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81 molecules are shown

Compile data set for download or QSAR
Wt: 457.5
BDBM190934
Wt: 496.5
BDBM190937
Wt: 497.4
BDBM190938
Wt: 511.5
BDBM190939
Wt: 459.5
BDBM190940
Wt: 495.5
BDBM190941
Wt: 488.5
BDBM190943
Wt: 488.5
BDBM190944
Wt: 510.5
BDBM190945
Wt: 467.4
BDBM190947
Wt: 439.4
BDBM190948
Wt: 461.5
BDBM190949
Wt: 449.5
BDBM190950
Wt: 463.4
BDBM190951
Wt: 515.5
BDBM191030
<<  First   |  Previous   |  Displayed 16 to 30 (of 81 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 43 hits for monomerid = 190934,190937,190938,190939,190940,190941,190943,190944,190945,190947,190948,190949,190950,190951,191030   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190937
PNG
(US10077266, Example 49 | US9181249, 49 | US9708313...)
Show SMILES CN(C)C(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H28F4N6O2/c1-31(2)23(34)33-10-7-17-18(13-33)30-22(21(29-17)28-12-20(26)27)32-8-5-15(6-9-32)35-19-4-3-14(24)11-16(19)25/h3-4,11,15,20H,5-10,12-13H2,1-2H3,(H,28,29)
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n/an/a 0.00910n/an/an/an/an/a37



