266, Example 24 | US9181249, 24 | US9708313...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C23H27F4N5O2/c1-13(2)28-21-22(30-17-7-10-32(12-18(17)29-21)23(33)20(26)27)31-8-5-15(6-9-31)34-19-4-3-14(24)11-16(19)25/h3-4,11,13,15,20H,5-10,12H2,1-2H3,(H,28,29)
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n/an/a 1.29E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190918
PNG
(US10077266, Example 29 | US9181249, 29 | US9708313...)
Show SMILES CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)C(C)=O
Show InChI InChI=1S/C23H27F4N5O2/c1-13-21-18(7-10-32(13)14(2)33)29-23(22(30-21)28-12-20(26)27)31-8-5-16(6-9-31)34-19-4-3-15(24)11-17(19)25/h3-4,11,13,16,20H,5-10,12H2,1-2H3,(H,28,30)
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n/an/a 1.78E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190920
PNG
(US10077266, Example 31 | US9181249, 31 | US9708313...)
Show SMILES COCC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1C
Show InChI InChI=1S/C24H29F4N5O3/c1-14-22-18(7-10-33(14)21(34)13-35-2)30-24(23(31-22)29-12-20(27)28)32-8-5-16(6-9-32)36-19-4-3-15(25)11-17(19)26/h3-4,11,14,16,20H,5-10,12-13H2,1-2H3,(H,29,31)
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n/an/a 2.08E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190921
PNG
(US10077266, Example 32 | US9181249, 32 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H27F4N5O2/c1-13-21-18(7-10-32(13)14(2)33)29-22(28-12-20(26)27)23(30-21)31-8-5-16(6-9-31)34-19-4-3-15(24)11-17(19)25/h3-4,11,13,16,20H,5-10,12H2,1-2H3,(H,28,29)
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n/an/a 7.60E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190923
PNG
(US10077266, Example 34 | US9181249, 34 | US9708313...)
Show SMILES COCC(=O)N1CCc2nc(NCC(F)F)c(nc2C1C)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C24H29F4N5O3/c1-14-22-18(7-10-33(14)21(34)13-35-2)30-23(29-12-20(27)28)24(31-22)32-8-5-16(6-9-32)36-19-4-3-15(25)11-17(19)26/h3-4,11,14,16,20H,5-10,12-13H2,1-2H3,(H,29,30)
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n/an/a 6.80E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190924
PNG
(US10077266, Example 35 | US9181249, 35 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H31F2N5O2/c1-14(2)27-23-24(29-22-15(3)31(16(4)32)12-9-20(22)28-23)30-10-7-18(8-11-30)33-21-6-5-17(25)13-19(21)26/h5-6,13-15,18H,7-12H2,1-4H3,(H,27,28)
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n/an/a 8.80E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190926
PNG
(US10077266, Example 37 | US9181249, 37 | US9708313...)
Show SMILES COCC(=O)N1CCc2nc(NC(C)C)c(nc2C1C)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C25H33F2N5O3/c1-15(2)28-24-25(30-23-16(3)32(22(33)14-34-4)12-9-20(23)29-24)31-10-7-18(8-11-31)35-21-6-5-17(26)13-19(21)27/h5-6,13,15-16,18H,7-12,14H2,1-4H3,(H,28,29)
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n/an/a 9.10E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190927
PNG
(US10077266, Example 38 | US9181249, 38 | US9708313...)
Show SMILES CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)C(=O)C1CC1
Show InChI InChI=1S/C25H29F4N5O2/c1-14-22-19(8-11-34(14)25(35)15-2-3-15)31-24(23(32-22)30-13-21(28)29)33-9-6-17(7-10-33)36-20-5-4-16(26)12-18(20)27/h4-5,12,14-15,17,21H,2-3,6-11,13H2,1H3,(H,30,32)
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n/an/a 8.50E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190928
PNG
(US10077266, Example 39 | US9181249, 39 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CC1
Show InChI InChI=1S/C25H29F4N5O2/c1-14-22-19(8-11-34(14)25(35)15-2-3-15)31-23(30-13-21(28)29)24(32-22)33-9-6-17(7-10-33)36-20-5-4-16(26)12-18(20)27/h4-5,12,14-15,17,21H,2-3,6-11,13H2,1H3,(H,30,31)
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n/an/a 1.26E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190929
PNG
(US10077266, Example 40 | US9181249, 40 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CC1
Show InChI InChI=1S/C26H33F2N5O2/c1-15(2)29-24-25(31-23-16(3)33(13-10-21(23)30-24)26(34)17-4-5-17)32-11-8-19(9-12-32)35-22-7-6-18(27)14-20(22)28/h6-7,14-17,19H,4-5,8-13H2,1-3H3,(H,29,30)
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n/an/a 2.59E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190930
PNG
(US10077266, Example 41 | US9181249, 41 | US9708313...)
