BindingDB logo
myBDB logout

11 similar compounds to monomer 190955

Compile data set for download or QSAR
Wt: 431.4
BDBM190954
Wt: 431.4
BDBM190956
Wt: 433.5
BDBM190957
Wt: 461.5
BDBM190958
Wt: 490.5
BDBM190959
Wt: 433.5
BDBM190962
Wt: 461.5
BDBM190963
Wt: 490.5
BDBM190964
Wt: 461.5
BDBM191004
Wt: 447.4
BDBM191005
Wt: 447.4
BDBM191006

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 190954,190956,190957,190958,190959,190962,190963,190964,191004,191005,191006   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190954
PNG
(US10077266, Example 67 | US9181249, 67 | US9708313...)
Show SMILES CN1CCc2nc(NC3CC3)c(nc2C1)N1CCC(CC1)C(F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H28F3N5/c1-30-9-8-19-20(13-30)29-23(22(28-19)27-16-3-4-16)31-10-6-14(7-11-31)21(26)17-5-2-15(24)12-18(17)25/h2,5,12,14,16,21H,3-4,6-11,13H2,1H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.00940n/an/an/an/an/a37



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191006
PNG
(US10077266, Example 119 | US9181249, 119 | US97083...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@@H](F)c1ccc(F)cc1F)C=O
Show InChI InChI=1S/C23H28F3N5O/c1-14(2)27-22-23(29-19-7-8-30(13-32)12-20(19)28-22)31-9-5-15(6-10-31)21(26)17-4-3-16(24)11-18(17)25/h3-4,11,13-15,21H,5-10,12H2,1-2H3,(H,27,28)/t21-/m1/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.36E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190958
PNG
(US10077266, Example 71 | US9181249, 71 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-21-13-32(15(3)33)11-8-20(21)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.00850n/an/an/an/an/a37



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190959
PNG
(US10077266, Example 72 | US9181249, 72 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H33F3N6O/c1-15(2)29-23-24(31-21-14-34(25(35)32(3)4)12-9-20(21)30-23)33-10-7-16(8-11-33)22(28)18-6-5-17(26)13-19(18)27/h5-6,13,15-16,22H,7-12,14H2,1-4H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0237n/an/an/an/an/a37



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190963
PNG
(US10077266, Example 76 | US9181249, 76 | US9708313...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0134n/an/an/an/an/a37



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190964
PNG
(US10077266, Example 77 | US9181249, 77 | US9708313...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H33F3N6O/c1-15(2)29-23-24(31-20-9-12-34(14-21(20)30-23)25(35)32(3)4)33-10-7-16(8-11-33)22(28)18-6-5-17(26)13-19(18)27/h5-6,13,15-16,22H,7-12,14H2,1-4H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0197n/an/an/an/an/a37