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191030
PNG
(US10077266, Example 142 | US9181249, 142 | US97083...)
Show SMILES CC(=O)O[C@@H]1C[C@@H](C1)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C26H31F2N5O4/c1-15(34)33-10-7-22-23(14-33)30-25(29-18-12-20(13-18)36-16(2)35)26(31-22)32-8-5-19(6-9-32)37-24-4-3-17(27)11-21(24)28/h3-4,11,18-20H,5-10,12-14H2,1-2H3,(H,29,30)/t18-,20+
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n/an/a 1.14E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190934
PNG
(US10077266, Example 45 | US9181249, 45 | US9708313...)
Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CCN(Cc3nc2NC(C)C)C(C)=O)c(F)c1
Show InChI InChI=1S/C24H32FN5O3/c1-15(2)26-23-24(28-20-9-12-30(16(3)31)14-21(20)27-23)29-10-7-17(8-11-29)33-22-6-5-18(32-4)13-19(22)25/h5-6,13,15,17H,7-12,14H2,1-4H3,(H,26,27)
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n/an/a 0.0741n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190938
PNG
(US10077266, Example 50 | US9181249, 50 | US9708313...)
Show SMILES COCC(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H27F4N5O3/c1-34-13-21(33)32-9-6-17-18(12-32)30-23(22(29-17)28-11-20(26)27)31-7-4-15(5-8-31)35-19-3-2-14(24)10-16(19)25/h2-3,10,15,20H,4-9,11-13H2,1H3,(H,28,29)
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n/an/a 0.0795n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190940
PNG
(US10077266, Example 52 | US9181249, 52 | US9708313...)
Show SMILES CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H31F2N5O2/c1-14(2)27-23-24(28-20-9-12-31(16(4)32)15(3)22(20)29-23)30-10-7-18(8-11-30)33-21-6-5-17(25)13-19(21)26/h5-6,13-15,18H,7-12H2,1-4H3,(H,27,29)
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n/an/a 0.0732n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190941
PNG
(US10077266, Example 53 | US9181249, 53 | US9708313...)
Show SMILES CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C24H29F4N5O2/c1-13(2)29-22-23(30-18-8-11-33(24(34)21(27)28)14(3)20(18)31-22)32-9-6-16(7-10-32)35-19-5-4-15(25)12-17(19)26/h4-5,12-14,16,21H,6-11H2,1-3H3,(H,29,31)
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n/an/a 0.0950n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190943
PNG
(US10077266, Example 55 | US9181249, 55 | US9708313...)
Show SMILES CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H34F2N6O2/c1-15(2)28-23-24(29-20-10-13-33(25(34)31(4)5)16(3)22(20)30-23)32-11-8-18(9-12-32)35-21-7-6-17(26)14-19(21)27/h6-7,14-16,18H,8-13H2,1-5H3,(H,28,30)
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n/an/a 0.110n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190944
PNG
(US10077266, Example 56 | US9181249, 56 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H34F2N6O2/c1-15(2)28-23-24(30-22-16(3)33(25(34)31(4)5)13-10-20(22)29-23)32-11-8-18(9-12-32)35-21-7-6-17(26)14-19(21)27/h6-7,14-16,18H,8-13H2,1-5H3,(H,28,29)
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n/an/a 0.179n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190945
PNG
(US10077266, Example 57 | US9181249, 57 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C24H30F4N6O2/c1-14-21-18(8-11-34(14)24(35)32(2)3)30-22(29-13-20(27)28)23(31-21)33-9-6-16(7-10-33)36-19-5-4-15(25)12-17(19)26/h4-5,12,14,16,20H,6-11,13H2,1-3H3,(H,29,30)
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n/an/a 0.0935n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190947
PNG
(US10077266, Example 59 | US9181249, 59 | US9708313...)
Show SMILES CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1
Show InChI InChI=1S/C22H25F4N5O2/c1-13(32)31-9-6-17-18(12-31)28-21(27-11-20(25)26)22(29-17)30-7-4-15(5-8-30)33-19-3-2-14(23)10-16(19)24/h2-3,10,15,20H,4-9,11-12H2,1H3,(H,27,28)
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n/an/a 0.0497n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190948
PNG
(US10077266, Example 60 | US9181249, 60 | US9708313...)
Show SMILES CN1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1
Show InChI InChI=1S/C21H25F4N5O/c1-29-7-6-16-17(12-29)27-20(26-11-19(24)25)21(28-16)30-8-4-14(5-9-30)31-18-3-2-13(22)10-15(18)23/h2-3,10,14,19H,4-9,11-12H2,1H3,(H,26,27)
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n/an/a>1n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190949
PNG
(US10077266, Example 61 | US9181249, 61 | US9708313...)
Show SMILES COC(=O)N1CCc2nc(NC(C)C)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H29F2N5O3/c1-14(2)26-21-22(28-19-13-30(23(31)32-3)11-8-18(19)27-21)29-9-6-16(7-10-29)33-20-5-4-15(24)12-17(20)25/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,26,27)
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n/an/a 0.132n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190950
PNG
(US10077266, Example 62 | US9181249, 62 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(CCF)Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H30F3N5O/c1-15(2)27-22-23(29-20-14-30(12-8-24)9-7-19(20)28-22)31-10-5-17(6-11-31)32-21-4-3-16(25)13-18(21)26/h3-4,13,15,17H,5-12,14H2,1-2H3,(H,27,28)
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n/an/a 0.0692n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190951
PNG
(US9181249, 63)
Show SMILES CC(C)Nc1nc2CN(CCc2nc1N1CCC(Oc2ccc(F)cc2F)[C@H](F)C1)C(C)=O
Show InChI InChI=1S/C23H28F3N5O2/c1-13(2)27-22-23(29-18-6-8-30(14(3)32)12-19(18)28-22)31-9-7-21(17(26)11-31)33-20-5-4-15(24)10-16(20)25/h4-5,10,13,17,21H,6-9,11-12H2,1-3H3,(H,27,28)/t17-,21?/m1/s1
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n/an/a 0.0378n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191030
PNG
(US10077266, Example 142 | US9181249, 142 | US97083...)
Show SMILES CC(=O)O[C@@H]1C[C@@H](C1)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C26H31F2N5O4/c1-15(34)33-10-7-22-23(14-33)30-25(29-18-12-20(13-18)36-16(2)35)26(31-22)32-8-5-19(6-9-32)37-24-4-3-17(27)11-21(24)28/h3-4,11,18-20H,5-10,12-14H2,1-2H3,(H,29,30)/t18-,20+
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n/an/a 0.114n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190934
PNG
(US10077266, Example 45 | US9181249, 45 | US9708313...)
Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CCN(Cc3nc2NC(C)C)C(C)=O)c(F)c1
Show InChI InChI=1S/C24H32FN5O3/c1-15(2)26-23-24(28-20-9-12-30(16(3)31)14-21(20)27-23)29-10-7-17(8-11-29)33-22-6-5-18(32-4)13-19(22)25/h5-6,13,15,17H,7-12,14H2,1-4H3,(H,26,27)
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n/an/a 7.41E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190937
PNG
(US10077266, Example 49 | US9181249, 49 | US9708313...)
Show SMILES CN(C)C(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H28F4N6O2/c1-31(2)23(34)33-10-7-17-18(13-33)30-22(21(29-17)28-12-20(26)27)32-8-5-15(6-9-32)35-19-4-3-14(24)11-16(19)25/h3-4,11,15,20H,5-10,12-13H2,1-2H3,(H,28,29)
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n/an/a 9.10E+3n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190938
PNG
(US10077266, Example 50 | US9181249, 50 | US9708313...)
Show SMILES COCC(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H27F4N5O3/c1-34-13-21(33)32-9-6-17-18(12-32)30-23(22(29-17)28-11-20(26)27)31-7-4-15(5-8-31)35-19-3-2-14(24)10-16(19)25/h2-3,10,15,20H,4-9,11-13H2,1H3,(H,28,29)
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n/an/a 7.95E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190939
PNG
(US10077266, Example 51 | US9181249, 51 | US9708313...)
Show SMILES CO[C@H](C)C(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C24H29F4N5O3/c1-14(35-2)24(34)33-10-7-18-19(13-33)31-23(22(30-18)29-12-21(27)28)32-8-5-16(6-9-32)36-20-4-3-15(25)11-17(20)26/h3-4,11,14,16,21H,5-10,12-13H2,1-2H3,(H,29,30)/t14-/m1/s1
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n/an/a 6.60E+3n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190940
PNG
(US10077266, Example 52 | US9181249, 52 | US9708313...)
Show SMILES CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H31F2N5O2/c1-14(2)27-23-24(28-20-9-12-31(16(4)32)15(3)22(20)29-23)30-10-7-18(8-11-30)33-21-6-5-17(25)13-19(21)26/h5-6,13-15,18H,7-12H2,1-4H3,(H,27,29)
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n/an/a 7.32E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190941
PNG
(US10077266, Example 53 | US9181249, 53 | US9708313...)
Show SMILES CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C24H29F4N5O2/c1-13(2)29-22-23(30-18-8-11-33(24(34)21(27)28)14(3)20(18)31-22)32-9-6-16(7-10-32)35-19-5-4-15(25)12-17(19)26/h4-5,12-14,16,21H,6-11H2,1-3H3,(H,29,31)
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n/an/a 9.50E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190943
PNG
(US10077266, Example 55 | US9181249, 55 | US9708313...)
Show SMILES CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H34F2N6O2/c1-15(2)28-23-24(29-20-10-13-33(25(34)31(4)5)16(3)22(20)30-23)32-11-8-18(9-12-32)35-21-7-6-17(26)14-19(21)27/h6-7,14-16,18H,8-13H2,1-5H3,(H,28,30)
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n/an/a 1.10E+5n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190944
PNG
(US10077266, Example 56 | US9181249, 56 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H34F2N6O2/c1-15(2)28-23-24(30-22-16(3)33(25(34)31(4)5)13-10-20(22)29-23)32-11-8-18(9-12-32)35-21-7-6-17(26)14-19(21)27/h6-7,14-16,18H,8-13H2,1-5H3,(H,28,29)
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n/an/a 1.79E+5n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190945
PNG
(US10077266, Example 57 | US9181249, 57 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C24H30F4N6O2/c1-14-21-18(8-11-34(14)24(35)32(2)3)30-22(29-13-20(27)28)23(31-21)33-9-6-16(7-10-33)36-19-5-4-15(25)12-17(19)26/h4-5,12,14,16,20H,6-11,13H2,1-3H3,(H,29,30)
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n/an/a 9.35E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190947
PNG
(US10077266, Example 59 | US9181249, 59 | US9708313...)
Show SMILES CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1
Show InChI InChI=1S/C22H25F4N5O2/c1-13(32)31-9-6-17-18(12-31)28-21(27-11-20(25)26)22(29-17)30-7-4-15(5-8-30)33-19-3-2-14(23)10-16(19)24/h2-3,10,15,20H,4-9,11-12H2,1H3,(H,27,28)
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n/an/a 4.97E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190948
PNG
(US10077266, Example 60 | US9181249, 60 | US9708313...)
Show SMILES CN1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1
Show InChI InChI=1S/C21H25F4N5O/c1-29-7-6-16-17(12-29)27-20(26-11-19(24)25)21(28-16)30-8-4-14(5-9-30)31-18-3-2-13(22)10-15(18)23/h2-3,10,14,19H,4-9,11-12H2,1H3,(H,26,27)
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n/an/a>1.00E+6n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190949
PNG
(US10077266, Example 61 | US9181249, 61 | US9708313...)
Show SMILES COC(=O)N1CCc2nc(NC(C)C)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H29F2N5O3/c1-14(2)26-21-22(28-19-13-30(23(31)32-3)11-8-18(19)27-21)29-9-6-16(7-10-29)33-20-5-4-15(24)12-17(20)25/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,26,27)
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n/an/a 1.32E+5n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190950
PNG
(US10077266, Example 62 | US9181249, 62 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(CCF)Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H30F3N5O/c1-15(2)27-22-23(29-20-14-30(12-8-24)9-7-19(20)28-22)31-10-5-17(6-11-31)32-21-4-3-16(25)13-18(21)26/h3-4,13,15,17H,5-12,14H2,1-2H3,(H,27,28)
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n/an/a 6.92E+4n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM191030
PNG
(US10077266, Example 142 | US9181249, 142 | US97083...)
Show SMILES CC(=O)O[C@@H]1C[C@@H](C1)Nc1nc2CN(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C26H31F2N5O4/c1-15(34)33-10-7-22-23(14-33)30-25(29-18-12-20(13-18)36-16(2)35)26(31-22)32-8-5-19(6-9-32)37-24-4-3-17(27)11-21(24)28/h3-4,11,18-20H,5-10,12-14H2,1-2H3,(H,29,30)/t18-,20+
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n/an/a 1.14E+5n/an/an/an/an/an/a



TAKEDA PHARMACEUTICAL COMPANY LIMITED

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US10077266 (2018)


BindingDB Entry DOI: 10.7270/Q2T155PB
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190934
PNG
(US10077266, Example 45 | US9181249, 45 | US9708313...)
Show SMILES COc1ccc(OC2CCN(CC2)c2nc3CCN(Cc3nc2NC(C)C)C(C)=O)c(F)c1
Show InChI InChI=1S/C24H32FN5O3/c1-15(2)26-23-24(28-20-9-12-30(16(3)31)14-21(20)27-23)29-10-7-17(8-11-29)33-22-6-5-18(32-4)13-19(22)25/h5-6,13,15,17H,7-12,14H2,1-4H3,(H,26,27)
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n/an/a 7.41E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190937
PNG
(US10077266, Example 49 | US9181249, 49 | US9708313...)
Show SMILES CN(C)C(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H28F4N6O2/c1-31(2)23(34)33-10-7-17-18(13-33)30-22(21(29-17)28-12-20(26)27)32-8-5-15(6-9-32)35-19-4-3-14(24)11-16(19)25/h3-4,11,15,20H,5-10,12-13H2,1-2H3,(H,28,29)
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n/an/a 9.10E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190938
PNG
(US10077266, Example 50 | US9181249, 50 | US9708313...)
Show SMILES COCC(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H27F4N5O3/c1-34-13-21(33)32-9-6-17-18(12-32)30-23(22(29-17)28-11-20(26)27)31-7-4-15(5-8-31)35-19-3-2-14(24)10-16(19)25/h2-3,10,15,20H,4-9,11-13H2,1H3,(H,28,29)
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n/an/a 7.95E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190939
PNG
(US10077266, Example 51 | US9181249, 51 | US9708313...)
Show SMILES CO[C@H](C)C(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C24H29F4N5O3/c1-14(35-2)24(34)33-10-7-18-19(13-33)31-23(22(30-18)29-12-21(27)28)32-8-5-16(6-9-32)36-20-4-3-15(25)11-17(20)26/h3-4,11,14,16,21H,5-10,12-13H2,1-2H3,(H,29,30)/t14-/m1/s1
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n/an/a 6.60E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Inhibition of cAMP Activity of GPR6 In Vitro AssayThis cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity o...


US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190940
PNG
(US10077266, Example 52 | US9181249, 52 | US9708313...)
Show SMILES CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(C)=O
Show InChI InChI=1S/C24H31F2N5O2/c1-14(2)27-23-24(28-20-9-12-31(16(4)32)15(3)22(20)29-23)30-10-7-18(8-11-30)33-21-6-5-17(25)13-19(21)26/h5-6,13-15,18H,7-12H2,1-4H3,(H,27,29)
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n/an/a 7.32E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190941
PNG
(US10077266, Example 53 | US9181249, 53 | US9708313...)
Show SMILES CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)C(F)F
Show InChI InChI=1S/C24H29F4N5O2/c1-13(2)29-22-23(30-18-8-11-33(24(34)21(27)28)14(3)20(18)31-22)32-9-6-16(7-10-32)35-19-5-4-15(25)12-17(19)26/h4-5,12-14,16,21H,6-11H2,1-3H3,(H,29,31)
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n/an/a 9.50E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190943
PNG
(US10077266, Example 55 | US9181249, 55 | US9708313...)
Show SMILES CC(C)Nc1nc2C(C)N(CCc2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H34F2N6O2/c1-15(2)28-23-24(29-20-10-13-33(25(34)31(4)5)16(3)22(20)30-23)32-11-8-18(9-12-32)35-21-7-6-17(26)14-19(21)27/h6-7,14-16,18H,8-13H2,1-5H3,(H,28,30)
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n/an/a 1.10E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190944
PNG
(US10077266, Example 56 | US9181249, 56 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(C(C)c2nc1N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C25H34F2N6O2/c1-15(2)28-23-24(30-22-16(3)33(25(34)31(4)5)13-10-20(22)29-23)32-11-8-18(9-12-32)35-21-7-6-17(26)14-19(21)27/h6-7,14-16,18H,8-13H2,1-5H3,(H,28,29)
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n/an/a 1.79E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190945
PNG
(US10077266, Example 57 | US9181249, 57 | US9708313...)
Show SMILES CC1N(CCc2nc(NCC(F)F)c(nc12)N1CCC(CC1)Oc1ccc(F)cc1F)C(=O)N(C)C
Show InChI InChI=1S/C24H30F4N6O2/c1-14-21-18(8-11-34(14)24(35)32(2)3)30-22(29-13-20(27)28)23(31-21)33-9-6-16(7-10-33)36-19-5-4-15(25)12-17(19)26/h4-5,12,14,16,20H,6-11,13H2,1-3H3,(H,29,30)
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n/an/a 9.35E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190947
PNG
(US10077266, Example 59 | US9181249, 59 | US9708313...)
Show SMILES CC(=O)N1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1
Show InChI InChI=1S/C22H25F4N5O2/c1-13(32)31-9-6-17-18(12-31)28-21(27-11-20(25)26)22(29-17)30-7-4-15(5-8-30)33-19-3-2-14(23)10-16(19)24/h2-3,10,15,20H,4-9,11-12H2,1H3,(H,27,28)
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n/an/a 4.97E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190948
PNG
(US10077266, Example 60 | US9181249, 60 | US9708313...)
Show SMILES CN1CCc2nc(N3CCC(CC3)Oc3ccc(F)cc3F)c(NCC(F)F)nc2C1
Show InChI InChI=1S/C21H25F4N5O/c1-29-7-6-16-17(12-29)27-20(26-11-19(24)25)21(28-16)30-8-4-14(5-9-30)31-18-3-2-13(22)10-15(18)23/h2-3,10,14,19H,4-9,11-12H2,1H3,(H,26,27)
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n/an/a>1.00E+6n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190949
PNG
(US10077266, Example 61 | US9181249, 61 | US9708313...)
Show SMILES COC(=O)N1CCc2nc(NC(C)C)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H29F2N5O3/c1-14(2)26-21-22(28-19-13-30(23(31)32-3)11-8-18(19)27-21)29-9-6-16(7-10-29)33-20-5-4-15(24)12-17(20)25/h4-5,12,14,16H,6-11,13H2,1-3H3,(H,26,27)
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n/an/a 1.32E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190950
PNG
(US10077266, Example 62 | US9181249, 62 | US9708313...)
Show SMILES CC(C)Nc1nc2CCN(CCF)Cc2nc1N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C23H30F3N5O/c1-15(2)27-22-23(29-20-14-30(12-8-24)9-7-19(20)28-22)31-10-5-17(6-11-31)32-21-4-3-16(25)13-18(21)26/h3-4,13,15,17H,5-12,14H2,1-2H3,(H,27,28)
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n/an/a 6.92E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9708313 (2017)


BindingDB Entry DOI: 10.7270/Q2ZP4858
More data for this
Ligand-Target Pair
G-protein coupled receptor 6


(Homo sapiens (Human))
BDBM190939
PNG
(US10077266, Example 51 | US9181249, 51 | US9708313...)
Show SMILES CO[C@H](C)C(=O)N1CCc2nc(NCC(F)F)c(nc2C1)N1CCC(CC1)Oc1ccc(F)cc1F
Show InChI InChI=1S/C24H29F4N5O3/c1-14(35-2)24(34)33-10-7-18-19(13-33)31-23(22(30-18)29-12-21(27)28)32-8-5-16(6-9-32)36-20-4-3-15(25)11-17(20)26/h3-4,11,14,16,21H,5-10,12-13H2,1-2H3,(H,29,30)/t14-/m1/s1
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n/an/a 0.00660n/an/an/an/an/a37



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
This cell based assay measures the ability of compounds to inhibit the constitutive cAMP activity of GPR6 receptor expressed in CHO-K1 cells. CHO cel...


US Patent US9181249 (2015)


BindingDB Entry DOI: 10.7270/Q2HM577D
More data for this
Ligand-Target Pair