Show SMILES CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)C(=O)C(F)F
Show InChI InChI=1S/C23H25F6N5O2/c1-12-19-16(6-9-34(12)23(35)20(28)29)31-22(21(32-19)30-11-18(26)27)33-7-4-14(5-8-33)36-17-3-2-13(24)10-15(17)25/h2-3,10,12,14,18,20H,4-9,11H2,1H3,(H,30,32)
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n/an/a 2.12E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190931
PNG
(US10077266, Example 42 | US9181249, 42 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C23H25F6N5O2/c1-12-19-16(6-9-34(12)23(35)20(28)29)31-21(30-11-18(26)27)22(32-19)33-7-4-14(5-8-33)36-17-3-2-13(24)10-15(17)25/h2-3,10,12,14,18,20H,4-9,11H2,1H3,(H,30,31)
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n/an/a 1.93E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190969
PNG
(US10077266, Example 156 | US9181249, 156 | US91812...)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-20-13-30(15(3)31)11-8-19(20)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
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n/an/a 7.37E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190936
PNG
(US10077266, Example 141 | US9181249, 141 | US91812...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-19-8-11-30(15(3)31)13-20(19)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
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n/an/a 3.37E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190913
PNG
(US10077266, Example 24 | US9181249, 24 | US9708313...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C23H27F4N5O2/c1-13(2)28-21-22(30-17-7-10-32(12-18(17)29-21)23(33)20(26)27)31-8-5-15(6-9-31)34-19-4-3-14(24)11-16(19)25/h3-4,11,13,15,20H,5-10,12H2,1-2H3,(H,28,29)
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n/an/a 1.29E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190918
PNG
(US10077266, Example 29 | US9181249, 29 | US9708313...)
Show SMILES CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)C(C)=O
Show InChI InChI=1S/C23H27F4N5O2/c1-13-21-18(7-10-32(13)14(2)33)29-23(22(30-21)28-12-20(26)27)31-8-5-16(6-9-31)34-19-4-3-15(24)11-17(19)25/h3-4,11,13,16,20H,5-10,12H2,1-2H3,(H,28,30)
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n/an/a 1.78E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190920
PNG
(US10077266, Example 31 | US9181249, 31 | US9708313...)
Show SMILES COCC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1C
Show InChI InChI=1S/C24H29F4N5O3/c1-14-22-18(7-10-33(14)21(34)13-35-2)30-24(23(31-22)29-12-20(27)28)32-8-5-16(6-9-32)36-19-4-3-15(25)11-17(19)26/h3-4,11,14,16,20H,5-10,12-13H2,1-2H3,(H,29,31)
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n/an/a 2.08E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190921
PNG
(US10077266, Example 32 | US9181249, 32 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H27F4N5O2/c1-13-21-18(7-10-32(13)14(2)33)29-22(28-12-20(26)27)23(30-21)31-8-5-16(6-9-31)34-19-4-3-15(24)11-17(19)25/h3-4,11,13,16,20H,5-10,12H2,1-2H3,(H,28,29)
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n/an/a 7.60E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190923
PNG
(US10077266, Example 34 | US9181249, 34 | US9708313...)
Show SMILES COCC(=O)N1CCc2nc(NCC(F)F)c(nc2C1C)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C24H29F4N5O3/c1-14-22-18(7-10-33(14)21(34)13-35-2)30-23(29-12-20(27)28)24(31-22)32-8-5-16(6-9-32)36-19-4-3-15(25)11-17(19)26/h3-4,11,14,16,20H,5-10,12-13H2,1-2H3,(H,29,30)
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n/an/a 6.80E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190924
PNG
(US10077266, Example 35 | US9181249, 35 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H31F2N5O2/c1-14(2)27-23-24(29-22-15(3)31(16(4)32)12-9-20(22)28-23)30-10-7-18(8-11-30)33-21-6-5-17(25)13-19(21)26/h5-6,13-15,18H,7-12H2,1-4H3,(H,27,28)
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n/an/a 8.80E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190926
PNG
(US10077266, Example 37 | US9181249, 37 | US9708313...)
Show SMILES COCC(=O)N1CCc2nc(NC(C)C)c(nc2C1C)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C25H33F2N5O3/c1-15(2)28-24-25(30-23-16(3)32(22(33)14-34-4)12-9-20(23)29-24)31-10-7-18(8-11-31)35-21-6-5-17(26)13-19(21)27/h5-6,13,15-16,18H,7-12,14H2,1-4H3,(H,28,29)
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n/an/a 9.10E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190927
PNG
(US10077266, Example 38 | US9181249, 38 | US9708313...)
Show SMILES CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)C(=O)C1CC1
Show InChI InChI=1S/C25H29F4N5O2/c1-14-22-19(8-11-34(14)25(35)15-2-3-15)31-24(23(32-22)30-13-21(28)29)33-9-6-17(7-10-33)36-20-5-4-16(26)12-18(20)27/h4-5,12,14-15,17,21H,2-3,6-11,13H2,1H3,(H,30,32)
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n/an/a 8.50E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190928
PNG
(US10077266, Example 39 | US9181249, 39 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CC1
Show InChI InChI=1S/C25H29F4N5O2/c1-14-22-19(8-11-34(14)25(35)15-2-3-15)31-23(30-13-21(28)29)24(32-22)33-9-6-17(7-10-33)36-20-5-4-16(26)12-18(20)27/h4-5,12,14-15,17,21H,2-3,6-11,13H2,1H3,(H,30,31)
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n/an/a 1.26E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190929
PNG
(US10077266, Example 40 | US9181249, 40 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C1CC1
Show InChI InChI=1S/C26H33F2N5O2/c1-15(2)29-24-25(31-23-16(3)33(13-10-21(23)30-24)26(34)17-4-5-17)32-11-8-19(9-12-32)35-22-7-6-18(27)14-20(22)28/h6-7,14-17,19H,4-5,8-13H2,1-3H3,(H,29,30)
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n/an/a 2.59E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190930
PNG
(US10077266, Example 41 | US9181249, 41 | US9708313...)
Show SMILES CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)C(=O)C(F)F
Show InChI InChI=1S/C23H25F6N5O2/c1-12-19-16(6-9-34(12)23(35)20(28)29)31-22(21(32-19)30-11-18(26)27)33-7-4-14(5-8-33)36-17-3-2-13(24)10-15(17)25/h2-3,10,12,14,18,20H,4-9,11H2,1H3,(H,30,32)
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n/an/a 2.12E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190931
PNG
(US10077266, Example 42 | US9181249, 42 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C23H25F6N5O2/c1-12-19-16(6-9-34(12)23(35)20(28)29)31-21(30-11-18(26)27)22(32-19)33-7-4-14(5-8-33)36-17-3-2-13(24)10-15(17)25/h2-3,10,12,14,18,20H,4-9,11H2,1H3,(H,30,31)
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n/an/a 1.93E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190932
PNG
(US10077266, Example 43 | US9181249, 43 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C24H29F4N5O2/c1-13(2)29-22-23(31-20-14(3)33(24(34)21(27)28)11-8-18(20)30-22)32-9-6-16(7-10-32)35-19-5-4-15(25)12-17(19)26/h4-5,12-14,16,21H,6-11H2,1-3H3,(H,29,30)
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n/an/a 1.16E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190936
PNG
(US10077266, Example 141 | US9181249, 141 | US91812...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-19-8-11-30(15(3)31)13-20(19)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
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n/an/a 2.46E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190969
PNG
(US10077266, Example 156 | US9181249, 156 | US91812...)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-20-13-30(15(3)31)11-8-19(20)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
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n/an/a 7.37E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))		BDBM190936
PNG
(US10077266, Example 141 | US9181249, 141 | US91812...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C23H29F2N5O2/c1-14(2)26-22-23(28-19-8-11-30(15(3)31)13-20(19)27-22)29-9-6-17(7-10-29)32-21-5-4-16(24)12-18(21)25/h4-5,12,14,17H,6-11,13H2,1-3H3,(H,26,27)
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n/an/a 1.38E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Co., Ltd

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...

US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
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