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190957
PNG
(US10077266, Example 70 | US9181249, 70 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C)Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H30F3N5/c1-14(2)27-22-23(29-20-13-30(3)9-8-19(20)28-22)31-10-6-15(7-11-31)21(26)17-5-4-16(24)12-18(17)25/h4-5,12,14-15,21H,6-11,13H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0171n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190962
PNG
(US10077266, Example 75 | US9181249, 75 | US9708313...)
Show SMILES CC(C)Nc1nc2CN(C)CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H30F3N5/c1-14(2)27-22-23(29-19-8-9-30(3)13-20(19)28-22)31-10-6-15(7-11-31)21(26)17-5-4-16(24)12-18(17)25/h4-5,12,14-15,21H,6-11,13H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0303n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191004
PNG
(US10077266, Example 117 | US9181249, 117 | US97083...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@H](F)c1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)/t22-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0274n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191005
PNG
(US10077266, Example 118 | US9181249, 118 | US97083...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@H](F)c1ccc(F)cc1F)C=O
Show InChI InChI=1S/C23H28F3N5O/c1-14(2)27-22-23(29-19-7-8-30(13-32)12-20(19)28-22)31-9-5-15(6-10-31)21(26)17-4-3-16(24)11-18(17)25/h3-4,11,13-15,21H,5-10,12H2,1-2H3,(H,27,28)/t21-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0114n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191006
PNG
(US10077266, Example 119 | US9181249, 119 | US97083...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@@H](F)c1ccc(F)cc1F)C=O
Show InChI InChI=1S/C23H28F3N5O/c1-14(2)27-22-23(29-19-7-8-30(13-32)12-20(19)28-22)31-9-5-15(6-10-31)21(26)17-4-3-16(24)11-18(17)25/h3-4,11,13-15,21H,5-10,12H2,1-2H3,(H,27,28)/t21-/m1/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0236n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190954
PNG
(US10077266, Example 67 | US9181249, 67 | US9708313...)
Show SMILES CN1CCc2nc(NC3CC3)c(nc2C1)N1CCC(CC1)C(F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H28F3N5/c1-30-9-8-19-20(13-30)29-23(22(28-19)27-16-3-4-16)31-10-6-14(7-11-31)21(26)17-5-2-15(24)12-18(17)25/h2,5,12,14,16,21H,3-4,6-11,13H2,1H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.40E+3n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190956
PNG
(US10077266, Example 69 | US9181249, 69 | US9708313...)
Show SMILES CN1CCc2nc(NC3CC3)c(nc2C1)N1CCC(CC1)[C@@H](F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H28F3N5/c1-30-9-8-19-20(13-30)29-23(22(28-19)27-16-3-4-16)31-10-6-14(7-11-31)21(26)17-5-2-15(24)12-18(17)25/h2,5,12,14,16,21H,3-4,6-11,13H2,1H3,(H,27,28)/t21-/m1/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.65E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190957
PNG
(US10077266, Example 70 | US9181249, 70 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C)Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H30F3N5/c1-14(2)27-22-23(29-20-13-30(3)9-8-19(20)28-22)31-10-6-15(7-11-31)21(26)17-5-4-16(24)12-18(17)25/h4-5,12,14-15,21H,6-11,13H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.71E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190958
PNG
(US10077266, Example 71 | US9181249, 71 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-21-13-32(15(3)33)11-8-20(21)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.50E+3n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190959
PNG
(US10077266, Example 72 | US9181249, 72 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H33F3N6O/c1-15(2)29-23-24(31-21-14-34(25(35)32(3)4)12-9-20(21)30-23)33-10-7-16(8-11-33)22(28)18-6-5-17(26)13-19(18)27/h5-6,13,15-16,22H,7-12,14H2,1-4H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.37E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190962
PNG
(US10077266, Example 75 | US9181249, 75 | US9708313...)
Show SMILES CC(C)Nc1nc2CN(C)CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H30F3N5/c1-14(2)27-22-23(29-19-8-9-30(3)13-20(19)28-22)31-10-6-15(7-11-31)21(26)17-5-4-16(24)12-18(17)25/h4-5,12,14-15,21H,6-11,13H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.03E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190963
PNG
(US10077266, Example 76 | US9181249, 76 | US9708313...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.34E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190964
PNG
(US10077266, Example 77 | US9181249, 77 | US9708313...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H33F3N6O/c1-15(2)29-23-24(31-20-9-12-34(14-21(20)30-23)25(35)32(3)4)33-10-7-16(8-11-33)22(28)18-6-5-17(26)13-19(18)27/h5-6,13,15-16,22H,7-12,14H2,1-4H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.97E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191004
PNG
(US10077266, Example 117 | US9181249, 117 | US97083...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@H](F)c1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)/t22-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.74E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191005
PNG
(US10077266, Example 118 | US9181249, 118 | US97083...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@H](F)c1ccc(F)cc1F)C=O
Show InChI InChI=1S/C23H28F3N5O/c1-14(2)27-22-23(29-19-7-8-30(13-32)12-20(19)28-22)31-9-5-15(6-10-31)21(26)17-4-3-16(24)11-18(17)25/h3-4,11,13-15,21H,5-10,12H2,1-2H3,(H,27,28)/t21-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.14E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191006
PNG
(US10077266, Example 119 | US9181249, 119 | US97083...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@@H](F)c1ccc(F)cc1F)C=O
Show InChI InChI=1S/C23H28F3N5O/c1-14(2)27-22-23(29-19-7-8-30(13-32)12-20(19)28-22)31-9-5-15(6-10-31)21(26)17-4-3-16(24)11-18(17)25/h3-4,11,13-15,21H,5-10,12H2,1-2H3,(H,27,28)/t21-/m1/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.36E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190954
PNG
(US10077266, Example 67 | US9181249, 67 | US9708313...)
Show SMILES CN1CCc2nc(NC3CC3)c(nc2C1)N1CCC(CC1)C(F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H28F3N5/c1-30-9-8-19-20(13-30)29-23(22(28-19)27-16-3-4-16)31-10-6-14(7-11-31)21(26)17-5-2-15(24)12-18(17)25/h2,5,12,14,16,21H,3-4,6-11,13H2,1H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 9.40E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190956
PNG
(US10077266, Example 69 | US9181249, 69 | US9708313...)
Show SMILES CN1CCc2nc(NC3CC3)c(nc2C1)N1CCC(CC1)[C@@H](F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H28F3N5/c1-30-9-8-19-20(13-30)29-23(22(28-19)27-16-3-4-16)31-10-6-14(7-11-31)21(26)17-5-2-15(24)12-18(17)25/h2,5,12,14,16,21H,3-4,6-11,13H2,1H3,(H,27,28)/t21-/m1/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.65E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190957
PNG
(US10077266, Example 70 | US9181249, 70 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C)Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H30F3N5/c1-14(2)27-22-23(29-20-13-30(3)9-8-19(20)28-22)31-10-6-15(7-11-31)21(26)17-5-4-16(24)12-18(17)25/h4-5,12,14-15,21H,6-11,13H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.71E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190958
PNG
(US10077266, Example 71 | US9181249, 71 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-21-13-32(15(3)33)11-8-20(21)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8.50E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190959
PNG
(US10077266, Example 72 | US9181249, 72 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(Cc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H33F3N6O/c1-15(2)29-23-24(31-21-14-34(25(35)32(3)4)12-9-20(21)30-23)33-10-7-16(8-11-33)22(28)18-6-5-17(26)13-19(18)27/h5-6,13,15-16,22H,7-12,14H2,1-4H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.37E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190962
PNG
(US10077266, Example 75 | US9181249, 75 | US9708313...)
Show SMILES CC(C)Nc1nc2CN(C)CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H30F3N5/c1-14(2)27-22-23(29-19-8-9-30(3)13-20(19)28-22)31-10-6-15(7-11-31)21(26)17-5-4-16(24)12-18(17)25/h4-5,12,14-15,21H,6-11,13H2,1-3H3,(H,27,28)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3.03E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190963
PNG
(US10077266, Example 76 | US9181249, 76 | US9708313...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.34E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190964
PNG
(US10077266, Example 77 | US9181249, 77 | US9708313...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)C(F)c1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H33F3N6O/c1-15(2)29-23-24(31-20-9-12-34(14-21(20)30-23)25(35)32(3)4)33-10-7-16(8-11-33)22(28)18-6-5-17(26)13-19(18)27/h5-6,13,15-16,22H,7-12,14H2,1-4H3,(H,29,30)
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.97E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191004
PNG
(US10077266, Example 117 | US9181249, 117 | US97083...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@H](F)c1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H30F3N5O/c1-14(2)28-23-24(30-20-8-11-32(15(3)33)13-21(20)29-23)31-9-6-16(7-10-31)22(27)18-5-4-17(25)12-19(18)26/h4-5,12,14,16,22H,6-11,13H2,1-3H3,(H,28,29)/t22-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.74E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191005
PNG
(US10077266, Example 118 | US9181249, 118 | US97083...)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(CC1)[C@H](F)c1ccc(F)cc1F)C=O
Show InChI InChI=1S/C23H28F3N5O/c1-14(2)27-22-23(29-19-7-8-30(13-32)12-20(19)28-22)31-9-5-15(6-10-31)21(26)17-4-3-16(24)11-18(17)25/h3-4,11,13-15,21H,5-10,12H2,1-2H3,(H,27,28)/t21-/m0/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.14E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)

More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190956
PNG
(US10077266, Example 69 | US9181249, 69 | US9708313...)
Show SMILES CN1CCc2nc(NC3CC3)c(nc2C1)N1CCC(CC1)[C@@H](F)c1ccc(F)cc1F
Show InChI InChI=1S/C23H28F3N5/c1-30-9-8-19-20(13-30)29-23(22(28-19)27-16-3-4-16)31-10-6-14(7-11-31)21(26)17-5-2-15(24)12-18(17)25/h2,5,12,14,16,21H,3-4,6-11,13H2,1H3,(H,27,28)/t21-/m1/s1
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0265n/an/an/an/an/a37



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair