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10 similar compounds to monomer 190999

Compile data set for download or QSAR
Wt: 517.5
BDBM190919
Wt: 517.5
BDBM190922
Wt: 495.5
BDBM190925
Wt: 495.5
BDBM190942
Wt: 493.5
BDBM191040
Wt: 503.5
BDBM190984
Wt: 503.5
BDBM190987
Wt: 481.5
BDBM190892
Wt: 481.5
BDBM190900
Wt: 509.6
BDBM190910

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 190919,190922,190925,190942,191040,190984,190987,190892,190900,190910   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190910
PNG
(US10077266, Example 21 | US9181249, 21 | US9708313...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(=O)(=O)C(C)C
Show InChI InChI=1S/C24H33F2N5O3S/c1-15(2)27-23-24(29-20-9-12-31(14-21(20)28-23)35(32,33)16(3)4)30-10-7-18(8-11-30)34-22-6-5-17(25)13-19(22)26/h5-6,13,15-16,18H,7-12,14H2,1-4H3,(H,27,28)
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US Patent
n/an/a 0.149n/an/an/an/an/a37



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191040
PNG
(US10077266, Example 152 | US9181249, 152 | US97083...)
Show SMILES CS(=O)(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC3CCC3)nc2C1
Show InChI InChI=1S/C23H29F2N5O3S/c1-34(31,32)30-12-9-19-20(14-30)27-22(26-16-3-2-4-16)23(28-19)29-10-7-17(8-11-29)33-21-6-5-15(24)13-18(21)25/h5-6,13,16-17H,2-4,7-12,14H2,1H3,(H,26,27)
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n/an/a 4.93E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190922
PNG
(US10077266, Example 33 | US9181249, 33 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H27F4N5O3S/c1-13-20-17(7-10-31(13)35(2,32)33)28-21(27-12-19(25)26)22(29-20)30-8-5-15(6-9-30)34-18-4-3-14(23)11-16(18)24/h3-4,11,13,15,19H,5-10,12H2,1-2H3,(H,27,28)
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n/an/a 0.0520n/an/an/an/an/a37



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190925
PNG
(US10077266, Example 36 | US9181249, 36 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H31F2N5O3S/c1-14(2)26-22-23(28-21-15(3)30(34(4,31)32)12-9-19(21)27-22)29-10-7-17(8-11-29)33-20-6-5-16(24)13-18(20)25/h5-6,13-15,17H,7-12H2,1-4H3,(H,26,27)
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n/an/a 0.0980n/an/an/an/an/a37



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190987
PNG
(US10077266, Example 100 | US9181249, 100 | US97083...)
Show SMILES CS(=O)(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1
Show InChI InChI=1S/C21H25F4N5O3S/c1-34(31,32)30-9-6-16-17(12-30)27-20(26-11-19(24)25)21(28-16)29-7-4-14(5-8-29)33-18-3-2-13(22)10-15(18)23/h2-3,10,14,19H,4-9,11-12H2,1H3,(H,26,27)
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n/an/a 0.0572n/an/an/an/an/a37



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190892
PNG
(US10077266, Example 3 | US9181249, 3 | US9708313, ...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H29F2N5O3S/c1-14(2)25-21-22(27-18-8-11-29(33(3,30)31)13-19(18)26-21)28-9-6-16(7-10-28)32-20-5-4-15(23)12-17(20)24/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,25,26)
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n/an/a 0.0618n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190900
PNG
(US10077266, Example 11 | US9181249, 11 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H29F2N5O3S/c1-14(2)25-21-22(27-19-13-29(33(3,30)31)11-8-18(19)26-21)28-9-6-16(7-10-28)32-20-5-4-15(23)12-17(20)24/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,25,26)
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n/an/a 0.0956n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190942
PNG
(US10077266, Example 54 | US9181249, 54 | US9708313...)
Show SMILES CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H31F2N5O3S/c1-14(2)26-22-23(27-19-9-12-30(34(4,31)32)15(3)21(19)28-22)29-10-7-17(8-11-29)33-20-6-5-16(24)13-18(20)25/h5-6,13-15,17H,7-12H2,1-4H3,(H,26,28)
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n/an/a 0.0593n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190984
PNG
(US10077266, Example 97 | US9181249, 97 | US9708313...)
Show SMILES CS(=O)(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C21H25F4N5O3S/c1-34(31,32)30-9-6-16-17(12-30)28-21(20(27-16)26-11-19(24)25)29-7-4-14(5-8-29)33-18-3-2-13(22)10-15(18)23/h2-3,10,14,19H,4-9,11-12H2,1H3,(H,26,27)
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n/an/a 0.163n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191040
PNG
(US10077266, Example 152 | US9181249, 152 | US97083...)
Show SMILES CS(=O)(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC3CCC3)nc2C1
Show InChI InChI=1S/C23H29F2N5O3S/c1-34(31,32)30-12-9-19-20(14-30)27-22(26-16-3-2-4-16)23(28-19)29-10-7-17(8-11-29)33-21-6-5-15(24)13-18(21)25/h5-6,13,16-17H,2-4,7-12,14H2,1H3,(H,26,27)
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n/an/a 0.0493n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190942
PNG
(US10077266, Example 54 | US9181249, 54 | US9708313...)
Show SMILES CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H31F2N5O3S/c1-14(2)26-22-23(27-19-9-12-30(34(4,31)32)15(3)21(19)28-22)29-10-7-17(8-11-29)33-20-6-5-16(24)13-18(20)25/h5-6,13-15,17H,7-12H2,1-4H3,(H,26,28)
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n/an/a 5.93E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191040
PNG
(US10077266, Example 152 | US9181249, 152 | US97083...)
Show SMILES CS(=O)(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NC3CCC3)nc2C1
Show InChI InChI=1S/C23H29F2N5O3S/c1-34(31,32)30-12-9-19-20(14-30)27-22(26-16-3-2-4-16)23(28-19)29-10-7-17(8-11-29)33-21-6-5-15(24)13-18(21)25/h5-6,13,16-17H,2-4,7-12,14H2,1H3,(H,26,27)
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n/an/a 4.93E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190892
PNG
(US10077266, Example 3 | US9181249, 3 | US9708313, ...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H29F2N5O3S/c1-14(2)25-21-22(27-18-8-11-29(33(3,30)31)13-19(18)26-21)28-9-6-16(7-10-28)32-20-5-4-15(23)12-17(20)24/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,25,26)
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n/an/a 6.18E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190900
PNG
(US10077266, Example 11 | US9181249, 11 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H29F2N5O3S/c1-14(2)25-21-22(27-19-13-29(33(3,30)31)11-8-18(19)26-21)28-9-6-16(7-10-28)32-20-5-4-15(23)12-17(20)24/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,25,26)
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n/an/a 9.56E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190910
PNG
(US10077266, Example 21 | US9181249, 21 | US9708313...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(=O)(=O)C(C)C
Show InChI InChI=1S/C24H33F2N5O3S/c1-15(2)27-23-24(29-20-9-12-31(14-21(20)28-23)35(32,33)16(3)4)30-10-7-18(8-11-30)34-22-6-5-17(25)13-19(22)26/h5-6,13,15-16,18H,7-12,14H2,1-4H3,(H,27,28)
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n/an/a 1.49E+5n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190919
PNG
(US10077266, Example 30 | US9181249, 30 | US9708313...)
Show SMILES CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)S(C)(=O)=O
Show InChI InChI=1S/C22H27F4N5O3S/c1-13-20-17(7-10-31(13)35(2,32)33)28-22(21(29-20)27-12-19(25)26)30-8-5-15(6-9-30)34-18-4-3-14(23)11-16(18)24/h3-4,11,13,15,19H,5-10,12H2,1-2H3,(H,27,29)
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n/an/a 8.70E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190922
PNG
(US10077266, Example 33 | US9181249, 33 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H27F4N5O3S/c1-13-20-17(7-10-31(13)35(2,32)33)28-21(27-12-19(25)26)22(29-20)30-8-5-15(6-9-30)34-18-4-3-14(23)11-16(18)24/h3-4,11,13,15,19H,5-10,12H2,1-2H3,(H,27,28)
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n/an/a 5.20E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190925
PNG
(US10077266, Example 36 | US9181249, 36 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H31F2N5O3S/c1-14(2)26-22-23(28-21-15(3)30(34(4,31)32)12-9-19(21)27-22)29-10-7-17(8-11-29)33-20-6-5-16(24)13-18(20)25/h5-6,13-15,17H,7-12H2,1-4H3,(H,26,27)
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n/an/a 9.80E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190984
PNG
(US10077266, Example 97 | US9181249, 97 | US9708313...)
Show SMILES CS(=O)(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C21H25F4N5O3S/c1-34(31,32)30-9-6-16-17(12-30)28-21(20(27-16)26-11-19(24)25)29-7-4-14(5-8-29)33-18-3-2-13(22)10-15(18)23/h2-3,10,14,19H,4-9,11-12H2,1H3,(H,26,27)
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n/an/a 1.63E+5n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190987
PNG
(US10077266, Example 100 | US9181249, 100 | US97083...)
Show SMILES CS(=O)(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1
Show InChI InChI=1S/C21H25F4N5O3S/c1-34(31,32)30-9-6-16-17(12-30)27-20(26-11-19(24)25)21(28-16)29-7-4-14(5-8-29)33-18-3-2-13(22)10-15(18)23/h2-3,10,14,19H,4-9,11-12H2,1H3,(H,26,27)
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n/an/a 5.72E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190892
PNG
(US10077266, Example 3 | US9181249, 3 | US9708313, ...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H29F2N5O3S/c1-14(2)25-21-22(27-18-8-11-29(33(3,30)31)13-19(18)26-21)28-9-6-16(7-10-28)32-20-5-4-15(23)12-17(20)24/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,25,26)
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n/an/a 6.18E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190900
PNG
(US10077266, Example 11 | US9181249, 11 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H29F2N5O3S/c1-14(2)25-21-22(27-19-13-29(33(3,30)31)11-8-18(19)26-21)28-9-6-16(7-10-28)32-20-5-4-15(23)12-17(20)24/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,25,26)
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n/an/a 9.56E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190910
PNG
(US10077266, Example 21 | US9181249, 21 | US9708313...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(=O)(=O)C(C)C
Show InChI InChI=1S/C24H33F2N5O3S/c1-15(2)27-23-24(29-20-9-12-31(14-21(20)28-23)35(32,33)16(3)4)30-10-7-18(8-11-30)34-22-6-5-17(25)13-19(22)26/h5-6,13,15-16,18H,7-12,14H2,1-4H3,(H,27,28)
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n/an/a 1.49E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190919
PNG
(US10077266, Example 30 | US9181249, 30 | US9708313...)
Show SMILES CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)S(C)(=O)=O
Show InChI InChI=1S/C22H27F4N5O3S/c1-13-20-17(7-10-31(13)35(2,32)33)28-22(21(29-20)27-12-19(25)26)30-8-5-15(6-9-30)34-18-4-3-14(23)11-16(18)24/h3-4,11,13,15,19H,5-10,12H2,1-2H3,(H,27,29)
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n/an/a 8.70E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190922
PNG
(US10077266, Example 33 | US9181249, 33 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C22H27F4N5O3S/c1-13-20-17(7-10-31(13)35(2,32)33)28-21(27-12-19(25)26)22(29-20)30-8-5-15(6-9-30)34-18-4-3-14(23)11-16(18)24/h3-4,11,13,15,19H,5-10,12H2,1-2H3,(H,27,28)
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n/an/a 5.20E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190925
PNG
(US10077266, Example 36 | US9181249, 36 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H31F2N5O3S/c1-14(2)26-22-23(28-21-15(3)30(34(4,31)32)12-9-19(21)27-22)29-10-7-17(8-11-29)33-20-6-5-16(24)13-18(20)25/h5-6,13-15,17H,7-12H2,1-4H3,(H,26,27)
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n/an/a 9.80E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190942
PNG
(US10077266, Example 54 | US9181249, 54 | US9708313...)
Show SMILES CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)S(C)(=O)=O
Show InChI InChI=1S/C23H31F2N5O3S/c1-14(2)26-22-23(27-19-9-12-30(34(4,31)32)15(3)21(19)28-22)29-10-7-17(8-11-29)33-20-6-5-16(24)13-18(20)25/h5-6,13-15,17H,7-12H2,1-4H3,(H,26,28)
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n/an/a 5.93E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190984
PNG
(US10077266, Example 97 | US9181249, 97 | US9708313...)
Show SMILES CS(=O)(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C21H25F4N5O3S/c1-34(31,32)30-9-6-16-17(12-30)28-21(20(27-16)26-11-19(24)25)29-7-4-14(5-8-29)33-18-3-2-13(22)10-15(18)23/h2-3,10,14,19H,4-9,11-12H2,1H3,(H,26,27)
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n/an/a 1.63E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190987
PNG
(US10077266, Example 100 | US9181249, 100 | US97083...)
Show SMILES CS(=O)(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1
Show InChI InChI=1S/C21H25F4N5O3S/c1-34(31,32)30-9-6-16-17(12-30)27-20(26-11-19(24)25)21(28-16)29-7-4-14(5-8-29)33-18-3-2-13(22)10-15(18)23/h2-3,10,14,19H,4-9,11-12H2,1H3,(H,26,27)
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n/an/a 5.72E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190919
PNG
(US10077266, Example 30 | US9181249, 30 | US9708313...)
Show SMILES CC1N(CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc12)S(C)(=O)=O
Show InChI InChI=1S/C22H27F4N5O3S/c1-13-20-17(7-10-31(13)35(2,32)33)28-22(21(29-20)27-12-19(25)26)30-8-5-15(6-9-30)34-18-4-3-14(23)11-16(18)24/h3-4,11,13,15,19H,5-10,12H2,1-2H3,(H,27,29)
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n/an/a 0.0870n/an/an/an/an/a37



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair